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Fusion Protein:DEPDC5-CELSR1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: DEPDC5-CELSR1 | FusionPDB ID: 22311 | FusionGDB2.0 ID: 22311 | Hgene | Tgene | Gene symbol | DEPDC5 | CELSR1 | Gene ID | 9681 | 9620 |
| Gene name | DEP domain containing 5, GATOR1 subcomplex subunit | cadherin EGF LAG seven-pass G-type receptor 1 | |
| Synonyms | DEP.5|FFEVF|FFEVF1 | ADGRC1|CDHF9|FMI2|HFMI2|ME2 | |
| Cytomap | 22q12.2-q12.3 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GATOR complex protein DEPDC5DEP domain containing 5DEP domain-containing protein 5 | cadherin EGF LAG seven-pass G-type receptor 1adhesion G protein-coupled receptor C1cadherin family member 9cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)flamingo homolog 2protocadherin flamingo 2 | |
| Modification date | 20200315 | 20200322 | |
| UniProtAcc | O75140 | Q9NYQ6 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000266091, ENST00000382105, ENST00000382111, ENST00000382112, ENST00000400246, ENST00000400248, ENST00000400249, ENST00000535622, ENST00000539165, ENST00000400242, ENST00000494060, ENST00000536766, | ENST00000395964, ENST00000497509, ENST00000262738, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 15 X 15 X 5=1125 | 7 X 7 X 4=196 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/1125*10)=-3.00642626915943 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: DEPDC5 [Title/Abstract] AND CELSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DEPDC5(32275603)-CELSR1(46792627), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DEPDC5-CELSR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DEPDC5-CELSR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DEPDC5-CELSR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DEPDC5-CELSR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DEPDC5-CELSR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DEPDC5-CELSR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DEPDC5-CELSR1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across DEPDC5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CELSR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF845393 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000535622 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9390 | 3718 | 78 | 3800 | 1240 |
| ENST00000400246 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9754 | 4082 | 142 | 4164 | 1340 |
| ENST00000266091 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9688 | 4016 | 142 | 4098 | 1318 |
| ENST00000400249 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9661 | 3989 | 142 | 4071 | 1309 |
| ENST00000382112 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9655 | 3983 | 70 | 4065 | 1331 |
| ENST00000382111 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9672 | 4000 | 60 | 4082 | 1340 |
| ENST00000400248 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 9578 | 3906 | 59 | 3988 | 1309 |
| ENST00000539165 | DEPDC5 | chr22 | 32275603 | + | ENST00000262738 | CELSR1 | chr22 | 46792627 | - | 6551 | 879 | 4398 | 5288 | 296 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000535622 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.000432727 | 0.9995672 |
| ENST00000400246 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.001252163 | 0.9987478 |
| ENST00000266091 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.001160179 | 0.9988398 |
| ENST00000400249 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.000796984 | 0.999203 |
| ENST00000382112 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.000885487 | 0.99911445 |
| ENST00000382111 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.001143906 | 0.99885607 |
| ENST00000400248 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.000722143 | 0.9992779 |
| ENST00000539165 | ENST00000262738 | DEPDC5 | chr22 | 32275603 | + | CELSR1 | chr22 | 46792627 | - | 0.4541822 | 0.5458178 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >22311_22311_1_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000266091_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1318AA_BP=1284 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAI QIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQG YQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFV EGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQ LLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRAEELVHSEIPAFLL -------------------------------------------------------------- >22311_22311_2_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000382111_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1340AA_BP=1306 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAI QIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQG YQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFV EGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP TYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASS LTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKI -------------------------------------------------------------- >22311_22311_3_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000382112_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1331AA_BP=1297 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAI QIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKT QKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRR HRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKD GAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTE ILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRA -------------------------------------------------------------- >22311_22311_4_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000400246_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1340AA_BP=1306 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAI QIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQG YQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFV EGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP TYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASS LTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKI -------------------------------------------------------------- >22311_22311_5_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000400248_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1309AA_BP=1275 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAI QIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKT QKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRR HRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLS PYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRAEELVHSEIPAFLLPWLPSRPAS -------------------------------------------------------------- >22311_22311_6_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000400249_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1309AA_BP=1275 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAI QIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKT QKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRR HRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLS PYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRAEELVHSEIPAFLLPWLPSRPAS -------------------------------------------------------------- >22311_22311_7_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000535622_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=1240AA_BP=1206 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVV DPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSL LVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESE NALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGMNPRTQ NKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQV FEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHY TYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADED EWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSA QSAESSSVAMTPTYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEI LEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRAE -------------------------------------------------------------- >22311_22311_8_DEPDC5-CELSR1_DEPDC5_chr22_32275603_ENST00000539165_CELSR1_chr22_46792627_ENST00000262738_length(amino acids)=296AA_BP= MAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGI PAIVTERGGPASEDCHLCRCVLVTGSPAGGLRPPEPGPHAALQPAQHSQAPRRGALPLSAGVRDWDQPDGKPALVGREGGLPGAASSCPG TGHMSPASAATQPALRCSWISPGVRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLARPPAEAGWP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:32275603/chr22:46792627) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DEPDC5 | CELSR1 |
| FUNCTION: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:29769719}. | FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2659_2663 | 0.0 | 3015.0 | Compositional bias | Note=Poly-Leu | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1000_1101 | 0.0 | 3015.0 | Domain | Cadherin 8 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1106_1224 | 0.0 | 3015.0 | Domain | Cadherin 9 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1303_1361 | 0.0 | 3015.0 | Domain | EGF-like 1%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1363_1399 | 0.0 | 3015.0 | Domain | EGF-like 2%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1403_1441 | 0.0 | 3015.0 | Domain | EGF-like 3%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1442_1646 | 0.0 | 3015.0 | Domain | Laminin G-like 1 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1649_1685 | 0.0 | 3015.0 | Domain | EGF-like 4%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1689_1870 | 0.0 | 3015.0 | Domain | Laminin G-like 2 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1872_1907 | 0.0 | 3015.0 | Domain | EGF-like 5%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1908_1946 | 0.0 | 3015.0 | Domain | EGF-like 6%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1947_1979 | 0.0 | 3015.0 | Domain | EGF-like 7%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 1981_2016 | 0.0 | 3015.0 | Domain | EGF-like 8%3B calcium-binding | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2003_2050 | 0.0 | 3015.0 | Domain | Laminin EGF-like | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2408_2460 | 0.0 | 3015.0 | Domain | GPS | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 246_353 | 0.0 | 3015.0 | Domain | Cadherin 1 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 354_459 | 0.0 | 3015.0 | Domain | Cadherin 2 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 460_565 | 0.0 | 3015.0 | Domain | Cadherin 3 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 566_687 | 0.0 | 3015.0 | Domain | Cadherin 4 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 688_789 | 0.0 | 3015.0 | Domain | Cadherin 5 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 790_892 | 0.0 | 3015.0 | Domain | Cadherin 6 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 893_999 | 0.0 | 3015.0 | Domain | Cadherin 7 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 22_2469 | 0.0 | 3015.0 | Topological domain | Extracellular | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2491_2501 | 0.0 | 3015.0 | Topological domain | Cytoplasmic | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2523_2527 | 0.0 | 3015.0 | Topological domain | Extracellular | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2549_2572 | 0.0 | 3015.0 | Topological domain | Cytoplasmic | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2594_2611 | 0.0 | 3015.0 | Topological domain | Extracellular | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2633_2655 | 0.0 | 3015.0 | Topological domain | Cytoplasmic | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2677_2683 | 0.0 | 3015.0 | Topological domain | Extracellular | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2705_3014 | 0.0 | 3015.0 | Topological domain | Cytoplasmic | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2470_2490 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D1 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2502_2522 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D2 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2528_2548 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D3 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2573_2593 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D4 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2612_2632 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D5 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2656_2676 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D6 | |
| Tgene | CELSR1 | chr22:32275603 | chr22:46792627 | ENST00000262738 | 0 | 35 | 2684_2704 | 0.0 | 3015.0 | Transmembrane | Helical%3B Name%3D7 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000266091 | + | 1 | 42 | 1187_1262 | 0 | 1582.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000382111 | + | 1 | 41 | 1187_1262 | 0 | 1553.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000382112 | + | 1 | 42 | 1187_1262 | 0 | 1595.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000400242 | + | 1 | 22 | 1187_1262 | 0 | 560.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000400246 | + | 1 | 42 | 1187_1262 | 0 | 1553.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000400248 | + | 1 | 41 | 1187_1262 | 0 | 1573.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000400249 | + | 1 | 42 | 1187_1262 | 0 | 1573.0 | Domain | DEP |
| Hgene | DEPDC5 | chr22:32275603 | chr22:46792627 | ENST00000535622 | + | 1 | 40 | 1187_1262 | 0 | 1504.0 | Domain | DEP |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| DEPDC5 | |
| CELSR1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to DEPDC5-CELSR1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to DEPDC5-CELSR1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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