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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DPP4-PDK1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DPP4-PDK1
	FusionPDB ID: 24022
	FusionGDB2.0 ID: 24022
		Hgene	Tgene
	Gene symbol	DPP4	PDK1
	Gene ID	1803	5170
	Gene name	dipeptidyl peptidase 4	3-phosphoinositide dependent protein kinase 1
	Synonyms	ADABP\|ADCP2\|CD26\|DPPIV\|TP103	PDK1\|PDPK2\|PDPK2P\|PRO0461
	Cytomap	2q24.2	16p13.3
	Type of gene	protein-coding	protein-coding
	Description	dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)	3-phosphoinositide-dependent protein kinase 13-phosphoinositide-dependent protein kinase 2 pseudogenePkB kinase like gene 1
	Modification date	20200322	20200313
	UniProtAcc	P27487	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000360534, ENST00000491591,	ENST00000282077, ENST00000392571, ENST00000410055, ENST00000543905, ENST00000544863,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 5 X 4=100	4 X 5 X 3=60
	# samples	6	5
	** MAII score	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DPP4 [Title/Abstract] AND PDK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DPP4(162902042)-PDK1(173451006), # samples:3
Anticipated loss of major functional domain due to fusion event.	DPP4-PDK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DPP4-PDK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DPP4	GO:0001666	response to hypoxia	16670267
Hgene	DPP4	GO:0006508	proteolysis	27198182
Hgene	DPP4	GO:0008284	positive regulation of cell proliferation	17549790
Hgene	DPP4	GO:0010716	negative regulation of extracellular matrix disassembly	16651416
Hgene	DPP4	GO:0031295	T cell costimulation	10900005\|17287217
Hgene	DPP4	GO:0033632	regulation of cell-cell adhesion mediated by integrin	11772392
Hgene	DPP4	GO:0042110	T cell activation	7594462
Hgene	DPP4	GO:0043542	endothelial cell migration	16651416
Tgene	PDK1	GO:0006468	protein phosphorylation	14585963
Tgene	PDK1	GO:0006469	negative regulation of protein kinase activity	9373175
Tgene	PDK1	GO:0018107	peptidyl-threonine phosphorylation	9368760
Tgene	PDK1	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	17327236
Tgene	PDK1	GO:0032148	activation of protein kinase B activity	9368760
Tgene	PDK1	GO:0035556	intracellular signal transduction	14749367
Tgene	PDK1	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	22454520

Fusion gene breakpoints across DPP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-Q2-A5QZ-01A	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+
ChimerDB4	KIRP	TCGA-Q2-A5QZ	DPP4	chr2	162902041	-	PDK1	chr2	173451005	+
ChimerDB4	KIRP	TCGA-Q2-A5QZ	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360534	DPP4	chr2	162902042	-	ENST00000543905	PDK1	chr2	173451006	+	1579	927	561	1292	243
ENST00000360534	DPP4	chr2	162902042	-	ENST00000544863	PDK1	chr2	173451006	+	1342	927	561	1292	243
ENST00000360534	DPP4	chr2	162902042	-	ENST00000282077	PDK1	chr2	173451006	+	13993	927	561	1292	243
ENST00000360534	DPP4	chr2	162902042	-	ENST00000392571	PDK1	chr2	173451006	+	1293	927	561	1292	243
ENST00000360534	DPP4	chr2	162902042	-	ENST00000410055	PDK1	chr2	173451006	+	2869	927	561	1292	243
ENST00000360534	DPP4	chr2	162902041	-	ENST00000543905	PDK1	chr2	173451005	+	1579	927	561	1292	243
ENST00000360534	DPP4	chr2	162902041	-	ENST00000544863	PDK1	chr2	173451005	+	1342	927	561	1292	243
ENST00000360534	DPP4	chr2	162902041	-	ENST00000282077	PDK1	chr2	173451005	+	13993	927	561	1292	243
ENST00000360534	DPP4	chr2	162902041	-	ENST00000392571	PDK1	chr2	173451005	+	1293	927	561	1292	243
ENST00000360534	DPP4	chr2	162902041	-	ENST00000410055	PDK1	chr2	173451005	+	2869	927	561	1292	243

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360534	ENST00000543905	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+	0.002091126	0.99790895
ENST00000360534	ENST00000544863	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+	0.002382908	0.99761707
ENST00000360534	ENST00000282077	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+	0.000334665	0.9996654
ENST00000360534	ENST00000392571	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+	0.002488071	0.99751186
ENST00000360534	ENST00000410055	DPP4	chr2	162902042	-	PDK1	chr2	173451006	+	0.00038574	0.99961424
ENST00000360534	ENST00000543905	DPP4	chr2	162902041	-	PDK1	chr2	173451005	+	0.002091126	0.99790895
ENST00000360534	ENST00000544863	DPP4	chr2	162902041	-	PDK1	chr2	173451005	+	0.002382908	0.99761707
ENST00000360534	ENST00000282077	DPP4	chr2	162902041	-	PDK1	chr2	173451005	+	0.000334665	0.9996654
ENST00000360534	ENST00000392571	DPP4	chr2	162902041	-	PDK1	chr2	173451005	+	0.002488071	0.99751186
ENST00000360534	ENST00000410055	DPP4	chr2	162902041	-	PDK1	chr2	173451005	+	0.00038574	0.99961424

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24022_24022_1_DPP4-PDK1_DPP4_chr2_162902041_ENST00000360534_PDK1_chr2_173451005_ENST00000282077_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_2_DPP4-PDK1_DPP4_chr2_162902041_ENST00000360534_PDK1_chr2_173451005_ENST00000392571_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_3_DPP4-PDK1_DPP4_chr2_162902041_ENST00000360534_PDK1_chr2_173451005_ENST00000410055_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_4_DPP4-PDK1_DPP4_chr2_162902041_ENST00000360534_PDK1_chr2_173451005_ENST00000543905_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_5_DPP4-PDK1_DPP4_chr2_162902041_ENST00000360534_PDK1_chr2_173451005_ENST00000544863_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_6_DPP4-PDK1_DPP4_chr2_162902042_ENST00000360534_PDK1_chr2_173451006_ENST00000282077_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_7_DPP4-PDK1_DPP4_chr2_162902042_ENST00000360534_PDK1_chr2_173451006_ENST00000392571_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_8_DPP4-PDK1_DPP4_chr2_162902042_ENST00000360534_PDK1_chr2_173451006_ENST00000410055_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_9_DPP4-PDK1_DPP4_chr2_162902042_ENST00000360534_PDK1_chr2_173451006_ENST00000543905_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

>24022_24022_10_DPP4-PDK1_DPP4_chr2_162902042_ENST00000360534_PDK1_chr2_173451006_ENST00000544863_length(amino acids)=243AA_BP=122
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:162902042/chr2:173451006)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DPP4 P27487	.
FUNCTION: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948). {ECO:0000269\|PubMed:10570924, ECO:0000269\|PubMed:10593948, ECO:0000269\|PubMed:10900005, ECO:0000269\|PubMed:10951221, ECO:0000269\|PubMed:11772392, ECO:0000269\|PubMed:14691230, ECO:0000269\|PubMed:16254193, ECO:0000269\|PubMed:16651416, ECO:0000269\|PubMed:17287217, ECO:0000269\|PubMed:17549790, ECO:0000269\|PubMed:18708048}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. {ECO:0000269\|PubMed:23835475}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DPP4

chr2:162902041

chr2:173451005

ENST00000360534

1_6

122.0

767.0

Topological domain

Cytoplasmic

Hgene

DPP4

chr2:162902042

chr2:173451006

ENST00000360534

1_6

122.0

767.0

Topological domain

Cytoplasmic

Hgene

DPP4

chr2:162902041

chr2:173451005

ENST00000360534

7_28

122.0

767.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

DPP4

chr2:162902042

chr2:173451006

ENST00000360534

7_28

122.0

767.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000282077

337_338

315.0

437.0

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000282077

354_359

315.0

437.0

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000410055

337_338

315.0

845.6666666666666

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000410055

354_359

315.0

845.6666666666666

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000282077

337_338

315.0

437.0

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000282077

354_359

315.0

437.0

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000410055

337_338

315.0

845.6666666666666

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000410055

354_359

315.0

845.6666666666666

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DPP4

chr2:162902041

chr2:173451005

ENST00000360534

29_766

122.0

767.0

Topological domain

Extracellular

Hgene

DPP4

chr2:162902042

chr2:173451006

ENST00000360534

29_766

122.0

767.0

Topological domain

Extracellular

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000282077

163_393

315.0

437.0

Domain

Histidine kinase

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000410055

163_393

315.0

845.6666666666666

Domain

Histidine kinase

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000282077

163_393

315.0

437.0

Domain

Histidine kinase

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000410055

163_393

315.0

845.6666666666666

Domain

Histidine kinase

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000282077

279_286

315.0

437.0

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902041

chr2:173451005

ENST00000410055

279_286

315.0

845.6666666666666

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000282077

279_286

315.0

437.0

Nucleotide binding

ATP

Tgene

PDK1

chr2:162902042

chr2:173451006

ENST00000410055

279_286

315.0

845.6666666666666

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>389_DPP4_162902042_PDK1_173451006_ranked_0.pdb	DPP4	162902041	162902042	ENST00000410055	PDK1	chr2	173451006	+	MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL	243

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DPP4_pLDDT.png

PDK1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DPP4
PDK1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DPP4-PDK1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DPP4-PDK1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source