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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCC3-KAT7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC3-KAT7
FusionPDB ID: 259
FusionGDB2.0 ID: 259
HgeneTgene
Gene symbol

ABCC3

KAT7

Gene ID

8714

11143

Gene nameATP binding cassette subfamily C member 3lysine acetyltransferase 7
SynonymsABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2HBO1|HBOA|MYST2|ZC2HC7
Cytomap

17q21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrughistone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1
Modification date2020031320200327
UniProtAcc

O15438

O95251

Ensembl transtripts involved in fusion geneENST idsENST00000285238, ENST00000427699, 
ENST00000515707, ENST00000510891, 
ENST00000513980, ENST00000259021, 
ENST00000424009, ENST00000435742, 
ENST00000454930, ENST00000503935, 
ENST00000509773, ENST00000510819, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 12 X 7=13445 X 4 X 3=60
# samples 185
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCC3 [Title/Abstract] AND KAT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC3(48712342)-KAT7(47893165), # samples:2
Anticipated loss of major functional domain due to fusion event.ABCC3-KAT7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-KAT7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-KAT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-KAT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC3

GO:0042908

xenobiotic transport

18698235|19334674

TgeneKAT7

GO:0006260

DNA replication

16387653

TgeneKAT7

GO:0018393

internal peptidyl-lysine acetylation

26221039

TgeneKAT7

GO:0031098

stress-activated protein kinase signaling cascade

21856198

TgeneKAT7

GO:0043966

histone H3 acetylation

16387653

TgeneKAT7

GO:0043981

histone H4-K5 acetylation

16387653

TgeneKAT7

GO:0043982

histone H4-K8 acetylation

16387653

TgeneKAT7

GO:0043983

histone H4-K12 acetylation

16387653

TgeneKAT7

GO:0043984

histone H4-K16 acetylation

16387653

TgeneKAT7

GO:1900182

positive regulation of protein localization to nucleus

24739512


check buttonFusion gene breakpoints across ABCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KAT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1738-01AABCC3chr17

48712342

+KAT7chr17

47893165

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285238ABCC3chr1748712342+ENST00000259021KAT7chr1747893165+2703125591108349
ENST00000285238ABCC3chr1748712342+ENST00000454930KAT7chr1747893165+1310125591108349
ENST00000285238ABCC3chr1748712342+ENST00000509773KAT7chr1747893165+1224125591108349
ENST00000285238ABCC3chr1748712342+ENST00000510819KAT7chr1747893165+1407125591108349
ENST00000285238ABCC3chr1748712342+ENST00000424009KAT7chr1747893165+2703125591108349
ENST00000285238ABCC3chr1748712342+ENST00000503935KAT7chr1747893165+2701125591108349
ENST00000285238ABCC3chr1748712342+ENST00000435742KAT7chr1747893165+2703125591108349
ENST00000515707ABCC3chr1748712342+ENST00000259021KAT7chr1747893165+267294491077342
ENST00000515707ABCC3chr1748712342+ENST00000454930KAT7chr1747893165+127994491077342
ENST00000515707ABCC3chr1748712342+ENST00000509773KAT7chr1747893165+119394491077342
ENST00000515707ABCC3chr1748712342+ENST00000510819KAT7chr1747893165+137694491077342
ENST00000515707ABCC3chr1748712342+ENST00000424009KAT7chr1747893165+267294491077342
ENST00000515707ABCC3chr1748712342+ENST00000503935KAT7chr1747893165+267094491077342
ENST00000515707ABCC3chr1748712342+ENST00000435742KAT7chr1747893165+267294491077342
ENST00000427699ABCC3chr1748712342+ENST00000259021KAT7chr1747893165+2703125591108349
ENST00000427699ABCC3chr1748712342+ENST00000454930KAT7chr1747893165+1310125591108349
ENST00000427699ABCC3chr1748712342+ENST00000509773KAT7chr1747893165+1224125591108349
ENST00000427699ABCC3chr1748712342+ENST00000510819KAT7chr1747893165+1407125591108349
ENST00000427699ABCC3chr1748712342+ENST00000424009KAT7chr1747893165+2703125591108349
ENST00000427699ABCC3chr1748712342+ENST00000503935KAT7chr1747893165+2701125591108349
ENST00000427699ABCC3chr1748712342+ENST00000435742KAT7chr1747893165+2703125591108349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285238ENST00000259021ABCC3chr1748712342+KAT7chr1747893165+0.0005765430.9994235
ENST00000285238ENST00000454930ABCC3chr1748712342+KAT7chr1747893165+0.0020163720.9979836
ENST00000285238ENST00000509773ABCC3chr1748712342+KAT7chr1747893165+0.0020284750.9979715
ENST00000285238ENST00000510819ABCC3chr1748712342+KAT7chr1747893165+0.0016019070.9983981
ENST00000285238ENST00000424009ABCC3chr1748712342+KAT7chr1747893165+0.0005765430.9994235
ENST00000285238ENST00000503935ABCC3chr1748712342+KAT7chr1747893165+0.000571550.99942845
ENST00000285238ENST00000435742ABCC3chr1748712342+KAT7chr1747893165+0.0005765430.9994235
ENST00000515707ENST00000259021ABCC3chr1748712342+KAT7chr1747893165+0.000457590.9995425
ENST00000515707ENST00000454930ABCC3chr1748712342+KAT7chr1747893165+0.00176420.9982358
ENST00000515707ENST00000509773ABCC3chr1748712342+KAT7chr1747893165+0.0017356830.9982644
ENST00000515707ENST00000510819ABCC3chr1748712342+KAT7chr1747893165+0.0014781060.99852186
ENST00000515707ENST00000424009ABCC3chr1748712342+KAT7chr1747893165+0.000457590.9995425
ENST00000515707ENST00000503935ABCC3chr1748712342+KAT7chr1747893165+0.000454950.99954504
ENST00000515707ENST00000435742ABCC3chr1748712342+KAT7chr1747893165+0.000457590.9995425
ENST00000427699ENST00000259021ABCC3chr1748712342+KAT7chr1747893165+0.0005765430.9994235
ENST00000427699ENST00000454930ABCC3chr1748712342+KAT7chr1747893165+0.0020163720.9979836
ENST00000427699ENST00000509773ABCC3chr1748712342+KAT7chr1747893165+0.0020284750.9979715
ENST00000427699ENST00000510819ABCC3chr1748712342+KAT7chr1747893165+0.0016019070.9983981
ENST00000427699ENST00000424009ABCC3chr1748712342+KAT7chr1747893165+0.0005765430.9994235
ENST00000427699ENST00000503935ABCC3chr1748712342+KAT7chr1747893165+0.000571550.99942845
ENST00000427699ENST00000435742ABCC3chr1748712342+KAT7chr1747893165+0.0005765430.9994235

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>259_259_1_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000259021_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_2_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000424009_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_3_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000435742_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_4_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000454930_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_5_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000503935_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_6_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000509773_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_7_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000285238_KAT7_chr17_47893165_ENST00000510819_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_8_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000259021_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_9_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000424009_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_10_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000435742_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_11_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000454930_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_12_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000503935_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_13_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000509773_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_14_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000427699_KAT7_chr17_47893165_ENST00000510819_length(amino acids)=349AA_BP=22
MQPRLGPMDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYH
SPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFL
FYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH

--------------------------------------------------------------

>259_259_15_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000259021_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

>259_259_16_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000424009_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

>259_259_17_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000435742_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

>259_259_18_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000454930_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

>259_259_19_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000503935_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

>259_259_20_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000509773_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

>259_259_21_ABCC3-KAT7_ABCC3_chr17_48712342_ENST00000515707_KAT7_chr17_47893165_ENST00000510819_length(amino acids)=342AA_BP=15
MDALCGSGELGSKFWEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEY
ARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEA
DNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48712342/chr17:47893165)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC3

O15438

KAT7

O95251

FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813). {ECO:0000250|UniProtKB:O88563, ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066}.FUNCTION: Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:26620551). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (PubMed:21753189). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (PubMed:10438470, PubMed:11278932, PubMed:18832067, PubMed:19187766, PubMed:20129055, PubMed:21856198, PubMed:24065767, PubMed:26620551). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (PubMed:27270040). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (PubMed:28719581). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (PubMed:16997280). {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:16997280, ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:26620551, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581, ECO:0000269|PubMed:31767635, ECO:0000269|PubMed:31827282}.; FUNCTION: Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282). {ECO:0000269|PubMed:31827282}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKAT7chr17:48712342chr17:47893165ENST00000259021615332_607284.0612.0DomainMYST-type HAT
TgeneKAT7chr17:48712342chr17:47893165ENST00000424009514332_607254.0582.0DomainMYST-type HAT
TgeneKAT7chr17:48712342chr17:47893165ENST00000454930413332_607145.0473.0DomainMYST-type HAT
TgeneKAT7chr17:48712342chr17:47893165ENST00000509773413332_607174.0502.0DomainMYST-type HAT
TgeneKAT7chr17:48712342chr17:47893165ENST00000510819312332_607115.0443.0DomainMYST-type HAT
TgeneKAT7chr17:48712342chr17:47893165ENST00000259021615483_488284.0612.0RegionWM-3835 inhibitor binding
TgeneKAT7chr17:48712342chr17:47893165ENST00000424009514483_488254.0582.0RegionWM-3835 inhibitor binding
TgeneKAT7chr17:48712342chr17:47893165ENST00000454930413483_488145.0473.0RegionWM-3835 inhibitor binding
TgeneKAT7chr17:48712342chr17:47893165ENST00000509773413483_488174.0502.0RegionWM-3835 inhibitor binding
TgeneKAT7chr17:48712342chr17:47893165ENST00000510819312483_488115.0443.0RegionWM-3835 inhibitor binding
TgeneKAT7chr17:48712342chr17:47893165ENST00000259021615365_390284.0612.0Zinc fingerC2HC MYST-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000424009514365_390254.0582.0Zinc fingerC2HC MYST-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000454930413176_219145.0473.0Zinc fingerCCHHC-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000454930413365_390145.0473.0Zinc fingerC2HC MYST-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000509773413176_219174.0502.0Zinc fingerCCHHC-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000509773413365_390174.0502.0Zinc fingerC2HC MYST-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000510819312176_219115.0443.0Zinc fingerCCHHC-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000510819312365_390115.0443.0Zinc fingerC2HC MYST-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311291_152315.01528.0DomainABC transporter 2
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131311_59415.01528.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131629_85115.01528.0DomainABC transporter 1
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131971_125215.01528.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121291_152315.0573.0DomainABC transporter 2
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112311_59415.0573.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112629_85115.0573.0DomainABC transporter 1
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112971_125215.0573.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311323_133015.01528.0Nucleotide bindingATP 2
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131661_66815.01528.0Nucleotide bindingATP 1
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121323_133015.0573.0Nucleotide bindingATP 2
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112661_66815.0573.0Nucleotide bindingATP 1
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311043_108515.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311107_110715.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311129_119915.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131121_13215.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311221_122215.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311244_152715.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131154_17115.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131193_30215.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311_3215.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131324_34915.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131371_42615.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131448_45015.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131472_53315.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+13154_7315.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131555_57615.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131598_96315.01528.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+13195_9915.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131985_102115.01528.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121043_108515.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121107_110715.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121129_119915.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112121_13215.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121221_122215.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121244_152715.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112154_17115.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112193_30215.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121_3215.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112324_34915.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112371_42615.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112448_45015.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112472_53315.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+11254_7315.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112555_57615.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112598_96315.0573.0Topological domainCytoplasmic
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+11295_9915.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112985_102115.0573.0Topological domainExtracellular
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131100_12015.01528.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311022_104215.01528.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311086_110615.01528.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311108_112815.01528.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311200_122015.01528.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+1311223_124315.01528.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131133_15315.01528.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131172_19215.01528.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131303_32315.01528.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+13133_5315.01528.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131350_37015.01528.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131427_44715.01528.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131451_47115.01528.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131534_55415.01528.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131577_59715.01528.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+13174_9415.01528.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48712342chr17:47893165ENST00000285238+131964_98415.01528.0TransmembraneHelical%3B Name%3D12
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112100_12015.0573.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121022_104215.0573.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121086_110615.0573.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121108_112815.0573.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121200_122015.0573.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+1121223_124315.0573.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112133_15315.0573.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112172_19215.0573.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112303_32315.0573.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+11233_5315.0573.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112350_37015.0573.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112427_44715.0573.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112451_47115.0573.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112534_55415.0573.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112577_59715.0573.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+11274_9415.0573.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48712342chr17:47893165ENST00000427699+112964_98415.0573.0TransmembraneHelical%3B Name%3D12
TgeneKAT7chr17:48712342chr17:47893165ENST0000025902161510_57284.0612.0Compositional biasNote=Ser-rich
TgeneKAT7chr17:48712342chr17:47893165ENST0000042400951410_57254.0582.0Compositional biasNote=Ser-rich
TgeneKAT7chr17:48712342chr17:47893165ENST0000045493041310_57145.0473.0Compositional biasNote=Ser-rich
TgeneKAT7chr17:48712342chr17:47893165ENST0000050977341310_57174.0502.0Compositional biasNote=Ser-rich
TgeneKAT7chr17:48712342chr17:47893165ENST0000051081931210_57115.0443.0Compositional biasNote=Ser-rich
TgeneKAT7chr17:48712342chr17:47893165ENST00000259021615176_219284.0612.0Zinc fingerCCHHC-type
TgeneKAT7chr17:48712342chr17:47893165ENST00000424009514176_219254.0582.0Zinc fingerCCHHC-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCC3
KAT7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABCC3-KAT7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC3-KAT7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource