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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EIF4A2-NUP107

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EIF4A2-NUP107
	FusionPDB ID: 25939
	FusionGDB2.0 ID: 25939
		Hgene	Tgene
	Gene symbol	EIF4A2	NUP107
	Gene ID	1974	57122
	Gene name	eukaryotic translation initiation factor 4A2	nucleoporin 107
	Synonyms	BM-010\|DDX2B\|EIF4A\|EIF4F\|eIF-4A-II\|eIF4A-II	NPHS11\|NUP84\|ODG6\|ODG6; GAMOS7
	Cytomap	3q27.3	12q15
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2	nuclear pore complex protein Nup107nucleoporin 107kDa
	Modification date	20200322	20200313
	UniProtAcc	Q14240	P57740
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000323963, ENST00000356531, ENST00000440191,	ENST00000401003, ENST00000229179, ENST00000378905, ENST00000539906,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 21 X 7=3087	27 X 22 X 9=5346
	# samples	23	37
	** MAII score	log2(23/3087*10)=-3.74649971667075 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(37/5346*10)=-3.85286266172677 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EIF4A2 [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EIF4A2(186504434)-NUP107(69109407), # samples:1
Anticipated loss of major functional domain due to fusion event.	EIF4A2-NUP107 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4A2-NUP107 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4A2-NUP107 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EIF4A2-NUP107 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF4A2	GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	11922617
Tgene	NUP107	GO:0006406	mRNA export from nucleus	11684705

Fusion gene breakpoints across EIF4A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8284-01A	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000323963	EIF4A2	chr3	186504434	+	ENST00000229179	NUP107	chr12	69109407	+	3187	835	64	2643	859
ENST00000323963	EIF4A2	chr3	186504434	+	ENST00000378905	NUP107	chr12	69109407	+	2601	835	64	2379	771
ENST00000323963	EIF4A2	chr3	186504434	+	ENST00000539906	NUP107	chr12	69109407	+	2713	835	64	2643	859
ENST00000440191	EIF4A2	chr3	186504434	+	ENST00000229179	NUP107	chr12	69109407	+	3160	808	34	2616	860
ENST00000440191	EIF4A2	chr3	186504434	+	ENST00000378905	NUP107	chr12	69109407	+	2574	808	34	2352	772
ENST00000440191	EIF4A2	chr3	186504434	+	ENST00000539906	NUP107	chr12	69109407	+	2686	808	34	2616	860
ENST00000356531	EIF4A2	chr3	186504434	+	ENST00000229179	NUP107	chr12	69109407	+	3000	648	162	2456	764
ENST00000356531	EIF4A2	chr3	186504434	+	ENST00000378905	NUP107	chr12	69109407	+	2414	648	162	2192	676
ENST00000356531	EIF4A2	chr3	186504434	+	ENST00000539906	NUP107	chr12	69109407	+	2526	648	162	2456	764

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000323963	ENST00000229179	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000410382	0.9995896
ENST00000323963	ENST00000378905	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000728906	0.9992711
ENST00000323963	ENST00000539906	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000835555	0.99916446
ENST00000440191	ENST00000229179	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000379677	0.9996203
ENST00000440191	ENST00000378905	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000808072	0.99919194
ENST00000440191	ENST00000539906	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000852632	0.9991473
ENST00000356531	ENST00000229179	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000166103	0.9998338
ENST00000356531	ENST00000378905	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000244261	0.9997557
ENST00000356531	ENST00000539906	EIF4A2	chr3	186504434	+	NUP107	chr12	69109407	+	0.000364974	0.999635

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25939_25939_1_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000323963_NUP107_chr12_69109407_ENST00000229179_length(amino acids)=859AA_BP=257
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAIS
ILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPLD
DLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERA
IYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQ
KFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYA
LFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIM
RKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKV
AHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQ

--------------------------------------------------------------

>25939_25939_2_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000323963_NUP107_chr12_69109407_ENST00000378905_length(amino acids)=771AA_BP=257
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAIS
ILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPLD
DLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERA
IYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQ
KFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQEDRLKIDVIDWLVFDPAQRAEALKQGNA
IMRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTE
KVAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQEC

--------------------------------------------------------------

>25939_25939_3_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000323963_NUP107_chr12_69109407_ENST00000539906_length(amino acids)=859AA_BP=257
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAIS
ILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPLD
DLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERA
IYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQ
KFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYA
LFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIM
RKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKV
AHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQ

--------------------------------------------------------------

>25939_25939_4_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000356531_NUP107_chr12_69109407_ENST00000229179_length(amino acids)=764AA_BP=162
MLTVLRSLPLFSRELLFPVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEA
DEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPLDDLDRE
DEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAAL
SGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLIL
GDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLES
VTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLA
SKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHEHK
EKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMV

--------------------------------------------------------------

>25939_25939_5_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000356531_NUP107_chr12_69109407_ENST00000378905_length(amino acids)=676AA_BP=162
MLTVLRSLPLFSRELLFPVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEA
DEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPLDDLDRE
DEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAAL
SGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLIL
GDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKF
LASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHE
HKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLAD

--------------------------------------------------------------

>25939_25939_6_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000356531_NUP107_chr12_69109407_ENST00000539906_length(amino acids)=764AA_BP=162
MLTVLRSLPLFSRELLFPVLKIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEA
DEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPLDDLDRE
DEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAAL
SGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLIL
GDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLES
VTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLA
SKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEKVAHEHK
EKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECLQLADMV

--------------------------------------------------------------

>25939_25939_7_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000440191_NUP107_chr12_69109407_ENST00000229179_length(amino acids)=860AA_BP=258
MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAI
SILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKM
FVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPL
DDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYER
AIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIV
QKFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQY
ALFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAI
MRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEK
VAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECL

--------------------------------------------------------------

>25939_25939_8_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000440191_NUP107_chr12_69109407_ENST00000378905_length(amino acids)=772AA_BP=258
MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAI
SILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKM
FVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPL
DDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYER
AIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIV
QKFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQEDRLKIDVIDWLVFDPAQRAEALKQGN
AIMRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFT
EKVAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQE

--------------------------------------------------------------

>25939_25939_9_EIF4A2-NUP107_EIF4A2_chr3_186504434_ENST00000440191_NUP107_chr12_69109407_ENST00000539906_length(amino acids)=860AA_BP=258
MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAI
SILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKM
FVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREDPDAPIRQKMPL
DDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELEPVEGNPYRRIWKISCWRMAEDELFNRYER
AIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQEIQTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIV
QKFLILGDIDGLMDEFSKWLSKSRNNLPGHLLRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQLLIREKHTNLIAFYTCHLPQDLAVAQY
ALFLESVTEFEQRHHCLELAKEADLDVATITKTVVENIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAI
MRKFLASKKHEAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIREHLCIRAYLEAHETFNEWFKHMNSVPQKPALIPQPTFTEK
VAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQYQECL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:186504434/chr12:69109407)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EIF4A2 Q14240	NUP107 P57740
FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269\|PubMed:12552102, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:30179222}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000323963

64_235

257.0

408.0

Domain

Helicase ATP-binding

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000440191

64_235

258.0

409.0

Domain

Helicase ATP-binding

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000323963

183_186

257.0

408.0

Motif

Note=DEAD box

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000323963

33_61

257.0

408.0

Motif

Note=Q motif

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000440191

183_186

258.0

409.0

Motif

Note=DEAD box

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000440191

33_61

258.0

409.0

Motif

Note=Q motif

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000323963

77_84

257.0

408.0

Nucleotide binding

ATP

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000440191

77_84

258.0

409.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000323963

246_407

257.0

408.0

Domain

Helicase C-terminal

Hgene

EIF4A2

chr3:186504434

chr12:69109407

ENST00000440191

246_407

258.0

409.0

Domain

Helicase C-terminal

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

NUP107

SEH1L, NUP133, NUP85, NUP160, NUP43, NUP37, SEC13, TPR, NUP214, KPNB1, Nup107, Nup98, SIRT7, NUP98, WRNIP1, CUL3, CENPF, NUP153, TP53BP1, PNPT1, EIF4B, CORO1B, MYL1, C1QBP, CPSF6, VCP, PYCARD, CUL7, OBSL1, SUZ12, EED, PNKD, NTRK1, IFI16, SYNE1, APC, PRKDC, RRP1B, NALCN, CD1E, ACTBL2, HSP90AB1, XPO1, SENP1, SENP2, AHCTF1, RANGAP1, H2AFV, NUP50, RANBP2, B9D2, ACLY, RCC1, GLE1, ITPR2, KPNA4, NUP88, RAN, UBE2I, SUMO1, AAAS, RAE1, NUP155, NUP93, NUPL1, WDR1, NXF1, IPO7, NUPL2, NUP205, NUP210, NUP188, NUP62, NXT1, SEC61A1, NUP54, TMEM214, SMPD4, NDC1, KRAS, IP6K3, TMEM209, NUP35, RPUSD3, RGPD8, POM121C, Ranbp2, Ube2i, Rcc1, Kifc1, Nup155, Nup214, FOXA3, FOXI2, FOXK2, FOXL1, FOXP3, FOXQ1, CDC5L, ZNF746, DUSP13, SPAST, UXS1, SIGLECL1, CD70, RAF1, PDHA1, TRIM25, BRCA1, EGLN3, TGFB1, NKX2-1, RNF4, CDC34, BPLF1, EZH2, DCPS, MYC, CDK9, CANX, EZR, LMNA, TOMM20, MGST3, PTRH2, KIAA1429, HIST1H4A, Dppa3, BIRC3, LMBR1L, PLEKHA4, GAPDH, M, nsp16, nsp4, nsp6, ORF6, MAU2, LRRC31, CIT, KIF14, PRC1, TRIM66, FKBP8, PTPN1, RHOT2, SLC25A46, SUMO2, NUPR1, CIC, LGALS9, DYRK1A, BKRF1, DNAJC1, ANAPC2, COX8A, DERL1, EMD, KRT8, LMNB1, LRRC59, RPN1, SEC61B, STIM1, SYNE3, TMPO, NAA40, VPS33A, RGPD1, EFNA4, COMTD1, SLFN11, FBXW7, FBXO32, RCHY1, SIRT6, GLI3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EIF4A2
NUP107

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to EIF4A2-NUP107

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to EIF4A2-NUP107

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NUP107	C4225228	NEPHROTIC SYNDROME, TYPE 11	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	NUP107	C0018051	Gonadal Dysgenesis	1	GENOMICS_ENGLAND
Tgene	NUP107	C0685837	Pure Gonadal Dysgenesis, 46, XX	1	ORPHANET
Tgene	NUP107	C0795949	Galloway Mowat syndrome	1	ORPHANET
Tgene	NUP107	C0949595	Gonadal Dysgenesis, 46,XX	1	ORPHANET
Tgene	NUP107	C1868672	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	1	ORPHANET
Tgene	NUP107	C4748084	OVARIAN DYSGENESIS 6	1	UNIPROT