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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DMD-TMEM117

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DMD-TMEM117
FusionPDB ID: 23243
FusionGDB2.0 ID: 23243
HgeneTgene
Gene symbol

DMD

TMEM117

Gene ID

1756

84216

Gene namedystrophintransmembrane protein 117
SynonymsBMD|CMD3B|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272|MRX85-
Cytomap

Xp21.2-p21.1

12q12

Type of geneprotein-codingprotein-coding
Descriptiondystrophintransmembrane protein 117
Modification date2020032920200313
UniProtAcc

P11532

.
Ensembl transtripts involved in fusion geneENST idsENST00000357033, ENST00000378677, 
ENST00000288447, ENST00000343523, 
ENST00000359836, ENST00000361471, 
ENST00000378680, ENST00000378702, 
ENST00000378707, ENST00000378723, 
ENST00000445312, ENST00000474231, 
ENST00000541735, 		ENST00000546978, 
ENST00000266534, ENST00000536799, 
ENST00000551577, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score32 X 35 X 5=560011 X 10 X 5=550
# samples 3611
** MAII scorelog2(36/5600*10)=-3.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/550*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DMD [Title/Abstract] AND TMEM117 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DMD(32536125)-TMEM117(44605073), # samples:2
Anticipated loss of major functional domain due to fusion event.DMD-TMEM117 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DMD-TMEM117 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDMD

GO:0043043

peptide biosynthetic process

16000376


check buttonFusion gene breakpoints across DMD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM117 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A240-01ADMDchrX

32536125

-TMEM117chr12

44605073

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378677DMDchrX32536125-ENST00000551577TMEM117chr1244605073+446624751952771858
ENST00000378677DMDchrX32536125-ENST00000266534TMEM117chr1244605073+4596247519535091104
ENST00000378677DMDchrX32536125-ENST00000536799TMEM117chr1244605073+3510247519535091104
ENST00000357033DMDchrX32536125-ENST00000551577TMEM117chr1244605073+449024992072795862
ENST00000357033DMDchrX32536125-ENST00000266534TMEM117chr1244605073+4620249920735331108
ENST00000357033DMDchrX32536125-ENST00000536799TMEM117chr1244605073+3534249920735331108

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378677ENST00000551577DMDchrX32536125-TMEM117chr1244605073+0.0007291330.99927086
ENST00000378677ENST00000266534DMDchrX32536125-TMEM117chr1244605073+0.0003916060.99960846
ENST00000378677ENST00000536799DMDchrX32536125-TMEM117chr1244605073+0.0005815310.9994185
ENST00000357033ENST00000551577DMDchrX32536125-TMEM117chr1244605073+0.0007103530.99928963
ENST00000357033ENST00000266534DMDchrX32536125-TMEM117chr1244605073+0.0003967740.9996032
ENST00000357033ENST00000536799DMDchrX32536125-TMEM117chr1244605073+0.0006132430.9993868

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23243_23243_1_DMD-TMEM117_DMD_chrX_32536125_ENST00000357033_TMEM117_chr12_44605073_ENST00000266534_length(amino acids)=1108AA_BP=764
MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVD
LVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH
QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST
LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLV
ITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYG
IIFLVLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLA
FVPSLIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPSEHSKDMGITRENTQASVEDPLNDPSLVCIRSDFNEIVYKSSHLTSE

--------------------------------------------------------------

>23243_23243_2_DMD-TMEM117_DMD_chrX_32536125_ENST00000357033_TMEM117_chr12_44605073_ENST00000536799_length(amino acids)=1108AA_BP=764
MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVD
LVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH
QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST
LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLV
ITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYG
IIFLVLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLA
FVPSLIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPSEHSKDMGITRENTQASVEDPLNDPSLVCIRSDFNEIVYKSSHLTSE

--------------------------------------------------------------

>23243_23243_3_DMD-TMEM117_DMD_chrX_32536125_ENST00000357033_TMEM117_chr12_44605073_ENST00000551577_length(amino acids)=862AA_BP=764
MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVD
LVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH
QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST
LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLV

--------------------------------------------------------------

>23243_23243_4_DMD-TMEM117_DMD_chrX_32536125_ENST00000378677_TMEM117_chr12_44605073_ENST00000266534_length(amino acids)=1104AA_BP=760
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNI
GSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHY
SQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNK
SVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTD
WISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFL
VLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLAFVPS
LIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPSEHSKDMGITRENTQASVEDPLNDPSLVCIRSDFNEIVYKSSHLTSENLSS

--------------------------------------------------------------

>23243_23243_5_DMD-TMEM117_DMD_chrX_32536125_ENST00000378677_TMEM117_chr12_44605073_ENST00000536799_length(amino acids)=1104AA_BP=760
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNI
GSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHY
SQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNK
SVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTD
WISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEFPHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFL
VLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLKDLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLAFVPS
LIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPSEHSKDMGITRENTQASVEDPLNDPSLVCIRSDFNEIVYKSSHLTSENLSS

--------------------------------------------------------------

>23243_23243_6_DMD-TMEM117_DMD_chrX_32536125_ENST00000378677_TMEM117_chr12_44605073_ENST00000551577_length(amino acids)=858AA_BP=760
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNI
GSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHY
SQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNK
SVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNVTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:32536125/chr12:44605073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMD

P11532

.
FUNCTION: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438176_198170.0515.0Topological domainCytoplasmic
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438220_239170.0515.0Topological domainExtracellular
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438261_295170.0515.0Topological domainCytoplasmic
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438317_394170.0515.0Topological domainExtracellular
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438416_514170.0515.0Topological domainCytoplasmic
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438199_219170.0515.0TransmembraneHelical
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438240_260170.0515.0TransmembraneHelical
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438296_316170.0515.0TransmembraneHelical
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438395_415170.0515.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116134_2400623.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-11615_1190623.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1163055_30880623.0DomainWW
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113134_2400526.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-11315_1190526.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1133055_30880526.0DomainWW
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118134_2400618.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-11815_1190618.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1183055_30880618.0DomainWW
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117134_2400636.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-11715_1190636.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1173055_30880636.0DomainWW
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161_2400623.0RegionNote=Actin-binding
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1163466_35180623.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-11663_720623.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131_2400526.0RegionNote=Actin-binding
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1133466_35180526.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-11363_720526.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181_2400618.0RegionNote=Actin-binding
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1183466_35180618.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-11863_720618.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171_2400636.0RegionNote=Actin-binding
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1173466_35180636.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-11763_720636.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161048_11540623.0RepeatNote=Spectrin 7
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161157_12630623.0RepeatNote=Spectrin 8
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161266_13670623.0RepeatNote=Spectrin 9
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161368_14630623.0RepeatNote=Spectrin 10
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161468_15680623.0RepeatNote=Spectrin 11
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161571_16760623.0RepeatNote=Spectrin 12
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161679_17780623.0RepeatNote=Spectrin 13
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161779_18740623.0RepeatNote=Spectrin 14
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161877_19790623.0RepeatNote=Spectrin 15
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161992_21010623.0RepeatNote=Spectrin 16
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162104_22080623.0RepeatNote=Spectrin 17
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162211_23180623.0RepeatNote=Spectrin 18
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162319_24230623.0RepeatNote=Spectrin 19
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162475_25770623.0RepeatNote=Spectrin 20
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162580_26860623.0RepeatNote=Spectrin 21
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162689_28020623.0RepeatNote=Spectrin 22
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162808_29300623.0RepeatNote=Spectrin 23
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1162935_30400623.0RepeatNote=Spectrin 24
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116339_4470623.0RepeatNote=Spectrin 1
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116448_5560623.0RepeatNote=Spectrin 2
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116559_6670623.0RepeatNote=Spectrin 3
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116719_8280623.0RepeatNote=Spectrin 4
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116830_9340623.0RepeatNote=Spectrin 5
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-116943_10450623.0RepeatNote=Spectrin 6
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131048_11540526.0RepeatNote=Spectrin 7
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131157_12630526.0RepeatNote=Spectrin 8
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131266_13670526.0RepeatNote=Spectrin 9
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131368_14630526.0RepeatNote=Spectrin 10
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131468_15680526.0RepeatNote=Spectrin 11
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131571_16760526.0RepeatNote=Spectrin 12
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131679_17780526.0RepeatNote=Spectrin 13
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131779_18740526.0RepeatNote=Spectrin 14
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131877_19790526.0RepeatNote=Spectrin 15
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131992_21010526.0RepeatNote=Spectrin 16
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132104_22080526.0RepeatNote=Spectrin 17
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132211_23180526.0RepeatNote=Spectrin 18
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132319_24230526.0RepeatNote=Spectrin 19
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132475_25770526.0RepeatNote=Spectrin 20
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132580_26860526.0RepeatNote=Spectrin 21
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132689_28020526.0RepeatNote=Spectrin 22
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132808_29300526.0RepeatNote=Spectrin 23
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1132935_30400526.0RepeatNote=Spectrin 24
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113339_4470526.0RepeatNote=Spectrin 1
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113448_5560526.0RepeatNote=Spectrin 2
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113559_6670526.0RepeatNote=Spectrin 3
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113719_8280526.0RepeatNote=Spectrin 4
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113830_9340526.0RepeatNote=Spectrin 5
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-113943_10450526.0RepeatNote=Spectrin 6
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181048_11540618.0RepeatNote=Spectrin 7
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181157_12630618.0RepeatNote=Spectrin 8
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181266_13670618.0RepeatNote=Spectrin 9
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181368_14630618.0RepeatNote=Spectrin 10
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181468_15680618.0RepeatNote=Spectrin 11
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181571_16760618.0RepeatNote=Spectrin 12
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181679_17780618.0RepeatNote=Spectrin 13
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181779_18740618.0RepeatNote=Spectrin 14
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181877_19790618.0RepeatNote=Spectrin 15
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181992_21010618.0RepeatNote=Spectrin 16
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182104_22080618.0RepeatNote=Spectrin 17
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182211_23180618.0RepeatNote=Spectrin 18
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182319_24230618.0RepeatNote=Spectrin 19
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182475_25770618.0RepeatNote=Spectrin 20
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182580_26860618.0RepeatNote=Spectrin 21
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182689_28020618.0RepeatNote=Spectrin 22
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182808_29300618.0RepeatNote=Spectrin 23
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1182935_30400618.0RepeatNote=Spectrin 24
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118339_4470618.0RepeatNote=Spectrin 1
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118448_5560618.0RepeatNote=Spectrin 2
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118559_6670618.0RepeatNote=Spectrin 3
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118719_8280618.0RepeatNote=Spectrin 4
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118830_9340618.0RepeatNote=Spectrin 5
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-118943_10450618.0RepeatNote=Spectrin 6
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171048_11540636.0RepeatNote=Spectrin 7
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171157_12630636.0RepeatNote=Spectrin 8
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171266_13670636.0RepeatNote=Spectrin 9
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171368_14630636.0RepeatNote=Spectrin 10
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171468_15680636.0RepeatNote=Spectrin 11
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171571_16760636.0RepeatNote=Spectrin 12
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171679_17780636.0RepeatNote=Spectrin 13
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171779_18740636.0RepeatNote=Spectrin 14
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171877_19790636.0RepeatNote=Spectrin 15
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171992_21010636.0RepeatNote=Spectrin 16
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172104_22080636.0RepeatNote=Spectrin 17
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172211_23180636.0RepeatNote=Spectrin 18
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172319_24230636.0RepeatNote=Spectrin 19
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172475_25770636.0RepeatNote=Spectrin 20
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172580_26860636.0RepeatNote=Spectrin 21
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172689_28020636.0RepeatNote=Spectrin 22
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172808_29300636.0RepeatNote=Spectrin 23
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1172935_30400636.0RepeatNote=Spectrin 24
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117339_4470636.0RepeatNote=Spectrin 1
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117448_5560636.0RepeatNote=Spectrin 2
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117559_6670636.0RepeatNote=Spectrin 3
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117719_8280636.0RepeatNote=Spectrin 4
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117830_9340636.0RepeatNote=Spectrin 5
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-117943_10450636.0RepeatNote=Spectrin 6
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1163307_33540623.0Zinc fingerZZ-type
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1133307_33540526.0Zinc fingerZZ-type
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1183307_33540618.0Zinc fingerZZ-type
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1173307_33540636.0Zinc fingerZZ-type
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438132_154170.0515.0Topological domainExtracellular
TgeneTMEM117chrX:32536125chr12:44605073ENST00000266534381_15170.0515.0Topological domainCytoplasmic
TgeneTMEM117chrX:32536125chr12:44605073ENST000002665343837_65170.0515.0Topological domainExtracellular
TgeneTMEM117chrX:32536125chr12:44605073ENST000002665343887_110170.0515.0Topological domainCytoplasmic
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438111_131170.0515.0TransmembraneHelical
TgeneTMEM117chrX:32536125chr12:44605073ENST0000026653438155_175170.0515.0TransmembraneHelical
TgeneTMEM117chrX:32536125chr12:44605073ENST000002665343816_36170.0515.0TransmembraneHelical
TgeneTMEM117chrX:32536125chr12:44605073ENST000002665343866_86170.0515.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DMD
TMEM117


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1161415_19130623.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000361471-1163058_34080623.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1131415_19130526.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000378680-1133058_34080526.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1181415_19130618.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000378702-1183058_34080618.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1171415_19130636.0SYNM
HgeneDMDchrX:32536125chr12:44605073ENST00000378723-1173058_34080636.0SYNM


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Related Drugs to DMD-TMEM117


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DMD-TMEM117


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource