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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DSG1-TNXB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DSG1-TNXB
FusionPDB ID: 24243
FusionGDB2.0 ID: 24243
HgeneTgene
Gene symbol

DSG1

TNXB

Gene ID

1828

7148

Gene namedesmoglein 1tenascin XB
SynonymsCDHF4|DG1|DSG|EPKHE|EPKHIA|PPKS1|SPPK1EDS3|EDSCLL|EDSCLL1|HXBL|TENX|TN-X|TNX|TNXB1|TNXB2|TNXBS|VUR8|XB|XBS
Cytomap

18q12.1

6p21.33-p21.32

Type of geneprotein-codingprotein-coding
Descriptiondesmoglein-1cadherin family member 4desmosomal glycoprotein 1pemphigus foliaceus antigentenascin-Xgrowth-inhibiting protein 45hexabrachion-like proteintenascin XB1tenascin XB2
Modification date2020031320200313
UniProtAcc

Q02413

.
Ensembl transtripts involved in fusion geneENST idsENST00000257192, ENST00000462981, 
ENST00000375247, ENST00000383159, 
ENST00000424718, ENST00000433037, 
ENST00000440248, ENST00000451343, 
ENST00000464376, ENST00000465958, 
ENST00000469250, ENST00000471059, 
ENST00000475986, ENST00000479795, 
ENST00000489006, ENST00000546684, 
ENST00000548628, ENST00000548649, 
ENST00000549232, ENST00000549652, 
ENST00000550212, ENST00000550539, 
ENST00000551201, ENST00000551808, 
ENST00000552149, ENST00000552665, 
ENST00000553092, ENST00000375244, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 3=486 X 6 X 5=180
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DSG1 [Title/Abstract] AND TNXB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DSG1(28919988)-TNXB(32038191), # samples:3
Anticipated loss of major functional domain due to fusion event.DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-TNXB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSG1

GO:0050821

protein stabilization

7983064


check buttonFusion gene breakpoints across DSG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNXB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A922-01ADSG1chr18

28919988

+TNXBchr6

32038191

-
ChimerDB4STADTCGA-VQ-A922DSG1chr18

28919988

+TNXBchr6

32038191

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257192DSG1chr1828919988+ENST00000375244TNXBchr632038191-9839189921296433143

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257192ENST00000375244DSG1chr1828919988+TNXBchr632038191-0.0012674290.9987326

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24243_24243_1_DSG1-TNXB_DSG1_chr18_28919988_ENST00000257192_TNXB_chr6_32038191_ENST00000375244_length(amino acids)=3143AA_BP=1202
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGV
GIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYME
QSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS
IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTK
EQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLL
SDNVHFGPAGIGLLIMGFLVLGFARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKDKDGPQVVPVEGHERSVTVTPL
DAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPEGQFDSFVVQYKDRDGQPQVVP
VEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVEEATSHTLHLSWMVTEGEFDSF
EIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTATPEPPIKPRLGELTVTDATPD
SLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVVGVTAAEEETPSPTEPSMEAPE
PAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSAVGVT
APEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRV
GPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNGDGQPKATRVPGHEDRVTISGL
EPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGR
PQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPPEEPLLGELTVTGSSPDSLSLS
WTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTEDEAETTQAVPTMTPEPPIKPRL
GELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETP
SPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVTVGGLEPGRKYKMHLYGLHEGR
RVGPVSTVGVTAPEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKVVRVPGHEDGVTISG
LEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGRFDSFTVQYKDRDG
RPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPRLGELTVTDATPDSLSLSWM
VPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPSPTEPSTEAPEAPEEPLLGE
LTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQRVGPVSTVGITAPLPTPLPV
EPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFGLQNGKRHGPVPVEARTAPD
TKPSPRLGELTVTDATPDSVGLSWTVPEGEFDSFVVQYKDKDGRLQVVPVAANQREVTVQGLEPSRKYRFLLYGLSGRKRLGPISADSTT
APLEKELPPHLGELTVAEETSSSLRLSWTVAQGPFDSFVVQYRDTDGQPRAVPVAADQRTVTVEDLEPGKKYKFLLYGLLGGKRLGPVSA
LGMTAPEEDTPAPELAPEAPEPPEEPRLGVLTVTDTTPDSMRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYR
FLLYGLHEGKRLGPLSAEGTTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMV
PGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSV
QVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAET
PGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFTTGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPG
GITSHQLLGLFPSTSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLV
FQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSMRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28919988/chr6:32038191)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSG1

Q02413

.
FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115159_270562.33333333333341050.0DomainCadherin 2
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115271_385562.33333333333341050.0DomainCadherin 3
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115386_497562.33333333333341050.0DomainCadherin 4
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+111550_158562.33333333333341050.0DomainCadherin 1
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+111550_548562.33333333333341050.0Topological domainExtracellular
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441674_17641663.33333333333334243.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441778_18681663.33333333333334243.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441883_19711663.33333333333334243.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441989_20891663.33333333333334243.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442097_21851663.33333333333334243.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442196_22961663.33333333333334243.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442305_23981663.33333333333334243.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442408_25021663.33333333333334243.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442519_26171663.33333333333334243.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442625_27231663.33333333333334243.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442733_28401663.33333333333334243.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442841_29391663.33333333333334243.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712442949_30421663.33333333333334243.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443062_31531663.33333333333334243.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443168_32601663.33333333333334243.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443264_33551663.33333333333334243.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443357_34461663.33333333333334243.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443451_35441663.33333333333334243.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443553_36471663.33333333333334243.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443657_37541663.33333333333334243.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443758_38471663.33333333333334243.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443848_39341663.33333333333334243.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712443935_40251663.33333333333334243.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712444021_42361663.33333333333334243.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131064_11530674.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131161_12490674.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131263_13520674.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131374_14680674.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131476_15720674.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013156_1680674.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131574_16690674.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131674_17640674.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131778_18680674.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013183_2130674.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131883_19710674.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131989_20890674.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132097_21850674.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013214_2440674.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132196_22960674.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132305_23980674.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132408_25020674.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013245_2750674.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132519_26170674.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132625_27230674.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132733_28400674.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013276_3060674.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132841_29390674.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430132949_30420674.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133062_31530674.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013307_3370674.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133168_32600674.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133264_33550674.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133357_34460674.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013338_3680674.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133451_35440674.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133553_36470674.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133657_37540674.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013369_3990674.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133758_38470674.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133848_39340674.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430133935_40250674.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013400_4300674.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430134021_42360674.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013431_4610674.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013462_4920674.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013493_5230674.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013524_5540674.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013555_5850674.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013586_6160674.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013617_6470674.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013648_6790674.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013684_7140674.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013715_7460674.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST00000451343013959_10510674.0DomainFibronectin type-III 1
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151064_11530674.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151161_12490674.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151263_13520674.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151374_14680674.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151476_15720674.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015156_1680674.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151574_16690674.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151674_17640674.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151778_18680674.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015183_2130674.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151883_19710674.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151989_20890674.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152097_21850674.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015214_2440674.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152196_22960674.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152305_23980674.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152408_25020674.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015245_2750674.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152519_26170674.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152625_27230674.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152733_28400674.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015276_3060674.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152841_29390674.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840152949_30420674.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153062_31530674.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015307_3370674.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153168_32600674.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153264_33550674.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153357_34460674.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015338_3680674.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153451_35440674.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153553_36470674.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153657_37540674.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015369_3990674.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153758_38470674.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153848_39340674.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840153935_40250674.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015400_4300674.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840154021_42360674.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015431_4610674.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015462_4920674.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015493_5230674.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015524_5540674.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015555_5850674.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015586_6160674.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015617_6470674.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015648_6790674.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015684_7140674.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015715_7460674.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST00000546684015959_10510674.0DomainFibronectin type-III 1
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151064_11530674.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151161_12490674.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151263_13520674.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151374_14680674.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151476_15720674.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015156_1680674.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151574_16690674.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151674_17640674.0DomainFibronectin type-III 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151778_18680674.0DomainFibronectin type-III 9
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015183_2130674.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151883_19710674.0DomainFibronectin type-III 10
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151989_20890674.0DomainFibronectin type-III 11
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152097_21850674.0DomainFibronectin type-III 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015214_2440674.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152196_22960674.0DomainFibronectin type-III 13
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152305_23980674.0DomainFibronectin type-III 14
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152408_25020674.0DomainFibronectin type-III 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015245_2750674.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152519_26170674.0DomainFibronectin type-III 16
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152625_27230674.0DomainFibronectin type-III 17
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152733_28400674.0DomainFibronectin type-III 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015276_3060674.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152841_29390674.0DomainFibronectin type-III 19
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390152949_30420674.0DomainFibronectin type-III 20
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153062_31530674.0DomainFibronectin type-III 21
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015307_3370674.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153168_32600674.0DomainFibronectin type-III 22
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153264_33550674.0DomainFibronectin type-III 23
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153357_34460674.0DomainFibronectin type-III 24
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015338_3680674.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153451_35440674.0DomainFibronectin type-III 25
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153553_36470674.0DomainFibronectin type-III 26
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153657_37540674.0DomainFibronectin type-III 27
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015369_3990674.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153758_38470674.0DomainFibronectin type-III 28
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153848_39340674.0DomainFibronectin type-III 29
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390153935_40250674.0DomainFibronectin type-III 30
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015400_4300674.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390154021_42360674.0DomainFibrinogen C-terminal
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015431_4610674.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015462_4920674.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015493_5230674.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015524_5540674.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015555_5850674.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015586_6160674.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015617_6470674.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015648_6790674.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015684_7140674.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015715_7460674.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST00000550539015959_10510674.0DomainFibronectin type-III 1
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441666_16681663.33333333333334243.0MotifCell attachment site
TgeneTNXBchr18:28919988chr6:32038191ENST000004513430131666_16680674.0MotifCell attachment site
TgeneTNXBchr18:28919988chr6:32038191ENST000005466840151666_16680674.0MotifCell attachment site
TgeneTNXBchr18:28919988chr6:32038191ENST000005505390151666_16680674.0MotifCell attachment site

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115969_1019562.33333333333341050.0Compositional biasNote=Gly/Ser-rich
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115813_839562.33333333333341050.0RepeatNote=Desmoglein repeat 1
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115840_869562.33333333333341050.0RepeatNote=Desmoglein repeat 2
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115870_899562.33333333333341050.0RepeatNote=Desmoglein repeat 3
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115900_927562.33333333333341050.0RepeatNote=Desmoglein repeat 4
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115928_956562.33333333333341050.0RepeatNote=Desmoglein repeat 5
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115570_1049562.33333333333341050.0Topological domainCytoplasmic
HgeneDSG1chr18:28919988chr6:32038191ENST00000257192+1115549_569562.33333333333341050.0TransmembraneHelical
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441064_11531663.33333333333334243.0DomainFibronectin type-III 2
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441161_12491663.33333333333334243.0DomainFibronectin type-III 3
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441263_13521663.33333333333334243.0DomainFibronectin type-III 4
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441374_14681663.33333333333334243.0DomainFibronectin type-III 5
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441476_15721663.33333333333334243.0DomainFibronectin type-III 6
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244156_1681663.33333333333334243.0DomainEGF-like 1%3B incomplete
TgeneTNXBchr18:28919988chr6:32038191ENST0000037524712441574_16691663.33333333333334243.0DomainFibronectin type-III 7
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244183_2131663.33333333333334243.0DomainEGF-like 2
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244214_2441663.33333333333334243.0DomainEGF-like 3
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244245_2751663.33333333333334243.0DomainEGF-like 4
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244276_3061663.33333333333334243.0DomainEGF-like 5
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244307_3371663.33333333333334243.0DomainEGF-like 6
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244338_3681663.33333333333334243.0DomainEGF-like 7
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244369_3991663.33333333333334243.0DomainEGF-like 8
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244400_4301663.33333333333334243.0DomainEGF-like 9
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244431_4611663.33333333333334243.0DomainEGF-like 10
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244462_4921663.33333333333334243.0DomainEGF-like 11
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244493_5231663.33333333333334243.0DomainEGF-like 12
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244524_5541663.33333333333334243.0DomainEGF-like 13
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244555_5851663.33333333333334243.0DomainEGF-like 14
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244586_6161663.33333333333334243.0DomainEGF-like 15
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244617_6471663.33333333333334243.0DomainEGF-like 16
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244648_6791663.33333333333334243.0DomainEGF-like 17
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244684_7141663.33333333333334243.0DomainEGF-like 18
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244715_7461663.33333333333334243.0DomainEGF-like 19
TgeneTNXBchr18:28919988chr6:32038191ENST000003752471244959_10511663.33333333333334243.0DomainFibronectin type-III 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DSG1_pLDDT.png
all structure
all structure
TNXB_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DSG1
TNXB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DSG1-TNXB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DSG1-TNXB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource