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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EIF4G1-AEBP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EIF4G1-AEBP1
FusionPDB ID: 26003
FusionGDB2.0 ID: 26003
HgeneTgene
Gene symbol

EIF4G1

AEBP1

Gene ID

1981

165

Gene nameeukaryotic translation initiation factor 4 gamma 1AE binding protein 1
SynonymsEIF-4G1|EIF4F|EIF4G|EIF4GI|P220|PARK18ACLP
Cytomap

3q27.1

7p13

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 1EIF4-gammaeIF-4-gamma 1eucaryotic translation initiation factor 4Gadipocyte enhancer-binding protein 1aortic carboxypeptidase-like protein
Modification date2020031320200315
UniProtAcc

Q04637

Q8IUX7

Ensembl transtripts involved in fusion geneENST idsENST00000319274, ENST00000342981, 
ENST00000346169, ENST00000350481, 
ENST00000352767, ENST00000382330, 
ENST00000392537, ENST00000411531, 
ENST00000414031, ENST00000424196, 
ENST00000427845, ENST00000434061, 
ENST00000435046, ENST00000441154, 
ENST00000450684, ENST00000454218, 
ENST00000223357, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 18 X 8=20167 X 7 X 4=196
# samples 187
** MAII scorelog2(18/2016*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EIF4G1 [Title/Abstract] AND AEBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EIF4G1(184045091)-AEBP1(44143960), # samples:1
Anticipated loss of major functional domain due to fusion event.EIF4G1-AEBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4G1-AEBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4G1-AEBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF4G1-AEBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4G1

GO:1905612

positive regulation of mRNA cap binding

23409027

HgeneEIF4G1

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027

TgeneAEBP1

GO:1904026

regulation of collagen fibril organization

29606302


check buttonFusion gene breakpoints across EIF4G1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AEBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-BF-A3DJ-01AEIF4G1chr3

184045091

-AEBP1chr7

44143960

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346169EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+7925384427138911206
ENST00000414031EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+7978389736639441192
ENST00000392537EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+7640355912736061159
ENST00000382330EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+7874379319938401213
ENST00000350481EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+73993318362370991158
ENST00000352767EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+773136505636971213
ENST00000427845EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+789238115538581267
ENST00000342981EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+8071399041440371207
ENST00000319274EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+8051397039740171206
ENST00000424196EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+8064398338940301213
ENST00000411531EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+75373456035031167
ENST00000441154EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+71653084338968651158
ENST00000434061EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+74373356366171371158
ENST00000435046EIF4G1chr3184045091-ENST00000223357AEBP1chr744143960+70833002330767831158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346169ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0039007880.99609923
ENST00000414031ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.00471430.9952857
ENST00000392537ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.042237120.95776284
ENST00000382330ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0035719220.9964281
ENST00000350481ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.039900490.96009946
ENST00000352767ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0031393790.9968606
ENST00000427845ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0426848830.95731515
ENST00000342981ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0068802470.9931197
ENST00000319274ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0041358470.99586415
ENST00000424196ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0038613440.99613863
ENST00000411531ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0050471260.9949529
ENST00000441154ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0381259020.9618741
ENST00000434061ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.037443430.96255654
ENST00000435046ENST00000223357EIF4G1chr3184045091-AEBP1chr744143960+0.0365474220.9634526

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26003_26003_1_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000319274_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1206AA_BP=1191
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMI
PSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSP
VLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS
PAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKP
EGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPN
FSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNW
VPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRSGVENGPP

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>26003_26003_2_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000342981_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1207AA_BP=1192
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMI
PSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSP
VLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS
PAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKP
EGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPQAGLGPRRSQQGPRKEPRKIIATV
LMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEP
NFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNI
KFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSN
WVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSID
SNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRSGVENGP

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>26003_26003_3_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000346169_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1206AA_BP=1191
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMI
PSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSP
VLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS
PAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKP
EGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPN
FSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNW
VPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRSGVENGPP

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>26003_26003_4_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000350481_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1158AA_BP=
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKT
KDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLE
WPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVW
PEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEK
GKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR
TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGC
SVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL
GRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPY
RVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHA
IFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTF
MEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRI
REIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEE

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>26003_26003_5_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000352767_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1213AA_BP=1198
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPA
GSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAP
KRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPS
PTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLAS
HTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPA
TAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDA
FKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFI
FASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPR
KIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFE
KAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARR
RSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVL
DLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKIT
KPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRS

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>26003_26003_6_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000382330_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1213AA_BP=1198
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPA
GSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAP
KRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPS
PTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLAS
HTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPA
TAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDA
FKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFI
FASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPR
KIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFE
KAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARR
RSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVL
DLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKIT
KPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRS

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>26003_26003_7_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000392537_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1159AA_BP=1144
MKHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTE
FGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVA
VIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEP
TPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGA
PSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQ
NLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENI
QPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTT
LSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSI
LNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDD
DEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLD
FEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPG
PPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQ

--------------------------------------------------------------

>26003_26003_8_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000411531_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1167AA_BP=1152
MNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFY
PGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQAN
GETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEP
YRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQP
EELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTP
IPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDK
IHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSF
ANLGRTTLSTRGPPRGGPGGELPRGPQAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQD
LFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQK
EFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLL
TTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSD
KRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATST

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>26003_26003_9_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000414031_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1192AA_BP=1177
MVSPLQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYY
IPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITE
EIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLS
IPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEV
ESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE
EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNP
GPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKA
NKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAW
KPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMA
LKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEA
IMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQ
IHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWG
KGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRSGVENGPPSLRGCARQLASRRI

--------------------------------------------------------------

>26003_26003_10_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000424196_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1213AA_BP=1198
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPA
GSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAP
KRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPS
PTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLAS
HTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPA
TAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDA
FKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFI
FASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPR
KIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFE
KAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARR
RSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVL
DLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKIT
KPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRS

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>26003_26003_11_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000427845_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1267AA_BP=1252
MTPALPGLHSWAAAGLASGPVRVPRRQAYPVCPWARPEPGVPGWGVGTPRPKQLAPFVIREPGASETWNFRSGWSGAPRSQVDTLTSQPQ
ALGCPEPVGRTVDLFLIEGHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQ
TGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSES
PVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEA
DETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPQAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGE
EDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNF
RKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDE
ESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIK
VQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAA
SEAARPATSTLNRFSALQQAVPTESTDNRRVVQSGLIVRGHLLPSGASARKWRSGVENGPPSLRGCARQLASRRIGTVGGMPRLSARECA

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>26003_26003_12_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000434061_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1158AA_BP=
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKT
KDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLE
WPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVW
PEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEK
GKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR
TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGC
SVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL
GRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPY
RVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHA
IFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTF
MEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRI
REIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEE

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>26003_26003_13_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000435046_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1158AA_BP=
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKT
KDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLE
WPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVW
PEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEK
GKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR
TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGC
SVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL
GRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPY
RVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHA
IFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTF
MEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRI
REIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEE

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>26003_26003_14_EIF4G1-AEBP1_EIF4G1_chr3_184045091_ENST00000441154_AEBP1_chr7_44143960_ENST00000223357_length(amino acids)=1158AA_BP=
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKT
KDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLE
WPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVW
PEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEK
GKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR
TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGC
SVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL
GRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPY
RVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHA
IFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTF
MEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRI
REIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEE

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:184045091/chr7:44143960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G1

Q04637

AEBP1

Q8IUX7

FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139}.FUNCTION: [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. {ECO:0000269|PubMed:29606302}.; FUNCTION: [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000250|UniProtKB:Q640N1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAEBP1chr3:184045091chr7:44143960ENST00000223357-1211079_113684.333333333333331159.0Compositional biasNote=Glu-rich
TgeneAEBP1chr3:184045091chr7:44143960ENST00000450684081079_11360734.0Compositional biasNote=Glu-rich
TgeneAEBP1chr3:184045091chr7:44143960ENST000004506840847_3260734.0Compositional biasNote=Pro-rich
TgeneAEBP1chr3:184045091chr7:44143960ENST00000223357-121383_54084.333333333333331159.0DomainF5/8 type C
TgeneAEBP1chr3:184045091chr7:44143960ENST0000045068408383_5400734.0DomainF5/8 type C
TgeneAEBP1chr3:184045091chr7:44143960ENST00000223357-121941_115884.333333333333331159.0RegionRequired for transcriptional repression
TgeneAEBP1chr3:184045091chr7:44143960ENST0000045068408941_11580734.0RegionRequired for transcriptional repression

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-132454_46701600.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-132501_50401600.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-132454_46701601.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-132501_50401601.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-133454_46701600.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-133501_50401600.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-129454_46701436.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-129501_50401436.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-133454_46701607.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-133501_50401607.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-134454_46701607.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-134501_50401607.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-130454_46701513.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-130501_50401513.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-133454_46701560.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-133501_50401560.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-132454_46701607.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-132501_50401607.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-126454_46701405.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-126501_50401405.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-126454_46701404.0Compositional biasNote=Poly-Glu
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-126501_50401404.0Compositional biasNote=Poly-Ala
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-1321241_136301600.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-1321433_159901600.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-132565_79201600.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-1321241_136301601.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-1321433_159901601.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-132565_79201601.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-1331241_136301600.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-1331433_159901600.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-133565_79201600.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-1291241_136301436.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-1291433_159901436.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-129565_79201436.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-1331241_136301607.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-1331433_159901607.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-133565_79201607.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-1341241_136301607.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-1341433_159901607.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-134565_79201607.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-1301241_136301513.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-1301433_159901513.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-130565_79201513.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-1331241_136301560.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-1331433_159901560.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-133565_79201560.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-1321241_136301607.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-1321433_159901607.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-132565_79201607.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-1261241_136301405.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-1261433_159901405.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-126565_79201405.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-1261241_136301404.0DomainMI
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-1261433_159901404.0DomainW2
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-126565_79201404.0DomainMIF4G
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-1321450_159901600.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-1321585_159901600.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-132172_20001600.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-132607_61801600.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000319274-132682_108501600.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-1321450_159901601.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-1321585_159901601.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-132172_20001601.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-132607_61801601.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000342981-132682_108501601.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-1331450_159901600.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-1331585_159901600.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-133172_20001600.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-133607_61801600.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000346169-133682_108501600.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-1291450_159901436.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-1291585_159901436.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-129172_20001436.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-129607_61801436.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000350481-129682_108501436.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-1331450_159901607.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-1331585_159901607.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-133172_20001607.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-133607_61801607.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000352767-133682_108501607.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-1341450_159901607.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-1341585_159901607.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-134172_20001607.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-134607_61801607.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000382330-134682_108501607.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-1301450_159901513.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-1301585_159901513.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-130172_20001513.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-130607_61801513.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000392537-130682_108501513.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-1331450_159901560.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-1331585_159901560.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-133172_20001560.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-133607_61801560.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000414031-133682_108501560.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-1321450_159901607.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-1321585_159901607.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-132172_20001607.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-132607_61801607.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000424196-132682_108501607.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-1261450_159901405.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-1261585_159901405.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-126172_20001405.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-126607_61801405.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000434061-126682_108501405.0RegionNote=eIF3/EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-1261450_159901404.0RegionNote=EIF4A-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-1261585_159901404.0RegionNote=Necessary but not sufficient for MKNK1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-126172_20001404.0RegionNote=PABPC1-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-126607_61801404.0RegionNote=EIF4E-binding
HgeneEIF4G1chr3:184045091chr7:44143960ENST00000435046-126682_108501404.0RegionNote=eIF3/EIF4A-binding
TgeneAEBP1chr3:184045091chr7:44143960ENST00000223357-12147_32684.333333333333331159.0Compositional biasNote=Pro-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EIF4G1
AEBP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EIF4G1-AEBP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EIF4G1-AEBP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource