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Fusion Protein:DIS3L2-DNM1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: DIS3L2-DNM1 | FusionPDB ID: 22901 | FusionGDB2.0 ID: 22901 | Hgene | Tgene | Gene symbol | DIS3L2 | DNM1 | Gene ID | 129563 | 1759 |
| Gene name | DIS3 like 3'-5' exoribonuclease 2 | dynamin 1 | |
| Synonyms | FAM6A|PRLMNS|hDIS3L2 | DNM|EIEE31 | |
| Cytomap | 2q37.1 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member A | dynamin-1 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q8IYB7 | O00429 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000325385, ENST00000409307, ENST00000273009, ENST00000360410, ENST00000409401, ENST00000470087, | ENST00000493925, ENST00000341179, ENST00000372923, ENST00000393594, ENST00000475805, ENST00000486160, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 27 X 9 X 12=2916 | 4 X 5 X 4=80 |
| # samples | 25 | 5 | |
| ** MAII score | log2(25/2916*10)=-3.54399071966485 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: DIS3L2 [Title/Abstract] AND DNM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DIS3L2(233128150)-DNM1(130996300), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | DIS3L2-DNM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIS3L2-DNM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DIS3L2-DNM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DIS3L2-DNM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DIS3L2 | GO:0010587 | miRNA catabolic process | 24141620 |
| Fusion gene breakpoints across DIS3L2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DNM1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-G9-A9S7-01A | DIS3L2 | chr2 | 233128150 | - | DNM1 | chr9 | 130996300 | + |
| ChimerDB4 | PRAD | TCGA-G9-A9S7-01A | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + |
| ChimerDB4 | PRAD | TCGA-G9-A9S7 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + |
| ChimerDB4 | PRAD | TCGA-G9-A9S7 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000475805 | DNM1 | chr9 | 130996300 | + | 3325 | 1935 | 240 | 3155 | 971 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000341179 | DNM1 | chr9 | 130996300 | + | 3755 | 1935 | 240 | 3155 | 971 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000372923 | DNM1 | chr9 | 130996300 | + | 3729 | 1935 | 240 | 3194 | 984 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000393594 | DNM1 | chr9 | 130996300 | + | 3757 | 1935 | 240 | 3155 | 971 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000486160 | DNM1 | chr9 | 130996300 | + | 3718 | 1935 | 240 | 3194 | 984 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000475805 | DNM1 | chr9 | 130996300 | + | 3049 | 1659 | 0 | 2879 | 959 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000341179 | DNM1 | chr9 | 130996300 | + | 3479 | 1659 | 0 | 2879 | 959 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000372923 | DNM1 | chr9 | 130996300 | + | 3453 | 1659 | 0 | 2918 | 972 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000393594 | DNM1 | chr9 | 130996300 | + | 3481 | 1659 | 0 | 2879 | 959 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000486160 | DNM1 | chr9 | 130996300 | + | 3442 | 1659 | 0 | 2918 | 972 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000475805 | DNM1 | chr9 | 130996299 | + | 3325 | 1935 | 240 | 3155 | 971 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000341179 | DNM1 | chr9 | 130996299 | + | 3755 | 1935 | 240 | 3155 | 971 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000372923 | DNM1 | chr9 | 130996299 | + | 3729 | 1935 | 240 | 3194 | 984 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000393594 | DNM1 | chr9 | 130996299 | + | 3757 | 1935 | 240 | 3155 | 971 |
| ENST00000325385 | DIS3L2 | chr2 | 233128150 | + | ENST00000486160 | DNM1 | chr9 | 130996299 | + | 3718 | 1935 | 240 | 3194 | 984 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000475805 | DNM1 | chr9 | 130996299 | + | 3049 | 1659 | 0 | 2879 | 959 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000341179 | DNM1 | chr9 | 130996299 | + | 3479 | 1659 | 0 | 2879 | 959 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000372923 | DNM1 | chr9 | 130996299 | + | 3453 | 1659 | 0 | 2918 | 972 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000393594 | DNM1 | chr9 | 130996299 | + | 3481 | 1659 | 0 | 2879 | 959 |
| ENST00000409307 | DIS3L2 | chr2 | 233128150 | + | ENST00000486160 | DNM1 | chr9 | 130996299 | + | 3442 | 1659 | 0 | 2918 | 972 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000325385 | ENST00000475805 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.00179722 | 0.9982028 |
| ENST00000325385 | ENST00000341179 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.001044987 | 0.998955 |
| ENST00000325385 | ENST00000372923 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.00094829 | 0.99905175 |
| ENST00000325385 | ENST00000393594 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.00104534 | 0.99895465 |
| ENST00000325385 | ENST00000486160 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.000975519 | 0.9990245 |
| ENST00000409307 | ENST00000475805 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.001468405 | 0.9985316 |
| ENST00000409307 | ENST00000341179 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.000846237 | 0.99915373 |
| ENST00000409307 | ENST00000372923 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.000748817 | 0.9992512 |
| ENST00000409307 | ENST00000393594 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.000845141 | 0.9991548 |
| ENST00000409307 | ENST00000486160 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996300 | + | 0.000772719 | 0.9992273 |
| ENST00000325385 | ENST00000475805 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.00179722 | 0.9982028 |
| ENST00000325385 | ENST00000341179 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.001044987 | 0.998955 |
| ENST00000325385 | ENST00000372923 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.00094829 | 0.99905175 |
| ENST00000325385 | ENST00000393594 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.00104534 | 0.99895465 |
| ENST00000325385 | ENST00000486160 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.000975519 | 0.9990245 |
| ENST00000409307 | ENST00000475805 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.001468405 | 0.9985316 |
| ENST00000409307 | ENST00000341179 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.000846237 | 0.99915373 |
| ENST00000409307 | ENST00000372923 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.000748817 | 0.9992512 |
| ENST00000409307 | ENST00000393594 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.000845141 | 0.9991548 |
| ENST00000409307 | ENST00000486160 | DIS3L2 | chr2 | 233128150 | + | DNM1 | chr9 | 130996299 | + | 0.000772719 | 0.9992273 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >22901_22901_1_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996299_ENST00000341179_length(amino acids)=971AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_2_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996299_ENST00000372923_length(amino acids)=984AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_3_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996299_ENST00000393594_length(amino acids)=971AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_4_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996299_ENST00000475805_length(amino acids)=971AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_5_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996299_ENST00000486160_length(amino acids)=984AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_6_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996300_ENST00000341179_length(amino acids)=971AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_7_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996300_ENST00000372923_length(amino acids)=984AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_8_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996300_ENST00000393594_length(amino acids)=971AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_9_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996300_ENST00000475805_length(amino acids)=971AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_10_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000325385_DNM1_chr9_130996300_ENST00000486160_length(amino acids)=984AA_BP=562 MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT -------------------------------------------------------------- >22901_22901_11_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996299_ENST00000341179_length(amino acids)=959AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_12_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996299_ENST00000372923_length(amino acids)=972AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_13_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996299_ENST00000393594_length(amino acids)=959AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_14_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996299_ENST00000475805_length(amino acids)=959AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_15_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996299_ENST00000486160_length(amino acids)=972AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_16_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996300_ENST00000341179_length(amino acids)=959AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_17_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996300_ENST00000372923_length(amino acids)=972AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_18_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996300_ENST00000393594_length(amino acids)=959AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_19_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996300_ENST00000475805_length(amino acids)=959AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- >22901_22901_20_DIS3L2-DNM1_DIS3L2_chr2_233128150_ENST00000409307_DNM1_chr9_130996300_ENST00000486160_length(amino acids)=972AA_BP=550 MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDG DRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSP SDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCE ELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR QQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIR KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEE VDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELL ANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPAR -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233128150/chr9:130996300) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DIS3L2 | DNM1 |
| FUNCTION: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}. | FUNCTION: Functions in mitochondrial and peroxisomal division (PubMed:9570752, PubMed:9786947, PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17553808, PubMed:17460227, PubMed:18695047, PubMed:18838687, PubMed:19638400, PubMed:19411255, PubMed:19342591, PubMed:23921378, PubMed:23283981, PubMed:23530241, PubMed:29478834, PubMed:32484300, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (PubMed:23530241, PubMed:23584531). The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:23921378, PubMed:23283981, PubMed:29899447). While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane (PubMed:29899447). Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner (PubMed:32484300). Plays an important role in mitochondrial fission during mitosis (PubMed:19411255, PubMed:26992161, PubMed:27301544, PubMed:27328748). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (PubMed:17460227, PubMed:27145208, PubMed:26992161, PubMed:27301544, PubMed:27328748). Facilitates developmentally regulated apoptosis during neural tube formation (By similarity). Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles (PubMed:9570752, PubMed:20688057, PubMed:23792689). Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles (PubMed:17015472, PubMed:23792689). Required for programmed necrosis execution (PubMed:22265414). Rhythmic control of its activity following phosphorylation at Ser-637 is essential for the circadian control of mitochondrial ATP production (PubMed:29478834). {ECO:0000250|UniProtKB:Q8K1M6, ECO:0000269|PubMed:11514614, ECO:0000269|PubMed:12499366, ECO:0000269|PubMed:17015472, ECO:0000269|PubMed:17301055, ECO:0000269|PubMed:17460227, ECO:0000269|PubMed:17553808, ECO:0000269|PubMed:18695047, ECO:0000269|PubMed:18838687, ECO:0000269|PubMed:19342591, ECO:0000269|PubMed:19411255, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:20688057, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23584531, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:26992161, ECO:0000269|PubMed:27145208, ECO:0000269|PubMed:27301544, ECO:0000269|PubMed:27328748, ECO:0000269|PubMed:29478834, ECO:0000269|PubMed:29899447, ECO:0000269|PubMed:32484300, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9786947}.; FUNCTION: [Isoform 1]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}.; FUNCTION: [Isoform 4]: Inhibits peroxisomal division when overexpressed. {ECO:0000269|PubMed:12618434}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 519_625 | 445.0 | 962.3333333333334 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 659_750 | 445.0 | 962.3333333333334 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 519_625 | 445.0 | 865.0 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 659_750 | 445.0 | 865.0 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 519_625 | 445.0 | 975.6666666666666 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 659_750 | 445.0 | 975.6666666666666 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 519_625 | 445.0 | 819.0 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 659_750 | 445.0 | 819.0 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 519_625 | 445.0 | 865.0 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 659_750 | 445.0 | 865.0 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 519_625 | 445.0 | 962.3333333333334 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 659_750 | 445.0 | 962.3333333333334 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 519_625 | 445.0 | 865.0 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 659_750 | 445.0 | 865.0 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 519_625 | 445.0 | 975.6666666666666 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 659_750 | 445.0 | 975.6666666666666 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 519_625 | 445.0 | 819.0 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 659_750 | 445.0 | 819.0 | Domain | GED | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 519_625 | 445.0 | 865.0 | Domain | PH | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 659_750 | 445.0 | 865.0 | Domain | GED |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 28_294 | 445.0 | 962.3333333333334 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 28_294 | 445.0 | 865.0 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 28_294 | 445.0 | 975.6666666666666 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 28_294 | 445.0 | 819.0 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 28_294 | 445.0 | 865.0 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 28_294 | 445.0 | 962.3333333333334 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 28_294 | 445.0 | 865.0 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 28_294 | 445.0 | 975.6666666666666 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 28_294 | 445.0 | 819.0 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 28_294 | 445.0 | 865.0 | Domain | Dynamin-type G | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 136_140 | 445.0 | 962.3333333333334 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 136_140 | 445.0 | 865.0 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 136_140 | 445.0 | 975.6666666666666 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 136_140 | 445.0 | 819.0 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 136_140 | 445.0 | 865.0 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 136_140 | 445.0 | 962.3333333333334 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 136_140 | 445.0 | 865.0 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 136_140 | 445.0 | 975.6666666666666 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 136_140 | 445.0 | 819.0 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 136_140 | 445.0 | 865.0 | Nucleotide binding | GTP | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 136_139 | 445.0 | 962.3333333333334 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 205_208 | 445.0 | 962.3333333333334 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 235_238 | 445.0 | 962.3333333333334 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 38_45 | 445.0 | 962.3333333333334 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000341179 | 9 | 23 | 64_66 | 445.0 | 962.3333333333334 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 136_139 | 445.0 | 865.0 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 205_208 | 445.0 | 865.0 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 235_238 | 445.0 | 865.0 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 38_45 | 445.0 | 865.0 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000372923 | 9 | 22 | 64_66 | 445.0 | 865.0 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 136_139 | 445.0 | 975.6666666666666 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 205_208 | 445.0 | 975.6666666666666 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 235_238 | 445.0 | 975.6666666666666 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 38_45 | 445.0 | 975.6666666666666 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000393594 | 9 | 23 | 64_66 | 445.0 | 975.6666666666666 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 136_139 | 445.0 | 819.0 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 205_208 | 445.0 | 819.0 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 235_238 | 445.0 | 819.0 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 38_45 | 445.0 | 819.0 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000475805 | 9 | 23 | 64_66 | 445.0 | 819.0 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 136_139 | 445.0 | 865.0 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 205_208 | 445.0 | 865.0 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 235_238 | 445.0 | 865.0 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 38_45 | 445.0 | 865.0 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996299 | ENST00000486160 | 9 | 22 | 64_66 | 445.0 | 865.0 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 136_139 | 445.0 | 962.3333333333334 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 205_208 | 445.0 | 962.3333333333334 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 235_238 | 445.0 | 962.3333333333334 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 38_45 | 445.0 | 962.3333333333334 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000341179 | 9 | 23 | 64_66 | 445.0 | 962.3333333333334 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 136_139 | 445.0 | 865.0 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 205_208 | 445.0 | 865.0 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 235_238 | 445.0 | 865.0 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 38_45 | 445.0 | 865.0 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000372923 | 9 | 22 | 64_66 | 445.0 | 865.0 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 136_139 | 445.0 | 975.6666666666666 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 205_208 | 445.0 | 975.6666666666666 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 235_238 | 445.0 | 975.6666666666666 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 38_45 | 445.0 | 975.6666666666666 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000393594 | 9 | 23 | 64_66 | 445.0 | 975.6666666666666 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 136_139 | 445.0 | 819.0 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 205_208 | 445.0 | 819.0 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 235_238 | 445.0 | 819.0 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 38_45 | 445.0 | 819.0 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000475805 | 9 | 23 | 64_66 | 445.0 | 819.0 | Region | G2 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 136_139 | 445.0 | 865.0 | Region | G3 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 205_208 | 445.0 | 865.0 | Region | G4 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 235_238 | 445.0 | 865.0 | Region | G5 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 38_45 | 445.0 | 865.0 | Region | G1 motif | |
| Tgene | DNM1 | chr2:233128150 | chr9:130996300 | ENST00000486160 | 9 | 22 | 64_66 | 445.0 | 865.0 | Region | G2 motif |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1785_DIS3L2_233128150_DNM1_130996300_ranked_0.pdb | DIS3L2 | 233128150 | 233128150 | ENST00000486160 | DNM1 | chr9 | 130996300 | + | MDLERRVTLEPIMSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPK KFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEA QFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKN SELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFS SEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQ KVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQA VLNLHGIAKQLRQQRFVDGALRLDQLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKK TSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMI NNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT | 984 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
DIS3L2_pLDDT.png  |
DNM1_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| DIS3L2 | |
| DNM1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to DIS3L2-DNM1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to DIS3L2-DNM1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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