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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DIP2C-CIZ1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DIP2C-CIZ1
	FusionPDB ID: 22858
	FusionGDB2.0 ID: 22858
		Hgene	Tgene
	Gene symbol	DIP2C	CIZ1
	Gene ID	22982	25792
	Gene name	disco interacting protein 2 homolog C	CDKN1A interacting zinc finger protein 1
	Synonyms	KIAA0934	LSFR1\|NP94\|ZNF356
	Cytomap	10p15.3	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	disco-interacting protein 2 homolog CDIP2 disco-interacting protein 2 homolog CDIP2 homolog C	cip1-interacting zinc finger proteinnuclear protein NP94zinc finger protein 356
	Modification date	20200313	20200313
	UniProtAcc	Q9Y2E4	Q9ULV3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000280886, ENST00000381496, ENST00000540204,	ENST00000476727, ENST00000277465, ENST00000325721, ENST00000357558, ENST00000372938, ENST00000372948, ENST00000372954, ENST00000393608, ENST00000538431, ENST00000541172,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	25 X 15 X 14=5250	9 X 9 X 4=324
	# samples	27	10
	** MAII score	log2(27/5250*10)=-4.28128611039002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DIP2C [Title/Abstract] AND CIZ1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DIP2C(735433)-CIZ1(130938754), # samples:1
Anticipated loss of major functional domain due to fusion event.	DIP2C-CIZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIP2C-CIZ1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIP2C-CIZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DIP2C-CIZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DIP2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CIZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4HD	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000280886	DIP2C	chr10	735433	-	ENST00000372954	CIZ1	chr9	130938754	-	1184	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000393608	CIZ1	chr9	130938754	-	1184	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000541172	CIZ1	chr9	130938754	-	1183	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000357558	CIZ1	chr9	130938754	-	1183	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000325721	CIZ1	chr9	130938754	-	1183	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000538431	CIZ1	chr9	130938754	-	1261	173	188	1129	313
ENST00000280886	DIP2C	chr10	735433	-	ENST00000277465	CIZ1	chr9	130938754	-	1178	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000372948	CIZ1	chr9	130938754	-	1178	173	188	1051	287
ENST00000280886	DIP2C	chr10	735433	-	ENST00000372938	CIZ1	chr9	130938754	-	1176	173	188	1051	287

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000280886	ENST00000372954	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020160545	0.9798394
ENST00000280886	ENST00000393608	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020160545	0.9798394
ENST00000280886	ENST00000541172	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020184994	0.979815
ENST00000280886	ENST00000357558	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020184994	0.979815
ENST00000280886	ENST00000325721	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020184994	0.979815
ENST00000280886	ENST00000538431	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.032174066	0.96782595
ENST00000280886	ENST00000277465	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020202836	0.9797972
ENST00000280886	ENST00000372948	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.020202836	0.9797972
ENST00000280886	ENST00000372938	DIP2C	chr10	735433	-	CIZ1	chr9	130938754	-	0.02024611	0.9797539

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22858_22858_1_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000277465_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_2_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000325721_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_3_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000357558_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_4_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000372938_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_5_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000372948_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_6_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000372954_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_7_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000393608_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

>22858_22858_8_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000538431_length(amino acids)=313AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKPPTPRRDVFAHVPVQGWSTARLVT
DMIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQ
VRSRDISREEWKGSETYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNA

--------------------------------------------------------------

>22858_22858_9_DIP2C-CIZ1_DIP2C_chr10_735433_ENST00000280886_CIZ1_chr9_130938754_ENST00000541172_length(amino acids)=287AA_BP=
MSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQLYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFV
EHVKSQGHKDKAKELKSLEKEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSETYSPNTAYGVD
FLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPTTRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:735433/chr9:130938754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DIP2C Q9Y2E4	CIZ1 Q9ULV3
	FUNCTION: May regulate the subcellular localization of CIP/WAF1.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000325721

741_761

577.0

870.0

Compositional bias

Note=Glu-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372938

741_761

606.0

899.0

Compositional bias

Note=Glu-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372948

741_761

550.0

843.0

Compositional bias

Note=Glu-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372954

741_761

526.0

819.0

Compositional bias

Note=Glu-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000393608

741_761

606.0

899.0

Compositional bias

Note=Glu-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000541172

741_761

505.0

798.0

Compositional bias

Note=Glu-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000325721

799_830

577.0

870.0

Zinc finger

Matrin-type

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372938

799_830

606.0

899.0

Zinc finger

Matrin-type

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372948

799_830

550.0

843.0

Zinc finger

Matrin-type

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372954

799_830

526.0

819.0

Zinc finger

Matrin-type

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000393608

799_830

606.0

899.0

Zinc finger

Matrin-type

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000541172

799_830

505.0

798.0

Zinc finger

Matrin-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DIP2C

chr10:735433

chr9:130938754

ENST00000280886

7_120

28.333333333333332

1557.0

Domain

DMAP1-binding

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000325721

276_470

577.0

870.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000325721

4_44

577.0

870.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372938

276_470

606.0

899.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372938

4_44

606.0

899.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372948

276_470

550.0

843.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372948

4_44

550.0

843.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372954

276_470

526.0

819.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000372954

4_44

526.0

819.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000393608

276_470

606.0

899.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000393608

4_44

606.0

899.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000541172

276_470

505.0

798.0

Compositional bias

Note=Gln-rich

Tgene

CIZ1

chr10:735433

chr9:130938754

ENST00000541172

4_44

505.0

798.0

Compositional bias

Note=Gln-rich

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DIP2C
CIZ1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DIP2C-CIZ1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DIP2C-CIZ1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source