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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ECHDC1-FYN

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ECHDC1-FYN
FusionPDB ID: 24876
FusionGDB2.0 ID: 24876
HgeneTgene
Gene symbol

ECHDC1

FYN

Gene ID

55862

2534

Gene nameethylmalonyl-CoA decarboxylase 1FYN proto-oncogene, Src family tyrosine kinase
SynonymsHEL-S-76|MMCD|dJ351K20.2SLK|SYN|p59-FYN
Cytomap

6q22.33

6q21

Type of geneprotein-codingprotein-coding
Descriptionethylmalonyl-CoA decarboxylaseenoyl CoA hydratase domain containing 1enoyl Coenzyme A hydratase domain containing 1enoyl-CoA hydratase domain-containing protein 1epididymis secretory protein Li 76methylmalonyl-CoA decarboxylasetyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)
Modification date2020031320200327
UniProtAcc

Q9NTX5

C1orf168

Ensembl transtripts involved in fusion geneENST idsENST00000368289, ENST00000368291, 
ENST00000528402, ENST00000309620, 
ENST00000430841, ENST00000454591, 
ENST00000454859, ENST00000474289, 
ENST00000531967, ENST00000488087, 
ENST00000229471, ENST00000354650, 
ENST00000368667, ENST00000368678, 
ENST00000368682, ENST00000476769, 
ENST00000229470, ENST00000356013, 
ENST00000538466, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 6=29419 X 14 X 12=3192
# samples 827
** MAII scorelog2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3192*10)=-3.56342933917152
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ECHDC1 [Title/Abstract] AND FYN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ECHDC1(127635961)-FYN(112029223), # samples:3
Anticipated loss of major functional domain due to fusion event.ECHDC1-FYN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECHDC1-FYN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECHDC1-FYN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ECHDC1-FYN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ECHDC1-FYN seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ECHDC1-FYN seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293


check buttonFusion gene breakpoints across ECHDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FYN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-97-8174-01AECHDC1chr6

127635961

-FYNchr6

112029223

-
ChimerDB4LUADTCGA-97-8174ECHDC1chr6

127635960

-FYNchr6

112029223

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000454591ECHDC1chr6127635961-ENST00000368682FYNchr6112029223-31725042321764510
ENST00000454591ECHDC1chr6127635961-ENST00000354650FYNchr6112029223-31815042321773513
ENST00000454591ECHDC1chr6127635961-ENST00000229471FYNchr6112029223-20665042321608458
ENST00000454591ECHDC1chr6127635961-ENST00000368667FYNchr6112029223-22315042321773513
ENST00000454591ECHDC1chr6127635961-ENST00000368678FYNchr6112029223-22185042321764510
ENST00000430841ECHDC1chr6127635961-ENST00000368682FYNchr6112029223-3268600551860601
ENST00000430841ECHDC1chr6127635961-ENST00000354650FYNchr6112029223-3277600551869604
ENST00000430841ECHDC1chr6127635961-ENST00000229471FYNchr6112029223-2162600551704549
ENST00000430841ECHDC1chr6127635961-ENST00000368667FYNchr6112029223-2327600551869604
ENST00000430841ECHDC1chr6127635961-ENST00000368678FYNchr6112029223-2314600551860601
ENST00000531967ECHDC1chr6127635961-ENST00000368682FYNchr6112029223-368710195042279591
ENST00000531967ECHDC1chr6127635961-ENST00000354650FYNchr6112029223-369610195042288594
ENST00000531967ECHDC1chr6127635961-ENST00000229471FYNchr6112029223-258110195042123539
ENST00000531967ECHDC1chr6127635961-ENST00000368667FYNchr6112029223-274610195042288594
ENST00000531967ECHDC1chr6127635961-ENST00000368678FYNchr6112029223-273310195042279591
ENST00000454591ECHDC1chr6127635960-ENST00000368682FYNchr6112029223-31725042321764510
ENST00000454591ECHDC1chr6127635960-ENST00000354650FYNchr6112029223-31815042321773513
ENST00000454591ECHDC1chr6127635960-ENST00000229471FYNchr6112029223-20665042321608458
ENST00000454591ECHDC1chr6127635960-ENST00000368667FYNchr6112029223-22315042321773513
ENST00000454591ECHDC1chr6127635960-ENST00000368678FYNchr6112029223-22185042321764510
ENST00000430841ECHDC1chr6127635960-ENST00000368682FYNchr6112029223-3268600551860601
ENST00000430841ECHDC1chr6127635960-ENST00000354650FYNchr6112029223-3277600551869604
ENST00000430841ECHDC1chr6127635960-ENST00000229471FYNchr6112029223-2162600551704549
ENST00000430841ECHDC1chr6127635960-ENST00000368667FYNchr6112029223-2327600551869604
ENST00000430841ECHDC1chr6127635960-ENST00000368678FYNchr6112029223-2314600551860601
ENST00000531967ECHDC1chr6127635960-ENST00000368682FYNchr6112029223-368710195042279591
ENST00000531967ECHDC1chr6127635960-ENST00000354650FYNchr6112029223-369610195042288594
ENST00000531967ECHDC1chr6127635960-ENST00000229471FYNchr6112029223-258110195042123539
ENST00000531967ECHDC1chr6127635960-ENST00000368667FYNchr6112029223-274610195042288594
ENST00000531967ECHDC1chr6127635960-ENST00000368678FYNchr6112029223-273310195042279591

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000454591ENST00000368682ECHDC1chr6127635961-FYNchr6112029223-0.0003551170.9996449
ENST00000454591ENST00000354650ECHDC1chr6127635961-FYNchr6112029223-0.000475530.9995245
ENST00000454591ENST00000229471ECHDC1chr6127635961-FYNchr6112029223-0.0010443060.9989557
ENST00000454591ENST00000368667ECHDC1chr6127635961-FYNchr6112029223-0.0011498640.9988501
ENST00000454591ENST00000368678ECHDC1chr6127635961-FYNchr6112029223-0.0007432530.9992568
ENST00000430841ENST00000368682ECHDC1chr6127635961-FYNchr6112029223-0.0008882790.9991117
ENST00000430841ENST00000354650ECHDC1chr6127635961-FYNchr6112029223-0.001017380.9989826
ENST00000430841ENST00000229471ECHDC1chr6127635961-FYNchr6112029223-0.0016828890.9983171
ENST00000430841ENST00000368667ECHDC1chr6127635961-FYNchr6112029223-0.0020889260.99791104
ENST00000430841ENST00000368678ECHDC1chr6127635961-FYNchr6112029223-0.0016670050.99833304
ENST00000531967ENST00000368682ECHDC1chr6127635961-FYNchr6112029223-0.0004445840.9995554
ENST00000531967ENST00000354650ECHDC1chr6127635961-FYNchr6112029223-0.0006214140.99937856
ENST00000531967ENST00000229471ECHDC1chr6127635961-FYNchr6112029223-0.0010112330.9989888
ENST00000531967ENST00000368667ECHDC1chr6127635961-FYNchr6112029223-0.0013709250.9986291
ENST00000531967ENST00000368678ECHDC1chr6127635961-FYNchr6112029223-0.0008687820.99913126
ENST00000454591ENST00000368682ECHDC1chr6127635960-FYNchr6112029223-0.0003551170.9996449
ENST00000454591ENST00000354650ECHDC1chr6127635960-FYNchr6112029223-0.000475530.9995245
ENST00000454591ENST00000229471ECHDC1chr6127635960-FYNchr6112029223-0.0010443060.9989557
ENST00000454591ENST00000368667ECHDC1chr6127635960-FYNchr6112029223-0.0011498640.9988501
ENST00000454591ENST00000368678ECHDC1chr6127635960-FYNchr6112029223-0.0007432530.9992568
ENST00000430841ENST00000368682ECHDC1chr6127635960-FYNchr6112029223-0.0008882790.9991117
ENST00000430841ENST00000354650ECHDC1chr6127635960-FYNchr6112029223-0.001017380.9989826
ENST00000430841ENST00000229471ECHDC1chr6127635960-FYNchr6112029223-0.0016828890.9983171
ENST00000430841ENST00000368667ECHDC1chr6127635960-FYNchr6112029223-0.0020889260.99791104
ENST00000430841ENST00000368678ECHDC1chr6127635960-FYNchr6112029223-0.0016670050.99833304
ENST00000531967ENST00000368682ECHDC1chr6127635960-FYNchr6112029223-0.0004445840.9995554
ENST00000531967ENST00000354650ECHDC1chr6127635960-FYNchr6112029223-0.0006214140.99937856
ENST00000531967ENST00000229471ECHDC1chr6127635960-FYNchr6112029223-0.0010112330.9989888
ENST00000531967ENST00000368667ECHDC1chr6127635960-FYNchr6112029223-0.0013709250.9986291
ENST00000531967ENST00000368678ECHDC1chr6127635960-FYNchr6112029223-0.0008687820.99913126

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24876_24876_1_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000430841_FYN_chr6_112029223_ENST00000229471_length(amino acids)=549AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKG
SLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATE

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>24876_24876_2_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000430841_FYN_chr6_112029223_ENST00000354650_length(amino acids)=604AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGN
TKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER
MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR

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>24876_24876_3_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000430841_FYN_chr6_112029223_ENST00000368667_length(amino acids)=604AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGN
TKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER
MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR

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>24876_24876_4_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000430841_FYN_chr6_112029223_ENST00000368678_length(amino acids)=601AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKV
AIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY
IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL

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>24876_24876_5_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000430841_FYN_chr6_112029223_ENST00000368682_length(amino acids)=601AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKV
AIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY
IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL

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>24876_24876_6_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000454591_FYN_chr6_112029223_ENST00000229471_length(amino acids)=458AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGS
LLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL
YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEP

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>24876_24876_7_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000454591_FYN_chr6_112029223_ENST00000354650_length(amino acids)=513AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT
KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM
NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE

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>24876_24876_8_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000454591_FYN_chr6_112029223_ENST00000368667_length(amino acids)=513AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT
KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM
NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE

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>24876_24876_9_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000454591_FYN_chr6_112029223_ENST00000368678_length(amino acids)=510AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVA
IKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI
HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE

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>24876_24876_10_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000454591_FYN_chr6_112029223_ENST00000368682_length(amino acids)=510AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVA
IKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI
HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE

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>24876_24876_11_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000531967_FYN_chr6_112029223_ENST00000229471_length(amino acids)=539AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE
GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

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>24876_24876_12_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000531967_FYN_chr6_112029223_ENST00000354650_length(amino acids)=594AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKP
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRS
ANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY

--------------------------------------------------------------

>24876_24876_13_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000531967_FYN_chr6_112029223_ENST00000368667_length(amino acids)=594AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKP
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRS
ANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY

--------------------------------------------------------------

>24876_24876_14_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000531967_FYN_chr6_112029223_ENST00000368678_length(amino acids)=591AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTM
SPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANI
LVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP

--------------------------------------------------------------

>24876_24876_15_ECHDC1-FYN_ECHDC1_chr6_127635960_ENST00000531967_FYN_chr6_112029223_ENST00000368682_length(amino acids)=591AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTM
SPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANI
LVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP

--------------------------------------------------------------

>24876_24876_16_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000430841_FYN_chr6_112029223_ENST00000229471_length(amino acids)=549AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKG
SLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA
LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATE

--------------------------------------------------------------

>24876_24876_17_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000430841_FYN_chr6_112029223_ENST00000354650_length(amino acids)=604AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGN
TKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER
MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR

--------------------------------------------------------------

>24876_24876_18_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000430841_FYN_chr6_112029223_ENST00000368667_length(amino acids)=604AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGN
TKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER
MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR

--------------------------------------------------------------

>24876_24876_19_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000430841_FYN_chr6_112029223_ENST00000368678_length(amino acids)=601AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKV
AIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY
IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL

--------------------------------------------------------------

>24876_24876_20_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000430841_FYN_chr6_112029223_ENST00000368682_length(amino acids)=601AA_BP=181
MRRTLSSFLPESFAEEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSG
VMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACD
FREGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHY
KIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKV
AIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY
IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVL

--------------------------------------------------------------

>24876_24876_21_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000454591_FYN_chr6_112029223_ENST00000229471_length(amino acids)=458AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGS
LLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL
YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEP

--------------------------------------------------------------

>24876_24876_22_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000454591_FYN_chr6_112029223_ENST00000354650_length(amino acids)=513AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT
KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM
NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE

--------------------------------------------------------------

>24876_24876_23_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000454591_FYN_chr6_112029223_ENST00000368667_length(amino acids)=513AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT
KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM
NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE

--------------------------------------------------------------

>24876_24876_24_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000454591_FYN_chr6_112029223_ENST00000368678_length(amino acids)=510AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVA
IKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI
HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE

--------------------------------------------------------------

>24876_24876_25_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000454591_FYN_chr6_112029223_ENST00000368682_length(amino acids)=510AA_BP=90
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDF
REGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYK
IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVA
IKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI
HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLE

--------------------------------------------------------------

>24876_24876_26_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000531967_FYN_chr6_112029223_ENST00000229471_length(amino acids)=539AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE
GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD

--------------------------------------------------------------

>24876_24876_27_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000531967_FYN_chr6_112029223_ENST00000354650_length(amino acids)=594AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKP
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRS
ANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY

--------------------------------------------------------------

>24876_24876_28_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000531967_FYN_chr6_112029223_ENST00000368667_length(amino acids)=594AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKP
GTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRS
ANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGY

--------------------------------------------------------------

>24876_24876_29_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000531967_FYN_chr6_112029223_ENST00000368678_length(amino acids)=591AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTM
SPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANI
LVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP

--------------------------------------------------------------

>24876_24876_30_ECHDC1-FYN_ECHDC1_chr6_127635961_ENST00000531967_FYN_chr6_112029223_ENST00000368682_length(amino acids)=591AA_BP=171
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKV
IELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFREGDWWEAR
SLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGY
YITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTM
SPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANI
LVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:127635961/chr6:112029223)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECHDC1

Q9NTX5

FYN

C1orf168

FUNCTION: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading (PubMed:22016388). Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity). {ECO:0000250|UniProtKB:Q9D9V3, ECO:0000269|PubMed:22016388}.728

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFYNchr6:127635960chr6:112029223ENST00000229471211149_246114.66666666666667483.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000229471211271_524114.66666666666667483.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000354650414149_246114.66666666666667538.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000354650414271_524114.66666666666667538.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000356013413149_246114.66666666666667483.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000356013413271_524114.66666666666667483.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000368667313149_246114.66666666666667538.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000368667313271_524114.66666666666667538.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000368678313149_246114.66666666666667535.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000368678313271_524114.66666666666667535.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000368682414149_246114.66666666666667535.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000368682414271_524114.66666666666667535.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000538466111149_246114.66666666666667535.0DomainSH2
TgeneFYNchr6:127635960chr6:112029223ENST00000538466111271_524114.66666666666667535.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000229471211149_246114.66666666666667483.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000229471211271_524114.66666666666667483.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000354650414149_246114.66666666666667538.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000354650414271_524114.66666666666667538.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000356013413149_246114.66666666666667483.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000356013413271_524114.66666666666667483.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000368667313149_246114.66666666666667538.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000368667313271_524114.66666666666667538.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000368678313149_246114.66666666666667535.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000368678313271_524114.66666666666667535.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000368682414149_246114.66666666666667535.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000368682414271_524114.66666666666667535.0DomainProtein kinase
TgeneFYNchr6:127635961chr6:112029223ENST00000538466111149_246114.66666666666667535.0DomainSH2
TgeneFYNchr6:127635961chr6:112029223ENST00000538466111271_524114.66666666666667535.0DomainProtein kinase
TgeneFYNchr6:127635960chr6:112029223ENST00000229471211277_285114.66666666666667483.0Nucleotide bindingATP
TgeneFYNchr6:127635960chr6:112029223ENST00000354650414277_285114.66666666666667538.0Nucleotide bindingATP
TgeneFYNchr6:127635960chr6:112029223ENST00000356013413277_285114.66666666666667483.0Nucleotide bindingATP
TgeneFYNchr6:127635960chr6:112029223ENST00000368667313277_285114.66666666666667538.0Nucleotide bindingATP
TgeneFYNchr6:127635960chr6:112029223ENST00000368678313277_285114.66666666666667535.0Nucleotide bindingATP
TgeneFYNchr6:127635960chr6:112029223ENST00000368682414277_285114.66666666666667535.0Nucleotide bindingATP
TgeneFYNchr6:127635960chr6:112029223ENST00000538466111277_285114.66666666666667535.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000229471211277_285114.66666666666667483.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000354650414277_285114.66666666666667538.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000356013413277_285114.66666666666667483.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000368667313277_285114.66666666666667538.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000368678313277_285114.66666666666667535.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000368682414277_285114.66666666666667535.0Nucleotide bindingATP
TgeneFYNchr6:127635961chr6:112029223ENST00000538466111277_285114.66666666666667535.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFYNchr6:127635960chr6:112029223ENST0000022947121182_143114.66666666666667483.0DomainSH3
TgeneFYNchr6:127635960chr6:112029223ENST0000035465041482_143114.66666666666667538.0DomainSH3
TgeneFYNchr6:127635960chr6:112029223ENST0000035601341382_143114.66666666666667483.0DomainSH3
TgeneFYNchr6:127635960chr6:112029223ENST0000036866731382_143114.66666666666667538.0DomainSH3
TgeneFYNchr6:127635960chr6:112029223ENST0000036867831382_143114.66666666666667535.0DomainSH3
TgeneFYNchr6:127635960chr6:112029223ENST0000036868241482_143114.66666666666667535.0DomainSH3
TgeneFYNchr6:127635960chr6:112029223ENST0000053846611182_143114.66666666666667535.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000022947121182_143114.66666666666667483.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000035465041482_143114.66666666666667538.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000035601341382_143114.66666666666667483.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000036866731382_143114.66666666666667538.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000036867831382_143114.66666666666667535.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000036868241482_143114.66666666666667535.0DomainSH3
TgeneFYNchr6:127635961chr6:112029223ENST0000053846611182_143114.66666666666667535.0DomainSH3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ECHDC1
FYN


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ECHDC1-FYN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ECHDC1-FYN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource