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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EHBP1-BCL11A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EHBP1-BCL11A
FusionPDB ID: 25525
FusionGDB2.0 ID: 25525
HgeneTgene
Gene symbol

EHBP1

BCL11A

Gene ID

23301

53335

Gene nameEH domain binding protein 1BAF chromatin remodeling complex subunit BCL11A
SynonymsHPC12|NACSINBCL11A-L|BCL11A-S|BCL11A-XL|BCL11a-M|CTIP1|DILOS|EVI9|HBFQTL5|ZNF856
Cytomap

2p15

2p16.1

Type of geneprotein-codingprotein-coding
DescriptionEH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50eB-cell lymphoma/leukemia 11AB cell CLL/lymphoma 11AB-cell CLL/lymphoma 11A (zinc finger protein) isoform 2BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1BCL11A, BAF complex componentC2H2-type zinc finger proteinCOUP-TF-interacting pro
Modification date2020031320200313
UniProtAcc

Q8N3D4

Q9H165

Ensembl transtripts involved in fusion geneENST idsENST00000263991, ENST00000354487, 
ENST00000405015, ENST00000405289, 
ENST00000431489, ENST00000496857, 
ENST00000335712, ENST00000358510, 
ENST00000477659, ENST00000356842, 
ENST00000359629, ENST00000538214, 
ENST00000537768, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 12 X 8=76810 X 9 X 3=270
# samples 209
** MAII scorelog2(20/768*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EHBP1 [Title/Abstract] AND BCL11A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EHBP1(63101667)-BCL11A(60679801), # samples:3
Anticipated loss of major functional domain due to fusion event.EHBP1-BCL11A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EHBP1-BCL11A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EHBP1-BCL11A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EHBP1-BCL11A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EHBP1-BCL11A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EHBP1-BCL11A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
EHBP1-BCL11A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCL11A

GO:0000122

negative regulation of transcription by RNA polymerase II

19153051


check buttonFusion gene breakpoints across EHBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BCL11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A147-01AEHBP1chr2

63101667

-BCL11Achr2

60679801

-
ChimerDB4BRCATCGA-D8-A147-01AEHBP1chr2

63101667

+BCL11Achr2

60679801

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405015EHBP1chr263101667+ENST00000537768BCL11Achr260679801-188017135191814431
ENST00000431489EHBP1chr263101667+ENST00000537768BCL11Achr260679801-195817915971892431
ENST00000354487EHBP1chr263101667+ENST00000537768BCL11Achr260679801-183416674731768431
ENST00000263991EHBP1chr263101667+ENST00000537768BCL11Achr260679801-193917724731873466
ENST00000405289EHBP1chr263101667+ENST00000537768BCL11Achr260679801-1352118501286428

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405015ENST00000537768EHBP1chr263101667+BCL11Achr260679801-0.001428610.9985714
ENST00000431489ENST00000537768EHBP1chr263101667+BCL11Achr260679801-0.0013986180.9986014
ENST00000354487ENST00000537768EHBP1chr263101667+BCL11Achr260679801-0.0013739420.9986261
ENST00000263991ENST00000537768EHBP1chr263101667+BCL11Achr260679801-0.0012681790.9987318
ENST00000405289ENST00000537768EHBP1chr263101667+BCL11Achr260679801-0.0025519050.9974481

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25525_25525_1_EHBP1-BCL11A_EHBP1_chr2_63101667_ENST00000263991_BCL11A_chr2_60679801_ENST00000537768_length(amino acids)=466AA_BP=429
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNS
NPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD
SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVLHTPPFGVVPRELKMC

--------------------------------------------------------------

>25525_25525_2_EHBP1-BCL11A_EHBP1_chr2_63101667_ENST00000354487_BCL11A_chr2_60679801_ENST00000537768_length(amino acids)=431AA_BP=394
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE

--------------------------------------------------------------

>25525_25525_3_EHBP1-BCL11A_EHBP1_chr2_63101667_ENST00000405015_BCL11A_chr2_60679801_ENST00000537768_length(amino acids)=431AA_BP=394
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE

--------------------------------------------------------------

>25525_25525_4_EHBP1-BCL11A_EHBP1_chr2_63101667_ENST00000405289_BCL11A_chr2_60679801_ENST00000537768_length(amino acids)=428AA_BP=391
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHA
EEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQ
ADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYN
NSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETER

--------------------------------------------------------------

>25525_25525_5_EHBP1-BCL11A_EHBP1_chr2_63101667_ENST00000431489_BCL11A_chr2_60679801_ENST00000537768_length(amino acids)=431AA_BP=394
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:63101667/chr2:60679801)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHBP1

Q8N3D4

BCL11A

Q9H165

FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.FUNCTION: Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). {ECO:0000250|UniProtKB:Q9QYE3, ECO:0000303|PubMed:26375765, ECO:0000303|PubMed:27453576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+1125185_210430.01232.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+1024185_210395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+1023185_210395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+923185_210395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+1023185_210395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+1125362_365430.01232.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+1024362_365395.01197.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+1023362_365395.01161.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+923362_365395.01197.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+1023362_365395.01161.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+11258_158430.01232.0DomainC2 NT-type
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+10248_158395.01197.0DomainC2 NT-type
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+10238_158395.01161.0DomainC2 NT-type
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+9238_158395.01197.0DomainC2 NT-type
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+10238_158395.01161.0DomainC2 NT-type
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204260_3730836.0Compositional biasNote=Pro-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204481_5090836.0Compositional biasNote=Glu-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003260_3730802.0Compositional biasNote=Pro-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003481_5090802.0Compositional biasNote=Glu-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935260_373210.0244.0Compositional biasNote=Pro-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935481_509210.0244.0Compositional biasNote=Glu-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST00000335712041_2100836.0RegionRequired for nuclear body formation and for SUMO1 recruitment
TgeneBCL11Achr2:63101667chr2:60679801ENST00000358510031_2100802.0RegionRequired for nuclear body formation and for SUMO1 recruitment
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204170_1930836.0Zinc fingerC2H2-type 1
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204377_3990836.0Zinc fingerC2H2-type 2
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204405_4290836.0Zinc fingerC2H2-type 3
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204742_7640836.0Zinc fingerC2H2-type 4
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204770_7920836.0Zinc fingerC2H2-type 5
TgeneBCL11Achr2:63101667chr2:60679801ENST0000033571204800_8230836.0Zinc fingerC2H2-type 6
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235742_764743.3333333333334774.0Zinc fingerC2H2-type 4
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235770_792743.3333333333334774.0Zinc fingerC2H2-type 5
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235800_823743.3333333333334774.0Zinc fingerC2H2-type 6
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003170_1930802.0Zinc fingerC2H2-type 1
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003377_3990802.0Zinc fingerC2H2-type 2
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003405_4290802.0Zinc fingerC2H2-type 3
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003742_7640802.0Zinc fingerC2H2-type 4
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003770_7920802.0Zinc fingerC2H2-type 5
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035851003800_8230802.0Zinc fingerC2H2-type 6
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935377_399210.0244.0Zinc fingerC2H2-type 2
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935405_429210.0244.0Zinc fingerC2H2-type 3
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935742_764210.0244.0Zinc fingerC2H2-type 4
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935770_792210.0244.0Zinc fingerC2H2-type 5
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935800_823210.0244.0Zinc fingerC2H2-type 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+11251076_1100430.01232.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+11251136_1230430.01232.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+1125808_879430.01232.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+10241076_1100395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+10241136_1230395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+1024808_879395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+10231076_1100395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+10231136_1230395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+1023808_879395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+9231076_1100395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+9231136_1230395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+923808_879395.01197.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+10231076_1100395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+10231136_1230395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+1023808_879395.01161.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+11251110_1113430.01232.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+10241110_1113395.01197.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+10231110_1113395.01161.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+9231110_1113395.01197.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+10231110_1113395.01161.0Compositional biasNote=Poly-Glu
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+11251056_1212430.01232.0DomainbMERB
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+1125443_548430.01232.0DomainCalponin-homology (CH)
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+10241056_1212395.01197.0DomainbMERB
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+1024443_548395.01197.0DomainCalponin-homology (CH)
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+10231056_1212395.01161.0DomainbMERB
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+1023443_548395.01161.0DomainCalponin-homology (CH)
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+9231056_1212395.01197.0DomainbMERB
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+923443_548395.01197.0DomainCalponin-homology (CH)
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+10231056_1212395.01161.0DomainbMERB
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+1023443_548395.01161.0DomainCalponin-homology (CH)
HgeneEHBP1chr2:63101667chr2:60679801ENST00000263991+11251228_1231430.01232.0MotifCAAX motif
HgeneEHBP1chr2:63101667chr2:60679801ENST00000354487+10241228_1231395.01197.0MotifCAAX motif
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405015+10231228_1231395.01161.0MotifCAAX motif
HgeneEHBP1chr2:63101667chr2:60679801ENST00000405289+9231228_1231395.01197.0MotifCAAX motif
HgeneEHBP1chr2:63101667chr2:60679801ENST00000431489+10231228_1231395.01161.0MotifCAAX motif
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235260_373743.3333333333334774.0Compositional biasNote=Pro-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235481_509743.3333333333334774.0Compositional biasNote=Glu-rich
TgeneBCL11Achr2:63101667chr2:60679801ENST00000356842351_210743.3333333333334774.0RegionRequired for nuclear body formation and for SUMO1 recruitment
TgeneBCL11Achr2:63101667chr2:60679801ENST00000359629351_210210.0244.0RegionRequired for nuclear body formation and for SUMO1 recruitment
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235170_193743.3333333333334774.0Zinc fingerC2H2-type 1
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235377_399743.3333333333334774.0Zinc fingerC2H2-type 2
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035684235405_429743.3333333333334774.0Zinc fingerC2H2-type 3
TgeneBCL11Achr2:63101667chr2:60679801ENST0000035962935170_193210.0244.0Zinc fingerC2H2-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EHBP1
BCL11A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EHBP1-BCL11A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EHBP1-BCL11A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource