UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:DTNA-ZNF521

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DTNA-ZNF521
FusionPDB ID: 24366
FusionGDB2.0 ID: 24366
HgeneTgene
Gene symbol

DTNA

ZNF521

Gene ID

1837

25925

Gene namedystrobrevin alphazinc finger protein 521
SynonymsD18S892E|DRP3|DTN|DTN-A|LVNC1EHZF|Evi3
Cytomap

18q12.1

18q11.2

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin alphadystrophin-related protein 3zinc finger protein 521LYST-interacting protein 3early hematopoietic zinc finger protein
Modification date2020031320200313
UniProtAcc

Q9Y4J8

.
Ensembl transtripts involved in fusion geneENST idsENST00000269190, ENST00000269191, 
ENST00000283365, ENST00000315456, 
ENST00000348997, ENST00000399113, 
ENST00000399121, ENST00000444659, 
ENST00000554864, ENST00000595022, 
ENST00000596745, ENST00000597599, 
ENST00000598142, ENST00000598334, 
ENST00000598774, ENST00000399097, 
ENST00000269192, ENST00000556414, 
ENST00000590831, ENST00000591182, 
ENST00000592449, ENST00000597674, 
ENST00000599844, ENST00000601125, 
ENST00000538137, ENST00000579111, 
ENST00000584787, ENST00000361524, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 5 X 5=17513 X 10 X 9=1170
# samples 715
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1170*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DTNA [Title/Abstract] AND ZNF521 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DTNA(32346005)-ZNF521(22902151), # samples:1
Anticipated loss of major functional domain due to fusion event.DTNA-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DTNA-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DTNA-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DTNA-ZNF521 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTNA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF521 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1R6-01ADTNAchr18

32346005

-ZNF521chr18

22902151

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283365DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-518149933943941351
ENST00000596745DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-516748532543801351
ENST00000315456DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-515447231243671351
ENST00000598334DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-515647431443691351
ENST00000554864DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-513745529543501351
ENST00000399121DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-513745529543501351
ENST00000595022DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-513044828843431351
ENST00000269190DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-513044828843431351
ENST00000598774DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-48872054541001351
ENST00000598142DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-48872054541001351
ENST00000348997DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-499331116342061347
ENST00000597599DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-498029815041931347
ENST00000269191DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-4831149140441347
ENST00000444659DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-4831149140441347
ENST00000399113DTNAchr1832346005-ENST00000361524ZNF521chr1822902151-4830148040431347

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283365ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0014974750.9985025
ENST00000596745ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0014589470.9985411
ENST00000315456ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0014179040.9985821
ENST00000598334ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011998790.99880016
ENST00000554864ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011849720.99881506
ENST00000399121ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011849720.99881506
ENST00000595022ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011664970.9988335
ENST00000269190ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011664970.9988335
ENST00000598774ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011095780.99889046
ENST00000598142ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011095780.99889046
ENST00000348997ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.001177320.9988226
ENST00000597599ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0011447990.99885523
ENST00000269191ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0010941480.9989059
ENST00000444659ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0010941480.9989059
ENST00000399113ENST00000361524DTNAchr1832346005-ZNF521chr1822902151-0.0010960120.998904

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24366_24366_1_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000269190_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_2_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000269191_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1347AA_BP=50
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQ
VFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL
PFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSG
SRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEE
LYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQL
FSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFAN
PAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNY
IHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVT
IHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHN
HLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTN
SQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLG
PVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQ
KTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVG
GLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLN

--------------------------------------------------------------

>24366_24366_3_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000283365_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_4_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000315456_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_5_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000348997_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1347AA_BP=50
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQ
VFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL
PFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSG
SRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEE
LYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQL
FSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFAN
PAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNY
IHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVT
IHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHN
HLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTN
SQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLG
PVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQ
KTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVG
GLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLN

--------------------------------------------------------------

>24366_24366_6_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000399113_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1347AA_BP=50
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQ
VFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL
PFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSG
SRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEE
LYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQL
FSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFAN
PAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNY
IHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVT
IHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHN
HLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTN
SQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLG
PVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQ
KTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVG
GLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLN

--------------------------------------------------------------

>24366_24366_7_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000399121_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_8_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000444659_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1347AA_BP=50
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQ
VFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL
PFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSG
SRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEE
LYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQL
FSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFAN
PAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNY
IHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVT
IHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHN
HLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTN
SQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLG
PVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQ
KTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVG
GLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLN

--------------------------------------------------------------

>24366_24366_9_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000554864_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_10_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000595022_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_11_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000596745_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_12_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000597599_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1347AA_BP=50
MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCDSCLQ
VFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKL
PFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDGSQSG
SRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFHTVEE
LYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYCNKQL
FSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSHGFAN
PAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPLALNY
IHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKHVT
IHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHN
HLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQTLLTN
SQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLG
PVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQ
KTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGKGKVG
GLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMIDEGLN

--------------------------------------------------------------

>24366_24366_13_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000598142_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_14_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000598334_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

>24366_24366_15_DTNA-ZNF521_DTNA_chr18_32346005_ENST00000598774_ZNF521_chr18_22902151_ENST00000361524_length(amino acids)=1351AA_BP=54
MNFRMIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNYPNCKLEDKTEDGEALDCKKRPEDGEELEDEAVHSCD
SCLQVFESLSDITEHKINQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHGEGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSH
SDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAICRRGFLSSSSLHGHMQVHERNKDG
SQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNEDRAALQCVYCHELFVEETSLMNHMEQVHSGEKKNSCSICSESFH
TVEELYSHMDSHQQPESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTPDMTGPSSKQAKVTYSCIYC
NKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLYNLNEHLKQVHEAQDPGLIVSAMPAIVYQCNFCSEVVNDLNTLQEHIRCSH
GFANPAAKDSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCTNSPIFNSVLKLNKHIKENHKNIPL
ALNYIHNGKKSRALSPLSPVAIEQTSLKMMQAVGGAPARPTGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLL
KHVTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLHLAVKHSNEKKVYRCTSCNWDFRNETDLQLH
VKHNHLENQGKVHKCIFCGESFGTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFETKTPNCGTNGASEQVQKEEVELQT
LLTNSQESHNSHDGSEEDVDTSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPGESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQ
THLGPVKHYMCPICGERFPSLLTLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGT
FHMQKTGNGSAVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGLPYGLCAGCVNLSKSASPGINVPPGTNRPGLGQNENLSAIEGK
GKVGGLKTRCSSCNVKFESESELQNHIQTIHRELVPDSNSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMVFYNEWDIQVHVANHMID
EGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:32346005/chr18:22902151)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTNA

Q9Y4J8

.
FUNCTION: May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181020_104213.3333333333333341312.0Zinc fingerC2H2-type 24
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181065_108313.3333333333333341312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181138_116113.3333333333333341312.0Zinc fingerC2H2-type 26
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418118_14013.3333333333333341312.0Zinc fingerC2H2-type 2
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181195_121713.3333333333333341312.0Zinc fingerC2H2-type 27
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181225_124713.3333333333333341312.0Zinc fingerC2H2-type 28
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181256_127913.3333333333333341312.0Zinc fingerC2H2-type 29
TgeneZNF521chr18:32346005chr18:22902151ENST00000361524181286_130913.3333333333333341312.0Zinc fingerC2H2-type 30
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418146_16813.3333333333333341312.0Zinc fingerC2H2-type 3
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418174_19613.3333333333333341312.0Zinc fingerC2H2-type 4
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418202_22413.3333333333333341312.0Zinc fingerC2H2-type 5
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418246_26913.3333333333333341312.0Zinc fingerC2H2-type 6
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418281_30413.3333333333333341312.0Zinc fingerC2H2-type 7
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418310_33213.3333333333333341312.0Zinc fingerC2H2-type 8
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418405_42913.3333333333333341312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418437_46013.3333333333333341312.0Zinc fingerC2H2-type 10
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418477_50013.3333333333333341312.0Zinc fingerC2H2-type 11
TgeneZNF521chr18:32346005chr18:22902151ENST000003615241847_6713.3333333333333341312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418513_53613.3333333333333341312.0Zinc fingerC2H2-type 12
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418560_58513.3333333333333341312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418634_65613.3333333333333341312.0Zinc fingerC2H2-type 14
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418664_68613.3333333333333341312.0Zinc fingerC2H2-type 15
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418694_71713.3333333333333341312.0Zinc fingerC2H2-type 16
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418722_74513.3333333333333341312.0Zinc fingerC2H2-type 17
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418752_77513.3333333333333341312.0Zinc fingerC2H2-type 18
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418783_80513.3333333333333341312.0Zinc fingerC2H2-type 19
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418809_83213.3333333333333341312.0Zinc fingerC2H2-type 20
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418886_90813.3333333333333341312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418930_95213.3333333333333341312.0Zinc fingerC2H2-type 22
TgeneZNF521chr18:32346005chr18:22902151ENST0000036152418959_98113.3333333333333341312.0Zinc fingerC2H2-type 23
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181020_104213.3333333333333341312.0Zinc fingerC2H2-type 24
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181065_108313.3333333333333341312.0Zinc fingerC2H2-type 25%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181138_116113.3333333333333341312.0Zinc fingerC2H2-type 26
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718118_14013.3333333333333341312.0Zinc fingerC2H2-type 2
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181195_121713.3333333333333341312.0Zinc fingerC2H2-type 27
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181225_124713.3333333333333341312.0Zinc fingerC2H2-type 28
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181256_127913.3333333333333341312.0Zinc fingerC2H2-type 29
TgeneZNF521chr18:32346005chr18:22902151ENST00000538137181286_130913.3333333333333341312.0Zinc fingerC2H2-type 30
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718146_16813.3333333333333341312.0Zinc fingerC2H2-type 3
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718174_19613.3333333333333341312.0Zinc fingerC2H2-type 4
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718202_22413.3333333333333341312.0Zinc fingerC2H2-type 5
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718246_26913.3333333333333341312.0Zinc fingerC2H2-type 6
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718281_30413.3333333333333341312.0Zinc fingerC2H2-type 7
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718310_33213.3333333333333341312.0Zinc fingerC2H2-type 8
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718405_42913.3333333333333341312.0Zinc fingerC2H2-type 9%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718437_46013.3333333333333341312.0Zinc fingerC2H2-type 10
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718477_50013.3333333333333341312.0Zinc fingerC2H2-type 11
TgeneZNF521chr18:32346005chr18:22902151ENST000005381371847_6713.3333333333333341312.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718513_53613.3333333333333341312.0Zinc fingerC2H2-type 12
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718560_58513.3333333333333341312.0Zinc fingerC2H2-type 13%3B atypical
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718634_65613.3333333333333341312.0Zinc fingerC2H2-type 14
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718664_68613.3333333333333341312.0Zinc fingerC2H2-type 15
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718694_71713.3333333333333341312.0Zinc fingerC2H2-type 16
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718722_74513.3333333333333341312.0Zinc fingerC2H2-type 17
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718752_77513.3333333333333341312.0Zinc fingerC2H2-type 18
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718783_80513.3333333333333341312.0Zinc fingerC2H2-type 19
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718809_83213.3333333333333341312.0Zinc fingerC2H2-type 20
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718886_90813.3333333333333341312.0Zinc fingerC2H2-type 21%3B degenerate
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718930_95213.3333333333333341312.0Zinc fingerC2H2-type 22
TgeneZNF521chr18:32346005chr18:22902151ENST0000053813718959_98113.3333333333333341312.0Zinc fingerC2H2-type 23

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTNAchr18:32346005chr18:22902151ENST00000269191-217461_55649.333333333333336571.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000269192-116461_5560440.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000283365-422461_55649.3333333333333361971.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000315456-413461_55649.333333333333336375.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000348997-317461_55649.333333333333336568.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000399097-422461_55601545.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000399113-221461_55649.333333333333336744.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000444659-222461_55649.3333333333333362081.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000554864-412461_55649.333333333333336372.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000556414-114461_5560335.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000591182-114461_5560388.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000595022-421461_55649.3333333333333361837.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000596745-411461_55649.333333333333336321.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000597674-18461_5560193.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000598142-321461_55649.333333333333336788.3333333333334Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000598774-316461_55649.333333333333336514.0Coiled coilOntology_term=ECO:0000255
HgeneDTNAchr18:32346005chr18:22902151ENST00000269191-217400_45049.333333333333336571.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000269192-116400_4500440.3333333333333RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000283365-422400_45049.3333333333333361971.6666666666667RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000315456-413400_45049.333333333333336375.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000348997-317400_45049.333333333333336568.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000399097-422400_45001545.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000399113-221400_45049.333333333333336744.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000444659-222400_45049.3333333333333362081.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000554864-412400_45049.333333333333336372.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000556414-114400_4500335.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000591182-114400_4500388.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000595022-421400_45049.3333333333333361837.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000596745-411400_45049.333333333333336321.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000597674-18400_4500193.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000598142-321400_45049.333333333333336788.3333333333334RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000598774-316400_45049.333333333333336514.0RegionNote=Syntrophin-binding region
HgeneDTNAchr18:32346005chr18:22902151ENST00000269191-217237_28449.333333333333336571.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000269192-116237_2840440.3333333333333Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000283365-422237_28449.3333333333333361971.6666666666667Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000315456-413237_28449.333333333333336375.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000348997-317237_28449.333333333333336568.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000399097-422237_28401545.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000399113-221237_28449.333333333333336744.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000444659-222237_28449.3333333333333362081.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000554864-412237_28449.333333333333336372.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000556414-114237_2840335.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000591182-114237_2840388.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000595022-421237_28449.3333333333333361837.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000596745-411237_28449.333333333333336321.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000597674-18237_2840193.0Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000598142-321237_28449.333333333333336788.3333333333334Zinc fingerZZ-type
HgeneDTNAchr18:32346005chr18:22902151ENST00000598774-316237_28449.333333333333336514.0Zinc fingerZZ-type


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DTNA
ZNF521


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDTNAchr18:32346005chr18:22902151ENST00000269191-2171_28849.333333333333336571.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000269192-1161_2880440.3333333333333MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000283365-4221_28849.3333333333333361971.6666666666667MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000315456-4131_28849.333333333333336375.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000348997-3171_28849.333333333333336568.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000399097-4221_28801545.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000399113-2211_28849.333333333333336744.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000444659-2221_28849.3333333333333362081.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000554864-4121_28849.333333333333336372.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000556414-1141_2880335.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000591182-1141_2880388.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000595022-4211_28849.3333333333333361837.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000596745-4111_28849.333333333333336321.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000597674-181_2880193.0MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000598142-3211_28849.333333333333336788.3333333333334MAGEE1
HgeneDTNAchr18:32346005chr18:22902151ENST00000598774-3161_28849.333333333333336514.0MAGEE1


Top

Related Drugs to DTNA-ZNF521


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to DTNA-ZNF521


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource