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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNAH1-CACNA1D

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNAH1-CACNA1D
FusionPDB ID: 23352
FusionGDB2.0 ID: 23352
HgeneTgene
Gene symbol

DNAH1

CACNA1D

Gene ID

25981

776

Gene namedynein axonemal heavy chain 1calcium voltage-gated channel subunit alpha1 D
SynonymsCILD37|DNAHC1|HDHC7|HL-11|HL11|HSRF-1|SPGF18|XLHSRF-1CACH3|CACN4|CACNL1A2|CCHL1A2|Cav1.3|PASNA|SANDD
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 1, axonemalaxonemal beta dynein heavy chain 1ciliary dynein heavy chain 1dynein, axonemal, heavy polypeptide 1heat shock regulated protein 1testicular tissue protein Li 60voltage-dependent L-type calcium channel subunit alpha-1Dcalcium channel, L type, alpha-1 polypeptidecalcium channel, neuroendocrine/brain-type, alpha 1 subunitcalcium channel, voltage-dependent, L type, alpha 1D subunitvoltage-gated calcium channel a
Modification date2020032020200313
UniProtAcc

Q9UFH2

Q01668

Ensembl transtripts involved in fusion geneENST idsENST00000420323, ENST00000466628, 
ENST00000498251, ENST00000540742, 
ENST00000544977, ENST00000288139, 
ENST00000350061, ENST00000422281, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=1445 X 6 X 3=90
# samples 66
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNAH1 [Title/Abstract] AND CACNA1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNAH1(52418047)-CACNA1D(53834276), # samples:1
CACNA1D(53535747)-DNAH1(52391630), # samples:2
Anticipated loss of major functional domain due to fusion event.DNAH1-CACNA1D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAH1-CACNA1D seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAH1-CACNA1D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAH1-CACNA1D seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA1D-DNAH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA1D-DNAH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAH1

GO:0036159

inner dynein arm assembly

24360805

TgeneCACNA1D

GO:0006816

calcium ion transport

11160515

TgeneCACNA1D

GO:0051928

positive regulation of calcium ion transport

1309651

TgeneCACNA1D

GO:0070509

calcium ion import

1309651


check buttonFusion gene breakpoints across DNAH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNA1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A74A-01ADNAH1chr3

52418047

-CACNA1Dchr3

53834276

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420323DNAH1chr352418047-ENST00000350061CACNA1Dchr353834276+107858583186101453319
ENST00000420323DNAH1chr352418047-ENST00000288139CACNA1Dchr353834276+124738583186101453319
ENST00000420323DNAH1chr352418047-ENST00000422281CACNA1Dchr353834276+101198583186101183310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420323ENST00000350061DNAH1chr352418047-CACNA1Dchr353834276+0.0036440650.996356
ENST00000420323ENST00000288139DNAH1chr352418047-CACNA1Dchr353834276+0.0017916190.9982084
ENST00000420323ENST00000422281DNAH1chr352418047-CACNA1Dchr353834276+0.0047929060.99520713

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23352_23352_1_DNAH1-CACNA1D_DNAH1_chr3_52418047_ENST00000420323_CACNA1D_chr3_53834276_ENST00000288139_length(amino acids)=3319AA_BP=1
MDSGKVAPPSGLEGSFGWGISLRSSMEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLPHLPLP
PAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIG
STTRLLAQTDFPLQAYEPKMQVPFQVLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFPIYLPL
KVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRP
ILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMR
KGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSK
VRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKY
MLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATH
AVPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT
HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP
ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI
HVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEK
NVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQDHIESI
SKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLE
EWLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLETKRSAF
PRFYFLSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQEDLEITHMYSAEGEEVQLCFSIYPSSNVEDWLREVERSMKASVHDIIEK
AIRAYPTMPRTQWVLNWPGQVTIAGCQTYWTMEVAEALEAGNLRSQLFPQLCQQLSDLVALVRGKLSRMQRAVLSALIVIEVHAKDVVSK
LIQENVVSVNDFQWISQLRYYWTNNDLYIRAVNAEFIYGYEYLGNSGRLVITPLTDRCYLTLTGALHLKFGGAPAGPAGTGKTETTKDLG
KALAIQTVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRIDIEVLSVVAQQITTIQKAQQQRVERFMFEGVEIPLVPSCAVFITMNP
GYAGRTELPDNLKALFRPVAMMVPDYAMITEISLYSFGFNEASVLAKKITTTFKLSSEQLSSQDHYDFGMRAVKTVISAAGNLKRENPSM
NEELICLRAIRDVNVPKFLQEDLKLFSGIVSDLFPTIKEEDTDYGILDEAIREACRNSNLKDVEGFLTKCIQLYETTVVRHGLMLVGPTG
SGKSTCYRVLAAAMTSLKGQPSISGGMYEAVNYYVLNPKSITMGQLYGEFDLLTHEWTDGIFSSFIRAGAITSDTNKKWYMFDGPVDAIW
IENMNTVLDDNKKLCLSSGEIIKLTEAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFIECWLRKLPPLLKPYEEHFKALFVSFL
EESISFVRSSVKEVIASTNCNLTMSLLKLLDCFFKPFLPREGLKKIPSEKLSRIVELIEPWFIFSLIWSVGATGDSSGRTSFSHWLRLKM
ENEQLTLLFPEEGLVFDYRLEDAGISGTNDSEDEEEEYKQVAWVKWMDSSAPFTMVPDTNYCNIIVPTMDTVQMSHLLDMLLTNKKPVLC
IGPTGTGKTLTISDKLLKNLALDYISHFLTFSARTSANQTQDFIDSKLDKRRKGVFGPPLGRNFIFFIDDLNMPALETYGAQPPIELLRQ
WMDHGGWYDRKIIGAFKNLVDINFVCAMGPPGGGRNTVTPRLMRHFNYLSFAEMDEVSKKRIFSTILGNWLDGLLGEKSYRERVPGAPHI
AHFTEPLVEATIMVYATITSQLLPTPAKSHYTFNLRDLSKVFQGMLMADPAKVEDQVQLLRLWYHENCRVFRDRLVNEEDRSWFDQLLKR
CMEQWEVTFNKVCPFQPILYGDFMSPGSDVKSYELITSESKMMQVIEEYIEDYNQINTAKLKLVLFMDAMSHICRISRTLRQALGNALLL
GVGGSGRSSLTRLASHMAEYECFQIELSKNYGMSEWRDDVKKVLLKAGLQNLPITFLFSDTQIKNESFLEDINNVLNSGDIPNLYTADEQ
DQIVSTMRPYIQEQGLQPTKANLMAAYTGRVRSNIHMVLCMSPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKSVATVFLNEIPELE
SSQEEIQGLAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPAS
DTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIR
SDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDS
RRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD
WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVS

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>23352_23352_2_DNAH1-CACNA1D_DNAH1_chr3_52418047_ENST00000420323_CACNA1D_chr3_53834276_ENST00000350061_length(amino acids)=3319AA_BP=1
MDSGKVAPPSGLEGSFGWGISLRSSMEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLPHLPLP
PAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIG
STTRLLAQTDFPLQAYEPKMQVPFQVLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFPIYLPL
KVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRP
ILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMR
KGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSK
VRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKY
MLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATH
AVPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT
HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP
ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI
HVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEK
NVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQDHIESI
SKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLE
EWLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLETKRSAF
PRFYFLSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQEDLEITHMYSAEGEEVQLCFSIYPSSNVEDWLREVERSMKASVHDIIEK
AIRAYPTMPRTQWVLNWPGQVTIAGCQTYWTMEVAEALEAGNLRSQLFPQLCQQLSDLVALVRGKLSRMQRAVLSALIVIEVHAKDVVSK
LIQENVVSVNDFQWISQLRYYWTNNDLYIRAVNAEFIYGYEYLGNSGRLVITPLTDRCYLTLTGALHLKFGGAPAGPAGTGKTETTKDLG
KALAIQTVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRIDIEVLSVVAQQITTIQKAQQQRVERFMFEGVEIPLVPSCAVFITMNP
GYAGRTELPDNLKALFRPVAMMVPDYAMITEISLYSFGFNEASVLAKKITTTFKLSSEQLSSQDHYDFGMRAVKTVISAAGNLKRENPSM
NEELICLRAIRDVNVPKFLQEDLKLFSGIVSDLFPTIKEEDTDYGILDEAIREACRNSNLKDVEGFLTKCIQLYETTVVRHGLMLVGPTG
SGKSTCYRVLAAAMTSLKGQPSISGGMYEAVNYYVLNPKSITMGQLYGEFDLLTHEWTDGIFSSFIRAGAITSDTNKKWYMFDGPVDAIW
IENMNTVLDDNKKLCLSSGEIIKLTEAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFIECWLRKLPPLLKPYEEHFKALFVSFL
EESISFVRSSVKEVIASTNCNLTMSLLKLLDCFFKPFLPREGLKKIPSEKLSRIVELIEPWFIFSLIWSVGATGDSSGRTSFSHWLRLKM
ENEQLTLLFPEEGLVFDYRLEDAGISGTNDSEDEEEEYKQVAWVKWMDSSAPFTMVPDTNYCNIIVPTMDTVQMSHLLDMLLTNKKPVLC
IGPTGTGKTLTISDKLLKNLALDYISHFLTFSARTSANQTQDFIDSKLDKRRKGVFGPPLGRNFIFFIDDLNMPALETYGAQPPIELLRQ
WMDHGGWYDRKIIGAFKNLVDINFVCAMGPPGGGRNTVTPRLMRHFNYLSFAEMDEVSKKRIFSTILGNWLDGLLGEKSYRERVPGAPHI
AHFTEPLVEATIMVYATITSQLLPTPAKSHYTFNLRDLSKVFQGMLMADPAKVEDQVQLLRLWYHENCRVFRDRLVNEEDRSWFDQLLKR
CMEQWEVTFNKVCPFQPILYGDFMSPGSDVKSYELITSESKMMQVIEEYIEDYNQINTAKLKLVLFMDAMSHICRISRTLRQALGNALLL
GVGGSGRSSLTRLASHMAEYECFQIELSKNYGMSEWRDDVKKVLLKAGLQNLPITFLFSDTQIKNESFLEDINNVLNSGDIPNLYTADEQ
DQIVSTMRPYIQEQGLQPTKANLMAAYTGRVRSNIHMVLCMSPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKSVATVFLNEIPELE
SSQEEIQGLAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPAS
DTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRTRYYETYIR
SDSGDEQLPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDS
RRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRD
WTPCYTPLIQVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVS

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>23352_23352_3_DNAH1-CACNA1D_DNAH1_chr3_52418047_ENST00000420323_CACNA1D_chr3_53834276_ENST00000422281_length(amino acids)=3310AA_BP=1
MDSGKVAPPSGLEGSFGWGISLRSSMEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLPHLPLP
PAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIG
STTRLLAQTDFPLQAYEPKMQVPFQVLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFPIYLPL
KVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRP
ILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMR
KGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSK
VRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKY
MLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATH
AVPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT
HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP
ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI
HVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEK
NVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQDHIESI
SKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLE
EWLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLETKRSAF
PRFYFLSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQEDLEITHMYSAEGEEVQLCFSIYPSSNVEDWLREVERSMKASVHDIIEK
AIRAYPTMPRTQWVLNWPGQVTIAGCQTYWTMEVAEALEAGNLRSQLFPQLCQQLSDLVALVRGKLSRMQRAVLSALIVIEVHAKDVVSK
LIQENVVSVNDFQWISQLRYYWTNNDLYIRAVNAEFIYGYEYLGNSGRLVITPLTDRCYLTLTGALHLKFGGAPAGPAGTGKTETTKDLG
KALAIQTVVFNCSDQLDFMAMGKFFKGLASAGAWACFDEFNRIDIEVLSVVAQQITTIQKAQQQRVERFMFEGVEIPLVPSCAVFITMNP
GYAGRTELPDNLKALFRPVAMMVPDYAMITEISLYSFGFNEASVLAKKITTTFKLSSEQLSSQDHYDFGMRAVKTVISAAGNLKRENPSM
NEELICLRAIRDVNVPKFLQEDLKLFSGIVSDLFPTIKEEDTDYGILDEAIREACRNSNLKDVEGFLTKCIQLYETTVVRHGLMLVGPTG
SGKSTCYRVLAAAMTSLKGQPSISGGMYEAVNYYVLNPKSITMGQLYGEFDLLTHEWTDGIFSSFIRAGAITSDTNKKWYMFDGPVDAIW
IENMNTVLDDNKKLCLSSGEIIKLTEAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFIECWLRKLPPLLKPYEEHFKALFVSFL
EESISFVRSSVKEVIASTNCNLTMSLLKLLDCFFKPFLPREGLKKIPSEKLSRIVELIEPWFIFSLIWSVGATGDSSGRTSFSHWLRLKM
ENEQLTLLFPEEGLVFDYRLEDAGISGTNDSEDEEEEYKQVAWVKWMDSSAPFTMVPDTNYCNIIVPTMDTVQMSHLLDMLLTNKKPVLC
IGPTGTGKTLTISDKLLKNLALDYISHFLTFSARTSANQTQDFIDSKLDKRRKGVFGPPLGRNFIFFIDDLNMPALETYGAQPPIELLRQ
WMDHGGWYDRKIIGAFKNLVDINFVCAMGPPGGGRNTVTPRLMRHFNYLSFAEMDEVSKKRIFSTILGNWLDGLLGEKSYRERVPGAPHI
AHFTEPLVEATIMVYATITSQLLPTPAKSHYTFNLRDLSKVFQGMLMADPAKVEDQVQLLRLWYHENCRVFRDRLVNEEDRSWFDQLLKR
CMEQWEVTFNKVCPFQPILYGDFMSPGSDVKSYELITSESKMMQVIEEYIEDYNQINTAKLKLVLFMDAMSHICRISRTLRQALGNALLL
GVGGSGRSSLTRLASHMAEYECFQIELSKNYGMSEWRDDVKKVLLKAGLQNLPITFLFSDTQIKNESFLEDINNVLNSGDIPNLYTADEQ
DQIVSTMRPYIQEQGLQPTKANLMAAYTGRVRSNIHMVLCMSPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKSVATVFLNEIPELE
SSQEEIQGLAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPSIPPAS
DTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGNLEHVSENGHHSSHKHDREPQRRSSVKRSDSGDEQLP
TICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSERPRGYHHPQGFLEDDDSPVCYDSRRSPRRRLL
PPTPASHRRSSFNFECLRRQSSQEEVPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLI
QVEQSEALDQVNGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52418047/chr3:53834276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
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5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH1

Q9UFH2

CACNA1D

Q01668

FUNCTION: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (Probable). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (PubMed:31178125). {ECO:0000269|PubMed:31178125, ECO:0000305|PubMed:31178125}.FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:18482979, ECO:0000269|PubMed:25620733, ECO:0000269|PubMed:28472301}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52782167_21722774.04266.0Compositional biasNote=Poly-Glu
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52781581_15882774.04266.0MotifNote=GPAGTGKT motif
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52781631_16372774.04266.0MotifNote=CFDEFNR motif
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52781862_18692774.04266.0Nucleotide bindingATP
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52782227_22342774.04266.0Nucleotide bindingATP
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52782586_25932774.04266.0Nucleotide bindingATP
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52781543_17642774.04266.0RegionAAA 1
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52781824_20572774.04266.0RegionAAA 2
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52781_15422774.04266.0RegionStem
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52782189_24492774.04266.0RegionAAA 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52783074_31222774.04266.0Coiled coilOntology_term=ECO:0000255
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52782547_27992774.04266.0RegionAAA 4
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52782814_31122774.04266.0RegionStalk
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52783197_34272774.04266.0RegionAAA 5
HgeneDNAH1chr3:52418047chr3:53834276ENST00000420323-52783640_38592774.04266.0RegionAAA 6
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491493_15041661.02182.0Calcium bindingOntology_term=ECO:0000250
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481493_15041641.02162.0Calcium bindingOntology_term=ECO:0000250
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461493_15041626.02138.0Calcium bindingOntology_term=ECO:0000250
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491_71661.02182.0Compositional biasNote=Poly-Met
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049653_6591661.02182.0Compositional biasNote=Poly-Leu
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049827_8381661.02182.0Compositional biasNote=Poly-Glu
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481_71641.02162.0Compositional biasNote=Poly-Met
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948653_6591641.02162.0Compositional biasNote=Poly-Leu
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948827_8381641.02162.0Compositional biasNote=Poly-Glu
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461_71626.02138.0Compositional biasNote=Poly-Met
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846653_6591626.02138.0Compositional biasNote=Poly-Leu
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846827_8381626.02138.0Compositional biasNote=Poly-Glu
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491075_11651661.02182.0RegionDihydropyridine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491420_14861661.02182.0RegionDihydropyridine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491432_14751661.02182.0RegionPhenylalkylamine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049429_4461661.02182.0RegionBinding to the beta subunit
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481075_11651641.02162.0RegionDihydropyridine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481420_14861641.02162.0RegionDihydropyridine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481432_14751641.02162.0RegionPhenylalkylamine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948429_4461641.02162.0RegionBinding to the beta subunit
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461075_11651626.02138.0RegionDihydropyridine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461420_14861626.02138.0RegionDihydropyridine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461432_14751626.02138.0RegionPhenylalkylamine binding
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846429_4461626.02138.0RegionBinding to the beta subunit
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049113_4091661.02182.0RepeatNote=I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491192_14671661.02182.0RepeatNote=IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049509_7551661.02182.0RepeatNote=II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049873_11551661.02182.0RepeatNote=III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948113_4091641.02162.0RepeatNote=I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481192_14671641.02162.0RepeatNote=IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948509_7551641.02162.0RepeatNote=II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948873_11551641.02162.0RepeatNote=III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846113_4091626.02138.0RepeatNote=I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461192_14671626.02138.0RepeatNote=IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846509_7551626.02138.0RepeatNote=II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846873_11551626.02138.0RepeatNote=III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491038_11271661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491149_12051661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491225_12391661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491260_12661661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491289_13131661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491334_13521661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491373_14391661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491465_21611661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049146_1631661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049184_1951661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491_1261661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049215_2351661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049255_2731661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049294_3811661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049407_5231661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049544_5581661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049578_5851661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049605_6141661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049634_6521661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049674_7271661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049753_8861661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049906_9211661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049942_9531661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049973_9781661.02182.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049999_10171661.02182.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481038_11271641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481149_12051641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481225_12391641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481260_12661641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481289_13131641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481334_13521641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481373_14391641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481465_21611641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948146_1631641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948184_1951641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481_1261641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948215_2351641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948255_2731641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948294_3811641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948407_5231641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948544_5581641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948578_5851641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948605_6141641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948634_6521641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948674_7271641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948753_8861641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948906_9211641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948942_9531641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948973_9781641.02162.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948999_10171641.02162.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461038_11271626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461149_12051626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461225_12391626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461260_12661626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461289_13131626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461334_13521626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461373_14391626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461465_21611626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846146_1631626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846184_1951626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461_1261626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846215_2351626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846255_2731626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846294_3811626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846407_5231626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846544_5581626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846578_5851626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846605_6141626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846634_6521626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846674_7271626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846753_8861626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846906_9211626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846942_9531626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846973_9781626.02138.0Topological domainExtracellular
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846999_10171626.02138.0Topological domainCytoplasmic
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491018_10371661.02182.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491128_11481661.02182.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491206_12241661.02182.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491240_12591661.02182.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491267_12881661.02182.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049127_1451661.02182.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491314_13331661.02182.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491353_13721661.02182.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000028813940491440_14641661.02182.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049164_1831661.02182.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049196_2141661.02182.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049236_2541661.02182.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049274_2931661.02182.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049382_4061661.02182.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049524_5431661.02182.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049559_5771661.02182.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049586_6041661.02182.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049615_6331661.02182.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049653_6731661.02182.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049728_7521661.02182.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049887_9051661.02182.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049922_9411661.02182.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049954_9721661.02182.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000002881394049979_9981661.02182.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481018_10371641.02162.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481128_11481641.02162.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481206_12241641.02162.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481240_12591641.02162.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481267_12881641.02162.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948127_1451641.02162.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481314_13331641.02162.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481353_13721641.02162.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000035006139481440_14641641.02162.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948164_1831641.02162.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948196_2141641.02162.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948236_2541641.02162.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948274_2931641.02162.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948382_4061641.02162.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948524_5431641.02162.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948559_5771641.02162.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948586_6041641.02162.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948615_6331641.02162.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948653_6731641.02162.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948728_7521641.02162.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948887_9051641.02162.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948922_9411641.02162.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948954_9721641.02162.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000003500613948979_9981641.02162.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461018_10371626.02138.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461128_11481626.02138.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461206_12241626.02138.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461240_12591626.02138.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461267_12881626.02138.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846127_1451626.02138.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461314_13331626.02138.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461353_13721626.02138.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST0000042228138461440_14641626.02138.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846164_1831626.02138.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846196_2141626.02138.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846236_2541626.02138.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846274_2931626.02138.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846382_4061626.02138.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846524_5431626.02138.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846559_5771626.02138.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846586_6041626.02138.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846615_6331626.02138.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846653_6731626.02138.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846728_7521626.02138.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846887_9051626.02138.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846922_9411626.02138.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846954_9721626.02138.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Dchr3:52418047chr3:53834276ENST000004222813846979_9981626.02138.0TransmembraneHelical%3B Name%3DS4 of repeat III


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNAH1
CACNA1D


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DNAH1-CACNA1D


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNAH1-CACNA1D


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource