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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DHRS12-ATP7B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DHRS12-ATP7B
FusionPDB ID: 22561
FusionGDB2.0 ID: 22561
HgeneTgene
Gene symbol

DHRS12

ATP7B

Gene ID

79758

540

Gene namedehydrogenase/reductase 12ATPase copper transporting beta
SynonymsSDR40C1PWD|WC1|WD|WND
Cytomap

13q14.3

13q14.3

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1copper-transporting ATPase 2ATPase, Cu(2+)- transporting, beta polypeptideATPase, Cu++ transporting, beta polypeptideWilson disease-associated proteincopper pump 2copper-transporting protein ATP7B
Modification date2020031320200329
UniProtAcc

A0PJE2

P35670

Ensembl transtripts involved in fusion geneENST idsENST00000218981, ENST00000280056, 
ENST00000444610, ENST00000490949, 
ENST00000482841, ENST00000542656, 
ENST00000417240, ENST00000242839, 
ENST00000344297, ENST00000400366, 
ENST00000400370, ENST00000418097, 
ENST00000448424, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 7 X 4=1685 X 6 X 3=90
# samples 75
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DHRS12 [Title/Abstract] AND ATP7B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DHRS12(52371962)-ATP7B(52518427), # samples:1
DHRS12(52373670)-ATP7B(52516690), # samples:1
Anticipated loss of major functional domain due to fusion event.DHRS12-ATP7B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DHRS12-ATP7B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DHRS12-ATP7B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATP7B

GO:0006825

copper ion transport

26004889

TgeneATP7B

GO:0015677

copper ion import

16472602

TgeneATP7B

GO:0046688

response to copper ion

15269005|16472602|16939419

TgeneATP7B

GO:0051208

sequestering of calcium ion

16472602


check buttonFusion gene breakpoints across DHRS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP7B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01ADHRS12chr13

52371962

-ATP7Bchr13

52518427

-
ChimerDB4STADTCGA-BR-A4QI-01ADHRS12chr13

52373670

-ATP7Bchr13

52516690

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000444610DHRS12chr1352371962-ENST00000242839ATP7Bchr1352518427-3708287141624536
ENST00000444610DHRS12chr1352371962-ENST00000400366ATP7Bchr1352518427-3707287141624536
ENST00000444610DHRS12chr1352371962-ENST00000344297ATP7Bchr1352518427-3707287141624536
ENST00000444610DHRS12chr1352371962-ENST00000400370ATP7Bchr1352518427-1695287141624536
ENST00000444610DHRS12chr1352371962-ENST00000448424ATP7Bchr1352518427-1695287141624536
ENST00000444610DHRS12chr1352371962-ENST00000418097ATP7Bchr1352518427-1688287141624536
ENST00000218981DHRS12chr1352373670-ENST00000242839ATP7Bchr1352516690-34762381121392426
ENST00000218981DHRS12chr1352373670-ENST00000400366ATP7Bchr1352516690-34752381121392426
ENST00000218981DHRS12chr1352373670-ENST00000344297ATP7Bchr1352516690-34752381121392426
ENST00000218981DHRS12chr1352373670-ENST00000400370ATP7Bchr1352516690-14632381121392426
ENST00000218981DHRS12chr1352373670-ENST00000448424ATP7Bchr1352516690-14632381121392426
ENST00000218981DHRS12chr1352373670-ENST00000418097ATP7Bchr1352516690-14562381121392426
ENST00000218981DHRS12chr1352373670-ENST00000417240ATP7Bchr1352516690-15452381121392426
ENST00000280056DHRS12chr1352373670-ENST00000242839ATP7Bchr1352516690-3417179531333426
ENST00000280056DHRS12chr1352373670-ENST00000400366ATP7Bchr1352516690-3416179531333426
ENST00000280056DHRS12chr1352373670-ENST00000344297ATP7Bchr1352516690-3416179531333426
ENST00000280056DHRS12chr1352373670-ENST00000400370ATP7Bchr1352516690-1404179531333426
ENST00000280056DHRS12chr1352373670-ENST00000448424ATP7Bchr1352516690-1404179531333426
ENST00000280056DHRS12chr1352373670-ENST00000418097ATP7Bchr1352516690-1397179531333426
ENST00000280056DHRS12chr1352373670-ENST00000417240ATP7Bchr1352516690-1486179531333426

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000444610ENST00000242839DHRS12chr1352371962-ATP7Bchr1352518427-0.0023958940.9976042
ENST00000444610ENST00000400366DHRS12chr1352371962-ATP7Bchr1352518427-0.002388050.997612
ENST00000444610ENST00000344297DHRS12chr1352371962-ATP7Bchr1352518427-0.002388050.997612
ENST00000444610ENST00000400370DHRS12chr1352371962-ATP7Bchr1352518427-0.0058583580.99414164
ENST00000444610ENST00000448424DHRS12chr1352371962-ATP7Bchr1352518427-0.0058583580.99414164
ENST00000444610ENST00000418097DHRS12chr1352371962-ATP7Bchr1352518427-0.0057079770.994292
ENST00000218981ENST00000242839DHRS12chr1352373670-ATP7Bchr1352516690-0.0017341910.9982658
ENST00000218981ENST00000400366DHRS12chr1352373670-ATP7Bchr1352516690-0.0017216040.9982784
ENST00000218981ENST00000344297DHRS12chr1352373670-ATP7Bchr1352516690-0.0017216040.9982784
ENST00000218981ENST00000400370DHRS12chr1352373670-ATP7Bchr1352516690-0.0034077450.9965922
ENST00000218981ENST00000448424DHRS12chr1352373670-ATP7Bchr1352516690-0.0034077450.9965922
ENST00000218981ENST00000418097DHRS12chr1352373670-ATP7Bchr1352516690-0.003409790.99659026
ENST00000218981ENST00000417240DHRS12chr1352373670-ATP7Bchr1352516690-0.0033139820.99668604
ENST00000280056ENST00000242839DHRS12chr1352373670-ATP7Bchr1352516690-0.0017725870.9982274
ENST00000280056ENST00000400366DHRS12chr1352373670-ATP7Bchr1352516690-0.0017604180.9982395
ENST00000280056ENST00000344297DHRS12chr1352373670-ATP7Bchr1352516690-0.0017604180.9982395
ENST00000280056ENST00000400370DHRS12chr1352373670-ATP7Bchr1352516690-0.0030969810.996903
ENST00000280056ENST00000448424DHRS12chr1352373670-ATP7Bchr1352516690-0.0030969810.996903
ENST00000280056ENST00000418097DHRS12chr1352373670-ATP7Bchr1352516690-0.0031005590.9968995
ENST00000280056ENST00000417240DHRS12chr1352373670-ATP7Bchr1352516690-0.0029361740.9970638

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22561_22561_1_DHRS12-ATP7B_DHRS12_chr13_52371962_ENST00000444610_ATP7B_chr13_52518427_ENST00000242839_length(amino acids)=536AA_BP=90
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGN
QIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNV
EGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVK
QEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD
VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKP

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>22561_22561_2_DHRS12-ATP7B_DHRS12_chr13_52371962_ENST00000444610_ATP7B_chr13_52518427_ENST00000344297_length(amino acids)=536AA_BP=90
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGN
QIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNV
EGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVK
QEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD
VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKP

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>22561_22561_3_DHRS12-ATP7B_DHRS12_chr13_52371962_ENST00000444610_ATP7B_chr13_52518427_ENST00000400366_length(amino acids)=536AA_BP=90
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGN
QIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNV
EGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVK
QEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD
VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKP

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>22561_22561_4_DHRS12-ATP7B_DHRS12_chr13_52371962_ENST00000444610_ATP7B_chr13_52518427_ENST00000400370_length(amino acids)=536AA_BP=90
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGN
QIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNV
EGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVK
QEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD
VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKP

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>22561_22561_5_DHRS12-ATP7B_DHRS12_chr13_52371962_ENST00000444610_ATP7B_chr13_52518427_ENST00000418097_length(amino acids)=536AA_BP=90
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGN
QIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNV
EGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVK
QEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD
VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKP

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>22561_22561_6_DHRS12-ATP7B_DHRS12_chr13_52371962_ENST00000444610_ATP7B_chr13_52518427_ENST00000448424_length(amino acids)=536AA_BP=90
MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGN
QIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNV
EGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVK
QEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTD
VAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKP

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>22561_22561_7_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000242839_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_8_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000344297_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_9_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000400366_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_10_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000400370_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_11_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000417240_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_12_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000418097_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_13_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000218981_ATP7B_chr13_52516690_ENST00000448424_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_14_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000242839_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_15_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000344297_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

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>22561_22561_16_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000400366_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

--------------------------------------------------------------

>22561_22561_17_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000400370_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

--------------------------------------------------------------

>22561_22561_18_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000417240_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

--------------------------------------------------------------

>22561_22561_19_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000418097_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

--------------------------------------------------------------

>22561_22561_20_DHRS12-ATP7B_DHRS12_chr13_52373670_ENST00000280056_ATP7B_chr13_52516690_ENST00000448424_length(amino acids)=426AA_BP=34
MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNE
AGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLI
TGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVA
SIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:52371962/chr13:52518427)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DHRS12

A0PJE2

ATP7B

P35670

FUNCTION: Putative oxidoreductase. {ECO:0000250}.FUNCTION: Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. {ECO:0000269|PubMed:18203200, ECO:0000269|PubMed:22240481, ECO:0000269|PubMed:24706876, ECO:0000269|PubMed:26004889}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS12chr13:52371962chr13:52518427ENST00000444610-31047_5391.0318.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:52516690ENST00000444610-21047_5363.333333333333336318.0Nucleotide bindingNAD or NADP
TgeneATP7Bchr13:52371962chr13:52518427ENST0000024283912211341_13511020.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST0000024283912211372_14651020.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000003442978171341_1351813.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000003442978171372_1465813.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817943_972813.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817995_1322813.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST0000040036613221341_1351909.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST0000040036613221372_1465909.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322943_972909.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322995_1322909.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST0000024283913211341_13511081.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST0000024283913211372_14651081.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000003442979171341_1351874.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST000003442979171372_1465874.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917943_972874.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917995_1322874.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST0000040036614221341_1351970.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST0000040036614221372_1465970.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422995_1322970.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST0000024283912211323_13401020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST0000024283912211352_13711020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000003442978171323_1340813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000003442978171352_1371813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817920_942813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817973_994813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST0000040036613221323_1340909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST0000040036613221352_1371909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322920_942909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322973_994909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST0000024283913211323_13401081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST0000024283913211352_13711081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000003442979171323_1340874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000003442979171352_1371874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917920_942874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917973_994874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST0000040036614221323_1340970.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST0000040036614221352_1371970.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422973_994970.01355.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDHRS12chr13:52371962chr13:52518427ENST00000218981-1847_530243.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52371962chr13:52518427ENST00000280056-1847_530272.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:52516690ENST00000218981-2847_5342.0243.0Nucleotide bindingNAD or NADP
HgeneDHRS12chr13:52373670chr13:52516690ENST00000280056-2847_5342.0272.0Nucleotide bindingNAD or NADP
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221340_3451020.01466.0Compositional biasNote=Poly-Ser
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817340_345813.01259.0Compositional biasNote=Poly-Ser
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322340_345909.01355.0Compositional biasNote=Poly-Ser
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321340_3451081.01466.0Compositional biasNote=Poly-Ser
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917340_345874.01259.0Compositional biasNote=Poly-Ser
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422340_345970.01355.0Compositional biasNote=Poly-Ser
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221144_2101020.01466.0DomainHMA 2
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221258_3271020.01466.0DomainHMA 3
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221360_4261020.01466.0DomainHMA 4
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221489_5551020.01466.0DomainHMA 5
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221565_6311020.01466.0DomainHMA 6
TgeneATP7Bchr13:52371962chr13:52518427ENST00000242839122159_1251020.01466.0DomainHMA 1
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817144_210813.01259.0DomainHMA 2
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817258_327813.01259.0DomainHMA 3
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817360_426813.01259.0DomainHMA 4
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817489_555813.01259.0DomainHMA 5
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817565_631813.01259.0DomainHMA 6
TgeneATP7Bchr13:52371962chr13:52518427ENST0000034429781759_125813.01259.0DomainHMA 1
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322144_210909.01355.0DomainHMA 2
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322258_327909.01355.0DomainHMA 3
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322360_426909.01355.0DomainHMA 4
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322489_555909.01355.0DomainHMA 5
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322565_631909.01355.0DomainHMA 6
TgeneATP7Bchr13:52371962chr13:52518427ENST00000400366132259_125909.01355.0DomainHMA 1
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321144_2101081.01466.0DomainHMA 2
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321258_3271081.01466.0DomainHMA 3
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321360_4261081.01466.0DomainHMA 4
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321489_5551081.01466.0DomainHMA 5
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321565_6311081.01466.0DomainHMA 6
TgeneATP7Bchr13:52373670chr13:52516690ENST00000242839132159_1251081.01466.0DomainHMA 1
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917144_210874.01259.0DomainHMA 2
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917258_327874.01259.0DomainHMA 3
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917360_426874.01259.0DomainHMA 4
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917489_555874.01259.0DomainHMA 5
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917565_631874.01259.0DomainHMA 6
TgeneATP7Bchr13:52373670chr13:52516690ENST0000034429791759_125874.01259.0DomainHMA 1
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422144_210970.01355.0DomainHMA 2
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422258_327970.01355.0DomainHMA 3
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422360_426970.01355.0DomainHMA 4
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422489_555970.01355.0DomainHMA 5
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422565_631970.01355.0DomainHMA 6
TgeneATP7Bchr13:52373670chr13:52516690ENST00000400366142259_125970.01355.0DomainHMA 1
TgeneATP7Bchr13:52371962chr13:52518427ENST0000024283912211_6531020.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221676_6971020.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221718_7241020.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221746_7641020.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221786_9191020.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221943_9721020.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221995_13221020.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000003442978171_653813.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817676_697813.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817718_724813.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817746_764813.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817786_919813.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST0000040036613221_653909.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322676_697909.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322718_724909.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322746_764909.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322786_919909.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST0000024283913211_6531081.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321676_6971081.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321718_7241081.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321746_7641081.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321786_9191081.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321943_9721081.01466.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321995_13221081.01466.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000003442979171_653874.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917676_697874.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917718_724874.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917746_764874.01259.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917786_919874.01259.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST0000040036614221_653970.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422676_697970.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422718_724970.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422746_764970.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422786_919970.01355.0Topological domainCytoplasmic
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422943_972970.01355.0Topological domainExtracellular
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221654_6751020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221698_7171020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221725_7451020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221765_7851020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221920_9421020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000002428391221973_9941020.01466.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817654_675813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817698_717813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817725_745813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST00000344297817765_785813.01259.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322654_675909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322698_717909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322725_745909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52371962chr13:52518427ENST000004003661322765_785909.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321654_6751081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321698_7171081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321725_7451081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321765_7851081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321920_9421081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000002428391321973_9941081.01466.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917654_675874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917698_717874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917725_745874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST00000344297917765_785874.01259.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422654_675970.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422698_717970.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422725_745970.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422765_785970.01355.0TransmembraneHelical
TgeneATP7Bchr13:52373670chr13:52516690ENST000004003661422920_942970.01355.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DHRS12
ATP7B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DHRS12-ATP7B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DHRS12-ATP7B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource