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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DSP-RCAN2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DSP-RCAN2
	FusionPDB ID: 24273
	FusionGDB2.0 ID: 24273
		Hgene	Tgene
	Gene symbol	DSP	RCAN2
	Gene ID	1834	10231
	Gene name	dentin sialophosphoprotein	regulator of calcineurin 2
	Synonyms	DFNA39\|DGI1\|DMP3\|DPP\|DSP	CSP2\|DSCR1L1\|MCIP2\|RCN2\|ZAKI-4\|ZAKI4
	Cytomap	4q22.1	6p12.3
	Type of gene	protein-coding	protein-coding
	Description	dentin sialophosphoproteindeafness, autosomal dominant 39dentin phosphophoryndentin phosphoproteindentin phosphoryndentin sialoprotein	calcipressin-2Down syndrome candidate region 1-like 1Down syndrome critical region gene 1-like 1myocyte-enriched calcineurin-interacting protein 2thyroid hormone-responsive (skin fibroblasts)thyroid hormone-responsive protein ZAKI-4
	Modification date	20200313	20200313
	UniProtAcc	P15924	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000379802, ENST00000418664,	ENST00000306764, ENST00000330430, ENST00000371374, ENST00000405162,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 19 X 11=3344	6 X 5 X 5=150
	# samples	22	6
	** MAII score	log2(22/3344*10)=-3.92599941855622 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DSP [Title/Abstract] AND RCAN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DSP(7572301)-RCAN2(46216633), # samples:4
Anticipated loss of major functional domain due to fusion event.	DSP-RCAN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSP-RCAN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSP-RCAN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DSP-RCAN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DSP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RCAN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-DG-A2KL-01A	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-
ChimerDB4	CESC	TCGA-DG-A2KL-01A	DSP	chr6	7572301	-	RCAN2	chr6	46216633	-
ChimerDB4	CESC	TCGA-DG-A2KL-01A	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-
ChimerDB4	CESC	TCGA-DG-A2KL	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000379802	DSP	chr6	7572301	+	ENST00000330430	RCAN2	chr6	46216633	-	5381	2471	329	2977	882
ENST00000379802	DSP	chr6	7572301	+	ENST00000371374	RCAN2	chr6	46216633	-	5381	2471	329	2977	882
ENST00000379802	DSP	chr6	7572301	+	ENST00000306764	RCAN2	chr6	46216633	-	5381	2471	329	2977	882
ENST00000379802	DSP	chr6	7572301	+	ENST00000405162	RCAN2	chr6	46216633	-	2978	2471	329	2977	883
ENST00000418664	DSP	chr6	7572301	+	ENST00000330430	RCAN2	chr6	46216633	-	5339	2429	287	2935	882
ENST00000418664	DSP	chr6	7572301	+	ENST00000371374	RCAN2	chr6	46216633	-	5339	2429	287	2935	882
ENST00000418664	DSP	chr6	7572301	+	ENST00000306764	RCAN2	chr6	46216633	-	5339	2429	287	2935	882
ENST00000418664	DSP	chr6	7572301	+	ENST00000405162	RCAN2	chr6	46216633	-	2936	2429	287	2935	883
ENST00000379802	DSP	chr6	7572300	+	ENST00000330430	RCAN2	chr6	46216632	-	5381	2471	329	2977	882
ENST00000379802	DSP	chr6	7572300	+	ENST00000371374	RCAN2	chr6	46216632	-	5381	2471	329	2977	882
ENST00000379802	DSP	chr6	7572300	+	ENST00000306764	RCAN2	chr6	46216632	-	5381	2471	329	2977	882
ENST00000379802	DSP	chr6	7572300	+	ENST00000405162	RCAN2	chr6	46216632	-	2978	2471	329	2977	883
ENST00000418664	DSP	chr6	7572300	+	ENST00000330430	RCAN2	chr6	46216632	-	5339	2429	287	2935	882
ENST00000418664	DSP	chr6	7572300	+	ENST00000371374	RCAN2	chr6	46216632	-	5339	2429	287	2935	882
ENST00000418664	DSP	chr6	7572300	+	ENST00000306764	RCAN2	chr6	46216632	-	5339	2429	287	2935	882
ENST00000418664	DSP	chr6	7572300	+	ENST00000405162	RCAN2	chr6	46216632	-	2936	2429	287	2935	883

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000379802	ENST00000330430	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.002018458	0.99798155
ENST00000379802	ENST00000371374	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.002018458	0.99798155
ENST00000379802	ENST00000306764	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.002018458	0.99798155
ENST00000379802	ENST00000405162	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.01468685	0.9853131
ENST00000418664	ENST00000330430	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.002017911	0.997982
ENST00000418664	ENST00000371374	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.002017911	0.997982
ENST00000418664	ENST00000306764	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.002017911	0.997982
ENST00000418664	ENST00000405162	DSP	chr6	7572301	+	RCAN2	chr6	46216633	-	0.014541736	0.98545825
ENST00000379802	ENST00000330430	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.002018458	0.99798155
ENST00000379802	ENST00000371374	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.002018458	0.99798155
ENST00000379802	ENST00000306764	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.002018458	0.99798155
ENST00000379802	ENST00000405162	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.01468685	0.9853131
ENST00000418664	ENST00000330430	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.002017911	0.997982
ENST00000418664	ENST00000371374	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.002017911	0.997982
ENST00000418664	ENST00000306764	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.002017911	0.997982
ENST00000418664	ENST00000405162	DSP	chr6	7572300	+	RCAN2	chr6	46216632	-	0.014541736	0.98545825

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24273_24273_1_DSP-RCAN2_DSP_chr6_7572300_ENST00000379802_RCAN2_chr6_46216632_ENST00000306764_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_2_DSP-RCAN2_DSP_chr6_7572300_ENST00000379802_RCAN2_chr6_46216632_ENST00000330430_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_3_DSP-RCAN2_DSP_chr6_7572300_ENST00000379802_RCAN2_chr6_46216632_ENST00000371374_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_4_DSP-RCAN2_DSP_chr6_7572300_ENST00000379802_RCAN2_chr6_46216632_ENST00000405162_length(amino acids)=883AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_5_DSP-RCAN2_DSP_chr6_7572300_ENST00000418664_RCAN2_chr6_46216632_ENST00000306764_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_6_DSP-RCAN2_DSP_chr6_7572300_ENST00000418664_RCAN2_chr6_46216632_ENST00000330430_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_7_DSP-RCAN2_DSP_chr6_7572300_ENST00000418664_RCAN2_chr6_46216632_ENST00000371374_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_8_DSP-RCAN2_DSP_chr6_7572300_ENST00000418664_RCAN2_chr6_46216632_ENST00000405162_length(amino acids)=883AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_9_DSP-RCAN2_DSP_chr6_7572301_ENST00000379802_RCAN2_chr6_46216633_ENST00000306764_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_10_DSP-RCAN2_DSP_chr6_7572301_ENST00000379802_RCAN2_chr6_46216633_ENST00000330430_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_11_DSP-RCAN2_DSP_chr6_7572301_ENST00000379802_RCAN2_chr6_46216633_ENST00000371374_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_12_DSP-RCAN2_DSP_chr6_7572301_ENST00000379802_RCAN2_chr6_46216633_ENST00000405162_length(amino acids)=883AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_13_DSP-RCAN2_DSP_chr6_7572301_ENST00000418664_RCAN2_chr6_46216633_ENST00000306764_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_14_DSP-RCAN2_DSP_chr6_7572301_ENST00000418664_RCAN2_chr6_46216633_ENST00000330430_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_15_DSP-RCAN2_DSP_chr6_7572301_ENST00000418664_RCAN2_chr6_46216633_ENST00000371374_length(amino acids)=882AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

>24273_24273_16_DSP-RCAN2_DSP_chr6_7572301_ENST00000418664_RCAN2_chr6_46216633_ENST00000405162_length(amino acids)=883AA_BP=714
MPADMSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAE
LIVQPELKYGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQS
GSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM
DHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQT
QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIV
QLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILAL
WNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL
PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKEKFEGL
FRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPIN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:7572301/chr6:46216633)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSP P15924	.
FUNCTION: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

458_515

710.0

2872.0

Domain

SH3

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

458_515

710.0

2273.0

Domain

SH3

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

458_515

710.0

2872.0

Domain

SH3

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

458_515

710.0

2273.0

Domain

SH3

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

178_271

710.0

2872.0

Repeat

Note=Spectrin 1

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

272_375

710.0

2872.0

Repeat

Note=Spectrin 2

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

376_446

710.0

2872.0

Repeat

Note=Spectrin 3a

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

516_545

710.0

2872.0

Repeat

Note=Spectrin 3b

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

546_627

710.0

2872.0

Repeat

Note=Spectrin 4

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

178_271

710.0

2273.0

Repeat

Note=Spectrin 1

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

272_375

710.0

2273.0

Repeat

Note=Spectrin 2

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

376_446

710.0

2273.0

Repeat

Note=Spectrin 3a

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

516_545

710.0

2273.0

Repeat

Note=Spectrin 3b

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

546_627

710.0

2273.0

Repeat

Note=Spectrin 4

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

178_271

710.0

2872.0

Repeat

Note=Spectrin 1

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

272_375

710.0

2872.0

Repeat

Note=Spectrin 2

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

376_446

710.0

2872.0

Repeat

Note=Spectrin 3a

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

516_545

710.0

2872.0

Repeat

Note=Spectrin 3b

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

546_627

710.0

2872.0

Repeat

Note=Spectrin 4

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

178_271

710.0

2273.0

Repeat

Note=Spectrin 1

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

272_375

710.0

2273.0

Repeat

Note=Spectrin 2

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

376_446

710.0

2273.0

Repeat

Note=Spectrin 3a

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

516_545

710.0

2273.0

Repeat

Note=Spectrin 3b

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

546_627

710.0

2273.0

Repeat

Note=Spectrin 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

1018_1945

710.0

2872.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

1018_1945

710.0

2273.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

1018_1945

710.0

2872.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

1018_1945

710.0

2273.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

1057_1945

710.0

2872.0

Region

Note=Central fibrous rod domain

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

1946_2871

710.0

2872.0

Region

Note=Globular 2

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

1960_2208

710.0

2872.0

Region

Note=4.5 X 38 AA tandem repeats (Domain A)

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

1_1056

710.0

2872.0

Region

Note=Globular 1

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2244_2446

710.0

2872.0

Region

Note=4.5 X 38 AA tandem repeats (Domain B)

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2609_2822

710.0

2872.0

Region

Note=4.5 X 38 AA tandem repeats (Domain C)

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2824_2847

710.0

2872.0

Region

Note=6 X 4 AA tandem repeats of G-S-R-[SR]

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

1057_1945

710.0

2273.0

Region

Note=Central fibrous rod domain

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

1946_2871

710.0

2273.0

Region

Note=Globular 2

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

1960_2208

710.0

2273.0

Region

Note=4.5 X 38 AA tandem repeats (Domain A)

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

1_1056

710.0

2273.0

Region

Note=Globular 1

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2244_2446

710.0

2273.0

Region

Note=4.5 X 38 AA tandem repeats (Domain B)

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2609_2822

710.0

2273.0

Region

Note=4.5 X 38 AA tandem repeats (Domain C)

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2824_2847

710.0

2273.0

Region

Note=6 X 4 AA tandem repeats of G-S-R-[SR]

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

1057_1945

710.0

2872.0

Region

Note=Central fibrous rod domain

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

1946_2871

710.0

2872.0

Region

Note=Globular 2

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

1960_2208

710.0

2872.0

Region

Note=4.5 X 38 AA tandem repeats (Domain A)

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

1_1056

710.0

2872.0

Region

Note=Globular 1

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2244_2446

710.0

2872.0

Region

Note=4.5 X 38 AA tandem repeats (Domain B)

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2609_2822

710.0

2872.0

Region

Note=4.5 X 38 AA tandem repeats (Domain C)

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2824_2847

710.0

2872.0

Region

Note=6 X 4 AA tandem repeats of G-S-R-[SR]

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

1057_1945

710.0

2273.0

Region

Note=Central fibrous rod domain

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

1946_2871

710.0

2273.0

Region

Note=Globular 2

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

1960_2208

710.0

2273.0

Region

Note=4.5 X 38 AA tandem repeats (Domain A)

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

1_1056

710.0

2273.0

Region

Note=Globular 1

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2244_2446

710.0

2273.0

Region

Note=4.5 X 38 AA tandem repeats (Domain B)

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2609_2822

710.0

2273.0

Region

Note=4.5 X 38 AA tandem repeats (Domain C)

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2824_2847

710.0

2273.0

Region

Note=6 X 4 AA tandem repeats of G-S-R-[SR]

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2009_2045

710.0

2872.0

Repeat

Note=Plectin 1

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2046_2083

710.0

2872.0

Repeat

Note=Plectin 2

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2084_2121

710.0

2872.0

Repeat

Note=Plectin 3

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2122_2159

710.0

2872.0

Repeat

Note=Plectin 4

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2163_2197

710.0

2872.0

Repeat

Note=Plectin 5

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2198_2233

710.0

2872.0

Repeat

Note=Plectin 6

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2251_2288

710.0

2872.0

Repeat

Note=Plectin 7

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2289_2326

710.0

2872.0

Repeat

Note=Plectin 8

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2327_2364

710.0

2872.0

Repeat

Note=Plectin 9

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2365_2402

710.0

2872.0

Repeat

Note=Plectin 10

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2406_2440

710.0

2872.0

Repeat

Note=Plectin 11

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2456_2493

710.0

2872.0

Repeat

Note=Plectin 12

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2507_2544

710.0

2872.0

Repeat

Note=Plectin 13

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2610_2647

710.0

2872.0

Repeat

Note=Plectin 14

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2648_2685

710.0

2872.0

Repeat

Note=Plectin 15

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2724_2761

710.0

2872.0

Repeat

Note=Plectin 16

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

2762_2799

710.0

2872.0

Repeat

Note=Plectin 17

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

654_769

710.0

2872.0

Repeat

Note=Spectrin 5

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000379802

770_883

710.0

2872.0

Repeat

Note=Spectrin 6

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2009_2045

710.0

2273.0

Repeat

Note=Plectin 1

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2046_2083

710.0

2273.0

Repeat

Note=Plectin 2

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2084_2121

710.0

2273.0

Repeat

Note=Plectin 3

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2122_2159

710.0

2273.0

Repeat

Note=Plectin 4

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2163_2197

710.0

2273.0

Repeat

Note=Plectin 5

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2198_2233

710.0

2273.0

Repeat

Note=Plectin 6

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2251_2288

710.0

2273.0

Repeat

Note=Plectin 7

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2289_2326

710.0

2273.0

Repeat

Note=Plectin 8

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2327_2364

710.0

2273.0

Repeat

Note=Plectin 9

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2365_2402

710.0

2273.0

Repeat

Note=Plectin 10

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2406_2440

710.0

2273.0

Repeat

Note=Plectin 11

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2456_2493

710.0

2273.0

Repeat

Note=Plectin 12

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2507_2544

710.0

2273.0

Repeat

Note=Plectin 13

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2610_2647

710.0

2273.0

Repeat

Note=Plectin 14

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2648_2685

710.0

2273.0

Repeat

Note=Plectin 15

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2724_2761

710.0

2273.0

Repeat

Note=Plectin 16

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

2762_2799

710.0

2273.0

Repeat

Note=Plectin 17

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

654_769

710.0

2273.0

Repeat

Note=Spectrin 5

Hgene

DSP

chr6:7572300

chr6:46216632

ENST00000418664

770_883

710.0

2273.0

Repeat

Note=Spectrin 6

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2009_2045

710.0

2872.0

Repeat

Note=Plectin 1

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2046_2083

710.0

2872.0

Repeat

Note=Plectin 2

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2084_2121

710.0

2872.0

Repeat

Note=Plectin 3

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2122_2159

710.0

2872.0

Repeat

Note=Plectin 4

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2163_2197

710.0

2872.0

Repeat

Note=Plectin 5

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2198_2233

710.0

2872.0

Repeat

Note=Plectin 6

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2251_2288

710.0

2872.0

Repeat

Note=Plectin 7

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2289_2326

710.0

2872.0

Repeat

Note=Plectin 8

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2327_2364

710.0

2872.0

Repeat

Note=Plectin 9

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2365_2402

710.0

2872.0

Repeat

Note=Plectin 10

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2406_2440

710.0

2872.0

Repeat

Note=Plectin 11

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2456_2493

710.0

2872.0

Repeat

Note=Plectin 12

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2507_2544

710.0

2872.0

Repeat

Note=Plectin 13

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2610_2647

710.0

2872.0

Repeat

Note=Plectin 14

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2648_2685

710.0

2872.0

Repeat

Note=Plectin 15

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2724_2761

710.0

2872.0

Repeat

Note=Plectin 16

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

2762_2799

710.0

2872.0

Repeat

Note=Plectin 17

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

654_769

710.0

2872.0

Repeat

Note=Spectrin 5

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000379802

770_883

710.0

2872.0

Repeat

Note=Spectrin 6

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2009_2045

710.0

2273.0

Repeat

Note=Plectin 1

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2046_2083

710.0

2273.0

Repeat

Note=Plectin 2

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2084_2121

710.0

2273.0

Repeat

Note=Plectin 3

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2122_2159

710.0

2273.0

Repeat

Note=Plectin 4

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2163_2197

710.0

2273.0

Repeat

Note=Plectin 5

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2198_2233

710.0

2273.0

Repeat

Note=Plectin 6

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2251_2288

710.0

2273.0

Repeat

Note=Plectin 7

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2289_2326

710.0

2273.0

Repeat

Note=Plectin 8

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2327_2364

710.0

2273.0

Repeat

Note=Plectin 9

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2365_2402

710.0

2273.0

Repeat

Note=Plectin 10

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2406_2440

710.0

2273.0

Repeat

Note=Plectin 11

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2456_2493

710.0

2273.0

Repeat

Note=Plectin 12

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2507_2544

710.0

2273.0

Repeat

Note=Plectin 13

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2610_2647

710.0

2273.0

Repeat

Note=Plectin 14

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2648_2685

710.0

2273.0

Repeat

Note=Plectin 15

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2724_2761

710.0

2273.0

Repeat

Note=Plectin 16

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

2762_2799

710.0

2273.0

Repeat

Note=Plectin 17

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

654_769

710.0

2273.0

Repeat

Note=Spectrin 5

Hgene

DSP

chr6:7572301

chr6:46216633

ENST00000418664

770_883

710.0

2273.0

Repeat

Note=Spectrin 6

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DSP_pLDDT.png

RCAN2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DSP
RCAN2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DSP-RCAN2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DSP-RCAN2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source