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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADCY9-GLYR1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADCY9-GLYR1
FusionPDB ID: 2258
FusionGDB2.0 ID: 2258
HgeneTgene
Gene symbol

ADCY9

GLYR1

Gene ID

115

84656

Gene nameadenylate cyclase 9glyoxylate reductase 1 homolog
SynonymsAC9|ACIXBM045|HIBDL|N-PAC|NP60|hNDF
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyaseputative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDanucleosome-destabilizing factor
Modification date2020031320200313
UniProtAcc

O60503

Q49A26

Ensembl transtripts involved in fusion geneENST idsENST00000294016, ENST00000571889, 
ENST00000586901, ENST00000321919, 
ENST00000381983, ENST00000436648, 
ENST00000591451, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 12 X 11=35649 X 6 X 7=378
# samples 2710
** MAII scorelog2(27/3564*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADCY9 [Title/Abstract] AND GLYR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADCY9(4038995)-GLYR1(4862249), # samples:3
GLYR1(4895075)-ADCY9(4057559), # samples:1
Anticipated loss of major functional domain due to fusion event.ADCY9-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCY9-GLYR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
GLYR1-ADCY9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

HgeneADCY9

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

9628827

TgeneGLYR1

GO:0035066

positive regulation of histone acetylation

29759984

TgeneGLYR1

GO:0045944

positive regulation of transcription by RNA polymerase II

29759984


check buttonFusion gene breakpoints across ADCY9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLYR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1RH-01AADCY9chr16

4038995

-GLYR1chr16

4862249

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294016ADCY9chr164038995-ENST00000436648GLYR1chr164862249-542528495393391950
ENST00000294016ADCY9chr164038995-ENST00000321919GLYR1chr164862249-542528495393391950
ENST00000294016ADCY9chr164038995-ENST00000381983GLYR1chr164862249-542228495393391950
ENST00000294016ADCY9chr164038995-ENST00000591451GLYR1chr164862249-357928495393391950

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294016ENST00000436648ADCY9chr164038995-GLYR1chr164862249-0.0012303970.9987696
ENST00000294016ENST00000321919ADCY9chr164038995-GLYR1chr164862249-0.0012303970.9987696
ENST00000294016ENST00000381983ADCY9chr164038995-GLYR1chr164862249-0.0012406040.9987594
ENST00000294016ENST00000591451ADCY9chr164038995-GLYR1chr164862249-0.0034730020.996527

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2258_2258_1_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000321919_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------

>2258_2258_2_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000381983_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------

>2258_2258_3_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000436648_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------

>2258_2258_4_ADCY9-GLYR1_ADCY9_chr16_4038995_ENST00000294016_GLYR1_chr16_4862249_ENST00000591451_length(amino acids)=950AA_BP=770
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW
WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP
SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTC
PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDC
SSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAHVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:4038995/chr16:4862249)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY9

O60503

GLYR1

Q49A26

FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}.FUNCTION: Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984). Facilitates Pol II transcription through nucleosomes (PubMed:29759984). Binds DNA (in vitro) (PubMed:29759984). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Promotes KDM1B demethylase activity (PubMed:23260659). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). Putative oxidoreductase (PubMed:23260659). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611394_521770.01354.0DomainGuanylate cyclase 1
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611399_404770.01354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611441_443770.01354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611139_141770.01354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611163_171770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611193_215770.01354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111_117770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611236_241770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611260_280770.01354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611118_138770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611142_162770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611172_192770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611216_235770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611242_259770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611281_301770.01354.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111058_1198770.01354.0DomainGuanylate cyclase 2
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111185_1187770.01354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-6111192_1196770.01354.0Nucleotide bindingATP
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611302_786770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611808_818770.01354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611840_867770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611889_891770.01354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611913_920770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611942_975770.01354.0Topological domainExtracellular
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611997_1353770.01354.0Topological domainCytoplasmic
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611787_807770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611819_839770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611868_888770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611892_912770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611921_941770.01354.0TransmembraneHelical
HgeneADCY9chr16:4038995chr16:4862249ENST00000294016-611976_996770.01354.0TransmembraneHelical
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116168_180373.0554.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015168_180356.0537.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015168_180292.0473.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116168_180367.0548.0DNA bindingA.T hook
TgeneGLYR1chr16:4038995chr16:4862249ENST0000032191911168_66373.0554.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST0000038198310158_66356.0537.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST0000043664810158_66292.0473.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST0000059145111168_66367.0548.0DomainPWWP
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116271_285373.0554.0Nucleotide bindingNAD
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015271_285356.0537.0Nucleotide bindingNAD
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015271_285292.0473.0Nucleotide bindingNAD
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116271_285367.0548.0Nucleotide bindingNAD


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADCY9
GLYR1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116214_217373.0554.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015214_217356.0537.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015214_217292.0473.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116214_217367.0548.0histone H3
TgeneGLYR1chr16:4038995chr16:4862249ENST000003219191116216_225373.0554.0KDM1B
TgeneGLYR1chr16:4038995chr16:4862249ENST000003819831015216_225356.0537.0KDM1B
TgeneGLYR1chr16:4038995chr16:4862249ENST000004366481015216_225292.0473.0KDM1B
TgeneGLYR1chr16:4038995chr16:4862249ENST000005914511116216_225367.0548.0KDM1B


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Related Drugs to ADCY9-GLYR1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADCY9-GLYR1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource