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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EIF4A1-DDX5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EIF4A1-DDX5
	FusionPDB ID: 25919
	FusionGDB2.0 ID: 25919
		Hgene	Tgene
	Gene symbol	EIF4A1	DDX5
	Gene ID	1973	1655
	Gene name	eukaryotic translation initiation factor 4A1	DEAD-box helicase 5
	Synonyms	DDX2A\|EIF-4A\|EIF4A\|eIF-4A-I\|eIF4A-I	G17P1\|HLR1\|HUMP68\|p68
	Cytomap	17p13.1	17q23.3
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4A	probable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA h
	Modification date	20200322	20200313
	UniProtAcc	P60842	Q5T1V6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000293831, ENST00000577269, ENST00000582746, ENST00000380512, ENST00000581808,	ENST00000580026, ENST00000225792, ENST00000450599, ENST00000578804,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 2 X 2=12	20 X 12 X 8=1920
	# samples	5	19
	** MAII score	log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(19/1920*10)=-3.33703498727757 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EIF4A1 [Title/Abstract] AND DDX5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EIF4A1(7476182)-DDX5(62500960), # samples:1
Anticipated loss of major functional domain due to fusion event.	EIF4A1-DDX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4A1-DDX5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4A1-DDX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4A1-DDX5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDX5	GO:0000122	negative regulation of transcription by RNA polymerase II	15298701
Tgene	DDX5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21343338
Tgene	DDX5	GO:0000956	nuclear-transcribed mRNA catabolic process	23788676

Fusion gene breakpoints across EIF4A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LAML	TCGA-AB-2812	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000293831	EIF4A1	chr17	7476182	+	ENST00000225792	DDX5	chr17	62500960	-	2147	39	16	1839	607
ENST00000293831	EIF4A1	chr17	7476182	+	ENST00000450599	DDX5	chr17	62500960	-	1904	39	16	1602	528
ENST00000293831	EIF4A1	chr17	7476182	+	ENST00000578804	DDX5	chr17	62500960	-	1849	39	16	1839	607
ENST00000577269	EIF4A1	chr17	7476182	+	ENST00000225792	DDX5	chr17	62500960	-	2136	28	5	1828	607
ENST00000577269	EIF4A1	chr17	7476182	+	ENST00000450599	DDX5	chr17	62500960	-	1893	28	5	1591	528
ENST00000577269	EIF4A1	chr17	7476182	+	ENST00000578804	DDX5	chr17	62500960	-	1838	28	5	1828	607
ENST00000582746	EIF4A1	chr17	7476182	+	ENST00000225792	DDX5	chr17	62500960	-	2131	23	0	1823	607
ENST00000582746	EIF4A1	chr17	7476182	+	ENST00000450599	DDX5	chr17	62500960	-	1888	23	0	1586	528
ENST00000582746	EIF4A1	chr17	7476182	+	ENST00000578804	DDX5	chr17	62500960	-	1833	23	0	1823	607

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000293831	ENST00000225792	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000700561	0.9992994
ENST00000293831	ENST00000450599	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000544928	0.99945503
ENST00000293831	ENST00000578804	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000839904	0.99916005
ENST00000577269	ENST00000225792	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000694341	0.9993056
ENST00000577269	ENST00000450599	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000563772	0.9994362
ENST00000577269	ENST00000578804	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000832822	0.9991672
ENST00000582746	ENST00000225792	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000676662	0.99932337
ENST00000582746	ENST00000450599	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000554501	0.9994455
ENST00000582746	ENST00000578804	EIF4A1	chr17	7476182	+	DDX5	chr17	62500960	-	0.000811592	0.99918836

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25919_25919_1_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000293831_DDX5_chr17_62500960_ENST00000225792_length(amino acids)=607AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFY
EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVA
AEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLM
WSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWP
AMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI
SVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGS

--------------------------------------------------------------

>25919_25919_2_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000293831_DDX5_chr17_62500960_ENST00000450599_length(amino acids)=528AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPT
RELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIV
DQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDE
LTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFT
PNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYS

--------------------------------------------------------------

>25919_25919_3_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000293831_DDX5_chr17_62500960_ENST00000578804_length(amino acids)=607AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFY
EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVA
AEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLM
WSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWP
AMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI
SVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGS

--------------------------------------------------------------

>25919_25919_4_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000577269_DDX5_chr17_62500960_ENST00000225792_length(amino acids)=607AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFY
EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVA
AEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLM
WSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWP
AMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI
SVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGS

--------------------------------------------------------------

>25919_25919_5_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000577269_DDX5_chr17_62500960_ENST00000450599_length(amino acids)=528AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPT
RELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIV
DQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDE
LTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFT
PNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYS

--------------------------------------------------------------

>25919_25919_6_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000577269_DDX5_chr17_62500960_ENST00000578804_length(amino acids)=607AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFY
EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVA
AEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLM
WSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWP
AMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI
SVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGS

--------------------------------------------------------------

>25919_25919_7_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000582746_DDX5_chr17_62500960_ENST00000225792_length(amino acids)=607AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFY
EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVA
AEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLM
WSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWP
AMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI
SVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGS

--------------------------------------------------------------

>25919_25919_8_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000582746_DDX5_chr17_62500960_ENST00000450599_length(amino acids)=528AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGDGPICLVLAPT
RELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIV
DQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDE
LTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFT
PNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYS

--------------------------------------------------------------

>25919_25919_9_EIF4A1-DDX5_EIF4A1_chr17_7476182_ENST00000582746_DDX5_chr17_62500960_ENST00000578804_length(amino acids)=607AA_BP=6
MSASQDSRFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFY
EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVA
AEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLM
WSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWP
AMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI
SVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:7476182/chr17:62500960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EIF4A1 P60842	DDX5 Q5T1V6
FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269\|PubMed:19153607, ECO:0000269\|PubMed:19204291}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

125_300

14.666666666666666

615.0

Domain

Helicase ATP-binding

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

328_475

14.666666666666666

615.0

Domain

Helicase C-terminal

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

248_251

14.666666666666666

615.0

Motif

Note=DEAD box

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

94_122

14.666666666666666

615.0

Motif

Note=Q motif

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

114_116

14.666666666666666

615.0

Nucleotide binding

Note=ATP

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

138_145

14.666666666666666

615.0

Nucleotide binding

Note=ATP

Tgene

DDX5

chr17:7476182

chr17:62500960

ENST00000225792

477_614

14.666666666666666

615.0

Region

Note=Transactivation domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000293831

245_406

7.666666666666667

407.0

Domain

Helicase C-terminal

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000293831

63_234

7.666666666666667

407.0

Domain

Helicase ATP-binding

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000577269

245_406

7.666666666666667

348.0

Domain

Helicase C-terminal

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000577269

63_234

7.666666666666667

348.0

Domain

Helicase ATP-binding

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000293831

182_185

7.666666666666667

407.0

Motif

Note=DEAD box

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000293831

32_60

7.666666666666667

407.0

Motif

Note=Q motif

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000577269

182_185

7.666666666666667

348.0

Motif

Note=DEAD box

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000577269

32_60

7.666666666666667

348.0

Motif

Note=Q motif

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000293831

76_83

7.666666666666667

407.0

Nucleotide binding

ATP

Hgene

EIF4A1

chr17:7476182

chr17:62500960

ENST00000577269

76_83

7.666666666666667

348.0

Nucleotide binding

ATP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

DDX5

STK24, HDAC1, CREBBP, EP300, AKAP8, FBL, OTUB1, MEPCE, CDK9, HNRNPA1, HNRNPH1, KHDRBS2, IPO11, TCEA1, AIRE, MYOD1, SMARCA4, TBP, POLR2A, MGMT, SRRM1, SRRM2, tat, PIAS1, MBD3, CHD3, ESR1, TADA2A, SMN1, CD4, DGCR8, ZWINT, Cdk1, AI837181, Ybx1, CALM1, EBNA-LP, PIK3CA, PSMA3, TNNT1, VHL, SMARCAD1, YY1, NDRG1, HDGF, CENPA, MBNL1, SF3A2, ARRB2, ERG, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDX5, DDX17, HDAC2, HDAC3, BBLF2-BBLF3, INPPL1, SHC1, CRK, AKT1, DHX15, SRSF1, SF3B3, U2AF2, DHX38, SNRPA1, EIF4A3, PRKDC, SF3A1, HNRNPM, HNRNPF, SNRPD1, RBMX, SYNCRIP, U2AF1, SART1, PRPF40A, IGF2BP3, SNW1, PRPF19, SNRPD2, VTN, MCM7, SYN1, RPS20, XRCC4, RPS16, HNRNPA0, EEF2, PRSS1, THRAP3, GOLIM4, EPRS, RPL19, SRP14, SMURF1, FN1, VCAM1, RBM10, WBP11, HNRNPK, DHX9, RBM4, HNRNPH2, HNRNPH3, KHDRBS1, RBFOX2, IL7R, MAP1LC3A, ITGA4, CTNNB1, CD81, IGSF8, FBXW4, FBXO46, SP1, MAPK10, FBXO6, TARDBP, PARK2, PIN1, DBNL, ERO1L, FKBP10, LRSAM1, PABPC4, PRPSAP1, WDR4, rev, RPA1, RPA2, RPA3, STAU1, MDM2, SPRTN, AURKA, AURKB, CEP250, TP53, TUBGCP3, FUS, MAPKAPK2, DROSHA, NXF1, CUL7, OBSL1, CCDC8, UBE2I, EZH2, SUZ12, EED, RNF2, SMAD3, ABL1, ARAF, CDK2, DAPK1, ILK, MAST3, SGK2, SRPK1, TNK1, TYK2, LUZP4, RPS6KB2, UNK, NTRK1, ATXN2, ATXN2L, C14orf166, CPSF6, DDX18, DNAJC2, ELAC2, GTPBP4, HNRNPR, IMPDH1, SBDS, SKIV2L2, TRMT6, DHX36, EDC4, EIF2A, GMPS, LUC7L2, NACA, UPF1, SFN, SCARNA22, FRS3, gag, XPO1, HNRNPU, RPL10, MATR3, Bcas2, Bag2, Fus, SKI, MCM2, MCM5, Ksr1, CDC5L, CDC37, CRBN, CBX7, RYBP, WWP2, DERL1, EGFR, YPEL5, RMND5A, MAEA, RANBP9, ARMC8, NR2E1, CYLD, CD2BP2, INO80B, TRIM25, HOTAIR, HEY1, BRCA1, LMNA, MTF1, FBXO7, IQGAP1, TMPO, WDR77, MTCH2, PCBP1, PPIE, CCNT1, GSK3A, MAP2K3, MED12, POLD1, TGFB1, TRIP4, ZNF217, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD4, LARP7, RNF4, TNF, RIOK1, SQSTM1, HEXIM1, RUNX1, DPF2, RNF123, NBN, SNAI1, AGR2, RECQL4, ZFP36L2, CNTNAP1, MYC, Prkaa1, Prkab1, CDK5RAP2, METTL3, METTL14, WTAP, KIAA1429, PSME3, PHF1, PHB, FAF1, RBX1, KIN, USP14, NR2C2, UCHL3, PPP1CC, SETD1A, ZFYVE21, XRCC6, CTCF, AGRN, VRK1, HIST1H4A, PSMD14, APEX1, SNRNP70, EWSR1, TAF15, SNRPC, ITFG1, GSK3B, CDC6, BIRC3, BRD7, ERCC6, SOX2, TRIM28, CMTR1, PLEKHA4, MAGEA3, KCTD10, PINK1, YAP1, TFCP2, FANCD2, ORF50, ZC3H18, PTK6, STAG2, MAU2, HSCB, CELF1, ELAVL1, DUX4L9, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, ACACA, C12orf49, INS, SUMO2, NDN, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, nsp13ab, LGALS9, IFI16, EIF3F, DDX58, OGT, SPOP, UFL1, DDRGK1, NR4A1, DDX23, NIFK, RPL31, SLC26A4-AS1, E2F1, FZR1, WDR5, PAGE4, NAA40, BTF3, AGO2, AGO1, RCHY1, NBR1, nsp14, RB1CC1, DDX3X, ZEB1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EIF4A1
DDX5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to EIF4A1-DDX5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to EIF4A1-DDX5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	DDX5	C0014175	Endometriosis	1	CTD_human
Tgene	DDX5	C0269102	Endometrioma	1	CTD_human