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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DPP6-ACTR3B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DPP6-ACTR3B
FusionPDB ID: 24024
FusionGDB2.0 ID: 24024
HgeneTgene
Gene symbol

DPP6

ACTR3B

Gene ID

1804

57180

Gene namedipeptidyl peptidase like 6actin related protein 3B
SynonymsDPL1|DPPX|MRD33|VF2ARP11|ARP3BETA
Cytomap

7q36.2

7q36.1-q36.2

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6actin-related protein 3BARP3 actin related protein 3 homolog BARP3-betaactin-like protein 3Bactin-related protein 3-betaactin-related protein ARP4actin-related protein Arp11
Modification date2020031320200313
UniProtAcc

P42658

Q9P1U1

Ensembl transtripts involved in fusion geneENST idsENST00000377770, ENST00000406326, 
ENST00000332007, ENST00000404039, 
ENST00000427557, ENST00000496611, 
ENST00000488782, ENST00000397282, 
ENST00000537264, ENST00000256001, 
ENST00000377776, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 10 X 5=4505 X 7 X 6=210
# samples 128
** MAII scorelog2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DPP6 [Title/Abstract] AND ACTR3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DPP6(153750148)-ACTR3B(152498705), # samples:24
Anticipated loss of major functional domain due to fusion event.DPP6-ACTR3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DPP6-ACTR3B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DPP6-ACTR3B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP6

GO:1901379

regulation of potassium ion transmembrane transport

18364354


check buttonFusion gene breakpoints across DPP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACTR3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YBDPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4ESCATCGA-V5-AASVDPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-02-2485DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-0125DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-0184-01ADPP6chr7

153750148

+ACTR3Bchr7

152480272

+
ChimerDB4GBMTCGA-06-0190-02ADPP6chr7

153750148

+ACTR3Bchr7

152480272

+
ChimerDB4GBMTCGA-06-0190DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-0210DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-06-0645DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-2558DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-2562DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-2567DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-06-5408DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-5412DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-06-5414DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-06-5415DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-12-3653DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-14-0790DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-14-1823DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-15-0742DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-19-1390DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-19-5960DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-26-5134DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-27-2523DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-1747DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-2514DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-5204DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-28-5207DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-28-5215DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-32-1982-01ADPP6chr7

153750148

+ACTR3Bchr7

152480272

+
ChimerDB4GBMTCGA-32-2638DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4GBMTCGA-41-2572DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4GBMTCGA-76-4928DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4OVTCGA-09-2045DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4OVTCGA-13-A5FTDPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-24-1419DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-24-1567DPP6chr7

153750148

+ACTR3Bchr7

152498705

+
ChimerDB4OVTCGA-59-2363DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-61-1995DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4OVTCGA-61-2110DPP6chr7

153750148

+ACTR3Bchr7

152480271

+
ChimerDB4STADTCGA-VQ-A8E2DPP6chr7

153750148

+ACTR3Bchr7

152498705

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406326DPP6chr7153750148+ENST00000377776ACTR3Bchr7152498705+18536461061467453
ENST00000406326DPP6chr7153750148+ENST00000256001ACTR3Bchr7152498705+25036461061677523
ENST00000377770DPP6chr7153750148+ENST00000377776ACTR3Bchr7152498705+1591384571205382
ENST00000377770DPP6chr7153750148+ENST00000256001ACTR3Bchr7152498705+2241384571415452

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406326ENST00000377776DPP6chr7153750148+ACTR3Bchr7152498705+0.0010181450.9989818
ENST00000406326ENST00000256001DPP6chr7153750148+ACTR3Bchr7152498705+0.0004010460.9995989
ENST00000377770ENST00000377776DPP6chr7153750148+ACTR3Bchr7152498705+0.0009481910.99905175
ENST00000377770ENST00000256001DPP6chr7153750148+ACTR3Bchr7152498705+0.0003708850.99962914

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24024_24024_1_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000377770_ACTR3B_chr7_152498705_ENST00000256001_length(amino acids)=452AA_BP=109
MERGGEWEPERKQNIKKPQRQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGG
AGGRPRFQYQARSDGDEEDWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAV
LALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICP
DIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGST
MFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGV

--------------------------------------------------------------

>24024_24024_2_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000377770_ACTR3B_chr7_152498705_ENST00000377776_length(amino acids)=382AA_BP=109
MERGGEWEPERKQNIKKPQRQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGG
AGGRPRFQYQARSDGDEEDWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAV
LALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICP
DIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKPEFFQVCHT

--------------------------------------------------------------

>24024_24024_3_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000406326_ACTR3B_chr7_152498705_ENST00000256001_length(amino acids)=523AA_BP=180
MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ
RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED
WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ
YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDA

--------------------------------------------------------------

>24024_24024_4_DPP6-ACTR3B_DPP6_chr7_153750148_ENST00000406326_ACTR3B_chr7_152498705_ENST00000377776_length(amino acids)=453AA_BP=180
MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ
RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED
WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ
YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKPEFFQVCHTKKDYEEYGPSICRHNPVFG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:153750148/chr7:152498705)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPP6

P42658

ACTR3B

Q9P1U1

FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}.FUNCTION: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269|PubMed:14651955}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPP6chr7:153750148chr7:152498705ENST00000332007+126117_8650804.0Topological domainExtracellular
HgeneDPP6chr7:153750148chr7:152498705ENST00000332007+1261_950804.0Topological domainCytoplasmic
HgeneDPP6chr7:153750148chr7:152498705ENST00000377770+126117_86581.0866.0Topological domainExtracellular
HgeneDPP6chr7:153750148chr7:152498705ENST00000377770+1261_9581.0866.0Topological domainCytoplasmic
HgeneDPP6chr7:153750148chr7:152498705ENST00000332007+12696_1160804.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneDPP6chr7:153750148chr7:152498705ENST00000377770+12696_11681.0866.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1119_DPP6_153750148_ACTR3B_152498705_1119_DPP6_153750148_ACTR3B_152498705_ranked_0.pdbDPP6153750148153750148ENST00000256001ACTR3Bchr7152498705+
MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ
RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED
WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ
YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDA
523


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DPP6_pLDDT.png
all structure
all structure
ACTR3B_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DPP6
ACTR3B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DPP6-ACTR3B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DPP6-ACTR3B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource