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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EHBP1-VAV2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EHBP1-VAV2
	FusionPDB ID: 25545
	FusionGDB2.0 ID: 25545
		Hgene	Tgene
	Gene symbol	EHBP1	VAV2
	Gene ID	23301	7410
	Gene name	EH domain binding protein 1	vav guanine nucleotide exchange factor 2
	Synonyms	HPC12\|NACSIN	VAV-2
	Cytomap	2p15	9q34.2
	Type of gene	protein-coding	protein-coding
	Description	EH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50e	guanine nucleotide exchange factor VAV2vav 2 oncogene
	Modification date	20200313	20200313
	UniProtAcc	Q8N3D4	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263991, ENST00000354487, ENST00000405015, ENST00000405289, ENST00000431489, ENST00000496857,	ENST00000486113, ENST00000371850, ENST00000371851, ENST00000406606,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 12 X 8=768	11 X 10 X 5=550
	# samples	20	12
	** MAII score	log2(20/768*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/550*10)=-2.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EHBP1 [Title/Abstract] AND VAV2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EHBP1(63101667)-VAV2(136726554), # samples:3
Anticipated loss of major functional domain due to fusion event.	EHBP1-VAV2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EHBP1-VAV2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EHBP1-VAV2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EHBP1-VAV2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EHBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VAV2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-NC-A5HN-01A	EHBP1	chr2	63101667	-	VAV2	chr9	136726554	-
ChimerDB4	LUSC	TCGA-NC-A5HN-01A	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-
ChimerDB4	LUSC	TCGA-NC-A5HN	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000405015	EHBP1	chr2	63101667	+	ENST00000406606	VAV2	chr9	136726554	-	6080	1713	519	3911	1130
ENST00000405015	EHBP1	chr2	63101667	+	ENST00000371850	VAV2	chr9	136726554	-	6197	1713	519	4028	1169
ENST00000405015	EHBP1	chr2	63101667	+	ENST00000371851	VAV2	chr9	136726554	-	6167	1713	519	3998	1159
ENST00000431489	EHBP1	chr2	63101667	+	ENST00000406606	VAV2	chr9	136726554	-	6158	1791	597	3989	1130
ENST00000431489	EHBP1	chr2	63101667	+	ENST00000371850	VAV2	chr9	136726554	-	6275	1791	597	4106	1169
ENST00000431489	EHBP1	chr2	63101667	+	ENST00000371851	VAV2	chr9	136726554	-	6245	1791	597	4076	1159
ENST00000354487	EHBP1	chr2	63101667	+	ENST00000406606	VAV2	chr9	136726554	-	6034	1667	473	3865	1130
ENST00000354487	EHBP1	chr2	63101667	+	ENST00000371850	VAV2	chr9	136726554	-	6151	1667	473	3982	1169
ENST00000354487	EHBP1	chr2	63101667	+	ENST00000371851	VAV2	chr9	136726554	-	6121	1667	473	3952	1159
ENST00000263991	EHBP1	chr2	63101667	+	ENST00000406606	VAV2	chr9	136726554	-	6139	1772	473	3970	1165
ENST00000263991	EHBP1	chr2	63101667	+	ENST00000371850	VAV2	chr9	136726554	-	6256	1772	473	4087	1204
ENST00000263991	EHBP1	chr2	63101667	+	ENST00000371851	VAV2	chr9	136726554	-	6226	1772	473	4057	1194
ENST00000405289	EHBP1	chr2	63101667	+	ENST00000406606	VAV2	chr9	136726554	-	5552	1185	0	3383	1127
ENST00000405289	EHBP1	chr2	63101667	+	ENST00000371850	VAV2	chr9	136726554	-	5669	1185	0	3500	1166
ENST00000405289	EHBP1	chr2	63101667	+	ENST00000371851	VAV2	chr9	136726554	-	5639	1185	0	3470	1156

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000405015	ENST00000406606	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.001264338	0.9987357
ENST00000405015	ENST00000371850	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000628411	0.9993716
ENST00000405015	ENST00000371851	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000977511	0.9990225
ENST00000431489	ENST00000406606	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.001272652	0.9987274
ENST00000431489	ENST00000371850	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000637636	0.9993624
ENST00000431489	ENST00000371851	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000993355	0.9990067
ENST00000354487	ENST00000406606	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.001201317	0.9987987
ENST00000354487	ENST00000371850	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.00059927	0.99940073
ENST00000354487	ENST00000371851	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.00092958	0.99907047
ENST00000263991	ENST00000406606	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000627208	0.9993728
ENST00000263991	ENST00000371850	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000969511	0.9990305
ENST00000263991	ENST00000371851	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.001297166	0.99870276
ENST00000405289	ENST00000406606	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000745071	0.9992549
ENST00000405289	ENST00000371850	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000379004	0.9996209
ENST00000405289	ENST00000371851	EHBP1	chr2	63101667	+	VAV2	chr9	136726554	-	0.000570172	0.99942976

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25545_25545_1_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000263991_VAV2_chr9_136726554_ENST00000371850_length(amino acids)=1204AA_BP=431
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNS
NPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD
SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNK
GIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYY
RTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASR
EDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIE
NLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHL
QGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKF
TSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSR
EIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKE
SFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVR

--------------------------------------------------------------

>25545_25545_2_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000263991_VAV2_chr9_136726554_ENST00000371851_length(amino acids)=1194AA_BP=431
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNS
NPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD
SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNK
GIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLED
IEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ
KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK
LEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFC
KTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASG
AGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWF
AGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLK
YPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQG

--------------------------------------------------------------

>25545_25545_3_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000263991_VAV2_chr9_136726554_ENST00000406606_length(amino acids)=1165AA_BP=431
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNS
NPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD
SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNK
GIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLED
IEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ
KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK
LEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFC
KTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASG
AGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWF
AGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLK

--------------------------------------------------------------

>25545_25545_4_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000354487_VAV2_chr9_136726554_ENST00000371850_length(amino acids)=1169AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIK
VHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKY
HLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFL
FDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKA
NANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVL
TFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRE
RPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYN

--------------------------------------------------------------

>25545_25545_5_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000354487_VAV2_chr9_136726554_ENST00000371851_length(amino acids)=1159AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF
LRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLK
ELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV
IVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY
TFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLEL
LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI
SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLS

--------------------------------------------------------------

>25545_25545_6_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000354487_VAV2_chr9_136726554_ENST00000406606_length(amino acids)=1130AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF
LRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLK
ELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV
IVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY
TFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLEL
LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI
SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFA

--------------------------------------------------------------

>25545_25545_7_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000405015_VAV2_chr9_136726554_ENST00000371850_length(amino acids)=1169AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIK
VHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKY
HLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFL
FDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKA
NANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVL
TFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRE
RPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYN

--------------------------------------------------------------

>25545_25545_8_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000405015_VAV2_chr9_136726554_ENST00000371851_length(amino acids)=1159AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF
LRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLK
ELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV
IVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY
TFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLEL
LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI
SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLS

--------------------------------------------------------------

>25545_25545_9_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000405015_VAV2_chr9_136726554_ENST00000406606_length(amino acids)=1130AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF
LRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLK
ELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV
IVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY
TFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLEL
LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI
SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFA

--------------------------------------------------------------

>25545_25545_10_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000405289_VAV2_chr9_136726554_ENST00000371850_length(amino acids)=1166AA_BP=393
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHA
EEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQ
ADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYN
NSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETER
RVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCV
PCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHH
SFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLL
LKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDK
VVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANAN
HHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQ
TGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPA
EAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSF

--------------------------------------------------------------

>25545_25545_11_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000405289_VAV2_chr9_136726554_ENST00000371851_length(amino acids)=1156AA_BP=393
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHA
EEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQ
ADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYN
NSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETER
RVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCV
PCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRA
IDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELL
SHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVC
KRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFD
KTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRG
DPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIK
FNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFAS

--------------------------------------------------------------

>25545_25545_12_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000405289_VAV2_chr9_136726554_ENST00000406606_length(amino acids)=1127AA_BP=393
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHA
EEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQ
ADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYN
NSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETER
RVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCV
PCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRA
IDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELL
SHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVC
KRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFD
KTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRG
DPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIK
FNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFAARD

--------------------------------------------------------------

>25545_25545_13_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000431489_VAV2_chr9_136726554_ENST00000371850_length(amino acids)=1169AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIK
VHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKY
HLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFL
FDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKA
NANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVL
TFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRE
RPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYN

--------------------------------------------------------------

>25545_25545_14_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000431489_VAV2_chr9_136726554_ENST00000371851_length(amino acids)=1159AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF
LRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLK
ELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV
IVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY
TFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLEL
LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI
SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLS

--------------------------------------------------------------

>25545_25545_15_EHBP1-VAV2_EHBP1_chr2_63101667_ENST00000431489_VAV2_chr9_136726554_ENST00000406606_length(amino acids)=1130AA_BP=396
MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD
PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS
MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDS
FYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIY
DCVPCEDGGDDIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSF
LRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLK
ELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVV
IVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY
TFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLEL
LRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI
SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:63101667/chr9:136726554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EHBP1 Q8N3D4	.
FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305\|PubMed:27552051}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

185_210

430.0

1232.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

185_210

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

185_210

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

185_210

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

185_210

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

362_365

430.0

1232.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

362_365

395.0

1197.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

362_365

395.0

1161.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

362_365

395.0

1197.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

362_365

395.0

1161.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

8_158

430.0

1232.0

Domain

C2 NT-type

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

8_158

395.0

1197.0

Domain

C2 NT-type

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

8_158

395.0

1161.0

Domain

C2 NT-type

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

8_158

395.0

1197.0

Domain

C2 NT-type

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

8_158

395.0

1161.0

Domain

C2 NT-type

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

198_376

107.0

879.0

Domain

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

405_512

107.0

879.0

Domain

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

586_652

107.0

879.0

Domain

SH3 1

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

673_767

107.0

879.0

Domain

SH2

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

816_877

107.0

879.0

Domain

SH3 2

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

198_376

107.0

869.0

Domain

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

405_512

107.0

869.0

Domain

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

586_652

107.0

869.0

Domain

SH3 1

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

673_767

107.0

869.0

Domain

SH2

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

816_877

107.0

869.0

Domain

SH3 2

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

198_376

107.0

840.0

Domain

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

405_512

107.0

840.0

Domain

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

586_652

107.0

840.0

Domain

SH3 1

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

673_767

107.0

840.0

Domain

SH2

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

816_877

107.0

840.0

Domain

SH3 2

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

523_572

107.0

879.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

523_572

107.0

869.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

523_572

107.0

840.0

Zinc finger

Phorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

1076_1100

430.0

1232.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

1136_1230

430.0

1232.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

808_879

430.0

1232.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

1076_1100

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

1136_1230

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

808_879

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

1076_1100

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

1136_1230

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

808_879

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

1076_1100

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

1136_1230

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

808_879

395.0

1197.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

1076_1100

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

1136_1230

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

808_879

395.0

1161.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

1110_1113

430.0

1232.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

1110_1113

395.0

1197.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

1110_1113

395.0

1161.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

1110_1113

395.0

1197.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

1110_1113

395.0

1161.0

Compositional bias

Note=Poly-Glu

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

1056_1212

430.0

1232.0

Domain

bMERB

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

443_548

430.0

1232.0

Domain

Calponin-homology (CH)

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

1056_1212

395.0

1197.0

Domain

bMERB

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

443_548

395.0

1197.0

Domain

Calponin-homology (CH)

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

1056_1212

395.0

1161.0

Domain

bMERB

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

443_548

395.0

1161.0

Domain

Calponin-homology (CH)

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

1056_1212

395.0

1197.0

Domain

bMERB

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

443_548

395.0

1197.0

Domain

Calponin-homology (CH)

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

1056_1212

395.0

1161.0

Domain

bMERB

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

443_548

395.0

1161.0

Domain

Calponin-homology (CH)

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000263991

1228_1231

430.0

1232.0

Motif

CAAX motif

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000354487

1228_1231

395.0

1197.0

Motif

CAAX motif

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405015

1228_1231

395.0

1161.0

Motif

CAAX motif

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000405289

1228_1231

395.0

1197.0

Motif

CAAX motif

Hgene

EHBP1

chr2:63101667

chr9:136726554

ENST00000431489

1228_1231

395.0

1161.0

Motif

CAAX motif

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371850

1_120

107.0

879.0

Domain

Calponin-homology (CH)

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000371851

1_120

107.0

869.0

Domain

Calponin-homology (CH)

Tgene

VAV2

chr2:63101667

chr9:136726554

ENST00000406606

1_120

107.0

840.0

Domain

Calponin-homology (CH)

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1933_EHBP1_63101667_VAV2_136726554_ranked_0.pdb	EHBP1	63101667	63101667	ENST00000371851	VAV2	chr9	136726554	-	MIIMASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKD PHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMS MKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNS NPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYAD SSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKVISAVSRLSLHSIAQNK GIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYY RTLEDIEKNYMSPLRLVLSPADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASR EDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIE NLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHL QGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKF TSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSR EIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKE SFKQLDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVR	1204

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EHBP1_pLDDT.png

VAV2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EHBP1
VAV2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to EHBP1-VAV2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EHBP1-VAV2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source