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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ADD3-MXI1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ADD3-MXI1
	FusionPDB ID: 2309
	FusionGDB2.0 ID: 2309
		Hgene	Tgene
	Gene symbol	ADD3	MXI1
	Gene ID	120	4601
	Gene name	adducin 3	MAX interactor 1, dimerization protein
	Synonyms	ADDL\|CPSQ3	MAD2\|MXD2\|MXI\|bHLHc11
	Cytomap	10q25.1-q25.2	10q25.2
	Type of gene	protein-coding	protein-coding
	Description	gamma-adducinadducin 3 (gamma)adducin-like protein 70	max-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11
	Modification date	20200313	20200313
	UniProtAcc	Q9UEY8	P50539
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000277900, ENST00000356080, ENST00000360162, ENST00000497125,	ENST00000369612, ENST00000485566, ENST00000239007, ENST00000332674, ENST00000361248, ENST00000393134,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 5=650	17 X 10 X 9=1530
	# samples	14	19
	** MAII score	log2(14/650*10)=-2.21501289097085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1530*10)=-3.00946032924907 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ADD3 [Title/Abstract] AND MXI1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ADD3(111886261)-MXI1(112039671), # samples:1 ADD3(111886261)-MXI1(112039672), # samples:1 MXI1(111988079)-ADD3(111878345), # samples:2
Anticipated loss of major functional domain due to fusion event.	ADD3-MXI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADD3-MXI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MXI1-ADD3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. MXI1-ADD3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. MXI1-ADD3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MXI1	GO:0000122	negative regulation of transcription by RNA polymerase II	11875718

Fusion gene breakpoints across ADD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MXI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-AA-3869-01A	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+
ChimerDB4	COAD	TCGA-AA-3869	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360162	ADD3	chr10	111886261	+	ENST00000332674	MXI1	chr10	112039671	+	4699	1985	377	2320	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000361248	MXI1	chr10	112039671	+	3840	1985	377	2320	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000239007	MXI1	chr10	112039671	+	3840	1985	377	2320	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000393134	MXI1	chr10	112039671	+	2426	1985	377	2320	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000332674	MXI1	chr10	112039671	+	4689	1975	367	2310	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000361248	MXI1	chr10	112039671	+	3830	1975	367	2310	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000239007	MXI1	chr10	112039671	+	3830	1975	367	2310	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000393134	MXI1	chr10	112039671	+	2416	1975	367	2310	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000332674	MXI1	chr10	112039671	+	4687	1973	365	2308	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000361248	MXI1	chr10	112039671	+	3828	1973	365	2308	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000239007	MXI1	chr10	112039671	+	3828	1973	365	2308	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000393134	MXI1	chr10	112039671	+	2414	1973	365	2308	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000332674	MXI1	chr10	112039672	+	4699	1985	377	2320	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000361248	MXI1	chr10	112039672	+	3840	1985	377	2320	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000239007	MXI1	chr10	112039672	+	3840	1985	377	2320	647
ENST00000360162	ADD3	chr10	111886261	+	ENST00000393134	MXI1	chr10	112039672	+	2426	1985	377	2320	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000332674	MXI1	chr10	112039672	+	4689	1975	367	2310	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000361248	MXI1	chr10	112039672	+	3830	1975	367	2310	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000239007	MXI1	chr10	112039672	+	3830	1975	367	2310	647
ENST00000356080	ADD3	chr10	111886261	+	ENST00000393134	MXI1	chr10	112039672	+	2416	1975	367	2310	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000332674	MXI1	chr10	112039672	+	4687	1973	365	2308	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000361248	MXI1	chr10	112039672	+	3828	1973	365	2308	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000239007	MXI1	chr10	112039672	+	3828	1973	365	2308	647
ENST00000277900	ADD3	chr10	111886261	+	ENST00000393134	MXI1	chr10	112039672	+	2414	1973	365	2308	647

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360162	ENST00000332674	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.000749765	0.99925023
ENST00000360162	ENST00000361248	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.001429951	0.9985701
ENST00000360162	ENST00000239007	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.001429951	0.9985701
ENST00000360162	ENST00000393134	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.002862467	0.99713755
ENST00000356080	ENST00000332674	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.000670222	0.9993298
ENST00000356080	ENST00000361248	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.001236903	0.9987631
ENST00000356080	ENST00000239007	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.001236903	0.9987631
ENST00000356080	ENST00000393134	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.002760678	0.99723935
ENST00000277900	ENST00000332674	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.000673259	0.9993267
ENST00000277900	ENST00000361248	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.001248553	0.9987514
ENST00000277900	ENST00000239007	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.001248553	0.9987514
ENST00000277900	ENST00000393134	ADD3	chr10	111886261	+	MXI1	chr10	112039671	+	0.002846079	0.9971539
ENST00000360162	ENST00000332674	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.000749765	0.99925023
ENST00000360162	ENST00000361248	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.001429951	0.9985701
ENST00000360162	ENST00000239007	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.001429951	0.9985701
ENST00000360162	ENST00000393134	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.002862467	0.99713755
ENST00000356080	ENST00000332674	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.000670222	0.9993298
ENST00000356080	ENST00000361248	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.001236903	0.9987631
ENST00000356080	ENST00000239007	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.001236903	0.9987631
ENST00000356080	ENST00000393134	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.002760678	0.99723935
ENST00000277900	ENST00000332674	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.000673259	0.9993267
ENST00000277900	ENST00000361248	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.001248553	0.9987514
ENST00000277900	ENST00000239007	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.001248553	0.9987514
ENST00000277900	ENST00000393134	ADD3	chr10	111886261	+	MXI1	chr10	112039672	+	0.002846079	0.9971539

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2309_2309_1_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039671_ENST00000239007_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_2_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039671_ENST00000332674_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

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>2309_2309_3_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039671_ENST00000361248_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_4_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039671_ENST00000393134_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_5_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039672_ENST00000239007_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_6_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039672_ENST00000332674_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_7_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039672_ENST00000361248_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_8_ADD3-MXI1_ADD3_chr10_111886261_ENST00000277900_MXI1_chr10_112039672_ENST00000393134_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

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>2309_2309_9_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039671_ENST00000239007_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_10_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039671_ENST00000332674_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_11_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039671_ENST00000361248_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_12_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039671_ENST00000393134_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_13_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039672_ENST00000239007_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_14_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039672_ENST00000332674_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_15_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039672_ENST00000361248_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_16_ADD3-MXI1_ADD3_chr10_111886261_ENST00000356080_MXI1_chr10_112039672_ENST00000393134_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_17_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039671_ENST00000239007_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_18_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039671_ENST00000332674_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_19_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039671_ENST00000361248_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_20_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039671_ENST00000393134_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_21_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039672_ENST00000239007_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_22_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039672_ENST00000332674_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_23_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039672_ENST00000361248_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

>2309_2309_24_ADD3-MXI1_ADD3_chr10_111886261_ENST00000360162_MXI1_chr10_112039672_ENST00000393134_length(amino acids)=647AA_BP=0
MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLA
LQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLS
FSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDVAYYDYQGSLE
EQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGS
HQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVN
VPEESRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVDKPPSKLEE
AERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:111886261/chr10:112039671)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADD3 Q9UEY8	MXI1 P50539
FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. {ECO:0000269\|PubMed:23836506}.	FUNCTION: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MXI1

chr10:111886261

chr10:112039671

ENST00000239007

67_119

117.0

229.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039671

ENST00000332674

67_119

184.0

296.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039671

ENST00000361248

67_119

71.0

183.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039671

ENST00000369612

67_119

81.0

193.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039672

ENST00000239007

67_119

117.0

229.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039672

ENST00000332674

67_119

184.0

296.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039672

ENST00000361248

67_119

71.0

183.0

Domain

bHLH

Tgene

MXI1

chr10:111886261

chr10:112039672

ENST00000369612

67_119

81.0

193.0

Domain

bHLH

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ADD3
MXI1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ADD3	chr10:111886261	chr10:112039671	ENST00000277900	+	12	14	684_701	536.0	675.0	calmodulin
Hgene	ADD3	chr10:111886261	chr10:112039671	ENST00000356080	+	12	15	684_701	536.0	707.0	calmodulin
Hgene	ADD3	chr10:111886261	chr10:112039671	ENST00000360162	+	12	14	684_701	536.0	675.0	calmodulin
Hgene	ADD3	chr10:111886261	chr10:112039672	ENST00000277900	+	12	14	684_701	536.0	675.0	calmodulin
Hgene	ADD3	chr10:111886261	chr10:112039672	ENST00000356080	+	12	15	684_701	536.0	707.0	calmodulin
Hgene	ADD3	chr10:111886261	chr10:112039672	ENST00000360162	+	12	14	684_701	536.0	675.0	calmodulin

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Related Drugs to ADD3-MXI1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ADD3-MXI1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ADD3	C0005586	Bipolar Disorder	1	CTD_human
Hgene	ADD3	C0005587	Depression, Bipolar	1	CTD_human
Hgene	ADD3	C0007786	Brain Ischemia	1	CTD_human
Hgene	ADD3	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	ADD3	C0024713	Manic Disorder	1	CTD_human
Hgene	ADD3	C0149504	Encephalopathy, Toxic	1	CTD_human
Hgene	ADD3	C0154659	Toxic Encephalitis	1	CTD_human
Hgene	ADD3	C0235032	Neurotoxicity Syndromes	1	CTD_human
Hgene	ADD3	C0338831	Manic	1	CTD_human
Hgene	ADD3	C0917798	Cerebral Ischemia	1	CTD_human
Hgene	ADD3	C2751938	Cerebral Palsy, Spastic Quadriplegic, 1	1	ORPHANET
Hgene	ADD3	C4310767	CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 3	1	CTD_human;GENOMICS_ENGLAND;UNIPROT