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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCC1-PRKCB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC1-PRKCB
FusionPDB ID: 241
FusionGDB2.0 ID: 241
HgeneTgene
Gene symbol

ABCC1

PRKCB

Gene ID

4363

5579

Gene nameATP binding cassette subfamily C member 1protein kinase C beta
SynonymsABC29|ABCC|GS-X|MRP|MRP1PKC-beta|PKCB|PKCI(2)|PKCbeta|PRKCB1|PRKCB2
Cytomap

16p13.11

16p12.2-p12.1

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 1ATP-binding cassette transporter variant ABCC1delta-ex13ATP-binding cassette transporter variant ABCC1delta-ex13&14ATP-binding cassette transporter variant ABCC1delta-ex25ATP-binding cassette transporter varianprotein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptide
Modification date2020031320200313
UniProtAcc

Q96J66

.
Ensembl transtripts involved in fusion geneENST idsENST00000345148, ENST00000346370, 
ENST00000349029, ENST00000351154, 
ENST00000399408, ENST00000399410, 
ENST00000576557, 
ENST00000482000, 
ENST00000498058, ENST00000303531, 
ENST00000321728, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 10 X 6=66020 X 15 X 13=3900
# samples 1425
** MAII scorelog2(14/660*10)=-2.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(25/3900*10)=-3.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCC1 [Title/Abstract] AND PRKCB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC1(16184445)-PRKCB(23999829), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC1-PRKCB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC1-PRKCB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC1-PRKCB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC1-PRKCB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKCB

GO:0010827

regulation of glucose transmembrane transport

25982116

TgenePRKCB

GO:0035408

histone H3-T6 phosphorylation

20228790


check buttonFusion gene breakpoints across ABCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKCB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8I7-01AABCC1chr16

16184445

-PRKCBchr16

23999829

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000399410ABCC1chr1616184445-ENST00000321728PRKCBchr1623999829+512828191046291539
ENST00000399410ABCC1chr1616184445-ENST00000303531PRKCBchr1623999829+1043128191046351541
ENST00000349029ABCC1chr1616184445-ENST00000321728PRKCBchr1623999829+478324741042841424
ENST00000349029ABCC1chr1616184445-ENST00000303531PRKCBchr1623999829+1008624741042901426
ENST00000351154ABCC1chr1616184445-ENST00000321728PRKCBchr1623999829+495126421044521480
ENST00000351154ABCC1chr1616184445-ENST00000303531PRKCBchr1623999829+1025426421044581482
ENST00000399408ABCC1chr1616184445-ENST00000321728PRKCBchr1623999829+512828191046291539
ENST00000399408ABCC1chr1616184445-ENST00000303531PRKCBchr1623999829+1043128191046351541
ENST00000345148ABCC1chr1616184445-ENST00000321728PRKCBchr1623999829+512828191046291539
ENST00000345148ABCC1chr1616184445-ENST00000303531PRKCBchr1623999829+1043128191046351541
ENST00000346370ABCC1chr1616184445-ENST00000321728PRKCBchr1623999829+496026511044611483
ENST00000346370ABCC1chr1616184445-ENST00000303531PRKCBchr1623999829+1026326511044671485

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399410ENST00000321728ABCC1chr1616184445-PRKCBchr1623999829+0.0015885280.9984114
ENST00000399410ENST00000303531ABCC1chr1616184445-PRKCBchr1623999829+0.0004080220.999592
ENST00000349029ENST00000321728ABCC1chr1616184445-PRKCBchr1623999829+0.0009076260.99909234
ENST00000349029ENST00000303531ABCC1chr1616184445-PRKCBchr1623999829+0.0005413120.99945873
ENST00000351154ENST00000321728ABCC1chr1616184445-PRKCBchr1623999829+0.0016943340.9983057
ENST00000351154ENST00000303531ABCC1chr1616184445-PRKCBchr1623999829+0.000529320.99947065
ENST00000399408ENST00000321728ABCC1chr1616184445-PRKCBchr1623999829+0.0015885280.9984114
ENST00000399408ENST00000303531ABCC1chr1616184445-PRKCBchr1623999829+0.0004080220.999592
ENST00000345148ENST00000321728ABCC1chr1616184445-PRKCBchr1623999829+0.0015885280.9984114
ENST00000345148ENST00000303531ABCC1chr1616184445-PRKCBchr1623999829+0.0004080220.999592
ENST00000346370ENST00000321728ABCC1chr1616184445-PRKCBchr1623999829+0.0016339210.99836606
ENST00000346370ENST00000303531ABCC1chr1616184445-PRKCBchr1623999829+0.0002847770.99971515

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>241_241_1_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000345148_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=1541AA_BP=936
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGK
ISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL
YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKT
KTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELR
QKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC
KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFV

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>241_241_2_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000345148_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=1539AA_BP=936
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGK
ISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL
YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKT
KTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELR
QKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC
KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSY

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>241_241_3_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000346370_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=1485AA_BP=880
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPG
ADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVR
DAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK
ASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVML
SERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA
EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ
APFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAEN

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>241_241_4_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000346370_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=1483AA_BP=880
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPG
ADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVR
DAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQK
ASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVML
SERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA
EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQ
APFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTS

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>241_241_5_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000349029_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=1426AA_BP=821
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYA
STEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNV
PSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKD
RRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSK
FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLY
FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY
IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH

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>241_241_6_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000349029_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=1424AA_BP=821
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYA
STEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNV
PSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKD
RRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSK
FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLY
FVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDY
IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEH

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>241_241_7_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000351154_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=1482AA_BP=877
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPK
GMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADK
GPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAK
NLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASV
DGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSER
KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA
IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDR

--------------------------------------------------------------

>241_241_8_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000351154_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=1480AA_BP=877
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPK
GMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADK
GPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAK
NLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASV
DGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSER
KGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA
IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF
EGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD

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>241_241_9_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000399408_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=1541AA_BP=936
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGK
ISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL
YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKT
KTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELR
QKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC
KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFV

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>241_241_10_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000399408_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=1539AA_BP=936
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGK
ISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL
YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKT
KTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELR
QKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC
KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSY

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>241_241_11_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000399410_PRKCB_chr16_23999829_ENST00000303531_length(amino acids)=1541AA_BP=936
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGK
ISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL
YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKT
KTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELR
QKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC
KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFV

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>241_241_12_ABCC1-PRKCB_ABCC1_chr16_16184445_ENST00000399410_PRKCB_chr16_23999829_ENST00000321728_length(amino acids)=1539AA_BP=936
MRPRPRLPAPPPPPPPALAPAAGPDHPPPGARRRPRQQPGPITRRPVPAAARATGMALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQN
TVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQ
LERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASF
LSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSP
QKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRI
KTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAM
KTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN
ILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGIT
FSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS
GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGK
ISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL
YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKT
KTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELR
QKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI
ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC
KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSY

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:16184445/chr16:23999829)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC1

Q96J66

.
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536). {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273, ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689, ECO:0000269|PubMed:25896536}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930325_608881.33333333333341467.0DomainABC transmembrane type-1 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930644_868881.33333333333341467.0DomainABC transporter 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830325_608825.33333333333341476.0DomainABC transmembrane type-1 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729325_608766.33333333333341417.0DomainABC transmembrane type-1 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830325_608822.33333333333341473.0DomainABC transmembrane type-1 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932325_608881.33333333333341542.0DomainABC transmembrane type-1 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932644_868881.33333333333341542.0DomainABC transporter 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931325_608881.33333333333341532.0DomainABC transmembrane type-1 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931644_868881.33333333333341532.0DomainABC transporter 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930678_685881.33333333333341467.0Nucleotide bindingNote=ATP 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830678_685825.33333333333341476.0Nucleotide bindingNote=ATP 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729678_685766.33333333333341417.0Nucleotide bindingNote=ATP 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830678_685822.33333333333341473.0Nucleotide bindingNote=ATP 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932678_685881.33333333333341542.0Nucleotide bindingNote=ATP 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931678_685881.33333333333341532.0Nucleotide bindingNote=ATP 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930122_133881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930155_172881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930194_316881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301_33881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930338_363881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930385_440881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930462_464881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930486_547881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-193055_74881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930569_590881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-193096_100881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830122_133825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830155_172825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830194_316825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301_33825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830338_363825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830385_440825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830462_464825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830486_547825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-183055_74825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830569_590825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-183096_100825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729122_133766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729155_172766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729194_316766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291_33766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729338_363766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729385_440766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729462_464766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729486_547766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-172955_74766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729569_590766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-172996_100766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830122_133822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830155_172822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830194_316822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301_33822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830338_363822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830385_440822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830462_464822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830486_547822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-183055_74822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830569_590822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-183096_100822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932122_133881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932155_172881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932194_316881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321_33881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932338_363881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932385_440881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932462_464881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932486_547881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-193255_74881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932569_590881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-193296_100881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931122_133881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931155_172881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931194_316881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311_33881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931338_363881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931385_440881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931462_464881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931486_547881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-193155_74881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931569_590881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-193196_100881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930101_121881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D3
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930134_154881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D4
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930173_193881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D5
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930317_337881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D6
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-193034_54881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D1
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930364_384881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D7
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930441_461881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D8
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930465_485881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D9
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930548_568881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D10
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930591_611881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D11
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-193075_95881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D2
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830101_121825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D3
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830134_154825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D4
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830173_193825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D5
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830317_337825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D6
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-183034_54825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D1
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830364_384825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D7
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830441_461825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D8
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830465_485825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D9
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830548_568825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D10
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830591_611825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D11
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-183075_95825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D2
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729101_121766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D3
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729134_154766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D4
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729173_193766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D5
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729317_337766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D6
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-172934_54766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D1
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729364_384766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D7
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729441_461766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D8
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729465_485766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D9
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729548_568766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D10
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729591_611766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D11
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-172975_95766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D2
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830101_121822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D3
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830134_154822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D4
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830173_193822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D5
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830317_337822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D6
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-183034_54822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D1
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830364_384822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D7
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830441_461822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D8
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830465_485822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D9
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830548_568822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D10
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830591_611822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D11
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-183075_95822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932101_121881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D3
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932134_154881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D4
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932173_193881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D5
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932317_337881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D6
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-193234_54881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932364_384881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D7
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932441_461881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D8
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932465_485881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D9
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932548_568881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D10
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932591_611881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D11
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-193275_95881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931101_121881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D3
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931134_154881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D4
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931173_193881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D5
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931317_337881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D6
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-193134_54881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D1
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931364_384881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D7
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931441_461881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D8
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931465_485881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D9
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931548_568881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D10
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931591_611881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D11
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-193175_95881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D2
TgenePRKCBchr16:16184445chr16:23999829ENST00000303531117158_27568.33333333333333674.0DomainC2
TgenePRKCBchr16:16184445chr16:23999829ENST00000303531117342_60068.33333333333333674.0DomainProtein kinase
TgenePRKCBchr16:16184445chr16:23999829ENST00000303531117601_67168.33333333333333674.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:16184445chr16:23999829ENST00000321728117158_27568.33333333333333672.0DomainC2
TgenePRKCBchr16:16184445chr16:23999829ENST00000321728117342_60068.33333333333333672.0DomainProtein kinase
TgenePRKCBchr16:16184445chr16:23999829ENST00000321728117601_67168.33333333333333672.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:16184445chr16:23999829ENST0000049805802158_275058.0DomainC2
TgenePRKCBchr16:16184445chr16:23999829ENST0000049805802342_600058.0DomainProtein kinase
TgenePRKCBchr16:16184445chr16:23999829ENST0000049805802601_671058.0DomainAGC-kinase C-terminal
TgenePRKCBchr16:16184445chr16:23999829ENST00000303531117348_35668.33333333333333674.0Nucleotide bindingATP
TgenePRKCBchr16:16184445chr16:23999829ENST00000321728117348_35668.33333333333333672.0Nucleotide bindingATP
TgenePRKCBchr16:16184445chr16:23999829ENST0000049805802348_356058.0Nucleotide bindingATP
TgenePRKCBchr16:16184445chr16:23999829ENST00000303531117101_15168.33333333333333674.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:16184445chr16:23999829ENST00000321728117101_15168.33333333333333672.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:16184445chr16:23999829ENST0000049805802101_151058.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCBchr16:16184445chr16:23999829ENST000004980580236_86058.0Zinc fingerPhorbol-ester/DAG-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301293_1527881.33333333333341467.0DomainABC transporter 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930975_1256881.33333333333341467.0DomainABC transmembrane type-1 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301293_1527825.33333333333341476.0DomainABC transporter 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830644_868825.33333333333341476.0DomainABC transporter 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830975_1256825.33333333333341476.0DomainABC transmembrane type-1 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291293_1527766.33333333333341417.0DomainABC transporter 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729644_868766.33333333333341417.0DomainABC transporter 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729975_1256766.33333333333341417.0DomainABC transmembrane type-1 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301293_1527822.33333333333341473.0DomainABC transporter 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830644_868822.33333333333341473.0DomainABC transporter 1
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830975_1256822.33333333333341473.0DomainABC transmembrane type-1 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321293_1527881.33333333333341542.0DomainABC transporter 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932975_1256881.33333333333341542.0DomainABC transmembrane type-1 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311293_1527881.33333333333341532.0DomainABC transporter 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931975_1256881.33333333333341532.0DomainABC transmembrane type-1 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301327_1334881.33333333333341467.0Nucleotide bindingATP 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301327_1334825.33333333333341476.0Nucleotide bindingATP 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291327_1334766.33333333333341417.0Nucleotide bindingATP 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301327_1334822.33333333333341473.0Nucleotide bindingATP 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321327_1334881.33333333333341542.0Nucleotide bindingATP 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311327_1334881.33333333333341532.0Nucleotide bindingATP 2
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301047_1089881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301111_1111881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301133_1203881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301225_1226881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301248_1531881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930612_967881.33333333333341467.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930989_1025881.33333333333341467.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301047_1089825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301111_1111825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301133_1203825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301225_1226825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301248_1531825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830612_967825.33333333333341476.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830989_1025825.33333333333341476.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291047_1089766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291111_1111766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291133_1203766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291225_1226766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291248_1531766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729612_967766.33333333333341417.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729989_1025766.33333333333341417.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301047_1089822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301111_1111822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301133_1203822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301225_1226822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301248_1531822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830612_967822.33333333333341473.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830989_1025822.33333333333341473.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321047_1089881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321111_1111881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321133_1203881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321225_1226881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321248_1531881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932612_967881.33333333333341542.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932989_1025881.33333333333341542.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311047_1089881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311111_1111881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311133_1203881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311225_1226881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311248_1531881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931612_967881.33333333333341532.0Topological domainNote=Cytoplasmic
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931989_1025881.33333333333341532.0Topological domainNote=Extracellular
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301026_1046881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D13
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301090_1110881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D14
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301112_1132881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D15
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301204_1224881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D16
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-19301227_1247881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D17
HgeneABCC1chr16:16184445chr16:23999829ENST00000345148-1930968_988881.33333333333341467.0TransmembraneNote=Helical%3B Name%3D12
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301026_1046825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D13
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301090_1110825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D14
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301112_1132825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D15
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301204_1224825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D16
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-18301227_1247825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D17
HgeneABCC1chr16:16184445chr16:23999829ENST00000346370-1830968_988825.33333333333341476.0TransmembraneNote=Helical%3B Name%3D12
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291026_1046766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D13
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291090_1110766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D14
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291112_1132766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D15
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291204_1224766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D16
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-17291227_1247766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D17
HgeneABCC1chr16:16184445chr16:23999829ENST00000349029-1729968_988766.33333333333341417.0TransmembraneNote=Helical%3B Name%3D12
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301026_1046822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D13
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301090_1110822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D14
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301112_1132822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D15
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301204_1224822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D16
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-18301227_1247822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D17
HgeneABCC1chr16:16184445chr16:23999829ENST00000351154-1830968_988822.33333333333341473.0TransmembraneNote=Helical%3B Name%3D12
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321026_1046881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D13
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321090_1110881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D14
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321112_1132881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D15
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321204_1224881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D16
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-19321227_1247881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D17
HgeneABCC1chr16:16184445chr16:23999829ENST00000399408-1932968_988881.33333333333341542.0TransmembraneNote=Helical%3B Name%3D12
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311026_1046881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D13
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311090_1110881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D14
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311112_1132881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D15
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311204_1224881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D16
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-19311227_1247881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D17
HgeneABCC1chr16:16184445chr16:23999829ENST00000399410-1931968_988881.33333333333341532.0TransmembraneNote=Helical%3B Name%3D12
TgenePRKCBchr16:16184445chr16:23999829ENST0000030353111736_8668.33333333333333674.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCBchr16:16184445chr16:23999829ENST0000032172811736_8668.33333333333333672.0Zinc fingerPhorbol-ester/DAG-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCC1
PRKCB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCC1-PRKCB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC1-PRKCB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource