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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EIF4A2-HIF1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EIF4A2-HIF1A
FusionPDB ID: 25934
FusionGDB2.0 ID: 25934
HgeneTgene
Gene symbol

EIF4A2

HIF1A

Gene ID

1974

3091

Gene nameeukaryotic translation initiation factor 4A2hypoxia inducible factor 1 subunit alpha
SynonymsBM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-IIHIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78
Cytomap

3q27.3

14q23.2

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2hypoxia-inducible factor 1-alphaARNT interacting proteinPAS domain-containing protein 8basic-helix-loop-helix-PAS protein MOP1class E basic helix-loop-helix protein 78hypoxia inducible factor 1 alpha subunithypoxia inducible factor 1, alpha subunit
Modification date2020032220200329
UniProtAcc

Q14240

Q9NWT6

Ensembl transtripts involved in fusion geneENST idsENST00000323963, ENST00000356531, 
ENST00000440191, 
ENST00000557206, 
ENST00000323441, ENST00000539097, 
ENST00000557538, ENST00000337138, 
ENST00000394997, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 21 X 7=30877 X 7 X 3=147
# samples 237
** MAII scorelog2(23/3087*10)=-3.74649971667075
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EIF4A2 [Title/Abstract] AND HIF1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EIF4A2(186505373)-HIF1A(62213652), # samples:1
Anticipated loss of major functional domain due to fusion event.EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
EIF4A2-HIF1A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4A2

GO:1900260

negative regulation of RNA-directed 5'-3' RNA polymerase activity

11922617

TgeneHIF1A

GO:0001666

response to hypoxia

8756616|9887100|11782478|15261140|18419598

TgeneHIF1A

GO:0006355

regulation of transcription, DNA-templated

11782478|15261140

TgeneHIF1A

GO:0010468

regulation of gene expression

18419598

TgeneHIF1A

GO:0010573

vascular endothelial growth factor production

12958148

TgeneHIF1A

GO:0010575

positive regulation of vascular endothelial growth factor production

8756616

TgeneHIF1A

GO:0010628

positive regulation of gene expression

15459207|24244340

TgeneHIF1A

GO:0032364

oxygen homeostasis

16956324

TgeneHIF1A

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

8089148|8387214

TgeneHIF1A

GO:0045893

positive regulation of transcription, DNA-templated

8089148|9887100|25043030

TgeneHIF1A

GO:0045944

positive regulation of transcription by RNA polymerase II

11573933

TgeneHIF1A

GO:0046886

positive regulation of hormone biosynthetic process

1448077

TgeneHIF1A

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

22735262

TgeneHIF1A

GO:0071456

cellular response to hypoxia

11573933|19528298|20889502

TgeneHIF1A

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19782034

TgeneHIF1A

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

24899725


check buttonFusion gene breakpoints across EIF4A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HIF1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01AEIF4A2chr3

186505373

+HIF1Achr14

62213652

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000323963EIF4A2chr3186505373+ENST00000394997HIF1Achr1462213652+23881063641068334
ENST00000323963EIF4A2chr3186505373+ENST00000337138HIF1Achr1462213652+23881063641068334
ENST00000440191EIF4A2chr3186505373+ENST00000394997HIF1Achr1462213652+23611036341041335
ENST00000440191EIF4A2chr3186505373+ENST00000337138HIF1Achr1462213652+23611036341041335
ENST00000356531EIF4A2chr3186505373+ENST00000394997HIF1Achr1462213652+2201876162881239
ENST00000356531EIF4A2chr3186505373+ENST00000337138HIF1Achr1462213652+2201876162881239

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000323963ENST00000394997EIF4A2chr3186505373+HIF1Achr1462213652+0.0002452610.9997547
ENST00000323963ENST00000337138EIF4A2chr3186505373+HIF1Achr1462213652+0.0002452610.9997547
ENST00000440191ENST00000394997EIF4A2chr3186505373+HIF1Achr1462213652+0.0002115760.99978846
ENST00000440191ENST00000337138EIF4A2chr3186505373+HIF1Achr1462213652+0.0002115760.99978846
ENST00000356531ENST00000394997EIF4A2chr3186505373+HIF1Achr1462213652+0.0003084580.9996916
ENST00000356531ENST00000337138EIF4A2chr3186505373+HIF1Achr1462213652+0.0003084580.9996916

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25934_25934_1_EIF4A2-HIF1A_EIF4A2_chr3_186505373_ENST00000323963_HIF1A_chr14_62213652_ENST00000337138_length(amino acids)=334AA_BP=
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAIS
ILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYET

--------------------------------------------------------------

>25934_25934_2_EIF4A2-HIF1A_EIF4A2_chr3_186505373_ENST00000323963_HIF1A_chr14_62213652_ENST00000394997_length(amino acids)=334AA_BP=
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAIS
ILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYET

--------------------------------------------------------------

>25934_25934_3_EIF4A2-HIF1A_EIF4A2_chr3_186505373_ENST00000356531_HIF1A_chr14_62213652_ENST00000337138_length(amino acids)=239AA_BP=
MLTVLRSLPLFSRELLFPVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEA
DEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQ

--------------------------------------------------------------

>25934_25934_4_EIF4A2-HIF1A_EIF4A2_chr3_186505373_ENST00000356531_HIF1A_chr14_62213652_ENST00000394997_length(amino acids)=239AA_BP=
MLTVLRSLPLFSRELLFPVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEA
DEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQ

--------------------------------------------------------------

>25934_25934_5_EIF4A2-HIF1A_EIF4A2_chr3_186505373_ENST00000440191_HIF1A_chr14_62213652_ENST00000337138_length(amino acids)=335AA_BP=
MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAI
SILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKM
FVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYE

--------------------------------------------------------------

>25934_25934_6_EIF4A2-HIF1A_EIF4A2_chr3_186505373_ENST00000440191_HIF1A_chr14_62213652_ENST00000394997_length(amino acids)=335AA_BP=
MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAI
SILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKM
FVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:186505373/chr14:62213652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4A2

Q14240

HIF1A

Q9NWT6

FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.FUNCTION: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000323963+91164_235333.0408.0DomainHelicase ATP-binding
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000440191+91164_235334.0409.0DomainHelicase ATP-binding
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000323963+911183_186333.0408.0MotifNote=DEAD box
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000323963+91133_61333.0408.0MotifNote=Q motif
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000440191+911183_186334.0409.0MotifNote=DEAD box
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000440191+91133_61334.0409.0MotifNote=Q motif
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000323963+91177_84333.0408.0Nucleotide bindingATP
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000440191+91177_84334.0409.0Nucleotide bindingATP
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214786_826734.0736.0RegionNote=CTAD
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315786_826776.3333333333334827.0RegionNote=CTAD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000323963+911246_407333.0408.0DomainHelicase C-terminal
HgeneEIF4A2chr3:186505373chr14:62213652ENST00000440191+911246_407334.0409.0DomainHelicase C-terminal
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214615_621734.0736.0Compositional biasNote=Poly-Thr
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315615_621776.3333333333334827.0Compositional biasNote=Poly-Thr
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315615_621800.3333333333334851.0Compositional biasNote=Poly-Thr
TgeneHIF1Achr3:186505373chr14:62213652ENST00000323441121417_70734.0736.0DomainbHLH
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214228_298734.0736.0DomainPAS 2
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214302_345734.0736.0DomainNote=PAC
TgeneHIF1Achr3:186505373chr14:62213652ENST00000323441121485_158734.0736.0DomainPAS 1
TgeneHIF1Achr3:186505373chr14:62213652ENST00000337138131517_70776.3333333333334827.0DomainbHLH
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315228_298776.3333333333334827.0DomainPAS 2
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315302_345776.3333333333334827.0DomainNote=PAC
TgeneHIF1Achr3:186505373chr14:62213652ENST00000337138131585_158776.3333333333334827.0DomainPAS 1
TgeneHIF1Achr3:186505373chr14:62213652ENST00000539097131517_70800.3333333333334851.0DomainbHLH
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315228_298800.3333333333334851.0DomainPAS 2
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315302_345800.3333333333334851.0DomainNote=PAC
TgeneHIF1Achr3:186505373chr14:62213652ENST00000539097131585_158800.3333333333334851.0DomainPAS 1
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214718_721734.0736.0MotifNuclear localization signal
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315718_721776.3333333333334827.0MotifNuclear localization signal
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315718_721800.3333333333334851.0MotifNuclear localization signal
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214170_191734.0736.0RegionRequired for heterodimer formation with ARNT
TgeneHIF1Achr3:186505373chr14:62213652ENST00000323441121421_30734.0736.0RegionDNA-binding
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214380_417734.0736.0RegionNote=N-terminal VHL recognition site
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214401_603734.0736.0RegionNote=ODD
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214531_575734.0736.0RegionNote=NTAD
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214556_572734.0736.0RegionNote=C-terminal VHL recognition site
TgeneHIF1Achr3:186505373chr14:62213652ENST000003234411214576_785734.0736.0RegionNote=ID
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315170_191776.3333333333334827.0RegionRequired for heterodimer formation with ARNT
TgeneHIF1Achr3:186505373chr14:62213652ENST00000337138131521_30776.3333333333334827.0RegionDNA-binding
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315380_417776.3333333333334827.0RegionNote=N-terminal VHL recognition site
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315401_603776.3333333333334827.0RegionNote=ODD
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315531_575776.3333333333334827.0RegionNote=NTAD
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315556_572776.3333333333334827.0RegionNote=C-terminal VHL recognition site
TgeneHIF1Achr3:186505373chr14:62213652ENST000003371381315576_785776.3333333333334827.0RegionNote=ID
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315170_191800.3333333333334851.0RegionRequired for heterodimer formation with ARNT
TgeneHIF1Achr3:186505373chr14:62213652ENST00000539097131521_30800.3333333333334851.0RegionDNA-binding
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315380_417800.3333333333334851.0RegionNote=N-terminal VHL recognition site
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315401_603800.3333333333334851.0RegionNote=ODD
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315531_575800.3333333333334851.0RegionNote=NTAD
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315556_572800.3333333333334851.0RegionNote=C-terminal VHL recognition site
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315576_785800.3333333333334851.0RegionNote=ID
TgeneHIF1Achr3:186505373chr14:62213652ENST000005390971315786_826800.3333333333334851.0RegionNote=CTAD


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EIF4A2
HIF1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHIF1Achr3:186505373chr14:62213652ENST0000032344112141_401734.0736.0TSGA10
TgeneHIF1Achr3:186505373chr14:62213652ENST0000033713813151_401776.3333333333334827.0TSGA10
TgeneHIF1Achr3:186505373chr14:62213652ENST0000053909713151_401800.3333333333334851.0TSGA10


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Related Drugs to EIF4A2-HIF1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EIF4A2-HIF1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource