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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ADNP-MMP24

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ADNP-MMP24
FusionPDB ID: 2502
FusionGDB2.0 ID: 2502
HgeneTgene
Gene symbol

ADNP

MMP24

Gene ID

23394

10893

Gene nameactivity dependent neuroprotector homeoboxmatrix metallopeptidase 24
SynonymsADNP1|HVDAS|MRD28MMP-24|MMP25|MT-MMP 5|MT-MMP5|MT5-MMP|MT5MMP|MTMMP5
Cytomap

20q13.13

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionactivity-dependent neuroprotector homeobox proteinADNP homeobox 1activity-dependent neuroprotective proteinactivity-dependent neuroprotectormatrix metalloproteinase-24matrix metallopeptidase 24 (membrane-inserted)matrix metalloproteinase 24 (membrane-inserted)membrane-type 5 matrix metalloproteinasemembrane-type matrix metalloproteinase 5
Modification date2020032220200313
UniProtAcc

Q6IQ32

Q9Y5R2

Ensembl transtripts involved in fusion geneENST idsENST00000349014, ENST00000371602, 
ENST00000396029, ENST00000396032, 
ENST00000246186, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 7 X 11=13096 X 7 X 5=210
# samples 226
** MAII scorelog2(22/1309*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ADNP [Title/Abstract] AND MMP24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ADNP(49518554)-MMP24(33862075), # samples:2
Anticipated loss of major functional domain due to fusion event.ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADNP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MMP24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08J-01AADNPchr20

49518554

-MMP24chr20

33859372

+
ChimerDB4BRCATCGA-A8-A08J-01AADNPchr20

49518554

-MMP24chr20

33862075

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396032ADNPchr2049518554-ENST00000246186MMP24chr2033862075+3529802361858165
ENST00000349014ADNPchr2049518554-ENST00000246186MMP24chr2033859372+34924981183434249

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396032ENST00000246186ADNPchr2049518554-MMP24chr2033862075+0.392322870.6076771
ENST00000349014ENST00000246186ADNPchr2049518554-MMP24chr2033859372+0.0047093910.99529064

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2502_2502_1_ADNP-MMP24_ADNP_chr20_49518554_ENST00000349014_MMP24_chr20_33859372_ENST00000246186_length(amino acids)=249AA_BP=1
MARAAPQTLVRKGLAGQTKWIERALGCSHPFLDWPLIVGDRLRACLVLELEDGVDQHQDAEGQDAGDDHGHGVHGARHIVDGHHDVHVVL
GQPPLLPPLHLLLVAAHPVTQDVARVAWLHAQFLVVKLPVVPALVEIGVISFLADEGSLGSLWDALPHGDGLRVARVRGPPLLAVAPVPL

--------------------------------------------------------------

>2502_2502_2_ADNP-MMP24_ADNP_chr20_49518554_ENST00000396032_MMP24_chr20_33862075_ENST00000246186_length(amino acids)=165AA_BP=16
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:49518554/chr20:33862075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADNP

Q6IQ32

MMP24

Q9Y5R2

FUNCTION: May be involved in transcriptional regulation.FUNCTION: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669643_645444.3333333333333646.0MotifNote=PDZ-binding
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679643_645533.3333333333334646.0MotifNote=PDZ-binding
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669473_521444.3333333333333646.0RepeatNote=Hemopexin 3
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669522_569444.3333333333333646.0RepeatNote=Hemopexin 4
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669624_645444.3333333333333646.0Topological domainCytoplasmic
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679624_645533.3333333333334646.0Topological domainCytoplasmic
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669603_623444.3333333333333646.0TransmembraneHelical
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679603_623533.3333333333334646.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34754_81467.01103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34354_36167.01103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-3474_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-2374_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-4574_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-3474_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-3474_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-2374_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-4574_9767.01103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34107_12967.01103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34165_18867.01103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34221_24467.01103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34447_46967.01103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34489_51067.01103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34512_53567.01103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34622_64767.01103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34662_68667.01103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-3474_9767.01103.0Zinc fingerC2H2-type 1
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669149_152444.3333333333333646.0Compositional biasNote=Poly-Arg
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679149_152533.3333333333334646.0Compositional biasNote=Poly-Arg
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669137_144444.3333333333333646.0MotifCysteine switch
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679137_144533.3333333333334646.0MotifCysteine switch
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669377_425444.3333333333333646.0RepeatNote=Hemopexin 1
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669426_471444.3333333333333646.0RepeatNote=Hemopexin 2
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679377_425533.3333333333334646.0RepeatNote=Hemopexin 1
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679426_471533.3333333333334646.0RepeatNote=Hemopexin 2
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679473_521533.3333333333334646.0RepeatNote=Hemopexin 3
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679522_569533.3333333333334646.0RepeatNote=Hemopexin 4
TgeneMMP24chr20:49518554chr20:33859372ENST000002461866953_602444.3333333333333646.0Topological domainExtracellular
TgeneMMP24chr20:49518554chr20:33862075ENST000002461867953_602533.3333333333334646.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ADNP
MMP24


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ADNP-MMP24


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ADNP-MMP24


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource