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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNM2-ANGPTL4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNM2-ANGPTL4
FusionPDB ID: 23631
FusionGDB2.0 ID: 23631
HgeneTgene
Gene symbol

DNM2

ANGPTL4

Gene ID

1785

51129

Gene namedynamin 2angiopoietin like 4
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5ARP4|FIAF|HARP|HFARP|NL2|PGAR|TGQTL|UNQ171|pp1158
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIangiopoietin-related protein 4PPARG angiopoietin related proteinfasting-induced adipose factorhepatic angiopoietin-related proteinhepatic fibrinogen/angiopoietin-related proteinperoxisome proliferator-activated receptor (PPAR) gamma induced angiopoie
Modification date2020032920200322
UniProtAcc

P50570

Q9BY76

Ensembl transtripts involved in fusion geneENST idsENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 
ENST00000541807, 
ENST00000301455, ENST00000393962, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 17 X 17=104044 X 4 X 3=48
# samples 496
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNM2 [Title/Abstract] AND ANGPTL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNM2(10829079)-ANGPTL4(8438589), # samples:3
Anticipated loss of major functional domain due to fusion event.DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNM2-ANGPTL4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneANGPTL4

GO:0043066

negative regulation of apoptotic process

10698685

TgeneANGPTL4

GO:0043335

protein unfolding

29899144

TgeneANGPTL4

GO:0051005

negative regulation of lipoprotein lipase activity

19542565|29899144


check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANGPTL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-KR-A7K8-01ADNM2chr19

10829079

-ANGPTL4chr19

8438589

+
ChimerDB4LIHCTCGA-KR-A7K8-01ADNM2chr19

10829079

+ANGPTL4chr19

8438589

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000585892DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+994325722222166
ENST00000585892DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+952325722222166
ENST00000314646DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+994325722222166
ENST00000314646DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+952325722222166
ENST00000359692DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+980311708208166
ENST00000359692DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+938311708208166
ENST00000389253DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+942273670170166
ENST00000389253DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+900273670170166
ENST00000355667DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+910241638138166
ENST00000355667DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+868241638138166
ENST00000408974DNM2chr1910829079+ENST00000301455ANGPTL4chr198438589+86519659393166
ENST00000408974DNM2chr1910829079+ENST00000393962ANGPTL4chr198438589+82319659393166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585892ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.093919310.90608066
ENST00000585892ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.08592720.9140728
ENST00000314646ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.093919310.90608066
ENST00000314646ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.08592720.9140728
ENST00000359692ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.093265650.9067343
ENST00000359692ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.0887280850.9112719
ENST00000389253ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.130651650.86934835
ENST00000389253ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.106396910.8936031
ENST00000355667ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.0658499750.93415
ENST00000355667ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.071436590.92856336
ENST00000408974ENST00000301455DNM2chr1910829079+ANGPTL4chr198438589+0.122914170.8770858
ENST00000408974ENST00000393962DNM2chr1910829079+ANGPTL4chr198438589+0.126748870.8732511

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23631_23631_1_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000314646_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_2_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000314646_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_3_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000355667_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_4_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000355667_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_5_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000359692_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_6_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000359692_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_7_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000389253_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_8_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000389253_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_9_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000408974_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_10_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000408974_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_11_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000585892_ANGPTL4_chr19_8438589_ENST00000301455_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

>23631_23631_12_DNM2-ANGPTL4_DNM2_chr19_10829079_ENST00000585892_ANGPTL4_chr19_8438589_ENST00000393962_length(amino acids)=166AA_BP=1
MSISCSLDLRRQRMQPPCTQKGGFSSRGLLLCPQVSRWPLLGAPAQAGNGHILGQSQESPSFVGLGPGPARTLGGCLCCHGLDQHGGGLQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10829079/chr19:8438589)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

ANGPTL4

Q9BY76

FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.FUNCTION: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9Z1P8, ECO:0000269|PubMed:14583458, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144, ECO:0000305|PubMed:29899519}.; FUNCTION: [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697). {ECO:0000269|PubMed:19270337, ECO:0000269|PubMed:21398697, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12138_4653.666666666666664871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12038_4653.666666666666664867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12138_4653.666666666666664871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12038_4653.666666666666664867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12138_4653.666666666666664870.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12138_4553.666666666666664871.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12038_4553.666666666666664867.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12138_4553.666666666666664871.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12038_4553.666666666666664867.0RegionG1 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12138_4553.666666666666664870.0RegionG1 motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121747_86653.666666666666664871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120747_86653.666666666666664867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121747_86653.666666666666664871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120747_86653.666666666666664867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121747_86653.666666666666664870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12128_29453.666666666666664871.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121519_62553.666666666666664871.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121653_74453.666666666666664871.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12028_29453.666666666666664867.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120519_62553.666666666666664867.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120653_74453.666666666666664867.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12128_29453.666666666666664871.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121519_62553.666666666666664871.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121653_74453.666666666666664871.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12028_29453.666666666666664867.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120519_62553.666666666666664867.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120653_74453.666666666666664867.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12128_29453.666666666666664870.0DomainDynamin-type G
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121519_62553.666666666666664870.0DomainPH
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121653_74453.666666666666664870.0DomainGED
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121205_21153.666666666666664871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121236_23953.666666666666664871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120205_21153.666666666666664867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120236_23953.666666666666664867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121205_21153.666666666666664871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121236_23953.666666666666664871.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120205_21153.666666666666664867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120236_23953.666666666666664867.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121205_21153.666666666666664870.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121236_23953.666666666666664870.0Nucleotide bindingGTP
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121136_13953.666666666666664871.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121205_20853.666666666666664871.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+121235_23853.666666666666664871.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000355667+12164_6653.666666666666664871.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120136_13953.666666666666664867.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120205_20853.666666666666664867.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+120235_23853.666666666666664867.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000359692+12064_6653.666666666666664867.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121136_13953.666666666666664871.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121205_20853.666666666666664871.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+121235_23853.666666666666664871.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000389253+12164_6653.666666666666664871.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120136_13953.666666666666664867.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120205_20853.666666666666664867.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+120235_23853.666666666666664867.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000408974+12064_6653.666666666666664867.0RegionG2 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121136_13953.666666666666664870.0RegionG3 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121205_20853.666666666666664870.0RegionG4 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+121235_23853.666666666666664870.0RegionG5 motif
HgeneDNM2chr19:10829079chr19:8438589ENST00000585892+12164_6653.666666666666664870.0RegionG2 motif
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000030145557100_143346.3333333333333407.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000039396246100_143308.3333333333333369.0Coiled coilOntology_term=ECO:0000255
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000030145557179_401346.3333333333333407.0DomainFibrinogen C-terminal
TgeneANGPTL4chr19:10829079chr19:8438589ENST0000039396246179_401308.3333333333333369.0DomainFibrinogen C-terminal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNM2
ANGPTL4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DNM2-ANGPTL4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNM2-ANGPTL4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource