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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADIPOR1-RGS8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADIPOR1-RGS8
FusionPDB ID: 2439
FusionGDB2.0 ID: 2439
HgeneTgene
Gene symbol

ADIPOR1

RGS8

Gene ID

51094

85397

Gene nameadiponectin receptor 1regulator of G protein signaling 8
SynonymsACDCR1|CGI-45|CGI45|PAQR1|TESBP1A-
Cytomap

1q32.1

1q25.3

Type of geneprotein-codingprotein-coding
Descriptionadiponectin receptor protein 1progestin and adipoQ receptor family member 1progestin and adipoQ receptor family member Iregulator of G-protein signaling 8regulator of G-protein signalling 8
Modification date2020031320200313
UniProtAcc

Q96A54

.
Ensembl transtripts involved in fusion geneENST idsENST00000340990, ENST00000436244, 
ENST00000367254, 		ENST00000491420, 
ENST00000258302, ENST00000367556, 
ENST00000367557, ENST00000483095, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 5 X 2=402 X 2 X 2=8
# samples 42
** MAII scorelog2(4/40*10)=0log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADIPOR1 [Title/Abstract] AND RGS8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADIPOR1(202912886)-RGS8(182617438), # samples:3
Anticipated loss of major functional domain due to fusion event.ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADIPOR1-RGS8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADIPOR1

GO:0009755

hormone-mediated signaling pathway

12802337

HgeneADIPOR1

GO:0019395

fatty acid oxidation

12802337

HgeneADIPOR1

GO:0033211

adiponectin-activated signaling pathway

12802337

TgeneRGS8

GO:0043547

positive regulation of GTPase activity

18434541


check buttonFusion gene breakpoints across ADIPOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RGS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A243-01AADIPOR1chr1

202912886

-RGS8chr1

182617438

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340990ADIPOR1chr1202912886-ENST00000483095RGS8chr1182617438-208511042991453384
ENST00000340990ADIPOR1chr1202912886-ENST00000258302RGS8chr1182617438-153211042991453384
ENST00000340990ADIPOR1chr1202912886-ENST00000367557RGS8chr1182617438-150311042991453384
ENST00000340990ADIPOR1chr1202912886-ENST00000367556RGS8chr1182617438-145411042991453385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340990ENST00000483095ADIPOR1chr1202912886-RGS8chr1182617438-0.0036007280.9963993
ENST00000340990ENST00000258302ADIPOR1chr1202912886-RGS8chr1182617438-0.0062019480.9937981
ENST00000340990ENST00000367557ADIPOR1chr1202912886-RGS8chr1182617438-0.0065632170.99343675
ENST00000340990ENST00000367556ADIPOR1chr1202912886-RGS8chr1182617438-0.0058510670.99414897

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2439_2439_1_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000258302_length(amino acids)=384AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

--------------------------------------------------------------

>2439_2439_2_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000367556_length(amino acids)=385AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

--------------------------------------------------------------

>2439_2439_3_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000367557_length(amino acids)=384AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

--------------------------------------------------------------

>2439_2439_4_ADIPOR1-RGS8_ADIPOR1_chr1_202912886_ENST00000340990_RGS8_chr1_182617438_ENST00000483095_length(amino acids)=384AA_BP=265
MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEG
RWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGA
VLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRADG
VAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202912886/chr1:182617438)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADIPOR1

Q96A54

.
FUNCTION: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). {ECO:0000250|UniProtKB:Q91VH1, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68158_170268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68192_203268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-681_136268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68225_234268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68256_264268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79158_170268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79192_203268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-791_136268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79225_234268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79256_264268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68137_157268.3333333333333376.0TransmembraneHelical%3B Name%3D1
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68171_191268.3333333333333376.0TransmembraneHelical%3B Name%3D2
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68204_224268.3333333333333376.0TransmembraneHelical%3B Name%3D3
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68235_255268.3333333333333376.0TransmembraneHelical%3B Name%3D4
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79137_157268.3333333333333376.0TransmembraneHelical%3B Name%3D1
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79171_191268.3333333333333376.0TransmembraneHelical%3B Name%3D2
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79204_224268.3333333333333376.0TransmembraneHelical%3B Name%3D3
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79235_255268.3333333333333376.0TransmembraneHelical%3B Name%3D4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68286_298268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68320_337268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68359_375268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79286_298268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79320_337268.3333333333333376.0Topological domainCytoplasmic
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79359_375268.3333333333333376.0Topological domainExtracellular
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68265_285268.3333333333333376.0TransmembraneHelical%3B Name%3D5
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68299_319268.3333333333333376.0TransmembraneHelical%3B Name%3D6
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000340990-68338_358268.3333333333333376.0TransmembraneHelical%3B Name%3D7
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79265_285268.3333333333333376.0TransmembraneHelical%3B Name%3D5
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79299_319268.3333333333333376.0TransmembraneHelical%3B Name%3D6
HgeneADIPOR1chr1:202912886chr1:182617438ENST00000436244-79338_358268.3333333333333376.0TransmembraneHelical%3B Name%3D7
TgeneRGS8chr1:202912886chr1:182617438ENST000002583023656_17182.33333333333333199.0DomainRGS
TgeneRGS8chr1:202912886chr1:182617438ENST000003675563656_17164.33333333333333181.0DomainRGS
TgeneRGS8chr1:202912886chr1:182617438ENST000003675574756_17164.33333333333333181.0DomainRGS
TgeneRGS8chr1:202912886chr1:182617438ENST000004830954756_17164.33333333333333181.0DomainRGS


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADIPOR1
RGS8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADIPOR1-RGS8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADIPOR1-RGS8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource