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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADCY6-DCTN2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADCY6-DCTN2
FusionPDB ID: 2243
FusionGDB2.0 ID: 2243
HgeneTgene
Gene symbol

ADCY6

DCTN2

Gene ID

112

10540

Gene nameadenylate cyclase 6dynactin subunit 2
SynonymsAC6|LCCS8DCTN50|DYNAMITIN|HEL-S-77|RBP50
Cytomap

12q13.12

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 6ATP pyrophosphate-lyase 6adenylate cyclase type VIca(2+)-inhibitable adenylyl cyclasedynactin subunit 250 kDa dynein-associated polypeptidedynactin 2 (p50)dynactin complex 50 kDa subunitepididymis secretory protein Li 77epididymis secretory sperm binding proteinp50 dynamitin
Modification date2020031320200313
UniProtAcc

O43306

Q13561

Ensembl transtripts involved in fusion geneENST idsENST00000307885, ENST00000357869, 
ENST00000550422, ENST00000552090, 
ENST00000551400, ENST00000434715, 
ENST00000537439, ENST00000543672, 
ENST00000548249, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 2=187 X 3 X 6=126
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADCY6 [Title/Abstract] AND DCTN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADCY6(49162720)-DCTN2(57926098), # samples:1
Anticipated loss of major functional domain due to fusion event.ADCY6-DCTN2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADCY6-DCTN2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADCY6-DCTN2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADCY6

GO:0006171

cAMP biosynthetic process

17916776|18403039

HgeneADCY6

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

17916776

HgeneADCY6

GO:0007212

dopamine receptor signaling pathway

18403039

HgeneADCY6

GO:0071380

cellular response to prostaglandin E stimulus

18403039

HgeneADCY6

GO:0071870

cellular response to catecholamine stimulus

18403039

HgeneADCY6

GO:1904322

cellular response to forskolin

17916776


check buttonFusion gene breakpoints across ADCY6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DCTN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A208-01AADCY6chr12

49162720

-DCTN2chr12

57926098

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357869ADCY6chr1249162720-ENST00000548249DCTN2chr1257926098-4751388266041631167
ENST00000357869ADCY6chr1249162720-ENST00000537439DCTN2chr1257926098-4542388266041631167
ENST00000357869ADCY6chr1249162720-ENST00000434715DCTN2chr1257926098-4542388266041631167
ENST00000357869ADCY6chr1249162720-ENST00000543672DCTN2chr1257926098-4542388266041631167
ENST00000307885ADCY6chr1249162720-ENST00000548249DCTN2chr1257926098-4945407669543571220
ENST00000307885ADCY6chr1249162720-ENST00000537439DCTN2chr1257926098-4736407669543571220
ENST00000307885ADCY6chr1249162720-ENST00000434715DCTN2chr1257926098-4736407669543571220
ENST00000307885ADCY6chr1249162720-ENST00000543672DCTN2chr1257926098-4736407669543571220

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357869ENST00000548249ADCY6chr1249162720-DCTN2chr1257926098-0.0023726590.9976273
ENST00000357869ENST00000537439ADCY6chr1249162720-DCTN2chr1257926098-0.0027018380.9972982
ENST00000357869ENST00000434715ADCY6chr1249162720-DCTN2chr1257926098-0.0027018380.9972982
ENST00000357869ENST00000543672ADCY6chr1249162720-DCTN2chr1257926098-0.0027018380.9972982
ENST00000307885ENST00000548249ADCY6chr1249162720-DCTN2chr1257926098-0.0027178910.99728215
ENST00000307885ENST00000537439ADCY6chr1249162720-DCTN2chr1257926098-0.0030603810.99693966
ENST00000307885ENST00000434715ADCY6chr1249162720-DCTN2chr1257926098-0.0030603810.99693966
ENST00000307885ENST00000543672ADCY6chr1249162720-DCTN2chr1257926098-0.0030603810.99693966

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2243_2243_1_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000307885_DCTN2_chr12_57926098_ENST00000434715_length(amino acids)=1220AA_BP=1126
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTC
SFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE
FYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLT

--------------------------------------------------------------

>2243_2243_2_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000307885_DCTN2_chr12_57926098_ENST00000537439_length(amino acids)=1220AA_BP=1126
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTC
SFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE
FYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLT

--------------------------------------------------------------

>2243_2243_3_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000307885_DCTN2_chr12_57926098_ENST00000543672_length(amino acids)=1220AA_BP=1126
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTC
SFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE
FYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLT

--------------------------------------------------------------

>2243_2243_4_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000307885_DCTN2_chr12_57926098_ENST00000548249_length(amino acids)=1220AA_BP=1126
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTC
SFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE
FYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLT

--------------------------------------------------------------

>2243_2243_5_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000357869_DCTN2_chr12_57926098_ENST00000434715_length(amino acids)=1167AA_BP=1073
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFD
NYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP
KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGL
NASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYE

--------------------------------------------------------------

>2243_2243_6_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000357869_DCTN2_chr12_57926098_ENST00000537439_length(amino acids)=1167AA_BP=1073
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFD
NYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP
KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGL
NASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYE

--------------------------------------------------------------

>2243_2243_7_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000357869_DCTN2_chr12_57926098_ENST00000543672_length(amino acids)=1167AA_BP=1073
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFD
NYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP
KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGL
NASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYE

--------------------------------------------------------------

>2243_2243_8_ADCY6-DCTN2_ADCY6_chr12_49162720_ENST00000357869_DCTN2_chr12_57926098_ENST00000548249_length(amino acids)=1167AA_BP=1073
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIRRGGPGKGKELGLRAVALG
FEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTL
HLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSR
AIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFD
NYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP
KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGL
NASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVHQLYE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:49162720/chr12:57926098)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY6

O43306

DCTN2

Q13561

FUNCTION: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (PubMed:17916776). Contributes to bone cell responses to mechanical stimuli (By similarity). {ECO:0000250|UniProtKB:Q01341, ECO:0000250|UniProtKB:Q03343, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:17916776}.FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-20211105_11071127.01169.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-20211112_11161127.01169.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021384_3891127.01169.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021426_4281127.01169.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920384_3891074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920426_4281074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021384_3891074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021426_4281074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-20211_1511127.01169.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021306_6731127.01169.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021760_8191127.01169.0Topological domainExtracellular
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-19201_1511074.01116.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920306_6731074.01116.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920760_8191074.01116.0Topological domainExtracellular
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-20211_1511074.01116.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021306_6731074.01116.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021760_8191074.01116.0Topological domainExtracellular
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021152_1681127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021181_1971127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021214_2301127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021239_2551127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021259_2751127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021289_3051127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021674_6911127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021702_7181127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021743_7591127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021820_8361127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021839_8551127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021897_9131127.01169.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920152_1681074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920181_1971074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920214_2301074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920239_2551074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920259_2751074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920289_3051074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920674_6911074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920702_7181074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920743_7591074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920820_8361074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920839_8551074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920897_9131074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021152_1681074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021181_1971074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021214_2301074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021239_2551074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021259_2751074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021289_3051074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021674_6911074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021702_7181074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021743_7591074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021820_8361074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021839_8551074.01116.0TransmembraneHelical
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021897_9131074.01116.0TransmembraneHelical
TgeneDCTN2chr12:49162720chr12:57926098ENST000004347151216379_399313.0407.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN2chr12:49162720chr12:57926098ENST000005482491014379_399308.0402.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-19201105_11071074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-19201112_11161074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-20211105_11071074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-20211112_11161074.01116.0Nucleotide bindingATP
HgeneADCY6chr12:49162720chr12:57926098ENST00000307885-2021914_11681127.01169.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000357869-1920914_11681074.01116.0Topological domainCytoplasmic
HgeneADCY6chr12:49162720chr12:57926098ENST00000550422-2021914_11681074.01116.0Topological domainCytoplasmic
TgeneDCTN2chr12:49162720chr12:57926098ENST000004347151216214_244313.0407.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN2chr12:49162720chr12:57926098ENST00000434715121699_132313.0407.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN2chr12:49162720chr12:57926098ENST000005482491014214_244308.0402.0Coiled coilOntology_term=ECO:0000255
TgeneDCTN2chr12:49162720chr12:57926098ENST00000548249101499_132308.0402.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADCY6
DCTN2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADCY6-DCTN2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADCY6-DCTN2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource