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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DHCR24-PCNXL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DHCR24-PCNXL2
FusionPDB ID: 22516
FusionGDB2.0 ID: 22516
HgeneTgene
Gene symbol

DHCR24

PCNXL2

Gene ID

1718

80003

Gene name24-dehydrocholesterol reductasepecanex 2
SynonymsDCE|Nbla03646|SELADIN1|seladin-1PCNXL2
Cytomap

1p32.3

1q42.2

Type of geneprotein-codingprotein-coding
Descriptiondelta(24)-sterol reductase3 beta-hydroxysterol delta 24-reductasedesmosterol-to-cholesterol enzymediminuto/dwarf1 homologseladin 1selective AD indicator 1pecanex-like protein 2pecanex homolog 2
Modification date2020032020200313
UniProtAcc

Q15392

.
Ensembl transtripts involved in fusion geneENST idsENST00000371269, ENST00000535035, 
ENST00000537443, 		ENST00000344698, 
ENST00000430153, ENST00000488780, 
ENST00000520463, ENST00000258229, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 16 X 8=26887 X 6 X 5=210
# samples 229
** MAII scorelog2(22/2688*10)=-3.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DHCR24 [Title/Abstract] AND PCNXL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DHCR24(55319710)-PCNXL2(233314921), # samples:2
Anticipated loss of major functional domain due to fusion event.DHCR24-PCNXL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHCR24-PCNXL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DHCR24-PCNXL2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHCR24

GO:0043066

negative regulation of apoptotic process

15688385

HgeneDHCR24

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

11007892


check buttonFusion gene breakpoints across DHCR24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCNXL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7253-01ADHCR24chr1

55319710

-PCNXL2chr1

233314921

-
ChimerDB4HNSCTCGA-CV-7253DHCR24chr1

55319709

-PCNXL2chr1

233314921

-
ChimerDB4HNSCTCGA-CV-7253DHCR24chr1

55319710

-PCNXL2chr1

233314921

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371269DHCR24chr155319709-ENST00000258229PCNXL2chr1233314921-55341317646641552
ENST00000535035DHCR24chr155319709-ENST00000258229PCNXL2chr1233314921-53951178245251507
ENST00000371269DHCR24chr155319710-ENST00000258229PCNXL2chr1233314921-55341317646641552
ENST00000535035DHCR24chr155319710-ENST00000258229PCNXL2chr1233314921-53951178245251507

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371269ENST00000258229DHCR24chr155319709-PCNXL2chr1233314921-0.0030893450.99691063
ENST00000535035ENST00000258229DHCR24chr155319709-PCNXL2chr1233314921-0.0027181890.9972818
ENST00000371269ENST00000258229DHCR24chr155319710-PCNXL2chr1233314921-0.0030893450.99691063
ENST00000535035ENST00000258229DHCR24chr155319710-PCNXL2chr1233314921-0.0027181890.9972818

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22516_22516_1_DHCR24-PCNXL2_DHCR24_chr1_55319709_ENST00000371269_PCNXL2_chr1_233314921_ENST00000258229_length(amino acids)=1552AA_BP=437
MWATGAERARRGAGGSDRRREPAALTARRRTMEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFK
LSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSI
GWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVK
LRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYH
RHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHEPWSMQHIPALFS
AFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFL
SIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHR
RLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSF
HVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTR
TLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLS
CNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAM
FNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKG
DFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDE
GADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQL
KNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKG
RSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSST
SSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCR

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>22516_22516_2_DHCR24-PCNXL2_DHCR24_chr1_55319709_ENST00000535035_PCNXL2_chr1_233314921_ENST00000258229_length(amino acids)=1507AA_BP=392
LRCGGGQDFLGGWGAGVGEGLERNKNVMGAGEQNRQSAHCVQGICGYLEGDEEGEEGEVRSTQVREWKEQGSKTFMCTGRPGWLTVSLRV
GKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVL
ADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVM
TDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETL
RKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAA
DPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQRE
VRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYK
DISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRP
VKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLV
TFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILI
RYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDS
DEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYED
PAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRN
PERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGG
APTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRL
SGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGP

--------------------------------------------------------------

>22516_22516_3_DHCR24-PCNXL2_DHCR24_chr1_55319710_ENST00000371269_PCNXL2_chr1_233314921_ENST00000258229_length(amino acids)=1552AA_BP=437
MWATGAERARRGAGGSDRRREPAALTARRRTMEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFK
LSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSI
GWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVK
LRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYH
RHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHEPWSMQHIPALFS
AFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFL
SIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHR
RLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSF
HVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTR
TLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLS
CNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAM
FNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKG
DFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDE
GADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQL
KNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKG
RSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSST
SSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCR

--------------------------------------------------------------

>22516_22516_4_DHCR24-PCNXL2_DHCR24_chr1_55319710_ENST00000535035_PCNXL2_chr1_233314921_ENST00000258229_length(amino acids)=1507AA_BP=392
LRCGGGQDFLGGWGAGVGEGLERNKNVMGAGEQNRQSAHCVQGICGYLEGDEEGEEGEVRSTQVREWKEQGSKTFMCTGRPGWLTVSLRV
GKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVL
ADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVM
TDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETL
RKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAA
DPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQRE
VRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYK
DISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRP
VKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLV
TFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILI
RYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDS
DEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYED
PAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRN
PERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGG
APTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKGRSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRL
SGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:55319710/chr1:233314921)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHCR24

Q15392

.
FUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011, ECO:0000269|PubMed:21671375, ECO:0000269|PubMed:22010141, ECO:0000269|PubMed:22178193, ECO:0000269|PubMed:25637936}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHCR24chr1:55319709chr1:233314921ENST00000371269-7958_234406.0517.0DomainFAD-binding PCMH-type
HgeneDHCR24chr1:55319710chr1:233314921ENST00000371269-7958_234406.0517.0DomainFAD-binding PCMH-type
HgeneDHCR24chr1:55319709chr1:233314921ENST00000371269-79163_175406.0517.0Nucleotide bindingFAD
HgeneDHCR24chr1:55319710chr1:233314921ENST00000371269-79163_175406.0517.0Nucleotide bindingFAD
HgeneDHCR24chr1:55319709chr1:233314921ENST00000371269-7923_31406.0517.0Topological domainLumenal
HgeneDHCR24chr1:55319710chr1:233314921ENST00000371269-7923_31406.0517.0Topological domainLumenal
HgeneDHCR24chr1:55319709chr1:233314921ENST00000371269-7932_52406.0517.0TransmembraneHelical
HgeneDHCR24chr1:55319710chr1:233314921ENST00000371269-7932_52406.0517.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341937_20631022.02138.0Compositional biasNote=Ser-rich
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101937_20630778.0Compositional biasNote=Ser-rich
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141937_20630287.0Compositional biasNote=Ser-rich
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341937_20631022.02138.0Compositional biasNote=Ser-rich
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101937_20630778.0Compositional biasNote=Ser-rich
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141937_20630287.0Compositional biasNote=Ser-rich
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341029_10491022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341099_11191022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341124_11441022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341193_12131022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341237_12571022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341265_12851022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341302_13221022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000025822914341324_13441022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101029_10490778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101099_11190778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101124_11440778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101193_12130778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101237_12570778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101265_12850778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101302_13220778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000003446980101324_13440778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000034469801034_540778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000034469801057_770778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000344698010844_8640778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000344698010868_8880778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000344698010901_9210778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000344698010952_9720778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000344698010983_10030778.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141029_10490287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141099_11190287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141124_11440287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141193_12130287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141237_12570287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141265_12850287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141302_13220287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000004301530141324_13440287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000043015301434_540287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST0000043015301457_770287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000430153014844_8640287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000430153014868_8880287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000430153014901_9210287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000430153014952_9720287.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000430153014983_10030287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341029_10491022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341099_11191022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341124_11441022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341193_12131022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341237_12571022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341265_12851022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341302_13221022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000025822914341324_13441022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101029_10490778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101099_11190778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101124_11440778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101193_12130778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101237_12570778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101265_12850778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101302_13220778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000003446980101324_13440778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000034469801034_540778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000034469801057_770778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000344698010844_8640778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000344698010868_8880778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000344698010901_9210778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000344698010952_9720778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000344698010983_10030778.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141029_10490287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141099_11190287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141124_11440287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141193_12130287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141237_12570287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141265_12850287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141302_13220287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000004301530141324_13440287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000043015301434_540287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST0000043015301457_770287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000430153014844_8640287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000430153014868_8880287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000430153014901_9210287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000430153014952_9720287.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000430153014983_10030287.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHCR24chr1:55319709chr1:233314921ENST00000371269-7953_516406.0517.0Topological domainCytoplasmic
HgeneDHCR24chr1:55319710chr1:233314921ENST00000371269-7953_516406.0517.0Topological domainCytoplasmic
TgenePCNXL2chr1:55319709chr1:233314921ENST00000258229143434_541022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST00000258229143457_771022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000002582291434844_8641022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000002582291434868_8881022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000002582291434901_9211022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000002582291434952_9721022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319709chr1:233314921ENST000002582291434983_10031022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000258229143434_541022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST00000258229143457_771022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000002582291434844_8641022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000002582291434868_8881022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000002582291434901_9211022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000002582291434952_9721022.02138.0TransmembraneHelical
TgenePCNXL2chr1:55319710chr1:233314921ENST000002582291434983_10031022.02138.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2080_DHCR24_55319710_PCNXL2_233314921_ranked_0.pdbDHCR245531971055319710ENST00000258229PCNXL2chr1233314921-
MWATGAERARRGAGGSDRRREPAALTARRRTMEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFK
LSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSI
GWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVK
LRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYH
RHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHEPWSMQHIPALFS
AFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFPKFLHQNLAESAADPLPKKMKDSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFL
SIVLFALAGAVGFVTHYVLPQLRKHHPWMWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHR
RLGTHWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDLLHKLQFVLTYVAPWQMAWGSSF
HVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYVRPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTR
TLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPGHLPHLLS
CNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVTSPKLLSWIKNESLLKSLQPFAKWHYIERDLAM
FNINIDDDYVPCLQGITRASFCNVYLEWIQHCARKRQEPSTTLDSDEDSPLVTLSFALCTLGRRALGTAAHNMAISLDSFLYGLHVLFKG
DFRITARDEWVFADMDLLHKVVAPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDE
GADEYKVIMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHRQL
KNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAPTTGGNNAPSGGSQESSAEQPRKGGAQHGVSSCEGTQRTGRRKG
RSQSVQAHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGHLSVRERAEALIRSSLGSST
SSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAASQATRHLSEPCEPPDATEQGQLHDRCLAEAVADTLGVVCR
1552


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DHCR24_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DHCR24
PCNXL2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DHCR24-PCNXL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DHCR24-PCNXL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource