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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DLG1-CRYBG3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DLG1-CRYBG3
FusionPDB ID: 23034
FusionGDB2.0 ID: 23034
HgeneTgene
Gene symbol

DLG1

CRYBG3

Gene ID

1739

131544

Gene namediscs large MAGUK scaffold protein 1crystallin beta-gamma domain containing 3
SynonymsDLGH1|SAP-97|SAP97|hdlgDKFZp667G2110|vlAKAP
Cytomap

3q29

3q11.2

Type of geneprotein-codingprotein-coding
Descriptiondisks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97very large A-kinase anchor proteinbeta-gamma crystallin domain containing 3beta/gamma crystallin domain-containing protein 3
Modification date2020032720200313
UniProtAcc

Q12959

Q68DQ2

Ensembl transtripts involved in fusion geneENST idsENST00000314062, ENST00000346964, 
ENST00000357674, ENST00000392382, 
ENST00000419354, ENST00000422288, 
ENST00000448528, ENST00000450955, 
ENST00000443183, ENST00000452595, 
ENST00000485409, 		ENST00000389622, 
ENST00000419587, ENST00000485253, 
ENST00000182096, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 18 X 14=68044 X 4 X 3=48
# samples 405
** MAII scorelog2(40/6804*10)=-4.08831123588866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DLG1 [Title/Abstract] AND CRYBG3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DLG1(196921296)-CRYBG3(97631011), # samples:3
Anticipated loss of major functional domain due to fusion event.DLG1-CRYBG3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-CRYBG3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-CRYBG3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLG1-CRYBG3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

HgeneDLG1

GO:0007015

actin filament organization

14699157

HgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

HgeneDLG1

GO:0042391

regulation of membrane potential

12970345

HgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

HgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

HgeneDLG1

GO:0098609

cell-cell adhesion

14699157

HgeneDLG1

GO:1902473

regulation of protein localization to synapse

23676497

HgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345


check buttonFusion gene breakpoints across DLG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CRYBG3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A59X-01ADLG1chr3

196921296

-CRYBG3chr3

97631011

+
ChimerDB4PRADTCGA-KK-A59XDLG1chr3

196888511

-CRYBG3chr3

97631011

+
ChimerDB4PRADTCGA-KK-A59XDLG1chr3

196921296

-CRYBG3chr3

97631011

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357674DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+32316731901581463
ENST00000314062DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+32316731901581463
ENST00000346964DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+32316731901581463
ENST00000419354DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+33287702871678463
ENST00000422288DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+304148301391463
ENST00000448528DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+32316731901581463
ENST00000450955DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+304148301391463
ENST00000392382DLG1chr3196921296-ENST00000182096CRYBG3chr397631011+3115557741465463
ENST00000346964DLG1chr3196888511-ENST00000182096CRYBG3chr397631011+33307721901680496
ENST00000419354DLG1chr3196888511-ENST00000182096CRYBG3chr397631011+34278692871777496
ENST00000448528DLG1chr3196888511-ENST00000182096CRYBG3chr397631011+33307721901680496

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357674ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0005972970.99940276
ENST00000314062ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0005972970.99940276
ENST00000346964ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0005972970.99940276
ENST00000419354ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0006341060.99936587
ENST00000422288ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0007029950.999297
ENST00000448528ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0005972970.99940276
ENST00000450955ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0007029950.999297
ENST00000392382ENST00000182096DLG1chr3196921296-CRYBG3chr397631011+0.0006459070.99935406
ENST00000346964ENST00000182096DLG1chr3196888511-CRYBG3chr397631011+0.0003252950.9996747
ENST00000419354ENST00000182096DLG1chr3196888511-CRYBG3chr397631011+0.0003521730.99964786
ENST00000448528ENST00000182096DLG1chr3196888511-CRYBG3chr397631011+0.0003252950.9996747

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23034_23034_1_DLG1-CRYBG3_DLG1_chr3_196888511_ENST00000346964_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=496AA_BP=194
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
VPAENTVILPTIPQLKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKP
IDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMK
QPAVYIRIKNRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNK

--------------------------------------------------------------

>23034_23034_2_DLG1-CRYBG3_DLG1_chr3_196888511_ENST00000419354_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=496AA_BP=194
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
VPAENTVILPTIPQLKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKP
IDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMK
QPAVYIRIKNRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNK

--------------------------------------------------------------

>23034_23034_3_DLG1-CRYBG3_DLG1_chr3_196888511_ENST00000448528_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=496AA_BP=194
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
VPAENTVILPTIPQLKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKP
IDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMK
QPAVYIRIKNRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNK

--------------------------------------------------------------

>23034_23034_4_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000314062_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_5_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000346964_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_6_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000357674_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_7_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000392382_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_8_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000419354_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_9_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000422288_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_10_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000448528_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

>23034_23034_11_DLG1-CRYBG3_DLG1_chr3_196921296_ENST00000450955_CRYBG3_chr3_97631011_ENST00000182096_length(amino acids)=463AA_BP=161
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:196921296/chr3:97631011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLG1

Q12959

CRYBG3

Q68DQ2

FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.FUNCTION: [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA). {ECO:0000269|PubMed:25097019}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-6264_64194.0927.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-6264_64194.0905.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-6264_64194.0905.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-5244_64161.0854.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-5264_64161.0927.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-5254_64161.0894.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-5254_64161.0872.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-5264_64161.0905.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-4234_64161.0854.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-5264_64161.0905.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-4244_64161.0894.0DomainL27
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192334_2383720.01023.0DomainBeta/gamma crystallin 'Greek key' 1
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192429_2467720.01023.0DomainBeta/gamma crystallin 'Greek key' 2
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192479_2523720.01023.0DomainBeta/gamma crystallin 'Greek key' 3
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192524_2566720.01023.0DomainBeta/gamma crystallin 'Greek key' 4
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192572_2613720.01023.0DomainBeta/gamma crystallin 'Greek key' 5
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192614_2656720.01023.0DomainBeta/gamma crystallin 'Greek key' 6
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192667_2703720.01023.0DomainBeta/gamma crystallin 'Greek key' 7
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192704_2746720.01023.0DomainBeta/gamma crystallin 'Greek key' 8
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192793_2834720.01023.0DomainBeta/gamma crystallin 'Greek key' 9
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611192836_2968720.01023.0DomainRicin B-type lectin
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192334_2383720.01023.0DomainBeta/gamma crystallin 'Greek key' 1
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192429_2467720.01023.0DomainBeta/gamma crystallin 'Greek key' 2
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192479_2523720.01023.0DomainBeta/gamma crystallin 'Greek key' 3
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192524_2566720.01023.0DomainBeta/gamma crystallin 'Greek key' 4
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192572_2613720.01023.0DomainBeta/gamma crystallin 'Greek key' 5
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192614_2656720.01023.0DomainBeta/gamma crystallin 'Greek key' 6
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192667_2703720.01023.0DomainBeta/gamma crystallin 'Greek key' 7
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192704_2746720.01023.0DomainBeta/gamma crystallin 'Greek key' 8
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192793_2834720.01023.0DomainBeta/gamma crystallin 'Greek key' 9
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611192836_2968720.01023.0DomainRicin B-type lectin
TgeneCRYBG3chr3:196888511chr3:97631011ENST0000018209611191299_1322720.01023.0RegionRII-binding helix
TgeneCRYBG3chr3:196921296chr3:97631011ENST0000018209611191299_1322720.01023.0RegionRII-binding helix

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-124224_3100854.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-124319_4050854.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-124466_5460854.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-1244_640854.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-124581_6510854.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-124714_8890854.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-626224_310194.0927.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-626319_405194.0927.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-626466_546194.0927.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-626581_651194.0927.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-626714_889194.0927.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-125224_3100894.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-125319_4050894.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-125466_5460894.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-1254_640894.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-125581_6510894.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-125714_8890894.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-125224_3100872.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-125319_4050872.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-125466_5460872.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-1254_640872.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-125581_6510872.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-125714_8890872.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-626224_310194.0905.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-626319_405194.0905.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-626466_546194.0905.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-626581_651194.0905.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-626714_889194.0905.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-123224_3100.0854.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-123319_4050.0854.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-123466_5460.0854.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-1234_640.0854.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-123581_6510.0854.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-123714_8890.0854.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-122224_3100801.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-122319_4050801.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-122466_5460801.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-1224_640801.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-122581_6510801.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-122714_8890801.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-626224_310194.0905.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-626319_405194.0905.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-626466_546194.0905.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-626581_651194.0905.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-626714_889194.0905.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-124224_3100.0894.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-124319_4050.0894.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-124466_5460.0894.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-1244_640.0894.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-124581_6510.0894.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-124714_8890.0894.0DomainGuanylate kinase-like
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-121224_3100789.0DomainPDZ 1
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-121319_4050789.0DomainPDZ 2
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-121466_5460789.0DomainPDZ 3
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-1214_640789.0DomainL27
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-121581_6510789.0DomainSH3
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-121714_8890789.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-524224_310161.0854.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-524319_405161.0854.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-524466_546161.0854.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-524581_651161.0854.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-524714_889161.0854.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-526224_310161.0927.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-526319_405161.0927.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-526466_546161.0927.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-526581_651161.0927.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-526714_889161.0927.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-525224_310161.0894.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-525319_405161.0894.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-525466_546161.0894.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-525581_651161.0894.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-525714_889161.0894.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-525224_310161.0872.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-525319_405161.0872.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-525466_546161.0872.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-525581_651161.0872.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-525714_889161.0872.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-526224_310161.0905.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-526319_405161.0905.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-526466_546161.0905.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-526581_651161.0905.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-526714_889161.0905.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-423224_310161.0854.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-423319_405161.0854.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-423466_546161.0854.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-423581_651161.0854.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-423714_889161.0854.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-122224_3100801.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-122319_4050801.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-122466_5460801.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-1224_640801.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-122581_6510801.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-122714_8890801.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-526224_310161.0905.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-526319_405161.0905.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-526466_546161.0905.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-526581_651161.0905.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-526714_889161.0905.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-424224_310161.0894.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-424319_405161.0894.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-424466_546161.0894.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-424581_651161.0894.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-424714_889161.0894.0DomainGuanylate kinase-like
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-121224_3100789.0DomainPDZ 1
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-121319_4050789.0DomainPDZ 2
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-121466_5460789.0DomainPDZ 3
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-1214_640789.0DomainL27
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-121581_6510789.0DomainSH3
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-121714_8890789.0DomainGuanylate kinase-like


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>969_DLG1_196921296_CRYBG3_97631011_969_DLG1_196921296_CRYBG3_97631011_ranked_0.pdbDLG1196888511196921296ENST00000182096CRYBG3chr397631011+
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSS
TVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKLKAFSKPGFQGECIDFTEE
TSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVL
NKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCI
SPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPL
463


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DLG1_pLDDT.png
all structure
all structure
CRYBG3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DLG1
CRYBG3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDLG1chr3:196888511chr3:97631011ENST00000314062-124162_2120854.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000346964-626162_212194.0927.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000357674-125162_2120894.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000392382-125162_2120872.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000419354-626162_212194.0905.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000422288-123162_2120.0854.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000443183-122162_2120801.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000448528-626162_212194.0905.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000450955-124162_2120.0894.0SH3 domains
HgeneDLG1chr3:196888511chr3:97631011ENST00000452595-121162_2120789.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000314062-524162_212161.0854.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000346964-526162_212161.0927.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000357674-525162_212161.0894.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000392382-525162_212161.0872.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000419354-526162_212161.0905.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000422288-423162_212161.0854.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000443183-122162_2120801.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000448528-526162_212161.0905.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000450955-424162_212161.0894.0SH3 domains
HgeneDLG1chr3:196921296chr3:97631011ENST00000452595-121162_2120789.0SH3 domains


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Related Drugs to DLG1-CRYBG3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DLG1-CRYBG3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource