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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DLC1-CLASP2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DLC1-CLASP2
FusionPDB ID: 22976
FusionGDB2.0 ID: 22976
HgeneTgene
Gene symbol

DLC1

CLASP2

Gene ID

10395

23122

Gene nameDLC1 Rho GTPase activating proteincytoplasmic linker associated protein 2
SynonymsARHGAP7|HP|STARD12|p122-RhoGAP-
Cytomap

8p22

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer variaCLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2
Modification date2020031320200313
UniProtAcc

Q96QB1

O75122

Ensembl transtripts involved in fusion geneENST idsENST00000512044, ENST00000276297, 
ENST00000316609, ENST00000358919, 
ENST00000510318, ENST00000511869, 
ENST00000520226, 		ENST00000313350, 
ENST00000333778, ENST00000482896, 
ENST00000487200, ENST00000307312, 
ENST00000359576, ENST00000399362, 
ENST00000461133, ENST00000468888, 
ENST00000480013, ENST00000539981, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 4=8015 X 10 X 9=1350
# samples 515
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DLC1 [Title/Abstract] AND CLASP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DLC1(13133771)-CLASP2(33592887), # samples:1
Anticipated loss of major functional domain due to fusion event.DLC1-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLC1-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLC1-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLC1-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLC1

GO:0006915

apoptotic process

17292327

HgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

HgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

HgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

HgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

HgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

HgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

HgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check buttonFusion gene breakpoints across DLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLASP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BR-6564-11ADLC1chr8

13133771

-CLASP2chr3

33592887

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000512044DLC1chr813133771-ENST00000468888CLASP2chr333592887-41832852461796516
ENST00000512044DLC1chr813133771-ENST00000399362CLASP2chr333592887-41832852461796516
ENST00000512044DLC1chr813133771-ENST00000539981CLASP2chr333592887-41792852461796516
ENST00000512044DLC1chr813133771-ENST00000359576CLASP2chr333592887-41792852461796516
ENST00000512044DLC1chr813133771-ENST00000307312CLASP2chr333592887-41792852461796516
ENST00000512044DLC1chr813133771-ENST00000480013CLASP2chr333592887-34352852461796516
ENST00000512044DLC1chr813133771-ENST00000461133CLASP2chr333592887-26732852461796516

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000512044ENST00000468888DLC1chr813133771-CLASP2chr333592887-0.000187290.9998128
ENST00000512044ENST00000399362DLC1chr813133771-CLASP2chr333592887-0.000187290.9998128
ENST00000512044ENST00000539981DLC1chr813133771-CLASP2chr333592887-0.000188910.9998111
ENST00000512044ENST00000359576DLC1chr813133771-CLASP2chr333592887-0.000188910.9998111
ENST00000512044ENST00000307312DLC1chr813133771-CLASP2chr333592887-0.000188910.9998111
ENST00000512044ENST00000480013DLC1chr813133771-CLASP2chr333592887-0.0002109980.99978906
ENST00000512044ENST00000461133DLC1chr813133771-CLASP2chr333592887-0.0003013010.99969876

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22976_22976_1_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000307312_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

>22976_22976_2_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000359576_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

>22976_22976_3_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000399362_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

>22976_22976_4_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000461133_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

>22976_22976_5_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000468888_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

>22976_22976_6_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000480013_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

>22976_22976_7_DLC1-CLASP2_DLC1_chr8_13133771_ENST00000512044_CLASP2_chr3_33592887_ENST00000539981_length(amino acids)=516AA_BP=12
MSFGKTLETDGWQVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQ
DGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQED
MNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQF
PDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFK
NYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:13133771/chr3:33592887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLC1

Q96QB1

CLASP2

O75122

FUNCTION: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. {ECO:0000269|PubMed:18786931, ECO:0000269|PubMed:19170769, ECO:0000269|PubMed:19710422}.FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131104_11080432.0Compositional biasNote=Poly-Leu
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013310_5870432.0Compositional biasNote=Ser-rich
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131017_12940432.0RegionNote=Required for cortical localization
TgeneCLASP2chr8:13133771chr3:33592887ENST0000031335001360_3110432.0RegionTOG 1
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013649_8810432.0RegionTOG 2
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131054_10910432.0RepeatHEAT 6
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131098_11350432.0RepeatHEAT 7
TgeneCLASP2chr8:13133771chr3:33592887ENST000003133500131216_12530432.0RepeatHEAT 8
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013173_2080432.0RepeatHEAT 1
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013209_2450432.0RepeatHEAT 2
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013250_2870432.0RepeatHEAT 3
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013710_7470432.0RepeatHEAT 4
TgeneCLASP2chr8:13133771chr3:33592887ENST00000313350013772_8090432.0RepeatHEAT 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118741_74701529.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118868_87401529.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16741_7470499.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16868_8740499.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114741_74701092.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114868_87401092.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15741_7470464.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15868_8740464.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114741_74701018.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114868_87401018.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-1181078_128401529.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-1181314_152101529.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118448_51501529.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-161078_12840499.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-161314_15210499.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16448_5150499.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-1141078_128401092.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-1141314_152101092.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114448_51501092.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-151078_12840464.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-151314_15210464.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15448_5150464.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-1141078_128401018.0DomainRho-GAP
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-1141314_152101018.0DomainSTART
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114448_51501018.0DomainNote=SAM
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-1181051_107301529.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000276297-118710_88401529.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-161051_10730499.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000316609-16710_8840499.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-1141051_107301092.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000358919-114710_88401092.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-151051_10730464.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000511869-15710_8840464.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-1141051_107301018.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:13133771chr3:33592887ENST00000520226-114710_88401018.0RegionNote=Focal adhesion-targeting (FAT)


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DLC1
CLASP2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DLC1-CLASP2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DLC1-CLASP2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource