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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DYNC1I1-ZC3HAV1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DYNC1I1-ZC3HAV1
	FusionPDB ID: 24615
	FusionGDB2.0 ID: 24615
		Hgene	Tgene
	Gene symbol	DYNC1I1	ZC3HAV1
	Gene ID	1780	56829
	Gene name	dynein cytoplasmic 1 intermediate chain 1	zinc finger CCCH-type containing, antiviral 1
	Synonyms	DNCI1\|DNCIC1	ARTD13\|FLB6421\|PARP13\|ZAP\|ZC3H2\|ZC3HDC2
	Cytomap	7q21.3	7q34
	Type of gene	protein-coding	protein-coding
	Description	cytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1	zinc finger CCCH-type antiviral protein 1ADP-ribosyltransferase diphtheria toxin-like 13inactive Poly [ADP-ribose] polymerase 13zinc finger CCCH domain-containing protein 2zinc finger CCCH-type, antiviral 1
	Modification date	20200313	20200313
	UniProtAcc	O14576	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000324972, ENST00000447467, ENST00000457059, ENST00000359388, ENST00000413338, ENST00000437599, ENST00000497626, ENST00000537881,	ENST00000242351, ENST00000464606, ENST00000471652,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 6=180	13 X 10 X 5=650
	# samples	7	16
	** MAII score	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/650*10)=-2.02236781302845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DYNC1I1 [Title/Abstract] AND ZC3HAV1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DYNC1I1(95457428)-ZC3HAV1(138774505), # samples:3
Anticipated loss of major functional domain due to fusion event.	DYNC1I1-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DYNC1I1-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DYNC1I1-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DYNC1I1-ZC3HAV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ZC3HAV1	GO:0006471	protein ADP-ribosylation	25043379
Tgene	ZC3HAV1	GO:0009615	response to virus	21876179
Tgene	ZC3HAV1	GO:0045071	negative regulation of viral genome replication	21876179
Tgene	ZC3HAV1	GO:0061014	positive regulation of mRNA catabolic process	21876179

Fusion gene breakpoints across DYNC1I1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZC3HAV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-B9-4116-01A	DYNC1I1	chr7	95457428	-	ZC3HAV1	chr7	138774505	-
ChimerDB4	KIRP	TCGA-B9-4116-01A	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-
ChimerDB4	KIRP	TCGA-B9-4116	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000447467	DYNC1I1	chr7	95457428	+	ENST00000242351	ZC3HAV1	chr7	138774505	-	7078	603	154	3003	949
ENST00000447467	DYNC1I1	chr7	95457428	+	ENST00000464606	ZC3HAV1	chr7	138774505	-	5048	603	154	3369	1071
ENST00000447467	DYNC1I1	chr7	95457428	+	ENST00000471652	ZC3HAV1	chr7	138774505	-	3089	603	154	2394	746
ENST00000324972	DYNC1I1	chr7	95457428	+	ENST00000242351	ZC3HAV1	chr7	138774505	-	7093	618	118	3018	966
ENST00000324972	DYNC1I1	chr7	95457428	+	ENST00000464606	ZC3HAV1	chr7	138774505	-	5063	618	118	3384	1088
ENST00000324972	DYNC1I1	chr7	95457428	+	ENST00000471652	ZC3HAV1	chr7	138774505	-	3104	618	118	2409	763
ENST00000457059	DYNC1I1	chr7	95457428	+	ENST00000242351	ZC3HAV1	chr7	138774505	-	6949	474	73	2874	933
ENST00000457059	DYNC1I1	chr7	95457428	+	ENST00000464606	ZC3HAV1	chr7	138774505	-	4919	474	73	3240	1055
ENST00000457059	DYNC1I1	chr7	95457428	+	ENST00000471652	ZC3HAV1	chr7	138774505	-	2960	474	73	2265	730

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000447467	ENST00000242351	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.000360587	0.9996394
ENST00000447467	ENST00000464606	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.000669382	0.99933064
ENST00000447467	ENST00000471652	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.010289913	0.98971015
ENST00000324972	ENST00000242351	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.000151576	0.99984837
ENST00000324972	ENST00000464606	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.000532655	0.9994673
ENST00000324972	ENST00000471652	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.005264727	0.9947353
ENST00000457059	ENST00000242351	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.000278589	0.99972135
ENST00000457059	ENST00000464606	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.00048819	0.99951184
ENST00000457059	ENST00000471652	DYNC1I1	chr7	95457428	+	ZC3HAV1	chr7	138774505	-	0.007195831	0.9928041

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24615_24615_1_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000324972_ZC3HAV1_chr7_138774505_ENST00000242351_length(amino acids)=966AA_BP=167
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEE
NFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHG
LNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRK
FTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARS
SLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATG
RIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHL
CSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGS
RNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEH
FKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAK

--------------------------------------------------------------

>24615_24615_2_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000324972_ZC3HAV1_chr7_138774505_ENST00000464606_length(amino acids)=1088AA_BP=167
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEE
NFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHG
LNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRK
FTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARS
SLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATG
RIADDADPRVALVNGKYKGKTLWASTFVHDIPNGSSQVVDKTTDVEKTGATGFGLTMAVKAEKDMLRTGSQSLRNLVPTTPGESTAPAQV
STLPQSPAALSSSNRAAVWGAQGQNCTQVPVSSASELTRKTTGSAQYSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHL
PYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEE
KDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATF
RPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDS
FLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYT

--------------------------------------------------------------

>24615_24615_3_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000324972_ZC3HAV1_chr7_138774505_ENST00000471652_length(amino acids)=763AA_BP=167
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEE
NFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHG
LNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRK
FTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARS
SLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATG
RIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHL
CSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGS

--------------------------------------------------------------

>24615_24615_4_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000447467_ZC3HAV1_chr7_138774505_ENST00000242351_length(amino acids)=949AA_BP=150
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEENFKVLKNHELSGLNKEE
LAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKH
MQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSS
KATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGT
GLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSL
SDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDS
FPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIAS
KTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIE
NSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEG

--------------------------------------------------------------

>24615_24615_5_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000447467_ZC3HAV1_chr7_138774505_ENST00000464606_length(amino acids)=1071AA_BP=150
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEENFKVLKNHELSGLNKEE
LAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKH
MQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSS
KATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGT
GLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNGKY
KGKTLWASTFVHDIPNGSSQVVDKTTDVEKTGATGFGLTMAVKAEKDMLRTGSQSLRNLVPTTPGESTAPAQVSTLPQSPAALSSSNRAA
VWGAQGQNCTQVPVSSASELTRKTTGSAQYSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEH
METIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESL
YQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLS
EIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFA

--------------------------------------------------------------

>24615_24615_6_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000447467_ZC3HAV1_chr7_138774505_ENST00000471652_length(amino acids)=746AA_BP=150
MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS
IGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEENFKVLKNHELSGLNKEE
LAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKH
MQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSS
KATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGT
GLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSL
SDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDS
FPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIAS

--------------------------------------------------------------

>24615_24615_7_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000457059_ZC3HAV1_chr7_138774505_ENST00000242351_length(amino acids)=933AA_BP=134
MEVMMMETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSP
SSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEI
CKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRR
NMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQR
FLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGT
QDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDS
EEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPA
NSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQW
YVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMK
EEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVD

--------------------------------------------------------------

>24615_24615_8_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000457059_ZC3HAV1_chr7_138774505_ENST00000464606_length(amino acids)=1055AA_BP=134
MEVMMMETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSP
SSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEI
CKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRR
NMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQR
FLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGT
QDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNGKYKGKTLWASTFVHDIPN
GSSQVVDKTTDVEKTGATGFGLTMAVKAEKDMLRTGSQSLRNLVPTTPGESTAPAQVSTLPQSPAALSSSNRAAVWGAQGQNCTQVPVSS
ASELTRKTTGSAQYSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLC
SVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSR
NYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHF
KASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKN

--------------------------------------------------------------

>24615_24615_9_DYNC1I1-ZC3HAV1_DYNC1I1_chr7_95457428_ENST00000457059_ZC3HAV1_chr7_138774505_ENST00000471652_length(amino acids)=730AA_BP=134
MEVMMMETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSP
SSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEI
CKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRR
NMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQR
FLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGT
QDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDS
EEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPA
NSVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQW

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:95457428/chr7:138774505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DYNC1I1 O14576	.
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

594_681

102.66666666666667

903.0

Domain

WWE

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

716_902

102.66666666666667

903.0

Domain

PARP catalytic

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

594_681

102.66666666666667

700.0

Domain

WWE

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

716_902

102.66666666666667

700.0

Domain

PARP catalytic

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

285_292

102.66666666666667

903.0

Motif

Nuclear export signal

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

285_292

102.66666666666667

700.0

Motif

Nuclear export signal

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

224_254

102.66666666666667

903.0

Region

Binding to EXOSC5

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

224_254

102.66666666666667

700.0

Region

Binding to EXOSC5

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

150_172

102.66666666666667

903.0

Zinc finger

C3H1-type 3

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

169_193

102.66666666666667

903.0

Zinc finger

C3H1-type 4

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

150_172

102.66666666666667

700.0

Zinc finger

C3H1-type 3

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

169_193

102.66666666666667

700.0

Zinc finger

C3H1-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

285_334

141.66666666666666

646.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

338_378

141.66666666666666

646.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

387_428

141.66666666666666

646.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

437_477

141.66666666666666

646.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

482_527

141.66666666666666

646.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

530_570

141.66666666666666

646.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000324972

576_615

141.66666666666666

646.0

Repeat

Note=WD 7

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

285_334

609.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

338_378

609.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

387_428

609.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

437_477

609.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

482_527

609.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

530_570

609.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000359388

576_615

609.0

Repeat

Note=WD 7

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

285_334

124.66666666666667

629.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

338_378

124.66666666666667

629.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

387_428

124.66666666666667

629.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

437_477

124.66666666666667

629.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

482_527

124.66666666666667

629.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

530_570

124.66666666666667

629.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000447467

576_615

124.66666666666667

629.0

Repeat

Note=WD 7

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

285_334

124.66666666666667

629.0

Repeat

Note=WD 1

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

338_378

124.66666666666667

629.0

Repeat

Note=WD 2

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

387_428

124.66666666666667

629.0

Repeat

Note=WD 3

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

437_477

124.66666666666667

629.0

Repeat

Note=WD 4

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

482_527

124.66666666666667

629.0

Repeat

Note=WD 5

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

530_570

124.66666666666667

629.0

Repeat

Note=WD 6

Hgene

DYNC1I1

chr7:95457428

chr7:138774505

ENST00000457059

576_615

124.66666666666667

629.0

Repeat

Note=WD 7

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

69_76

102.66666666666667

903.0

Motif

Nuclear localization signal

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

69_76

102.66666666666667

700.0

Motif

Nuclear localization signal

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

2_254

102.66666666666667

903.0

Region

Note=N-terminal domain

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

2_254

102.66666666666667

700.0

Region

Note=N-terminal domain

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

73_86

102.66666666666667

903.0

Zinc finger

C3H1-type 1

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000242351

88_110

102.66666666666667

903.0

Zinc finger

C3H1-type 2

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

73_86

102.66666666666667

700.0

Zinc finger

C3H1-type 1

Tgene

ZC3HAV1

chr7:95457428

chr7:138774505

ENST00000471652

88_110

102.66666666666667

700.0

Zinc finger

C3H1-type 2

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1859_DYNC1I1_95457428_ZC3HAV1_138774505_ranked_0.pdb	DYNC1I1	95457428	95457428	ENST00000471652	ZC3HAV1	chr7	138774505	-	MPPPRSRRRLGEPSSAAAERVQETNMSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQS IGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGNLCKYSHEVLSEE NFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRGNCRFPNCLRSHNLMDRKVLAIMREHG LNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRK FTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWKSLTSWTNDQGARRKTVFSPTLPAARS SLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATG RIADDADPRVALVNGKYKGKTLWASTFVHDIPNGSSQVVDKTTDVEKTGATGFGLTMAVKAEKDMLRTGSQSLRNLVPTTPGESTAPAQV STLPQSPAALSSSNRAAVWGAQGQNCTQVPVSSASELTRKTTGSAQYSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHL PYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEE KDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYELSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATF RPQEDFCFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKEEGKLLFYATSRAYVESICSNNFDS FLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVMFVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYT	1088

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DYNC1I1_pLDDT.png

ZC3HAV1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DYNC1I1
ZC3HAV1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	DYNC1I1	chr7:95457428	chr7:138774505	ENST00000359388	+	1	16	2_123	0	609.0	DCTN1
Hgene	DYNC1I1	chr7:95457428	chr7:138774505	ENST00000324972	+	5	17	147_163	141.66666666666666	646.0	DYNLT1
Hgene	DYNC1I1	chr7:95457428	chr7:138774505	ENST00000359388	+	1	16	147_163	0	609.0	DYNLT1
Hgene	DYNC1I1	chr7:95457428	chr7:138774505	ENST00000447467	+	5	17	147_163	124.66666666666667	629.0	DYNLT1
Hgene	DYNC1I1	chr7:95457428	chr7:138774505	ENST00000457059	+	5	17	147_163	124.66666666666667	629.0	DYNLT1

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Related Drugs to DYNC1I1-ZC3HAV1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DYNC1I1-ZC3HAV1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source