UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:DNM2-ZDHHC7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNM2-ZDHHC7
FusionPDB ID: 23665
FusionGDB2.0 ID: 23665
HgeneTgene
Gene symbol

DNM2

ZDHHC7

Gene ID

1785

55625

Gene namedynamin 2zinc finger DHHC-type palmitoyltransferase 7
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5DHHC7|SERZ-B|SERZ1|ZNF370
Cytomap

19p13.2

16q24.1

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIpalmitoyltransferase ZDHHC7DHHC-7Sertoli cell gene with zinc finger domain-I(2)Sertoli cell gene with zinc finger domain-betazinc finger DHHC domain-containing protein 7zinc finger DHHC-type containing 7zinc finger protein 370zinc finger, DHHC doma
Modification date2020032920200327
UniProtAcc

P50570

.
Ensembl transtripts involved in fusion geneENST idsENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
ENST00000591819, 		ENST00000569488, 
ENST00000313732, ENST00000564466, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 17 X 17=104047 X 6 X 6=252
# samples 498
** MAII scorelog2(49/10404*10)=-4.40821274494042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNM2 [Title/Abstract] AND ZDHHC7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNM2(10916643)-ZDHHC7(85015600), # samples:1
Anticipated loss of major functional domain due to fusion event.DNM2-ZDHHC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ZDHHC7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ZDHHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM2-ZDHHC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneZDHHC7

GO:0018230

peptidyl-L-cysteine S-palmitoylation

28196865

TgeneZDHHC7

GO:0018345

protein palmitoylation

23034182


check buttonFusion gene breakpoints across DNM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZDHHC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer61NDNM2chr19

10916643

+ZDHHC7chr16

85015600

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000585892DNM2chr1910916643+ENST00000313732ZDHHC7chr1685015600-448317091642320718
ENST00000585892DNM2chr1910916643+ENST00000564466ZDHHC7chr1685015600-245117091642320718
ENST00000314646DNM2chr1910916643+ENST00000313732ZDHHC7chr1685015600-448317091642320718
ENST00000314646DNM2chr1910916643+ENST00000564466ZDHHC7chr1685015600-245117091642320718
ENST00000359692DNM2chr1910916643+ENST00000313732ZDHHC7chr1685015600-446916951502306718
ENST00000359692DNM2chr1910916643+ENST00000564466ZDHHC7chr1685015600-243716951502306718
ENST00000389253DNM2chr1910916643+ENST00000313732ZDHHC7chr1685015600-443116571122268718
ENST00000389253DNM2chr1910916643+ENST00000564466ZDHHC7chr1685015600-239916571122268718
ENST00000355667DNM2chr1910916643+ENST00000313732ZDHHC7chr1685015600-43991625802236718
ENST00000355667DNM2chr1910916643+ENST00000564466ZDHHC7chr1685015600-23671625802236718
ENST00000408974DNM2chr1910916643+ENST00000313732ZDHHC7chr1685015600-43541580352191718
ENST00000408974DNM2chr1910916643+ENST00000564466ZDHHC7chr1685015600-23221580352191718

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000585892ENST00000313732DNM2chr1910916643+ZDHHC7chr1685015600-0.0027259770.997274
ENST00000585892ENST00000564466DNM2chr1910916643+ZDHHC7chr1685015600-0.0123472610.9876528
ENST00000314646ENST00000313732DNM2chr1910916643+ZDHHC7chr1685015600-0.0026260660.99737394
ENST00000314646ENST00000564466DNM2chr1910916643+ZDHHC7chr1685015600-0.0112059260.98879415
ENST00000359692ENST00000313732DNM2chr1910916643+ZDHHC7chr1685015600-0.0026412660.99735874
ENST00000359692ENST00000564466DNM2chr1910916643+ZDHHC7chr1685015600-0.0118167340.9881833
ENST00000389253ENST00000313732DNM2chr1910916643+ZDHHC7chr1685015600-0.0024367650.99756324
ENST00000389253ENST00000564466DNM2chr1910916643+ZDHHC7chr1685015600-0.0103821540.98961776
ENST00000355667ENST00000313732DNM2chr1910916643+ZDHHC7chr1685015600-0.0025234940.9974765
ENST00000355667ENST00000564466DNM2chr1910916643+ZDHHC7chr1685015600-0.0111557640.9888442
ENST00000408974ENST00000313732DNM2chr1910916643+ZDHHC7chr1685015600-0.0024977170.99750227
ENST00000408974ENST00000564466DNM2chr1910916643+ZDHHC7chr1685015600-0.0109520140.98904806

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23665_23665_1_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000314646_ZDHHC7_chr16_85015600_ENST00000313732_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_2_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000314646_ZDHHC7_chr16_85015600_ENST00000564466_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_3_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000355667_ZDHHC7_chr16_85015600_ENST00000313732_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_4_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000355667_ZDHHC7_chr16_85015600_ENST00000564466_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_5_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000359692_ZDHHC7_chr16_85015600_ENST00000313732_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_6_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000359692_ZDHHC7_chr16_85015600_ENST00000564466_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_7_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000389253_ZDHHC7_chr16_85015600_ENST00000313732_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_8_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000389253_ZDHHC7_chr16_85015600_ENST00000564466_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_9_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000408974_ZDHHC7_chr16_85015600_ENST00000313732_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_10_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000408974_ZDHHC7_chr16_85015600_ENST00000564466_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_11_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000585892_ZDHHC7_chr16_85015600_ENST00000313732_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

>23665_23665_12_DNM2-ZDHHC7_DNM2_chr19_10916643_ENST00000585892_ZDHHC7_chr16_85015600_ENST00000564466_length(amino acids)=718AA_BP=515
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKK
FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMAD
RMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYP
RLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGAVPKGNATKEYMESLQLKPGEVIY
KCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10916643/chr16:85015600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

.
FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+132128_294515.0871.0DomainDynamin-type G
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+132028_294515.0867.0DomainDynamin-type G
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+132128_294515.0871.0DomainDynamin-type G
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+132028_294515.0867.0DomainDynamin-type G
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+132128_294515.0870.0DomainDynamin-type G
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321205_211515.0871.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321236_239515.0871.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+132138_46515.0871.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320205_211515.0867.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320236_239515.0867.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+132038_46515.0867.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321205_211515.0871.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321236_239515.0871.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+132138_46515.0871.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320205_211515.0867.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320236_239515.0867.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+132038_46515.0867.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321205_211515.0870.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321236_239515.0870.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+132138_46515.0870.0Nucleotide bindingGTP
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321136_139515.0871.0RegionG3 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321205_208515.0871.0RegionG4 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321235_238515.0871.0RegionG5 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+132138_45515.0871.0RegionG1 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+132164_66515.0871.0RegionG2 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320136_139515.0867.0RegionG3 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320205_208515.0867.0RegionG4 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320235_238515.0867.0RegionG5 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+132038_45515.0867.0RegionG1 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+132064_66515.0867.0RegionG2 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321136_139515.0871.0RegionG3 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321205_208515.0871.0RegionG4 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321235_238515.0871.0RegionG5 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+132138_45515.0871.0RegionG1 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+132164_66515.0871.0RegionG2 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320136_139515.0867.0RegionG3 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320205_208515.0867.0RegionG4 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320235_238515.0867.0RegionG5 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+132038_45515.0867.0RegionG1 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+132064_66515.0867.0RegionG2 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321136_139515.0870.0RegionG3 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321205_208515.0870.0RegionG4 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321235_238515.0870.0RegionG5 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+132138_45515.0870.0RegionG1 motif
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+132164_66515.0870.0RegionG2 motif
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000031373228130_180105.0309.0DomainDHHC
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000031373228195_217105.0309.0Topological domainLumenal
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000031373228239_308105.0309.0Topological domainCytoplasmic
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000056446639195_217142.0346.0Topological domainLumenal
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000056446639239_308142.0346.0Topological domainCytoplasmic
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000031373228174_194105.0309.0TransmembraneHelical
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000031373228218_238105.0309.0TransmembraneHelical
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000056446639174_194142.0346.0TransmembraneHelical
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000056446639218_238142.0346.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321747_866515.0871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320747_866515.0867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321747_866515.0871.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320747_866515.0867.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321747_866515.0870.0Compositional biasNote=Pro-rich
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321519_625515.0871.0DomainPH
HgeneDNM2chr19:10916643chr16:85015600ENST00000355667+1321653_744515.0871.0DomainGED
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320519_625515.0867.0DomainPH
HgeneDNM2chr19:10916643chr16:85015600ENST00000359692+1320653_744515.0867.0DomainGED
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321519_625515.0871.0DomainPH
HgeneDNM2chr19:10916643chr16:85015600ENST00000389253+1321653_744515.0871.0DomainGED
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320519_625515.0867.0DomainPH
HgeneDNM2chr19:10916643chr16:85015600ENST00000408974+1320653_744515.0867.0DomainGED
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321519_625515.0870.0DomainPH
HgeneDNM2chr19:10916643chr16:85015600ENST00000585892+1321653_744515.0870.0DomainGED
TgeneZDHHC7chr19:10916643chr16:85015600ENST0000056446639130_180142.0346.0DomainDHHC
TgeneZDHHC7chr19:10916643chr16:85015600ENST00000313732281_50105.0309.0Topological domainCytoplasmic
TgeneZDHHC7chr19:10916643chr16:85015600ENST000003137322872_75105.0309.0Topological domainLumenal
TgeneZDHHC7chr19:10916643chr16:85015600ENST000003137322897_173105.0309.0Topological domainCytoplasmic
TgeneZDHHC7chr19:10916643chr16:85015600ENST00000564466391_50142.0346.0Topological domainCytoplasmic
TgeneZDHHC7chr19:10916643chr16:85015600ENST000005644663972_75142.0346.0Topological domainLumenal
TgeneZDHHC7chr19:10916643chr16:85015600ENST000005644663997_173142.0346.0Topological domainCytoplasmic
TgeneZDHHC7chr19:10916643chr16:85015600ENST000003137322851_71105.0309.0TransmembraneHelical
TgeneZDHHC7chr19:10916643chr16:85015600ENST000003137322876_96105.0309.0TransmembraneHelical
TgeneZDHHC7chr19:10916643chr16:85015600ENST000005644663951_71142.0346.0TransmembraneHelical
TgeneZDHHC7chr19:10916643chr16:85015600ENST000005644663976_96142.0346.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNM2
ZDHHC7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to DNM2-ZDHHC7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to DNM2-ZDHHC7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource