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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DIDO1-PSMA7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DIDO1-PSMA7
FusionPDB ID: 22806
FusionGDB2.0 ID: 22806
HgeneTgene
Gene symbol

DIDO1

PSMA7

Gene ID

11083

5688

Gene namedeath inducer-obliterator 1proteasome 20S subunit alpha 7
SynonymsBYE1|C20orf158|DATF-1|DATF1|DIDO2|DIDO3|DIO-1|DIO1|dJ885L7.8C6|HEL-S-276|HSPC|RC6-1|XAPC7
Cytomap

20q13.33

20q13.33

Type of geneprotein-codingprotein-coding
Descriptiondeath-inducer obliterator 1death-associated transcription factor 1proteasome subunit alpha type-7epididymis secretory protein Li 276proteasome (prosome, macropain) subunit, alpha type, 7proteasome subunit RC6-1proteasome subunit XAPC7proteasome subunit alpha 4proteasome subunit alpha 7testicular tissue protein Li
Modification date2020031320200327
UniProtAcc

Q9BTC0

.
Ensembl transtripts involved in fusion geneENST idsENST00000266070, ENST00000266071, 
ENST00000354665, ENST00000370366, 
ENST00000370368, ENST00000370371, 
ENST00000395335, ENST00000395340, 
ENST00000395343, 		ENST00000370858, 
ENST00000370861, ENST00000484488, 
ENST00000370873, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 9 X 8=8648 X 8 X 4=256
# samples 1311
** MAII scorelog2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/256*10)=-1.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DIDO1 [Title/Abstract] AND PSMA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DIDO1(61538498)-PSMA7(60716000), # samples:1
Anticipated loss of major functional domain due to fusion event.DIDO1-PSMA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DIDO1-PSMA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DIDO1-PSMA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DIDO1-PSMA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DIDO1-PSMA7 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DIDO1-PSMA7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DIDO1-PSMA7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DIDO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer91NDIDO1chr20

61538498

-PSMA7chr20

60716000

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370366DIDO1chr2061538498-ENST00000370873PSMA7chr2060716000-234615731032223706

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370366ENST00000370873DIDO1chr2061538498-PSMA7chr2060716000-0.0052396320.99476033

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22806_22806_1_DIDO1-PSMA7_DIDO1_chr20_61538498_ENST00000370366_PSMA7_chr20_60716000_ENST00000370873_length(amino acids)=706AA_BP=490
MSAWTQRFRLPGFLVVFRISGKSVQAFSVGAGMDDKGDPSNEEAPKAIKPTSKEFRKTWGFRRTTIAKREGAGDAEADPLEPPPPQQQLG
LSLRRSGRQPKRTERVEQFLTIARRRGRRSMPVSLEDSGEPTSCPATDAETASEGSVESASETRSGPQSASTAVKERPASSEKVKGGDDH
DDTSDSDSDGLTLKELQNRLRRKREQEPTERPLKGIQSRLRKKRREEGPAETVGSEASDTVEGVLPSKQEPENDQGVVSQAGKDDRESKL
EGKAAQDIKDEEPGDLGRPKPECEGYDPNALYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDET
HSETADQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCIGPGCCHVAQPDSVYCSNDCI
LKHAAATMKFLSSGKEQKPKPKEKMKMKPEKPSLPKCGAQVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARI
VINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:61538498/chr20:60716000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIDO1

Q9BTC0

.
FUNCTION: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. {ECO:0000250, ECO:0000269|PubMed:16127461}.; FUNCTION: [Isoform 2]: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. {ECO:0000269|PubMed:16127461}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-516165_173458.02241.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-516185_193458.02241.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-57165_173458.0545.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-57185_193458.0545.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-56165_173458.0563.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-56185_193458.0563.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-46165_173458.0545.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-46185_193458.0545.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-56165_173458.0563.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-56185_193458.0563.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-56165_173458.0563.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-56185_193458.0563.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-515165_173458.01190.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-515185_193458.01190.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-515165_173458.01190.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-515185_193458.01190.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-516165_173458.02241.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-516185_193458.02241.0MotifNuclear localization signal
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-516268_322458.02241.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-57268_322458.0545.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-56268_322458.0563.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-46268_322458.0545.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-56268_322458.0563.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-56268_322458.0563.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-515268_322458.01190.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-515268_322458.01190.0Zinc fingerPHD-type
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-516268_322458.02241.0Zinc fingerPHD-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-5161257_1286458.02241.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-5161725_2034458.02241.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-5162108_2214458.02241.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-571257_1286458.0545.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-571725_2034458.0545.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-572108_2214458.0545.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-561257_1286458.0563.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-561725_2034458.0563.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-562108_2214458.0563.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-461257_1286458.0545.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-461725_2034458.0545.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-462108_2214458.0545.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-561257_1286458.0563.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-561725_2034458.0563.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-562108_2214458.0563.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-561257_1286458.0563.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-561725_2034458.0563.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-562108_2214458.0563.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-5151257_1286458.01190.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-5151725_2034458.01190.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-5152108_2214458.01190.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-5151257_1286458.01190.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-5151725_2034458.01190.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-5152108_2214458.01190.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-5161257_1286458.02241.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-5161725_2034458.02241.0Compositional biasNote=Pro-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-5162108_2214458.02241.0Compositional biasNote=Arg-rich
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266070-516670_790458.02241.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000266071-57670_790458.0545.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000354665-56670_790458.0563.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370366-46670_790458.0545.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370368-56670_790458.0563.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000370371-56670_790458.0563.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395335-515670_790458.01190.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395340-515670_790458.01190.0DomainTFIIS central
HgeneDIDO1chr20:61538498chr20:60716000ENST00000395343-516670_790458.02241.0DomainTFIIS central


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DIDO1
PSMA7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DIDO1-PSMA7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DIDO1-PSMA7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource