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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNMT3B-DUSP15

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNMT3B-DUSP15
FusionPDB ID: 23716
FusionGDB2.0 ID: 23716
HgeneTgene
Gene symbol

DNMT3B

DUSP15

Gene ID

1789

128853

Gene nameDNA methyltransferase 3 betadual specificity phosphatase 15
SynonymsICF|ICF1|M.HsaIIIBC20orf57|VHY
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIBdual specificity protein phosphatase 15VH1-related member Ydual specificity phosphatase-like 15vaccinia virus VH1-related dual-specific protein phosphatase Y
Modification date2020031320200313
UniProtAcc

Q9UBC3

.
Ensembl transtripts involved in fusion geneENST idsENST00000201963, ENST00000328111, 
ENST00000344505, ENST00000348286, 
ENST00000353855, ENST00000375623, 
ENST00000443239, ENST00000456297, 
ENST00000339738, ENST00000375966, 
ENST00000398083, ENST00000398084, 
ENST00000486996, ENST00000493115, 
ENST00000278979, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 5=2455 X 3 X 4=60
# samples 85
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNMT3B [Title/Abstract] AND DUSP15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNMT3B(31376818)-DUSP15(30457400), # samples:3
Anticipated loss of major functional domain due to fusion event.DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNMT3B-DUSP15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076

TgeneDUSP15

GO:0016311

dephosphorylation

24531476


check buttonFusion gene breakpoints across DNMT3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DUSP15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-K4-A3WS-01ADNMT3Bchr20

31376818

-DUSP15chr20

30457400

-
ChimerDB4BLCATCGA-K4-A3WS-01ADNMT3Bchr20

31376818

+DUSP15chr20

30457400

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328111DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-277711341172009630
ENST00000348286DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-27381095781970630
ENST00000353855DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-27381095781970630
ENST00000443239DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2440797951672525
ENST00000344505DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2553910821785567
ENST00000375623DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2418775731650525
ENST00000456297DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-2292649491524491
ENST00000201963DNMT3Bchr2031376818+ENST00000278979DUSP15chr2030457400-275611132191988589

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328111ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.0881693140.91183066
ENST00000348286ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.089927930.91007215
ENST00000353855ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.089927930.91007215
ENST00000443239ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.08919410.9108059
ENST00000344505ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.0837438550.9162561
ENST00000375623ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.087504520.91249543
ENST00000456297ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.147181170.8528188
ENST00000201963ENST00000278979DNMT3Bchr2031376818+DUSP15chr2030457400-0.0678449350.9321551

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23716_23716_1_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000201963_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=589AA_BP=298
MSWVLASEPSGQPVHMEPSPEPPSLESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSL
LSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATAS
AGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMV
VSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKE
CINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQC
PPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQ

--------------------------------------------------------------

>23716_23716_2_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000328111_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=630AA_BP=339
MAVGRAGGNAARPAALGLSGPSKPSSAIGAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQPALRQESMKGDTRHLNGEEDAGGREDSIL
VNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVS
SRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMES
PQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGR
NKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI
KATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPP
HVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

--------------------------------------------------------------

>23716_23716_3_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000344505_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=567AA_BP=276
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTP
VMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTE
DTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFG
DGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAG
ISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALV
REATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSST

--------------------------------------------------------------

>23716_23716_4_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000348286_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=630AA_BP=339
MAVGRAGGNAARPAALGLSGPSKPSSAIGAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQPALRQESMKGDTRHLNGEEDAGGREDSIL
VNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVS
SRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMES
PQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGR
NKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI
KATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPP
HVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

--------------------------------------------------------------

>23716_23716_5_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000353855_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=630AA_BP=339
MAVGRAGGNAARPAALGLSGPSKPSSAIGAGDSRAQRPARPPAGLPPASPDPRLRRPAAPQPALRQESMKGDTRHLNGEEDAGGREDSIL
VNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVS
SRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMES
PQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGR
NKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAI
KATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPP
HVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSCTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASSSCTR

--------------------------------------------------------------

>23716_23716_6_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000375623_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=525AA_BP=234
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTP
VMPKLFRETRTRSESPASLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEY
QDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQP
LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQ
QLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQIC

--------------------------------------------------------------

>23716_23716_7_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000443239_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=525AA_BP=234
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTP
VMPKLFRETRTRSESPASLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEY
QDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQP
LLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQ
QLEEFGWASSQKGARHRTSKTSGAQCPPMTSATCLLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQIC

--------------------------------------------------------------

>23716_23716_8_DNMT3B-DUSP15_DNMT3B_chr20_31376818_ENST00000456297_DUSP15_chr20_30457400_ENST00000278979_length(amino acids)=491AA_BP=200
MRQESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQSLRRRATASAGTPWPSP
PSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSK
RQAMSGMRWVQWFGDGKFSEVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCC
RLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKGARHRTSKTSGAQCPPMTSATC
LLAARVALLSAALVREATGRTAQRCRLSPRAAAERLLGPPPHVAAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMADVQVQLRPGSSSC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:31376818/chr20:30457400)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT3B

Q9UBC3

.
FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722225_283283.0846.0DomainPWWP
TgeneDUSP15chr20:31376818chr20:30457400ENST000002789790101_1414.0296.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000375966071_1414.0233.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000398083071_1410133.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000398084071_1410133.0DomainTyrosine-protein phosphatase
TgeneDUSP15chr20:31376818chr20:30457400ENST00000486996061_1410133.0DomainTyrosine-protein phosphatase

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722423_555283.0846.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722575_853283.0846.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723225_283271.0854.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723423_555271.0854.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723575_853271.0854.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721225_283271.0793.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721423_555271.0793.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721575_853271.0793.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720225_283271.0771.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720423_555271.0771.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720575_853271.0771.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722225_283271.0834.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722423_555271.0834.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722575_853271.0834.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619225_283229.0729.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619423_555229.0729.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619575_853229.0729.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518225_283195.0695.0DomainPWWP
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518423_555195.0695.0DomainADD
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518575_853195.0695.0DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722582_586283.0846.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722627_629283.0846.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722832_834283.0846.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723582_586271.0854.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723627_629271.0854.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723832_834271.0854.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721582_586271.0793.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721627_629271.0793.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721832_834271.0793.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720582_586271.0771.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720627_629271.0771.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720832_834271.0771.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722582_586271.0834.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722627_629271.0834.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722832_834271.0834.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619582_586229.0729.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619627_629229.0729.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619832_834229.0729.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518582_586195.0695.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518627_629195.0695.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518832_834195.0695.0RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722434_464283.0846.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722475_531283.0846.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723434_464271.0854.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723475_531271.0854.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721434_464271.0793.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721475_531271.0793.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720434_464271.0771.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720475_531271.0771.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722434_464271.0834.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722475_531271.0834.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619434_464229.0729.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619475_531229.0729.0Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518434_464195.0695.0Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518475_531195.0695.0Zinc fingerPHD-type%3B atypical
TgeneDUSP15chr20:31376818chr20:30457400ENST00000339738071_1417.0236.0DomainTyrosine-protein phosphatase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNMT3B
DUSP15


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+7221_298283.0846.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+7231_298271.0854.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+7211_298271.0793.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+7201_298271.0771.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+7221_298271.0834.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+6191_298229.0729.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+5181_298195.0695.0DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000201963+722435_527283.0846.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000328111+723435_527271.0854.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000344505+721435_527271.0793.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000348286+720435_527271.0771.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000353855+722435_527271.0834.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000443239+619435_527229.0729.0the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31376818chr20:30457400ENST00000456297+518435_527195.0695.0the PRC2/EED-EZH2 complex


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Related Drugs to DNMT3B-DUSP15


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNMT3B-DUSP15


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource