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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADIPOR2-FOXJ2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADIPOR2-FOXJ2
FusionPDB ID: 2445
FusionGDB2.0 ID: 2445
HgeneTgene
Gene symbol

ADIPOR2

FOXJ2

Gene ID

79602

55810

Gene nameadiponectin receptor 2forkhead box J2
SynonymsACDCR2|PAQR2FHX
Cytomap

12p13.33

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionadiponectin receptor protein 2progestin and adipoQ receptor family member 2progestin and adipoQ receptor family member IIforkhead box protein J2FOXJ2 forkhead factorfork head homologous X
Modification date2020031320200313
UniProtAcc

Q86V24

Q9P0K8

Ensembl transtripts involved in fusion geneENST idsENST00000357103, ENST00000544470, 
ENST00000539192, ENST00000162391, 
ENST00000428177, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 10 X 8=14403 X 4 X 2=24
# samples 224
** MAII scorelog2(22/1440*10)=-2.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADIPOR2 [Title/Abstract] AND FOXJ2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADIPOR2(1863680)-FOXJ2(8197356), # samples:3
Anticipated loss of major functional domain due to fusion event.ADIPOR2-FOXJ2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR2-FOXJ2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR2-FOXJ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADIPOR2-FOXJ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADIPOR2

GO:0033211

adiponectin-activated signaling pathway

12802337

TgeneFOXJ2

GO:0045944

positive regulation of transcription by RNA polymerase II

10777590

TgeneFOXJ2

GO:0110059

negative regulation of blood vessel endothelial cell differentiation

24792364

TgeneFOXJ2

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

24792364


check buttonFusion gene breakpoints across ADIPOR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FOXJ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LL-01AADIPOR2chr12

1863680

-FOXJ2chr12

8197356

+
ChimerDB4BRCATCGA-E2-A1LL-01AADIPOR2chr12

1863680

+FOXJ2chr12

8197356

+
ChimerDB4BRCATCGA-E2-A1LLADIPOR2chr12

1863680

+FOXJ2chr12

8197355

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357103ADIPOR2chr121863680+ENST00000162391FOXJ2chr128197356+41824222511528425
ENST00000357103ADIPOR2chr121863680+ENST00000428177FOXJ2chr128197356+19924222511384377
ENST00000357103ADIPOR2chr121863680+ENST00000162391FOXJ2chr128197355+41824222511528425
ENST00000357103ADIPOR2chr121863680+ENST00000428177FOXJ2chr128197355+19924222511384377

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357103ENST00000162391ADIPOR2chr121863680+FOXJ2chr128197356+0.0016155880.9983845
ENST00000357103ENST00000428177ADIPOR2chr121863680+FOXJ2chr128197356+0.0205072520.9794927
ENST00000357103ENST00000162391ADIPOR2chr121863680+FOXJ2chr128197355+0.0016155880.9983845
ENST00000357103ENST00000428177ADIPOR2chr121863680+FOXJ2chr128197355+0.0205072520.9794927

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2445_2445_1_ADIPOR2-FOXJ2_ADIPOR2_chr12_1863680_ENST00000357103_FOXJ2_chr12_8197355_ENST00000162391_length(amino acids)=425AA_BP=57
MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKGTGSVDGGAVAAGASGRESAEGPPPLYNTNHDF
KFSYSEINFQDLSWSFRNLYKSMLEKSSSSSQHGFSSLLGDIPPSNNYYMYQQQQPPPPQQQQQQQQPPQPPPQQSQPQQQQAPAQGPSA
VGGAPPLHTPSTDGCTPPGGKQAGAEGYGPPPVMAMHPPPLQHGGYHPHQHHPHSHPAQQPPPPQPQAQGQAPINNTGFAFPSDWCSNID
SLKESFKMVNRLNWSSIEQSQFSELMESLRQAEQKNWTLDQHHIANLCDSLNHFLTQTGHVPPQGGTHRPPAPARIADSCALTSGKQESA

--------------------------------------------------------------

>2445_2445_2_ADIPOR2-FOXJ2_ADIPOR2_chr12_1863680_ENST00000357103_FOXJ2_chr12_8197355_ENST00000428177_length(amino acids)=377AA_BP=57
MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKGTGSVDGGAVAAGASGRESAEGPPPLYNTNHDF
KFSYSEINFQDLSWSFRNLYKSMLEKSSSSSQHGFSSLLGDIPPSNNYYMYQQQQPPPPQQQQQQQQPPQPPPQQSQPQQQQAPAQGPSA
VGGAPPLHTPSTDGCTPPGGKQAGAEGYGPPPVMAMHPPPLQHGGYHPHQHHPHSHPAQQPPPPQPQAQGQAPINNTGFAFPSDWCSNID
SLKESFKMVNRLNWSSIEQSQFSELMESLRQAEQKNWTLDQHHIANLCDSLNHFLTQTGHVPPQGGTHRPPAPARIADSCALTSGKQESA

--------------------------------------------------------------

>2445_2445_3_ADIPOR2-FOXJ2_ADIPOR2_chr12_1863680_ENST00000357103_FOXJ2_chr12_8197356_ENST00000162391_length(amino acids)=425AA_BP=57
MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKGTGSVDGGAVAAGASGRESAEGPPPLYNTNHDF
KFSYSEINFQDLSWSFRNLYKSMLEKSSSSSQHGFSSLLGDIPPSNNYYMYQQQQPPPPQQQQQQQQPPQPPPQQSQPQQQQAPAQGPSA
VGGAPPLHTPSTDGCTPPGGKQAGAEGYGPPPVMAMHPPPLQHGGYHPHQHHPHSHPAQQPPPPQPQAQGQAPINNTGFAFPSDWCSNID
SLKESFKMVNRLNWSSIEQSQFSELMESLRQAEQKNWTLDQHHIANLCDSLNHFLTQTGHVPPQGGTHRPPAPARIADSCALTSGKQESA

--------------------------------------------------------------

>2445_2445_4_ADIPOR2-FOXJ2_ADIPOR2_chr12_1863680_ENST00000357103_FOXJ2_chr12_8197356_ENST00000428177_length(amino acids)=377AA_BP=57
MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEPILEASVLSSHHKKGTGSVDGGAVAAGASGRESAEGPPPLYNTNHDF
KFSYSEINFQDLSWSFRNLYKSMLEKSSSSSQHGFSSLLGDIPPSNNYYMYQQQQPPPPQQQQQQQQPPQPPPQQSQPQQQQAPAQGPSA
VGGAPPLHTPSTDGCTPPGGKQAGAEGYGPPPVMAMHPPPLQHGGYHPHQHHPHSHPAQQPPPPQPQAQGQAPINNTGFAFPSDWCSNID
SLKESFKMVNRLNWSSIEQSQFSELMESLRQAEQKNWTLDQHHIANLCDSLNHFLTQTGHVPPQGGTHRPPAPARIADSCALTSGKQESA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:1863680/chr12:8197356)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADIPOR2

Q86V24

FOXJ2

Q9P0K8

FUNCTION: Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). {ECO:0000250|UniProtKB:Q8BQS5, ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:25855295}.FUNCTION: [Isoform FOXJ2.L]: Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q9ES18, ECO:0000269|PubMed:10777590, ECO:0000269|PubMed:10966786}.; FUNCTION: [Isoform FOXJ2.S]: Transcriptional activator. {ECO:0000269|PubMed:10966786}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFOXJ2chr12:1863680chr12:8197355ENST00000162391411266_270206.0575.0Compositional biasNote=Poly-Ser
TgeneFOXJ2chr12:1863680chr12:8197355ENST00000162391411291_294206.0575.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197355ENST00000162391411295_298206.0575.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197355ENST00000162391411299_306206.0575.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197355ENST00000162391411313_321206.0575.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197355ENST00000162391411390_395206.0575.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000042817749266_270206.0527.0Compositional biasNote=Poly-Ser
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000042817749291_294206.0527.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000042817749295_298206.0527.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000042817749299_306206.0527.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000042817749313_321206.0527.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000042817749390_395206.0527.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197356ENST00000162391411266_270206.0575.0Compositional biasNote=Poly-Ser
TgeneFOXJ2chr12:1863680chr12:8197356ENST00000162391411291_294206.0575.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197356ENST00000162391411295_298206.0575.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197356ENST00000162391411299_306206.0575.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197356ENST00000162391411313_321206.0575.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197356ENST00000162391411390_395206.0575.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000042817749266_270206.0527.0Compositional biasNote=Poly-Ser
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000042817749291_294206.0527.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000042817749295_298206.0527.0Compositional biasNote=Poly-Pro
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000042817749299_306206.0527.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000042817749313_321206.0527.0Compositional biasNote=Poly-Gln
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000042817749390_395206.0527.0Compositional biasNote=Poly-Pro

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28169_18157.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+281_14757.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28203_21357.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28235_24557.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28267_27357.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28295_30957.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28331_34857.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28370_38657.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28169_18157.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+281_14757.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28203_21357.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28235_24557.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28267_27357.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28295_30957.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28331_34857.0387.0Topological domainCytoplasmic
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28370_38657.0387.0Topological domainExtracellular
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28148_16857.0387.0TransmembraneHelical%3B Name%3D1
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28182_20257.0387.0TransmembraneHelical%3B Name%3D2
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28214_23457.0387.0TransmembraneHelical%3B Name%3D3
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28246_26657.0387.0TransmembraneHelical%3B Name%3D4
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28274_29457.0387.0TransmembraneHelical%3B Name%3D5
HgeneADIPOR2chr12:1863680chr12:8197355ENST00000357103+28349_36957.0387.0TransmembraneHelical%3B Name%3D7
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28148_16857.0387.0TransmembraneHelical%3B Name%3D1
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28182_20257.0387.0TransmembraneHelical%3B Name%3D2
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28214_23457.0387.0TransmembraneHelical%3B Name%3D3
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28246_26657.0387.0TransmembraneHelical%3B Name%3D4
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28274_29457.0387.0TransmembraneHelical%3B Name%3D5
HgeneADIPOR2chr12:1863680chr12:8197356ENST00000357103+28349_36957.0387.0TransmembraneHelical%3B Name%3D7
TgeneFOXJ2chr12:1863680chr12:8197355ENST0000016239141166_143206.0575.0DNA bindingFork-head
TgeneFOXJ2chr12:1863680chr12:8197355ENST000004281774966_143206.0527.0DNA bindingFork-head
TgeneFOXJ2chr12:1863680chr12:8197356ENST0000016239141166_143206.0575.0DNA bindingFork-head
TgeneFOXJ2chr12:1863680chr12:8197356ENST000004281774966_143206.0527.0DNA bindingFork-head


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADIPOR2
FOXJ2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADIPOR2-FOXJ2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADIPOR2-FOXJ2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource