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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DENND1A-NDUFA8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DENND1A-NDUFA8
FusionPDB ID: 22200
FusionGDB2.0 ID: 22200
HgeneTgene
Gene symbol

DENND1A

NDUFA8

Gene ID

57706

4702

Gene nameDENN domain containing 1ANADH:ubiquinone oxidoreductase subunit A8
SynonymsFAM31A|KIAA1608CI-19KD|CI-PGIV|PGIV
Cytomap

9q33.3

9q33.2

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDaNADH-ubiquinone oxidoreductase 19 kDa subunitNADH:ubiquinone oxidoreductase PGIV subunitcomplex I-19kDcomplex I-PGIV
Modification date2020032020200313
UniProtAcc

Q8TEH3

P51970

Ensembl transtripts involved in fusion geneENST idsENST00000473039, ENST00000373618, 
ENST00000394215, ENST00000542603, 
ENST00000373620, ENST00000373624, 
ENST00000394219, 		ENST00000373768, 
ENST00000537618, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 18 X 14=45368 X 5 X 6=240
# samples 269
** MAII scorelog2(26/4536*10)=-4.12483711191377
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DENND1A [Title/Abstract] AND NDUFA8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DENND1A(126371715)-NDUFA8(124914687), # samples:3
Anticipated loss of major functional domain due to fusion event.DENND1A-NDUFA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-NDUFA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-NDUFA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-NDUFA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DENND1A-NDUFA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DENND1A-NDUFA8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDENND1A

GO:0032483

regulation of Rab protein signal transduction

20937701


check buttonFusion gene breakpoints across DENND1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDUFA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-H7-A76A-01ADENND1Achr9

126371715

-NDUFA8chr9

124914687

-
ChimerDB4HNSCTCGA-H7-A76ADENND1Achr9

126371714

-NDUFA8chr9

124914687

-
ChimerDB4HNSCTCGA-H7-A76ADENND1Achr9

126371715

-NDUFA8chr9

124914687

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373624DENND1Achr9126371715-ENST00000537618NDUFA8chr9124914687-18069671931302369
ENST00000373624DENND1Achr9126371715-ENST00000373768NDUFA8chr9124914687-16189671931434413
ENST00000394219DENND1Achr9126371715-ENST00000537618NDUFA8chr9124914687-16988591901194334
ENST00000394219DENND1Achr9126371715-ENST00000373768NDUFA8chr9124914687-15108591901326378
ENST00000373620DENND1Achr9126371715-ENST00000537618NDUFA8chr9124914687-18259862121321369
ENST00000373620DENND1Achr9126371715-ENST00000373768NDUFA8chr9124914687-16379862121453413
ENST00000373624DENND1Achr9126371714-ENST00000537618NDUFA8chr9124914687-18069671931302369
ENST00000373624DENND1Achr9126371714-ENST00000373768NDUFA8chr9124914687-16189671931434413
ENST00000394219DENND1Achr9126371714-ENST00000537618NDUFA8chr9124914687-16988591901194334
ENST00000394219DENND1Achr9126371714-ENST00000373768NDUFA8chr9124914687-15108591901326378
ENST00000373620DENND1Achr9126371714-ENST00000537618NDUFA8chr9124914687-18259862121321369
ENST00000373620DENND1Achr9126371714-ENST00000373768NDUFA8chr9124914687-16379862121453413

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373624ENST00000537618DENND1Achr9126371715-NDUFA8chr9124914687-0.0019870380.9980129
ENST00000373624ENST00000373768DENND1Achr9126371715-NDUFA8chr9124914687-0.0014625660.9985374
ENST00000394219ENST00000537618DENND1Achr9126371715-NDUFA8chr9124914687-0.0035707690.99642926
ENST00000394219ENST00000373768DENND1Achr9126371715-NDUFA8chr9124914687-0.0028195760.99718046
ENST00000373620ENST00000537618DENND1Achr9126371715-NDUFA8chr9124914687-0.0019719430.998028
ENST00000373620ENST00000373768DENND1Achr9126371715-NDUFA8chr9124914687-0.0014835870.9985164
ENST00000373624ENST00000537618DENND1Achr9126371714-NDUFA8chr9124914687-0.0019870380.9980129
ENST00000373624ENST00000373768DENND1Achr9126371714-NDUFA8chr9124914687-0.0014625660.9985374
ENST00000394219ENST00000537618DENND1Achr9126371714-NDUFA8chr9124914687-0.0035707690.99642926
ENST00000394219ENST00000373768DENND1Achr9126371714-NDUFA8chr9124914687-0.0028195760.99718046
ENST00000373620ENST00000537618DENND1Achr9126371714-NDUFA8chr9124914687-0.0019719430.998028
ENST00000373620ENST00000373768DENND1Achr9126371714-NDUFA8chr9124914687-0.0014835870.9985164

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22200_22200_1_DENND1A-NDUFA8_DENND1A_chr9_126371714_ENST00000373620_NDUFA8_chr9_124914687_ENST00000373768_length(amino acids)=413AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_2_DENND1A-NDUFA8_DENND1A_chr9_126371714_ENST00000373620_NDUFA8_chr9_124914687_ENST00000537618_length(amino acids)=369AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_3_DENND1A-NDUFA8_DENND1A_chr9_126371714_ENST00000373624_NDUFA8_chr9_124914687_ENST00000373768_length(amino acids)=413AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_4_DENND1A-NDUFA8_DENND1A_chr9_126371714_ENST00000373624_NDUFA8_chr9_124914687_ENST00000537618_length(amino acids)=369AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_5_DENND1A-NDUFA8_DENND1A_chr9_126371714_ENST00000394219_NDUFA8_chr9_124914687_ENST00000373768_length(amino acids)=378AA_BP=223
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVN
KCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEI

--------------------------------------------------------------

>22200_22200_6_DENND1A-NDUFA8_DENND1A_chr9_126371714_ENST00000394219_NDUFA8_chr9_124914687_ENST00000537618_length(amino acids)=334AA_BP=223
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVN

--------------------------------------------------------------

>22200_22200_7_DENND1A-NDUFA8_DENND1A_chr9_126371715_ENST00000373620_NDUFA8_chr9_124914687_ENST00000373768_length(amino acids)=413AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_8_DENND1A-NDUFA8_DENND1A_chr9_126371715_ENST00000373620_NDUFA8_chr9_124914687_ENST00000537618_length(amino acids)=369AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_9_DENND1A-NDUFA8_DENND1A_chr9_126371715_ENST00000373624_NDUFA8_chr9_124914687_ENST00000373768_length(amino acids)=413AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_10_DENND1A-NDUFA8_DENND1A_chr9_126371715_ENST00000373624_NDUFA8_chr9_124914687_ENST00000537618_length(amino acids)=369AA_BP=258
MGTMGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFC
RLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFV
AVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAA
HHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVR

--------------------------------------------------------------

>22200_22200_11_DENND1A-NDUFA8_DENND1A_chr9_126371715_ENST00000394219_NDUFA8_chr9_124914687_ENST00000373768_length(amino acids)=378AA_BP=223
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVN
KCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEI

--------------------------------------------------------------

>22200_22200_12_DENND1A-NDUFA8_DENND1A_chr9_126371715_ENST00000394219_NDUFA8_chr9_124914687_ENST00000537618_length(amino acids)=334AA_BP=223
MRRPGDHGLQDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYTTK
RQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIH
GSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:126371715/chr9:124914687)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1A

Q8TEH3

NDUFA8

P51970

FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373618-101913_145223.0467.0DomainuDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373620-112113_145255.0560.0DomainuDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373624-112213_145255.01010.0DomainuDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394215-102013_145225.0530.0DomainuDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394219-92113_145223.01021.0DomainuDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373618-101913_145223.0467.0DomainuDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373620-112113_145255.0560.0DomainuDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373624-112213_145255.01010.0DomainuDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394215-102013_145225.0530.0DomainuDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394219-92113_145223.01021.0DomainuDENN
TgeneNDUFA8chr9:126371714chr9:124914687ENST000003737680433_7417.0173.0DomainCHCH 1
TgeneNDUFA8chr9:126371714chr9:124914687ENST000003737680475_11817.0173.0DomainCHCH 2
TgeneNDUFA8chr9:126371715chr9:124914687ENST000003737680433_7417.0173.0DomainCHCH 1
TgeneNDUFA8chr9:126371715chr9:124914687ENST000003737680475_11817.0173.0DomainCHCH 2
TgeneNDUFA8chr9:126371714chr9:124914687ENST0000037376804100_11017.0173.0MotifCx9C motif 4
TgeneNDUFA8chr9:126371714chr9:124914687ENST000003737680436_4617.0173.0MotifCx9C motif 1
TgeneNDUFA8chr9:126371714chr9:124914687ENST000003737680456_6617.0173.0MotifCx9C motif 2
TgeneNDUFA8chr9:126371714chr9:124914687ENST000003737680478_8817.0173.0MotifCx9C motif 3
TgeneNDUFA8chr9:126371715chr9:124914687ENST0000037376804100_11017.0173.0MotifCx9C motif 4
TgeneNDUFA8chr9:126371715chr9:124914687ENST000003737680436_4617.0173.0MotifCx9C motif 1
TgeneNDUFA8chr9:126371715chr9:124914687ENST000003737680456_6617.0173.0MotifCx9C motif 2
TgeneNDUFA8chr9:126371715chr9:124914687ENST000003737680478_8817.0173.0MotifCx9C motif 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373618-1019649_995223.0467.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373620-1121649_995255.0560.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373624-1122649_995255.01010.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394215-1020649_995225.0530.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394219-921649_995223.01021.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371714chr9:124914687ENST00000542603-314649_99539.0795.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373618-1019649_995223.0467.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373620-1121649_995255.0560.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373624-1122649_995255.01010.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394215-1020649_995225.0530.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394219-921649_995223.01021.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371715chr9:124914687ENST00000542603-314649_99539.0795.0Compositional biasNote=Pro-rich
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373618-1019162_298223.0467.0DomaincDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373618-1019300_378223.0467.0DomaindDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373620-1121162_298255.0560.0DomaincDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373620-1121300_378255.0560.0DomaindDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373624-1122162_298255.01010.0DomaincDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373624-1122300_378255.01010.0DomaindDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394215-1020162_298225.0530.0DomaincDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394215-1020300_378225.0530.0DomaindDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394219-921162_298223.01021.0DomaincDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394219-921300_378223.01021.0DomaindDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000542603-31413_14539.0795.0DomainuDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000542603-314162_29839.0795.0DomaincDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000542603-314300_37839.0795.0DomaindDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373618-1019162_298223.0467.0DomaincDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373618-1019300_378223.0467.0DomaindDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373620-1121162_298255.0560.0DomaincDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373620-1121300_378255.0560.0DomaindDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373624-1122162_298255.01010.0DomaincDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373624-1122300_378255.01010.0DomaindDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394215-1020162_298225.0530.0DomaincDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394215-1020300_378225.0530.0DomaindDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394219-921162_298223.01021.0DomaincDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394219-921300_378223.01021.0DomaindDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000542603-31413_14539.0795.0DomainuDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000542603-314162_29839.0795.0DomaincDENN
HgeneDENND1Achr9:126371715chr9:124914687ENST00000542603-314300_37839.0795.0DomaindDENN
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373618-1019381_385223.0467.0MotifFXDXF motif
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373618-1019569_578223.0467.0MotifClathrin box
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373620-1121381_385255.0560.0MotifFXDXF motif
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373620-1121569_578255.0560.0MotifClathrin box
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373624-1122381_385255.01010.0MotifFXDXF motif
HgeneDENND1Achr9:126371714chr9:124914687ENST00000373624-1122569_578255.01010.0MotifClathrin box
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394215-1020381_385225.0530.0MotifFXDXF motif
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394215-1020569_578225.0530.0MotifClathrin box
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394219-921381_385223.01021.0MotifFXDXF motif
HgeneDENND1Achr9:126371714chr9:124914687ENST00000394219-921569_578223.01021.0MotifClathrin box
HgeneDENND1Achr9:126371714chr9:124914687ENST00000542603-314381_38539.0795.0MotifFXDXF motif
HgeneDENND1Achr9:126371714chr9:124914687ENST00000542603-314569_57839.0795.0MotifClathrin box
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373618-1019381_385223.0467.0MotifFXDXF motif
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373618-1019569_578223.0467.0MotifClathrin box
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373620-1121381_385255.0560.0MotifFXDXF motif
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373620-1121569_578255.0560.0MotifClathrin box
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373624-1122381_385255.01010.0MotifFXDXF motif
HgeneDENND1Achr9:126371715chr9:124914687ENST00000373624-1122569_578255.01010.0MotifClathrin box
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394215-1020381_385225.0530.0MotifFXDXF motif
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394215-1020569_578225.0530.0MotifClathrin box
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394219-921381_385223.01021.0MotifFXDXF motif
HgeneDENND1Achr9:126371715chr9:124914687ENST00000394219-921569_578223.01021.0MotifClathrin box
HgeneDENND1Achr9:126371715chr9:124914687ENST00000542603-314381_38539.0795.0MotifFXDXF motif
HgeneDENND1Achr9:126371715chr9:124914687ENST00000542603-314569_57839.0795.0MotifClathrin box


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DENND1A_pLDDT.png
all structure
all structure
NDUFA8_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DENND1A
NDUFA8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DENND1A-NDUFA8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DENND1A-NDUFA8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource