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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DVL2-TFE3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DVL2-TFE3
	FusionPDB ID: 24544
	FusionGDB2.0 ID: 24544
		Hgene	Tgene
	Gene symbol	DVL2	TFE3
	Gene ID	1856	7030
	Gene name	dishevelled segment polarity protein 2	transcription factor binding to IGHM enhancer 3
	Synonyms	-	RCCP2\|RCCX1\|TFEA\|bHLHe33
	Cytomap	17p13.1	Xp11.23
	Type of gene	protein-coding	protein-coding
	Description	segment polarity protein dishevelled homolog DVL-2dishevelled 2 (homologous to Drosophila dsh)dishevelled, dsh homolog 2	transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
	Modification date	20200327	20200327
	UniProtAcc	O14641	P19532
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000005340, ENST00000575458, ENST00000574642,	ENST00000487451, ENST00000315869,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 8 X 4=192	14 X 15 X 6=1260
	# samples	8	15
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1260*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DVL2 [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DVL2(7133127)-TFE3(48896935), # samples:3 TFE3(48897982)-DVL2(7132766), # samples:3
Anticipated loss of major functional domain due to fusion event.	DVL2-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DVL2-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DVL2-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DVL2-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFE3-DVL2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TFE3-DVL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TFE3-DVL2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DVL2	GO:0006366	transcription by RNA polymerase II	11742073
Hgene	DVL2	GO:0043507	positive regulation of JUN kinase activity	17593335
Hgene	DVL2	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation	18787224
Hgene	DVL2	GO:0045893	positive regulation of transcription, DNA-templated	12805222\|17593335
Hgene	DVL2	GO:0051091	positive regulation of DNA-binding transcription factor activity	17593335
Hgene	DVL2	GO:0060070	canonical Wnt signaling pathway	17593335
Hgene	DVL2	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	12805222

Fusion gene breakpoints across DVL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-J7-8537-01A	DVL2	chr17	7133127	-	TFE3	chrX	48896935	-
ChimerDB4	KIRP	TCGA-J7-8537	DVL2	chr17	7133126	-	TFE3	chrX	48896935	-
ChimerDB4	KIRP	TCGA-J7-8537	DVL2	chr17	7133127	-	TFE3	chrX	48896935	-
ChimerKB4	.	.	DVL2	chr17	7133474	-	TFE3	chrX	7133474	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000005340	DVL2	chr17	7133127	-	ENST00000315869	TFE3	chrX	48896935	-	3864	939	283	2436	717
ENST00000575458	DVL2	chr17	7133127	-	ENST00000315869	TFE3	chrX	48896935	-	3619	694	56	2191	711
ENST00000005340	DVL2	chr17	7133126	-	ENST00000315869	TFE3	chrX	48896935	-	3864	939	283	2436	717
ENST00000575458	DVL2	chr17	7133126	-	ENST00000315869	TFE3	chrX	48896935	-	3619	694	56	2191	711

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000005340	ENST00000315869	DVL2	chr17	7133127	-	TFE3	chrX	48896935	-	0.016605936	0.9833941
ENST00000575458	ENST00000315869	DVL2	chr17	7133127	-	TFE3	chrX	48896935	-	0.02252927	0.97747076
ENST00000005340	ENST00000315869	DVL2	chr17	7133126	-	TFE3	chrX	48896935	-	0.016605936	0.9833941
ENST00000575458	ENST00000315869	DVL2	chr17	7133126	-	TFE3	chrX	48896935	-	0.02252927	0.97747076

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24544_24544_1_DVL2-TFE3_DVL2_chr17_7133126_ENST00000005340_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=717AA_BP=218
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV
SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTG
GPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQ
ERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTP
PPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSS
QGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRK
LQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAP

--------------------------------------------------------------

>24544_24544_2_DVL2-TFE3_DVL2_chr17_7133126_ENST00000575458_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=711AA_BP=212
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV
SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLE
RHLAGYESSSTLMTSELESTSLGDSDEEDTMSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERR
EQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPAS
AQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP
AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ
RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA

--------------------------------------------------------------

>24544_24544_3_DVL2-TFE3_DVL2_chr17_7133127_ENST00000005340_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=717AA_BP=218
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV
SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTG
GPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQ
ERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTP
PPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSS
QGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRK
LQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAP

--------------------------------------------------------------

>24544_24544_4_DVL2-TFE3_DVL2_chr17_7133127_ENST00000575458_TFE3_chrX_48896935_ENST00000315869_length(amino acids)=711AA_BP=212
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV
SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLE
RHLAGYESSSTLMTSELESTSLGDSDEEDTMSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERR
EQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPAS
AQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP
AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ
RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:7133127/chrX:48896935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DVL2 O14641	TFE3 P19532
FUNCTION: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250\|UniProtKB:Q60838, ECO:0000269\|PubMed:19252499}.	FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250\|UniProtKB:Q64092, ECO:0000269\|PubMed:2338243, ECO:0000269\|PubMed:29146937, ECO:0000269\|PubMed:30733432, ECO:0000269\|PubMed:31672913}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DVL2

chr17:7133126

chrX:48896935

ENST00000005340

7_12

218.66666666666666

737.0

Compositional bias

Note=Poly-Gly

Hgene

DVL2

chr17:7133127

chrX:48896935

ENST00000005340

7_12

218.66666666666666

737.0

Compositional bias

Note=Poly-Gly

Hgene

DVL2

chr17:7133126

chrX:48896935

ENST00000005340

11_93

218.66666666666666

737.0

Domain

DIX

Hgene

DVL2

chr17:7133127

chrX:48896935

ENST00000005340

11_93

218.66666666666666

737.0

Domain

DIX

Tgene

TFE3

chr17:7133126

chrX:48896935

ENST00000315869

346_399

76.66666666666667

576.0

Domain

bHLH

Tgene

TFE3

chr17:7133127

chrX:48896935

ENST00000315869

346_399

76.66666666666667

576.0

Domain

bHLH

Tgene

TFE3

chr17:7133126

chrX:48896935

ENST00000315869

260_271

76.66666666666667

576.0

Region

Strong transcription activation domain

Tgene

TFE3

chr17:7133126

chrX:48896935

ENST00000315869

409_430

76.66666666666667

576.0

Region

Note=Leucine-zipper

Tgene

TFE3

chr17:7133127

chrX:48896935

ENST00000315869

260_271

76.66666666666667

576.0

Region

Strong transcription activation domain

Tgene

TFE3

chr17:7133127

chrX:48896935

ENST00000315869

409_430

76.66666666666667

576.0

Region

Note=Leucine-zipper

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DVL2

chr17:7133126

chrX:48896935

ENST00000005340

235_240

218.66666666666666

737.0

Compositional bias

Note=Poly-Arg

Hgene

DVL2

chr17:7133126

chrX:48896935

ENST00000005340

686_694

218.66666666666666

737.0

Compositional bias

Note=Poly-Pro

Hgene

DVL2

chr17:7133127

chrX:48896935

ENST00000005340

235_240

218.66666666666666

737.0

Compositional bias

Note=Poly-Arg

Hgene

DVL2

chr17:7133127

chrX:48896935

ENST00000005340

686_694

218.66666666666666

737.0

Compositional bias

Note=Poly-Pro

Hgene

DVL2

chr17:7133126

chrX:48896935

ENST00000005340

267_339

218.66666666666666

737.0

Domain

PDZ

Hgene

DVL2

chr17:7133126

chrX:48896935

ENST00000005340

433_507

218.66666666666666

737.0

Domain

DEP

Hgene

DVL2

chr17:7133127

chrX:48896935

ENST00000005340

267_339

218.66666666666666

737.0

Domain

PDZ

Hgene

DVL2

chr17:7133127

chrX:48896935

ENST00000005340

433_507

218.66666666666666

737.0

Domain

DEP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1458_DVL2_7133127_TFE3_48896935_ranked_0.pdb	DVL2	7133126	7133127	ENST00000315869	TFE3	chrX	48896935	-	MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTG GPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQLMRAQAQEQ ERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTP PPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSS QGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRK LQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAP	717

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DVL2_pLDDT.png

TFE3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
TFE3	AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB, Arrb2, TARDBP, HIST1H4A, LAMTOR3, nsp2, nsp7, AIM2, NR3C1, DDX58, YWHAG, YWHAQ, HDAC5, BTF3, nsp16, IRF8, KLF12, KLF16, KLF3, KLF5, KLF8, SOX2, TLX3, VSX1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DVL2
TFE3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DVL2-TFE3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DVL2-TFE3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TFE3	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET
Tgene	TFE3	C0206657	Alveolar Soft Part Sarcoma	1	ORPHANET
Tgene	TFE3	C0206732	Epithelioid hemangioendothelioma	1	ORPHANET