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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DNM2-MARS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DNM2-MARS
	FusionPDB ID: 23645
	FusionGDB2.0 ID: 23645
		Hgene	Tgene
	Gene symbol	DNM2	MARS
	Gene ID	1785	84174
	Gene name	dynamin 2	Src like adaptor 2
	Synonyms	CMT2M\|CMTDI1\|CMTDIB\|DI-CMTB\|DYN2\|DYNII\|LCCS5	C20orf156\|MARS\|SLAP-2\|SLAP2
	Cytomap	19p13.2	20q11.23
	Type of gene	protein-coding	protein-coding
	Description	dynamin-2dynamin II	src-like-adapter 2Src-like adapter protein-2modulator of antigen receptor signaling
	Modification date	20200329	20200313
	UniProtAcc	P50570	P56192
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000314646, ENST00000355667, ENST00000359692, ENST00000389253, ENST00000408974, ENST00000585892, ENST00000591819,	ENST00000447721, ENST00000262027, ENST00000315473,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	36 X 17 X 17=10404	16 X 19 X 8=2432
	# samples	49	23
	** MAII score	log2(49/10404*10)=-4.40821274494042 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/2432*10)=-3.40243746249921 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DNM2 [Title/Abstract] AND MARS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DNM2(10897382)-MARS(57891940), # samples:1
Anticipated loss of major functional domain due to fusion event.	DNM2-MARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DNM2-MARS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DNM2-MARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DNM2-MARS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DNM2	GO:1903526	negative regulation of membrane tubulation	18388313
Tgene	MARS	GO:0000122	negative regulation of transcription by RNA polymerase II	11696592
Tgene	MARS	GO:0050849	negative regulation of calcium-mediated signaling	11696592

Fusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GN-01A	DNM2	chr19	10897382	+	MARS	chr12	57891940	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000585892	DNM2	chr19	10897382	+	ENST00000262027	MARS	chr12	57891940	+	3157	1156	164	3088	974
ENST00000585892	DNM2	chr19	10897382	+	ENST00000315473	MARS	chr12	57891940	+	3139	1156	164	2995	943
ENST00000314646	DNM2	chr19	10897382	+	ENST00000262027	MARS	chr12	57891940	+	3157	1156	164	3088	974
ENST00000314646	DNM2	chr19	10897382	+	ENST00000315473	MARS	chr12	57891940	+	3139	1156	164	2995	943
ENST00000359692	DNM2	chr19	10897382	+	ENST00000262027	MARS	chr12	57891940	+	3143	1142	150	3074	974
ENST00000359692	DNM2	chr19	10897382	+	ENST00000315473	MARS	chr12	57891940	+	3125	1142	150	2981	943
ENST00000389253	DNM2	chr19	10897382	+	ENST00000262027	MARS	chr12	57891940	+	3105	1104	112	3036	974
ENST00000389253	DNM2	chr19	10897382	+	ENST00000315473	MARS	chr12	57891940	+	3087	1104	112	2943	943
ENST00000355667	DNM2	chr19	10897382	+	ENST00000262027	MARS	chr12	57891940	+	3073	1072	80	3004	974
ENST00000355667	DNM2	chr19	10897382	+	ENST00000315473	MARS	chr12	57891940	+	3055	1072	80	2911	943
ENST00000408974	DNM2	chr19	10897382	+	ENST00000262027	MARS	chr12	57891940	+	3028	1027	35	2959	974
ENST00000408974	DNM2	chr19	10897382	+	ENST00000315473	MARS	chr12	57891940	+	3010	1027	35	2866	943

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000585892	ENST00000262027	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002621197	0.9973788
ENST00000585892	ENST00000315473	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002693366	0.9973066
ENST00000314646	ENST00000262027	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002621197	0.9973788
ENST00000314646	ENST00000315473	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002693366	0.9973066
ENST00000359692	ENST00000262027	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002537275	0.99746275
ENST00000359692	ENST00000315473	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002618713	0.99738127
ENST00000389253	ENST00000262027	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002465432	0.9975345
ENST00000389253	ENST00000315473	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002546461	0.9974535
ENST00000355667	ENST00000262027	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002469544	0.9975305
ENST00000355667	ENST00000315473	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002562372	0.9974376
ENST00000408974	ENST00000262027	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.002555815	0.99744415
ENST00000408974	ENST00000315473	DNM2	chr19	10897382	+	MARS	chr12	57891940	+	0.00267739	0.9973226

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23645_23645_1_DNM2-MARS_DNM2_chr19_10897382_ENST00000314646_MARS_chr12_57891940_ENST00000262027_length(amino acids)=974AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSP

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>23645_23645_2_DNM2-MARS_DNM2_chr19_10897382_ENST00000314646_MARS_chr12_57891940_ENST00000315473_length(amino acids)=943AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLK

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>23645_23645_3_DNM2-MARS_DNM2_chr19_10897382_ENST00000355667_MARS_chr12_57891940_ENST00000262027_length(amino acids)=974AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSP

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>23645_23645_4_DNM2-MARS_DNM2_chr19_10897382_ENST00000355667_MARS_chr12_57891940_ENST00000315473_length(amino acids)=943AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLK

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>23645_23645_5_DNM2-MARS_DNM2_chr19_10897382_ENST00000359692_MARS_chr12_57891940_ENST00000262027_length(amino acids)=974AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSP

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>23645_23645_6_DNM2-MARS_DNM2_chr19_10897382_ENST00000359692_MARS_chr12_57891940_ENST00000315473_length(amino acids)=943AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLK

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>23645_23645_7_DNM2-MARS_DNM2_chr19_10897382_ENST00000389253_MARS_chr12_57891940_ENST00000262027_length(amino acids)=974AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSP

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>23645_23645_8_DNM2-MARS_DNM2_chr19_10897382_ENST00000389253_MARS_chr12_57891940_ENST00000315473_length(amino acids)=943AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLK

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>23645_23645_9_DNM2-MARS_DNM2_chr19_10897382_ENST00000408974_MARS_chr12_57891940_ENST00000262027_length(amino acids)=974AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSP

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>23645_23645_10_DNM2-MARS_DNM2_chr19_10897382_ENST00000408974_MARS_chr12_57891940_ENST00000315473_length(amino acids)=943AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLK

--------------------------------------------------------------

>23645_23645_11_DNM2-MARS_DNM2_chr19_10897382_ENST00000585892_MARS_chr12_57891940_ENST00000262027_length(amino acids)=974AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSP

--------------------------------------------------------------

>23645_23645_12_DNM2-MARS_DNM2_chr19_10897382_ENST00000585892_MARS_chr12_57891940_ENST00000315473_length(amino acids)=943AA_BP=331
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQLPVAGERNVLITSALPYVNNVPHLGNIIG
CVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKR
GFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLG
RTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDN
VPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSEL
LNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQ
RAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQVRKLK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10897382/chr12:57891940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DNM2 P50570	MARS P56192
FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250\|UniProtKB:P39052, ECO:0000250\|UniProtKB:P39054, ECO:0000269\|PubMed:12498685}.	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:11714285). Plays a role in the synthesis of ribosomal RNA in the nucleolus (PubMed:10791971). {ECO:0000269\|PubMed:10791971, ECO:0000269\|PubMed:11714285}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

28_294

330.6666666666667

871.0

Domain

Dynamin-type G

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

28_294

330.6666666666667

867.0

Domain

Dynamin-type G

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

28_294

330.6666666666667

871.0

Domain

Dynamin-type G

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

28_294

330.6666666666667

867.0

Domain

Dynamin-type G

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

28_294

330.6666666666667

870.0

Domain

Dynamin-type G

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

205_211

330.6666666666667

871.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

236_239

330.6666666666667

871.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

38_46

330.6666666666667

871.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

205_211

330.6666666666667

867.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

236_239

330.6666666666667

867.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

38_46

330.6666666666667

867.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

205_211

330.6666666666667

871.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

236_239

330.6666666666667

871.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

38_46

330.6666666666667

871.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

205_211

330.6666666666667

867.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

236_239

330.6666666666667

867.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

38_46

330.6666666666667

867.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

205_211

330.6666666666667

870.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

236_239

330.6666666666667

870.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

38_46

330.6666666666667

870.0

Nucleotide binding

GTP

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

136_139

330.6666666666667

871.0

Region

G3 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

205_208

330.6666666666667

871.0

Region

G4 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

235_238

330.6666666666667

871.0

Region

G5 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

38_45

330.6666666666667

871.0

Region

G1 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

64_66

330.6666666666667

871.0

Region

G2 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

136_139

330.6666666666667

867.0

Region

G3 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

205_208

330.6666666666667

867.0

Region

G4 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

235_238

330.6666666666667

867.0

Region

G5 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

38_45

330.6666666666667

867.0

Region

G1 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

64_66

330.6666666666667

867.0

Region

G2 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

136_139

330.6666666666667

871.0

Region

G3 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

205_208

330.6666666666667

871.0

Region

G4 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

235_238

330.6666666666667

871.0

Region

G5 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

38_45

330.6666666666667

871.0

Region

G1 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

64_66

330.6666666666667

871.0

Region

G2 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

136_139

330.6666666666667

867.0

Region

G3 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

205_208

330.6666666666667

867.0

Region

G4 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

235_238

330.6666666666667

867.0

Region

G5 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

38_45

330.6666666666667

867.0

Region

G1 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

64_66

330.6666666666667

867.0

Region

G2 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

136_139

330.6666666666667

870.0

Region

G3 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

205_208

330.6666666666667

870.0

Region

G4 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

235_238

330.6666666666667

870.0

Region

G5 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

38_45

330.6666666666667

870.0

Region

G1 motif

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

64_66

330.6666666666667

870.0

Region

G2 motif

Tgene

MARS

chr19:10897382

chr12:57891940

ENST00000262027

841_897

256.6666666666667

901.0

Domain

Note=WHEP-TRS

Tgene

MARS

chr19:10897382

chr12:57891940

ENST00000262027

273_283

256.6666666666667

901.0

Motif

Note='HIGH' region

Tgene

MARS

chr19:10897382

chr12:57891940

ENST00000262027

593_597

256.6666666666667

901.0

Motif

Note='KMSKS' region

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

747_866

330.6666666666667

871.0

Compositional bias

Note=Pro-rich

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

747_866

330.6666666666667

867.0

Compositional bias

Note=Pro-rich

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

747_866

330.6666666666667

871.0

Compositional bias

Note=Pro-rich

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

747_866

330.6666666666667

867.0

Compositional bias

Note=Pro-rich

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

747_866

330.6666666666667

870.0

Compositional bias

Note=Pro-rich

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

519_625

330.6666666666667

871.0

Domain

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000355667

653_744

330.6666666666667

871.0

Domain

GED

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

519_625

330.6666666666667

867.0

Domain

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000359692

653_744

330.6666666666667

867.0

Domain

GED

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

519_625

330.6666666666667

871.0

Domain

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000389253

653_744

330.6666666666667

871.0

Domain

GED

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

519_625

330.6666666666667

867.0

Domain

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000408974

653_744

330.6666666666667

867.0

Domain

GED

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

519_625

330.6666666666667

870.0

Domain

Hgene

DNM2

chr19:10897382

chr12:57891940

ENST00000585892

653_744

330.6666666666667

870.0

Domain

GED

Tgene

MARS

chr19:10897382

chr12:57891940

ENST00000262027

74_198

256.6666666666667

901.0

Domain

Note=GST C-terminal

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DNM2
MARS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DNM2-MARS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DNM2-MARS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source