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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DYNLL1-MYLK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DYNLL1-MYLK
FusionPDB ID: 24657
FusionGDB2.0 ID: 24657
HgeneTgene
Gene symbol

DYNLL1

MYLK

Gene ID

8655

4638

Gene namedynein light chain LC8-type 1myosin light chain kinase
SynonymsDLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|PIN|hdlc1AAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCK
Cytomap

12q24.31

3q21.1

Type of geneprotein-codingprotein-coding
Descriptiondynein light chain 1, cytoplasmic8 kDa dynein light chaincytoplasmic dynein light polypeptidedynein, cytoplasmic, light polypeptide 1protein inhibitor of neuronal nitric oxide synthasemyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2020032220200320
UniProtAcc

P63167

Q86YV6

Ensembl transtripts involved in fusion geneENST idsENST00000242577, ENST00000392508, 
ENST00000392509, ENST00000548214, 
ENST00000548342, ENST00000549989, 
ENST00000550178, ENST00000550845, 
ENST00000552870, ENST00000552316, 
ENST00000346322, ENST00000354792, 
ENST00000418370, ENST00000475616, 
ENST00000578202, ENST00000583087, 
ENST00000510775, ENST00000359169, 
ENST00000360304, ENST00000360772, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 7 X 5=31514 X 15 X 4=840
# samples 1015
** MAII scorelog2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DYNLL1 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DYNLL1(120934356)-MYLK(123339183), # samples:1
Anticipated loss of major functional domain due to fusion event.DYNLL1-MYLK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNLL1-MYLK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNLL1-MYLK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNLL1-MYLK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DYNLL1-MYLK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DYNLL1-MYLK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DYNLL1-MYLK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYNLL1

GO:0042326

negative regulation of phosphorylation

18579519

TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonFusion gene breakpoints across DYNLL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer265NDYNLL1chr12

120934356

+MYLKchr3

123339183

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392509DYNLL1chr12120934356+ENST00000360772MYLKchr3123339183-4956393234899221
ENST00000392509DYNLL1chr12120934356+ENST00000359169MYLKchr3123339183-2707393234899221
ENST00000392509DYNLL1chr12120934356+ENST00000360304MYLKchr3123339183-2707393234899221
ENST00000548342DYNLL1chr12120934356+ENST00000360772MYLKchr3123339183-50604973651003212
ENST00000548342DYNLL1chr12120934356+ENST00000359169MYLKchr3123339183-28114973651003212
ENST00000548342DYNLL1chr12120934356+ENST00000360304MYLKchr3123339183-28114973651003212
ENST00000242577DYNLL1chr12120934356+ENST00000360772MYLKchr3123339183-4862299167805212
ENST00000242577DYNLL1chr12120934356+ENST00000359169MYLKchr3123339183-2613299167805212
ENST00000242577DYNLL1chr12120934356+ENST00000360304MYLKchr3123339183-2613299167805212
ENST00000392508DYNLL1chr12120934356+ENST00000360772MYLKchr3123339183-4841278146784212
ENST00000392508DYNLL1chr12120934356+ENST00000359169MYLKchr3123339183-2592278146784212
ENST00000392508DYNLL1chr12120934356+ENST00000360304MYLKchr3123339183-2592278146784212
ENST00000549989DYNLL1chr12120934356+ENST00000360772MYLKchr3123339183-5004441309947212
ENST00000549989DYNLL1chr12120934356+ENST00000359169MYLKchr3123339183-2755441309947212
ENST00000549989DYNLL1chr12120934356+ENST00000360304MYLKchr3123339183-2755441309947212
ENST00000552870DYNLL1chr12120934356+ENST00000360772MYLKchr3123339183-4805242110748212
ENST00000552870DYNLL1chr12120934356+ENST00000359169MYLKchr3123339183-2556242110748212
ENST00000552870DYNLL1chr12120934356+ENST00000360304MYLKchr3123339183-2556242110748212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392509ENST00000360772DYNLL1chr12120934356+MYLKchr3123339183-0.0006751550.9993249
ENST00000392509ENST00000359169DYNLL1chr12120934356+MYLKchr3123339183-0.000963960.9990361
ENST00000392509ENST00000360304DYNLL1chr12120934356+MYLKchr3123339183-0.000963960.9990361
ENST00000548342ENST00000360772DYNLL1chr12120934356+MYLKchr3123339183-0.0006291490.9993709
ENST00000548342ENST00000359169DYNLL1chr12120934356+MYLKchr3123339183-0.00054040.99945956
ENST00000548342ENST00000360304DYNLL1chr12120934356+MYLKchr3123339183-0.00054040.99945956
ENST00000242577ENST00000360772DYNLL1chr12120934356+MYLKchr3123339183-0.0005573330.99944264
ENST00000242577ENST00000359169DYNLL1chr12120934356+MYLKchr3123339183-0.0006796710.9993204
ENST00000242577ENST00000360304DYNLL1chr12120934356+MYLKchr3123339183-0.0006796710.9993204
ENST00000392508ENST00000360772DYNLL1chr12120934356+MYLKchr3123339183-0.000535770.9994642
ENST00000392508ENST00000359169DYNLL1chr12120934356+MYLKchr3123339183-0.000613240.9993868
ENST00000392508ENST00000360304DYNLL1chr12120934356+MYLKchr3123339183-0.000613240.9993868
ENST00000549989ENST00000360772DYNLL1chr12120934356+MYLKchr3123339183-0.0005265780.9994734
ENST00000549989ENST00000359169DYNLL1chr12120934356+MYLKchr3123339183-0.0005853880.9994147
ENST00000549989ENST00000360304DYNLL1chr12120934356+MYLKchr3123339183-0.0005853880.9994147
ENST00000552870ENST00000360772DYNLL1chr12120934356+MYLKchr3123339183-0.0005391120.9994609
ENST00000552870ENST00000359169DYNLL1chr12120934356+MYLKchr3123339183-0.000501520.9994985
ENST00000552870ENST00000360304DYNLL1chr12120934356+MYLKchr3123339183-0.000501520.9994985

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24657_24657_1_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000242577_MYLK_chr3_123339183_ENST00000359169_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_2_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000242577_MYLK_chr3_123339183_ENST00000360304_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_3_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000242577_MYLK_chr3_123339183_ENST00000360772_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_4_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000392508_MYLK_chr3_123339183_ENST00000359169_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_5_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000392508_MYLK_chr3_123339183_ENST00000360304_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_6_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000392508_MYLK_chr3_123339183_ENST00000360772_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_7_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000392509_MYLK_chr3_123339183_ENST00000359169_length(amino acids)=221AA_BP=53
MSRPPPQVTMCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNA
EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVC

--------------------------------------------------------------

>24657_24657_8_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000392509_MYLK_chr3_123339183_ENST00000360304_length(amino acids)=221AA_BP=53
MSRPPPQVTMCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNA
EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVC

--------------------------------------------------------------

>24657_24657_9_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000392509_MYLK_chr3_123339183_ENST00000360772_length(amino acids)=221AA_BP=53
MSRPPPQVTMCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNA
EKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVC

--------------------------------------------------------------

>24657_24657_10_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000548342_MYLK_chr3_123339183_ENST00000359169_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_11_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000548342_MYLK_chr3_123339183_ENST00000360304_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_12_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000548342_MYLK_chr3_123339183_ENST00000360772_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_13_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000549989_MYLK_chr3_123339183_ENST00000359169_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_14_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000549989_MYLK_chr3_123339183_ENST00000360304_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_15_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000549989_MYLK_chr3_123339183_ENST00000360772_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_16_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000552870_MYLK_chr3_123339183_ENST00000359169_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_17_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000552870_MYLK_chr3_123339183_ENST00000360304_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

>24657_24657_18_DYNLL1-MYLK_DYNLL1_chr12_120934356_ENST00000552870_MYLK_chr3_123339183_ENST00000360772_length(amino acids)=212AA_BP=44
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV
SQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:120934356/chr3:123339183)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNLL1

P63167

MYLK

Q86YV6

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.; FUNCTION: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.; FUNCTION: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331906_19141677.01846.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331906_19141695.01864.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341906_19141746.01915.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341906_19141695.01864.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031906_19140155.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311906_19141746.01915.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041906_19140155.0Compositional biasNote=Poly-Glu
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331809_18981677.01846.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331809_18981695.01864.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341809_18981746.01915.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341809_18981695.01864.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031098_11860155.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031238_13260155.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031334_14260155.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031464_17190155.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003161_2490155.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031809_18980155.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST000004183700333_1220155.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003414_5030155.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003514_5990155.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003620_7110155.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003721_8210155.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311809_18981746.01915.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041098_11860155.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041238_13260155.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041334_14260155.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041464_17190155.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704161_2490155.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041809_18980155.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr12:120934356chr3:123339183ENST000005830870433_1220155.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704414_5030155.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704514_5990155.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704620_7110155.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704721_8210155.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031470_14780155.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041470_14780155.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331711_17741677.01846.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331711_17741695.01864.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341711_17741695.01864.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031711_17740155.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003948_9630155.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041711_17740155.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704948_9630155.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031004_10150155.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031016_10270155.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031028_10390155.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031040_10510155.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST00000418370031052_10630155.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003868_8950155.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003896_9230155.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003924_9510155.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003952_9790155.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003980_9980155.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST0000041837003999_10030155.0RepeatNote=2-1%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041004_10150155.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041016_10270155.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041028_10390155.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041040_10510155.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST00000583087041052_10630155.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704868_8950155.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704896_9230155.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704924_9510155.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704952_9790155.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704980_9980155.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST0000058308704999_10030155.0RepeatNote=2-1%3B truncated

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331098_11861677.01846.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331238_13261677.01846.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331334_14261677.01846.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331464_17191677.01846.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933161_2491677.01846.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000346322293333_1221677.01846.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933414_5031677.01846.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933514_5991677.01846.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933620_7111677.01846.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933721_8211677.01846.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331098_11861695.01864.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331238_13261695.01864.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331334_14261695.01864.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331464_17191695.01864.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933161_2491695.01864.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000359169293333_1221695.01864.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933414_5031695.01864.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933514_5991695.01864.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933620_7111695.01864.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933721_8211695.01864.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341098_11861746.01915.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341238_13261746.01915.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341334_14261746.01915.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341464_17191746.01915.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034161_2491746.01915.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000360304303433_1221746.01915.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034414_5031746.01915.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034514_5991746.01915.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034620_7111746.01915.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034721_8211746.01915.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341098_11861695.01864.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341238_13261695.01864.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341334_14261695.01864.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341464_17191695.01864.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034161_2491695.01864.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000360772303433_1221695.01864.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034414_5031695.01864.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034514_5991695.01864.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034620_7111695.01864.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034721_8211695.01864.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311098_11861746.01915.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311238_13261746.01915.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311334_14261746.01915.0DomainFibronectin type-III
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311464_17191746.01915.0DomainProtein kinase
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731161_2491746.01915.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr12:120934356chr3:123339183ENST00000475616273133_1221746.01915.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731414_5031746.01915.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731514_5991746.01915.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731620_7111746.01915.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731721_8211746.01915.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331470_14781677.01846.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331470_14781695.01864.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341470_14781746.01915.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341470_14781695.01864.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311470_14781746.01915.0Nucleotide bindingATP
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331061_14601677.01846.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933868_9981677.01846.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933923_9631677.01846.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933948_9631677.01846.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933999_10631677.01846.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331061_14601695.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933868_9981695.01864.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933923_9631695.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933948_9631695.01864.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933999_10631695.01864.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341061_14601746.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341711_17741746.01915.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034868_9981746.01915.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034923_9631746.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034948_9631746.01915.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034999_10631746.01915.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341061_14601695.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034868_9981695.01864.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034923_9631695.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034948_9631695.01864.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034999_10631695.01864.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311061_14601746.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311711_17741746.01915.0RegionNote=Calmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731868_9981746.01915.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731923_9631746.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731948_9631746.01915.0RegionCalmodulin-binding
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731999_10631746.01915.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331004_10151677.01846.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331016_10271677.01846.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331028_10391677.01846.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331040_10511677.01846.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST0000034632229331052_10631677.01846.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933868_8951677.01846.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933896_9231677.01846.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933924_9511677.01846.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933952_9791677.01846.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933980_9981677.01846.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST000003463222933999_10031677.01846.0RepeatNote=2-1%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331004_10151695.01864.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331016_10271695.01864.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331028_10391695.01864.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331040_10511695.01864.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST0000035916929331052_10631695.01864.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933868_8951695.01864.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933896_9231695.01864.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933924_9511695.01864.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933952_9791695.01864.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933980_9981695.01864.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST000003591692933999_10031695.01864.0RepeatNote=2-1%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341004_10151746.01915.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341016_10271746.01915.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341028_10391746.01915.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341040_10511746.01915.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST0000036030430341052_10631746.01915.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034868_8951746.01915.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034896_9231746.01915.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034924_9511746.01915.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034952_9791746.01915.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034980_9981746.01915.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST000003603043034999_10031746.01915.0RepeatNote=2-1%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341004_10151695.01864.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341016_10271695.01864.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341028_10391695.01864.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341040_10511695.01864.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST0000036077230341052_10631695.01864.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034868_8951695.01864.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034896_9231695.01864.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034924_9511695.01864.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034952_9791695.01864.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034980_9981695.01864.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST000003607723034999_10031695.01864.0RepeatNote=2-1%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311004_10151746.01915.0RepeatNote=2-2
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311016_10271746.01915.0RepeatNote=2-3
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311028_10391746.01915.0RepeatNote=2-4
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311040_10511746.01915.0RepeatNote=2-5
TgeneMYLKchr12:120934356chr3:123339183ENST0000047561627311052_10631746.01915.0RepeatNote=2-6
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731868_8951746.01915.0RepeatNote=1-1
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731896_9231746.01915.0RepeatNote=1-2
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731924_9511746.01915.0RepeatNote=1-3
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731952_9791746.01915.0RepeatNote=1-4
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731980_9981746.01915.0RepeatNote=1-5%3B truncated
TgeneMYLKchr12:120934356chr3:123339183ENST000004756162731999_10031746.01915.0RepeatNote=2-1%3B truncated


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DYNLL1
MYLK


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDYNLL1chr12:120934356chr3:123339183ENST00000242577+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr3:123339183ENST00000392508+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr3:123339183ENST00000392509+2367_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr3:123339183ENST00000548342+4567_8944.090.0ESR1
HgeneDYNLL1chr12:120934356chr3:123339183ENST00000549989+1267_8944.090.0ESR1


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Related Drugs to DYNLL1-MYLK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DYNLL1-MYLK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource