UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DDX42-BRIP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DDX42-BRIP1
	FusionPDB ID: 21999
	FusionGDB2.0 ID: 21999
		Hgene	Tgene
	Gene symbol	DDX42	BRIP1
	Gene ID	11325	83990
	Gene name	DEAD-box helicase 42	BRCA1 interacting protein C-terminal helicase 1
	Synonyms	DDX42P\|RHELP\|RNAHP\|SF3B8\|SF3b125	BACH1\|FANCJ\|OF
	Cytomap	17q23.3	17q23.2
	Type of gene	protein-coding	protein-coding
	Description	ATP-dependent RNA helicase DDX42DEAD (Asp-Glu-Ala-Asp) box helicase 42DEAD (Asp-Glu-Ala-Asp) box polypeptide 42SF3b DEAD box proteinsplicing factor 3B-associated 125 kDa proteinsplicing factor 3b, subunit 8	Fanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1
	Modification date	20200313	20200315
	UniProtAcc	Q86XP3	Q9BX63
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000359353, ENST00000389924, ENST00000457800, ENST00000578681, ENST00000583590, ENST00000582985,	ENST00000583837, ENST00000259008, ENST00000577598,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 12 X 6=864	12 X 15 X 7=1260
	# samples	14	13
	** MAII score	log2(14/864*10)=-2.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1260*10)=-3.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DDX42 [Title/Abstract] AND BRIP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DDX42(61884014)-BRIP1(59886118), # samples:4
Anticipated loss of major functional domain due to fusion event.	DDX42-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDX42-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDX42-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DDX42-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DDX42	GO:0008104	protein localization	19377511
Tgene	BRIP1	GO:0006357	regulation of transcription by RNA polymerase II	14504288

Fusion gene breakpoints across DDX42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A25B-01A	DDX42	chr17	61884014	-	BRIP1	chr17	59886118	-
ChimerDB4	BRCA	TCGA-A2-A25B-01A	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-
ChimerDB4	BRCA	TCGA-A2-A25B	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000578681	DDX42	chr17	61884014	+	ENST00000259008	BRIP1	chr17	59886118	-	6600	1447	571	4569	1332
ENST00000578681	DDX42	chr17	61884014	+	ENST00000577598	BRIP1	chr17	59886118	-	4789	1447	571	3804	1077
ENST00000583590	DDX42	chr17	61884014	+	ENST00000259008	BRIP1	chr17	59886118	-	6411	1258	412	4380	1322
ENST00000583590	DDX42	chr17	61884014	+	ENST00000577598	BRIP1	chr17	59886118	-	4600	1258	412	3615	1067
ENST00000359353	DDX42	chr17	61884014	+	ENST00000259008	BRIP1	chr17	59886118	-	5965	812	311	3934	1207
ENST00000359353	DDX42	chr17	61884014	+	ENST00000577598	BRIP1	chr17	59886118	-	4154	812	311	3169	952
ENST00000389924	DDX42	chr17	61884014	+	ENST00000259008	BRIP1	chr17	59886118	-	6185	1032	186	4154	1322
ENST00000389924	DDX42	chr17	61884014	+	ENST00000577598	BRIP1	chr17	59886118	-	4374	1032	186	3389	1067
ENST00000457800	DDX42	chr17	61884014	+	ENST00000259008	BRIP1	chr17	59886118	-	5999	846	0	3968	1322
ENST00000457800	DDX42	chr17	61884014	+	ENST00000577598	BRIP1	chr17	59886118	-	4188	846	0	3203	1067

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000578681	ENST00000259008	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000180416	0.9998196
ENST00000578681	ENST00000577598	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000301487	0.9996985
ENST00000583590	ENST00000259008	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000145718	0.9998542
ENST00000583590	ENST00000577598	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000238588	0.9997614
ENST00000359353	ENST00000259008	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000125828	0.9998741
ENST00000359353	ENST00000577598	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000136606	0.9998634
ENST00000389924	ENST00000259008	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.00011149	0.99988854
ENST00000389924	ENST00000577598	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000177653	0.9998223
ENST00000457800	ENST00000259008	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	8.81E-05	0.9999119
ENST00000457800	ENST00000577598	DDX42	chr17	61884014	+	BRIP1	chr17	59886118	-	0.000141314	0.9998586

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21999_21999_1_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000359353_BRIP1_chr17_59886118_ENST00000259008_length(amino acids)=1207AA_BP=166
MEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDH
SEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQPPGHCSRCCCSTK
QGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYF
YHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCA
RESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQG
HFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQ
KTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEF
QDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCR
GKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNN
PSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKIC
VQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASS
PPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFE
TEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGN

--------------------------------------------------------------

>21999_21999_2_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000359353_BRIP1_chr17_59886118_ENST00000577598_length(amino acids)=952AA_BP=166
MEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDH
SEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQPPGHCSRCCCSTK
QGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYF
YHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCA
RESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQG
HFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQ
KTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEF
QDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCR
GKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNN
PSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKIC

--------------------------------------------------------------

>21999_21999_3_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000389924_BRIP1_chr17_59886118_ENST00000259008_length(amino acids)=1322AA_BP=281
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPY
IPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRK
SEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPE
VVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQI
RESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKI
WSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYS
WTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVW
VGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE
LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQ
ALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYS
TSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNS
LGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEE
ALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKA

--------------------------------------------------------------

>21999_21999_4_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000389924_BRIP1_chr17_59886118_ENST00000577598_length(amino acids)=1067AA_BP=281
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPY
IPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRK
SEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPE
VVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQI
RESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKI
WSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYS
WTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVW
VGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE
LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQ
ALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYS

--------------------------------------------------------------

>21999_21999_5_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000457800_BRIP1_chr17_59886118_ENST00000259008_length(amino acids)=1322AA_BP=281
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPY
IPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRK
SEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPE
VVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQI
RESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKI
WSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYS
WTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVW
VGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE
LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQ
ALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYS
TSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNS
LGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEE
ALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKA

--------------------------------------------------------------

>21999_21999_6_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000457800_BRIP1_chr17_59886118_ENST00000577598_length(amino acids)=1067AA_BP=281
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPY
IPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRK
SEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPE
VVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQI
RESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKI
WSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYS
WTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVW
VGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE
LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQ
ALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYS

--------------------------------------------------------------

>21999_21999_7_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000578681_BRIP1_chr17_59886118_ENST00000259008_length(amino acids)=1332AA_BP=291
MAHKRSVIGTMNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEE
EDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTA
GVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGF
DEQLMHQIRKSEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILS
SRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFC
PYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLV
ERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADD
YKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEA
NHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEP
QGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWY
EIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNES
TLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQT
KRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKN
HSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIK

--------------------------------------------------------------

>21999_21999_8_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000578681_BRIP1_chr17_59886118_ENST00000577598_length(amino acids)=1077AA_BP=291
MAHKRSVIGTMNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEE
EDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTA
GVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGF
DEQLMHQIRKSEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILS
SRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFC
PYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLV
ERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADD
YKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEA
NHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEP
QGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWY
EIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNES

--------------------------------------------------------------

>21999_21999_9_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000583590_BRIP1_chr17_59886118_ENST00000259008_length(amino acids)=1322AA_BP=281
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPY
IPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRK
SEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPE
VVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQI
RESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKI
WSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYS
WTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVW
VGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE
LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQ
ALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYS
TSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNS
LGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEE
ALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKA

--------------------------------------------------------------

>21999_21999_10_DDX42-BRIP1_DDX42_chr17_61884014_ENST00000583590_BRIP1_chr17_59886118_ENST00000577598_length(amino acids)=1067AA_BP=281
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPY
IPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDN
LEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRK
SEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPE
VVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQI
RESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKI
WSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYS
WTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVW
VGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDE
LLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQ
ALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:61884014/chr17:59886118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DDX42 Q86XP3	BRIP1 Q9BX63
FUNCTION: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269\|PubMed:16397294, ECO:0000269\|PubMed:19377511}.	FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269\|PubMed:11301010, ECO:0000269\|PubMed:14983014, ECO:0000269\|PubMed:16116421, ECO:0000269\|PubMed:16153896}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

116_157

163.0

820.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

116_157

282.0

939.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

116_157

282.0

939.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

116_157

282.0

939.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

116_157

282.0

939.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

43_46

163.0

820.0

Compositional bias

Note=Poly-Ser

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

175_178

282.0

939.0

Compositional bias

Note=Poly-Glu

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

43_46

282.0

939.0

Compositional bias

Note=Poly-Ser

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

175_178

282.0

939.0

Compositional bias

Note=Poly-Glu

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

43_46

282.0

939.0

Compositional bias

Note=Poly-Ser

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

175_178

282.0

939.0

Compositional bias

Note=Poly-Glu

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

43_46

282.0

939.0

Compositional bias

Note=Poly-Ser

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

175_178

282.0

939.0

Compositional bias

Note=Poly-Glu

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

43_46

282.0

939.0

Compositional bias

Note=Poly-Ser

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

253_281

282.0

939.0

Motif

Note=Q motif

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

253_281

282.0

939.0

Motif

Note=Q motif

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

253_281

282.0

939.0

Motif

Note=Q motif

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

253_281

282.0

939.0

Motif

Note=Q motif

Tgene

BRIP1

chr17:61884014

chr17:59886118

ENST00000259008

393_396

209.0

1250.0

Motif

Note=DEAH box

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

175_178

163.0

820.0

Compositional bias

Note=Poly-Glu

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

654_659

163.0

820.0

Compositional bias

Note=Poly-Gly

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

762_883

163.0

820.0

Compositional bias

Note=Gly-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

819_871

163.0

820.0

Compositional bias

Note=His-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

654_659

282.0

939.0

Compositional bias

Note=Poly-Gly

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

762_883

282.0

939.0

Compositional bias

Note=Gly-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

819_871

282.0

939.0

Compositional bias

Note=His-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

654_659

282.0

939.0

Compositional bias

Note=Poly-Gly

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

762_883

282.0

939.0

Compositional bias

Note=Gly-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

819_871

282.0

939.0

Compositional bias

Note=His-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

654_659

282.0

939.0

Compositional bias

Note=Poly-Gly

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

762_883

282.0

939.0

Compositional bias

Note=Gly-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

819_871

282.0

939.0

Compositional bias

Note=His-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

654_659

282.0

939.0

Compositional bias

Note=Poly-Gly

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

762_883

282.0

939.0

Compositional bias

Note=Gly-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

819_871

282.0

939.0

Compositional bias

Note=His-rich

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

284_459

163.0

820.0

Domain

Helicase ATP-binding

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

487_632

163.0

820.0

Domain

Helicase C-terminal

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

284_459

282.0

939.0

Domain

Helicase ATP-binding

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

487_632

282.0

939.0

Domain

Helicase C-terminal

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

284_459

282.0

939.0

Domain

Helicase ATP-binding

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

487_632

282.0

939.0

Domain

Helicase C-terminal

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

284_459

282.0

939.0

Domain

Helicase ATP-binding

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

487_632

282.0

939.0

Domain

Helicase C-terminal

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

284_459

282.0

939.0

Domain

Helicase ATP-binding

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

487_632

282.0

939.0

Domain

Helicase C-terminal

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

253_281

163.0

820.0

Motif

Note=Q motif

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

407_410

163.0

820.0

Motif

Note=DEAD box

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

407_410

282.0

939.0

Motif

Note=DEAD box

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

407_410

282.0

939.0

Motif

Note=DEAD box

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

407_410

282.0

939.0

Motif

Note=DEAD box

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

407_410

282.0

939.0

Motif

Note=DEAD box

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000359353

297_304

163.0

820.0

Nucleotide binding

ATP

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000389924

297_304

282.0

939.0

Nucleotide binding

ATP

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000457800

297_304

282.0

939.0

Nucleotide binding

ATP

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000578681

297_304

282.0

939.0

Nucleotide binding

ATP

Hgene

DDX42

chr17:61884014

chr17:59886118

ENST00000583590

297_304

282.0

939.0

Nucleotide binding

ATP

Tgene

BRIP1

chr17:61884014

chr17:59886118

ENST00000259008

11_442

209.0

1250.0

Domain

Helicase ATP-binding

Tgene

BRIP1

chr17:61884014

chr17:59886118

ENST00000259008

158_175

209.0

1250.0

Motif

Nuclear localization signal

Tgene

BRIP1

chr17:61884014

chr17:59886118

ENST00000259008

185_192

209.0

1250.0

Nucleotide binding

ATP

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2008_DDX42_61884014_BRIP1_59886118_ranked_0.pdb	DDX42	61884014	61884014	ENST00000577598	BRIP1	chr17	59886118	-	MAHKRSVIGTMNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEE EDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTA GVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGF DEQLMHQIRKSEYTQPTPIQCQPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILS SRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFC PYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLV ERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADD YKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEA NHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEP QGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWY EIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNES TLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQT KRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKN HSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIK	1332

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DDX42_pLDDT.png

BRIP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DDX42
BRIP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DDX42-BRIP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DDX42-BRIP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source