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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ELAC2-COX10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ELAC2-COX10
	FusionPDB ID: 26124
	FusionGDB2.0 ID: 26124
		Hgene	Tgene
	Gene symbol	ELAC2	COX10
	Gene ID	60528	1352
	Gene name	elaC ribonuclease Z 2	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
	Synonyms	COXPD17\|ELC2\|HPC2	-
	Cytomap	17p12	17p12
	Type of gene	protein-coding	protein-coding
	Description	zinc phosphodiesterase ELAC protein 2RNase Z 2elaC homolog 2elaC homolog protein 2elaC-like protein 2heredity prostate cancer protein 2putative prostate cancer susceptibility protein HPC2/ELAC2ribonuclease Z 2tRNA 3 endonuclease 2tRNase Z (long f	protoheme IX farnesyltransferase, mitochondrialCOX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferaseCOX10, heme A:farnesyltransferase cytochrome c oxidase assembly factorcytochrome c oxidase assembly homolog 10cytochrome c
	Modification date	20200315	20200313
	UniProtAcc	Q9BQ52	Q12887
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000338034, ENST00000395962, ENST00000426905, ENST00000578071, ENST00000609345,	ENST00000537334, ENST00000429152, ENST00000261643, ENST00000536205,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 6 X 4=96	2 X 3 X 2=12
	# samples	5	3
	** MAII score	log2(5/96*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ELAC2 [Title/Abstract] AND COX10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ELAC2(12919085)-COX10(14063194), # samples:3
Anticipated loss of major functional domain due to fusion event.	ELAC2-COX10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ELAC2-COX10 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ELAC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COX10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7213-01A	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+
ChimerDB4	PRAD	TCGA-HC-7213	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+
ChimerDB4	PRAD	TCGA-HC-7213	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000338034	ELAC2	chr17	12919085	-	ENST00000261643	COX10	chr17	14063194	+	2844	672	240	1379	379
ENST00000338034	ELAC2	chr17	12919085	-	ENST00000536205	COX10	chr17	14063194	+	1680	672	240	1379	379
ENST00000395962	ELAC2	chr17	12919085	-	ENST00000261643	COX10	chr17	14063194	+	2621	449	74	1156	360
ENST00000395962	ELAC2	chr17	12919085	-	ENST00000536205	COX10	chr17	14063194	+	1457	449	74	1156	360
ENST00000426905	ELAC2	chr17	12919085	-	ENST00000261643	COX10	chr17	14063194	+	2656	484	52	1191	379
ENST00000426905	ELAC2	chr17	12919085	-	ENST00000536205	COX10	chr17	14063194	+	1492	484	52	1191	379
ENST00000338034	ELAC2	chr17	12919084	-	ENST00000261643	COX10	chr17	14063193	+	2844	672	240	1379	379
ENST00000338034	ELAC2	chr17	12919084	-	ENST00000536205	COX10	chr17	14063193	+	1680	672	240	1379	379
ENST00000395962	ELAC2	chr17	12919084	-	ENST00000261643	COX10	chr17	14063193	+	2621	449	74	1156	360
ENST00000395962	ELAC2	chr17	12919084	-	ENST00000536205	COX10	chr17	14063193	+	1457	449	74	1156	360
ENST00000426905	ELAC2	chr17	12919084	-	ENST00000261643	COX10	chr17	14063193	+	2656	484	52	1191	379
ENST00000426905	ELAC2	chr17	12919084	-	ENST00000536205	COX10	chr17	14063193	+	1492	484	52	1191	379

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000338034	ENST00000261643	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+	0.07643659	0.92356336
ENST00000338034	ENST00000536205	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+	0.16374677	0.83625317
ENST00000395962	ENST00000261643	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+	0.09607704	0.90392303
ENST00000395962	ENST00000536205	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+	0.20640521	0.7935948
ENST00000426905	ENST00000261643	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+	0.07395462	0.92604536
ENST00000426905	ENST00000536205	ELAC2	chr17	12919085	-	COX10	chr17	14063194	+	0.17299695	0.82700306
ENST00000338034	ENST00000261643	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+	0.07643659	0.92356336
ENST00000338034	ENST00000536205	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+	0.16374677	0.83625317
ENST00000395962	ENST00000261643	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+	0.09607704	0.90392303
ENST00000395962	ENST00000536205	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+	0.20640521	0.7935948
ENST00000426905	ENST00000261643	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+	0.07395462	0.92604536
ENST00000426905	ENST00000536205	ELAC2	chr17	12919084	-	COX10	chr17	14063193	+	0.17299695	0.82700306

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26124_26124_1_ELAC2-COX10_ELAC2_chr17_12919084_ENST00000338034_COX10_chr17_14063193_ENST00000261643_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_2_ELAC2-COX10_ELAC2_chr17_12919084_ENST00000338034_COX10_chr17_14063193_ENST00000536205_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_3_ELAC2-COX10_ELAC2_chr17_12919084_ENST00000395962_COX10_chr17_14063193_ENST00000261643_length(amino acids)=360AA_BP=125
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGVQRLMQEHKLKVARLDNIF
LTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALG
LFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLC
RRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

--------------------------------------------------------------

>26124_26124_4_ELAC2-COX10_ELAC2_chr17_12919084_ENST00000395962_COX10_chr17_14063193_ENST00000536205_length(amino acids)=360AA_BP=125
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGVQRLMQEHKLKVARLDNIF
LTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALG
LFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLC
RRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

--------------------------------------------------------------

>26124_26124_5_ELAC2-COX10_ELAC2_chr17_12919084_ENST00000426905_COX10_chr17_14063193_ENST00000261643_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_6_ELAC2-COX10_ELAC2_chr17_12919084_ENST00000426905_COX10_chr17_14063193_ENST00000536205_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_7_ELAC2-COX10_ELAC2_chr17_12919085_ENST00000338034_COX10_chr17_14063194_ENST00000261643_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_8_ELAC2-COX10_ELAC2_chr17_12919085_ENST00000338034_COX10_chr17_14063194_ENST00000536205_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_9_ELAC2-COX10_ELAC2_chr17_12919085_ENST00000395962_COX10_chr17_14063194_ENST00000261643_length(amino acids)=360AA_BP=125
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGVQRLMQEHKLKVARLDNIF
LTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALG
LFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLC
RRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

--------------------------------------------------------------

>26124_26124_10_ELAC2-COX10_ELAC2_chr17_12919085_ENST00000395962_COX10_chr17_14063194_ENST00000536205_length(amino acids)=360AA_BP=125
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGVQRLMQEHKLKVARLDNIF
LTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALG
LFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLC
RRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

--------------------------------------------------------------

>26124_26124_11_ELAC2-COX10_ELAC2_chr17_12919085_ENST00000426905_COX10_chr17_14063194_ENST00000261643_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

>26124_26124_12_ELAC2-COX10_ELAC2_chr17_12919085_ENST00000426905_COX10_chr17_14063194_ENST00000536205_length(amino acids)=379AA_BP=144
MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG
VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA
VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR
EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:12919085/chr17:14063194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ELAC2 Q9BQ52	COX10 Q12887
FUNCTION: Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694). {ECO:0000269\|PubMed:21593607, ECO:0000269\|PubMed:24703694}.	FUNCTION: Converts protoheme IX and farnesyl diphosphate to heme O. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

235_255

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

257_277

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

280_300

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

309_329

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

364_384

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

411_431

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

235_255

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

257_277

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

280_300

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

309_329

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

364_384

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

411_431

208.0

444.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COX10

chr17:12919084

chr17:14063193

ENST00000261643

174_194

208.0

444.0

Transmembrane

Helical

Tgene

COX10

chr17:12919085

chr17:14063194

ENST00000261643

174_194

208.0

444.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>751_ELAC2_12919085_COX10_14063194_ranked_0.pdb	ELAC2	12919084	12919085	ENST00000536205	COX10	chr17	14063194	+	MWALCSLLRSAAGRTMSQGRTISQAPARRERPRKDPLRHLRTREKRGPSGCSGGPNTVYLQVVAAGSRDSGAALYVFSEFNRYLFNCGEG VQRLMQEHKLKVARLDNIFLTRMHWSNVGGLSGMILTLKETGLPKCVLSGPPQLFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCA VPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLR EDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLL	379

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ELAC2_pLDDT.png

COX10_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ELAC2
COX10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ELAC2-COX10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ELAC2-COX10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source