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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DYRK1A-KCNJ6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DYRK1A-KCNJ6
	FusionPDB ID: 24698
	FusionGDB2.0 ID: 24698
		Hgene	Tgene
	Gene symbol	DYRK1A	KCNJ6
	Gene ID	1859	3763
	Gene name	dual specificity tyrosine phosphorylation regulated kinase 1A	potassium inwardly rectifying channel subfamily J member 6
	Synonyms	DYRK\|DYRK1\|HP86\|MNB\|MNBH\|MRD7	BIR1\|GIRK-2\|GIRK2\|KATP-2\|KATP2\|KCNJ7\|KIR3.2\|KPLBS\|hiGIRK2
	Cytomap	21q22.13	21q22.13
	Type of gene	protein-coding	protein-coding
	Description	dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs	G protein-activated inward rectifier potassium channel 2inward rectifier K(+) channel Kir3.2inward rectifier potassium channel KIR3.2potassium channel, inwardly rectifying subfamily J, member 6potassium voltage-gated channel subfamily J member 6
	Modification date	20200315	20200313
	UniProtAcc	Q13627	P48051
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000321219, ENST00000338785, ENST00000339659, ENST00000398956, ENST00000398960, ENST00000451934, ENST00000455387, ENST00000462274,	ENST00000288309, ENST00000609713,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	32 X 23 X 11=8096	13 X 9 X 6=702
	# samples	40	14
	** MAII score	log2(40/8096*10)=-4.33913738491959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/702*10)=-2.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DYRK1A [Title/Abstract] AND KCNJ6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DYRK1A(38792686)-KCNJ6(39087434), # samples:3
Anticipated loss of major functional domain due to fusion event.	DYRK1A-KCNJ6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DYRK1A-KCNJ6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DYRK1A-KCNJ6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DYRK1A-KCNJ6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DYRK1A	GO:0018108	peptidyl-tyrosine phosphorylation	9748265
Hgene	DYRK1A	GO:0033120	positive regulation of RNA splicing	28377597
Hgene	DYRK1A	GO:0038083	peptidyl-tyrosine autophosphorylation	24327345

Fusion gene breakpoints across DYRK1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KCNJ6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-XK-AAJA-01A	DYRK1A	chr21	38792686	-	KCNJ6	chr21	39087434	-
ChimerDB4	PRAD	TCGA-XK-AAJA-01A	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-
ChimerDB4	PRAD	TCGA-XK-AAJA	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338785	DYRK1A	chr21	38792686	+	ENST00000609713	KCNJ6	chr21	39087434	-	19269	239	229	1485	418
ENST00000338785	DYRK1A	chr21	38792686	+	ENST00000288309	KCNJ6	chr21	39087434	-	1486	239	229	1485	419
ENST00000451934	DYRK1A	chr21	38792686	+	ENST00000609713	KCNJ6	chr21	39087434	-	20510	1480	1470	2726	418
ENST00000451934	DYRK1A	chr21	38792686	+	ENST00000288309	KCNJ6	chr21	39087434	-	2727	1480	1470	2726	418
ENST00000321219	DYRK1A	chr21	38792686	+	ENST00000609713	KCNJ6	chr21	39087434	-	20510	1480	1470	2726	418
ENST00000321219	DYRK1A	chr21	38792686	+	ENST00000288309	KCNJ6	chr21	39087434	-	2727	1480	1470	2726	418
ENST00000339659	DYRK1A	chr21	38792686	+	ENST00000609713	KCNJ6	chr21	39087434	-	20510	1480	1470	2726	418
ENST00000339659	DYRK1A	chr21	38792686	+	ENST00000288309	KCNJ6	chr21	39087434	-	2727	1480	1470	2726	418
ENST00000398960	DYRK1A	chr21	38792686	+	ENST00000609713	KCNJ6	chr21	39087434	-	19115	85	75	1331	418
ENST00000398960	DYRK1A	chr21	38792686	+	ENST00000288309	KCNJ6	chr21	39087434	-	1332	85	75	1331	418
ENST00000398956	DYRK1A	chr21	38792686	+	ENST00000609713	KCNJ6	chr21	39087434	-	19040	10	0	1256	418
ENST00000398956	DYRK1A	chr21	38792686	+	ENST00000288309	KCNJ6	chr21	39087434	-	1257	10	0	1256	418

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338785	ENST00000609713	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000223972	0.99977607
ENST00000338785	ENST00000288309	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.001761385	0.99823856
ENST00000451934	ENST00000609713	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000203769	0.9997962
ENST00000451934	ENST00000288309	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000237494	0.9997625
ENST00000321219	ENST00000609713	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000203769	0.9997962
ENST00000321219	ENST00000288309	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000237494	0.9997625
ENST00000339659	ENST00000609713	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000203769	0.9997962
ENST00000339659	ENST00000288309	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000237494	0.9997625
ENST00000398960	ENST00000609713	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000220298	0.99977976
ENST00000398960	ENST00000288309	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.00140191	0.99859804
ENST00000398956	ENST00000609713	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.000219428	0.9997806
ENST00000398956	ENST00000288309	DYRK1A	chr21	38792686	+	KCNJ6	chr21	39087434	-	0.001443066	0.9985569

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24698_24698_1_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000321219_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_2_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000321219_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_3_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000338785_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=419AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_4_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000338785_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_5_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000339659_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_6_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000339659_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_7_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398956_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_8_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398956_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_9_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398960_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_10_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000398960_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_11_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000451934_KCNJ6_chr21_39087434_ENST00000288309_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

>24698_24698_12_DYRK1A-KCNJ6_DYRK1A_chr21_38792686_ENST00000451934_KCNJ6_chr21_39087434_ENST00000609713_length(amino acids)=418AA_BP=3
MHTANVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLI
FVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFM
VGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVS
PLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:38792686/chr21:39087434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DYRK1A Q13627	KCNJ6 P48051
FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250\|UniProtKB:Q61214, ECO:0000250\|UniProtKB:Q9NR20, ECO:0000269\|PubMed:20981014, ECO:0000269\|PubMed:21127067, ECO:0000269\|PubMed:23665168, ECO:0000269\|PubMed:8769099}.	FUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

139_150

8.333333333333334

424.0

Intramembrane

Helical%3B Pore-forming%3B Name%3DH5

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

151_157

8.333333333333334

424.0

Intramembrane

Pore-forming

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

152_157

8.333333333333334

424.0

Motif

Selectivity filter

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

420_423

8.333333333333334

424.0

Motif

Note=PDZ-binding

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

115_138

8.333333333333334

424.0

Topological domain

Extracellular

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

158_166

8.333333333333334

424.0

Topological domain

Extracellular

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

189_423

8.333333333333334

424.0

Topological domain

Cytoplasmic

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

167_188

8.333333333333334

424.0

Transmembrane

Helical%3B Name%3DM2

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

90_114

8.333333333333334

424.0

Transmembrane

Helical%3B Name%3DM1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

509_515

3.3333333333333335

1723.3333333333333

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

599_602

3.3333333333333335

1723.3333333333333

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

607_619

3.3333333333333335

1723.3333333333333

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

656_672

3.3333333333333335

1723.3333333333333

Compositional bias

Note=Ser/Thr-rich

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

664_671

3.3333333333333335

1723.3333333333333

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

509_515

3.3333333333333335

755.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

599_602

3.3333333333333335

755.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

607_619

3.3333333333333335

755.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

656_672

3.3333333333333335

755.0

Compositional bias

Note=Ser/Thr-rich

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

664_671

3.3333333333333335

755.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

509_515

3.3333333333333335

530.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

599_602

3.3333333333333335

530.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

607_619

3.3333333333333335

530.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

656_672

3.3333333333333335

530.0

Compositional bias

Note=Ser/Thr-rich

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

664_671

3.3333333333333335

530.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

509_515

3.3333333333333335

764.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

599_602

3.3333333333333335

764.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

607_619

3.3333333333333335

764.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

656_672

3.3333333333333335

764.0

Compositional bias

Note=Ser/Thr-rich

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

664_671

3.3333333333333335

764.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

509_515

3.3333333333333335

585.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

599_602

3.3333333333333335

585.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

607_619

3.3333333333333335

585.0

Compositional bias

Note=Poly-His

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

656_672

3.3333333333333335

585.0

Compositional bias

Note=Ser/Thr-rich

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

664_671

3.3333333333333335

585.0

Compositional bias

Note=Poly-Ser

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

159_479

3.3333333333333335

1723.3333333333333

Domain

Protein kinase

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

159_479

3.3333333333333335

755.0

Domain

Protein kinase

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

159_479

3.3333333333333335

530.0

Domain

Protein kinase

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

159_479

3.3333333333333335

764.0

Domain

Protein kinase

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

159_479

3.3333333333333335

585.0

Domain

Protein kinase

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

117_134

3.3333333333333335

1723.3333333333333

Motif

Bipartite nuclear localization signal

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

117_134

3.3333333333333335

755.0

Motif

Bipartite nuclear localization signal

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

117_134

3.3333333333333335

530.0

Motif

Bipartite nuclear localization signal

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

117_134

3.3333333333333335

764.0

Motif

Bipartite nuclear localization signal

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

117_134

3.3333333333333335

585.0

Motif

Bipartite nuclear localization signal

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

165_173

3.3333333333333335

1723.3333333333333

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000338785

238_241

3.3333333333333335

1723.3333333333333

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

165_173

3.3333333333333335

755.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000339659

238_241

3.3333333333333335

755.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

165_173

3.3333333333333335

530.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398956

238_241

3.3333333333333335

530.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

165_173

3.3333333333333335

764.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000398960

238_241

3.3333333333333335

764.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

165_173

3.3333333333333335

585.0

Nucleotide binding

ATP

Hgene

DYRK1A

chr21:38792686

chr21:39087434

ENST00000451934

238_241

3.3333333333333335

585.0

Nucleotide binding

ATP

Tgene

KCNJ6

chr21:38792686

chr21:39087434

ENST00000288309

1_89

8.333333333333334

424.0

Topological domain

Cytoplasmic

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DYRK1A_pLDDT.png

KCNJ6_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DYRK1A
KCNJ6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DYRK1A-KCNJ6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DYRK1A-KCNJ6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source