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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ELN-METTL2B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ELN-METTL2B
FusionPDB ID: 26282
FusionGDB2.0 ID: 26282
HgeneTgene
Gene symbol

ELN

METTL2B

Gene ID

100130933

55798

Gene namesmall integral membrane protein 6methyltransferase like 2B
SynonymsC17orf110|ELNMETL|METTL2|METTL2A|PSENIP1
Cytomap

17q25.1

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionsmall integral membrane protein 6endoregulintRNA N(3)-methylcytidine methyltransferase METTL2Bmethyltransferase-like protein 2B
Modification date2020031320200313
UniProtAcc

P15502

Q6P1Q9

Ensembl transtripts involved in fusion geneENST idsENST00000252034, ENST00000320399, 
ENST00000320492, ENST00000357036, 
ENST00000358929, ENST00000380553, 
ENST00000380562, ENST00000380575, 
ENST00000380576, ENST00000380584, 
ENST00000414324, ENST00000429192, 
ENST00000445912, ENST00000458204, 
ENST00000466878, 		ENST00000473488, 
ENST00000262432, ENST00000480046, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 7 X 4=2525 X 8 X 4=160
# samples 98
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ELN [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ELN(73442599)-METTL2B(128133857), # samples:1
ELN(73442599)-METTL2B(128140956), # samples:1
ELN(73442599)-METTL2B(128133858), # samples:1
Anticipated loss of major functional domain due to fusion event.ELN-METTL2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ELN-METTL2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ELN-METTL2B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ELN-METTL2B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ELN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across METTL2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0J3-01AELNchr7

73442599

-METTL2Bchr7

128133858

+
ChimerDB4BRCATCGA-AO-A0J3ELNchr7

73442599

+METTL2Bchr7

128133857

+
ChimerDB4BRCATCGA-AO-A0J3ELNchr7

73442599

+METTL2Bchr7

128140956

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000445912ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1710481935489148
ENST00000445912ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5388481935489148
ENST00000252034ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1710481935489148
ENST00000252034ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5388481935489148
ENST00000358929ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1402173627181148
ENST00000358929ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5080173627181148
ENST00000320492ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1393164618172148
ENST00000320492ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5071164618172148
ENST00000414324ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1370141595149148
ENST00000414324ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5048141595149148
ENST00000380562ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1358129583137148
ENST00000380562ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5036129583137148
ENST00000380575ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1342113567121148
ENST00000380575ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5020113567121148
ENST00000380584ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1341112566120148
ENST00000380584ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5019112566120148
ENST00000458204ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1336107561115148
ENST00000458204ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5014107561115148
ENST00000357036ELNchr773442599+ENST00000262432METTL2Bchr7128140956+1329100554108148
ENST00000357036ELNchr773442599+ENST00000480046METTL2Bchr7128140956+5007100554108148
ENST00000429192ELNchr773442599+ENST00000262432METTL2Bchr7128140956+132697551105148
ENST00000429192ELNchr773442599+ENST00000480046METTL2Bchr7128140956+500497551105148
ENST00000380553ELNchr773442599+ENST00000262432METTL2Bchr7128140956+132495549103148
ENST00000380553ELNchr773442599+ENST00000480046METTL2Bchr7128140956+500295549103148
ENST00000380576ELNchr773442599+ENST00000262432METTL2Bchr7128140956+132495549103148
ENST00000380576ELNchr773442599+ENST00000480046METTL2Bchr7128140956+500295549103148
ENST00000320399ELNchr773442599+ENST00000262432METTL2Bchr7128140956+13118253690148
ENST00000320399ELNchr773442599+ENST00000480046METTL2Bchr7128140956+49898253690148

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000445912ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.772857960.22714202
ENST00000445912ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.5741010.4258991
ENST00000252034ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.772857960.22714202
ENST00000252034ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.5741010.4258991
ENST00000358929ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.616582040.38341796
ENST00000358929ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.491894330.50810564
ENST00000320492ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.51699170.48300827
ENST00000320492ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.487114430.5128856
ENST00000414324ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.53312830.4668717
ENST00000414324ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.494669380.5053306
ENST00000380562ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.466870340.53312963
ENST00000380562ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.492788820.5072112
ENST00000380575ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.303503070.6964969
ENST00000380575ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.490198850.5098011
ENST00000380584ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.314023670.6859764
ENST00000380584ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.490708260.5092917
ENST00000458204ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.47706280.5229372
ENST00000458204ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.484250780.5157492
ENST00000357036ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.470043240.52995676
ENST00000357036ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.481057350.51894265
ENST00000429192ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.36092610.6390739
ENST00000429192ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.482114260.51788574
ENST00000380553ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.328628660.67137134
ENST00000380553ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.483524350.5164757
ENST00000380576ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.328628660.67137134
ENST00000380576ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.483524350.5164757
ENST00000320399ENST00000262432ELNchr773442599+METTL2Bchr7128140956+0.257743950.74225605
ENST00000320399ENST00000480046ELNchr773442599+METTL2Bchr7128140956+0.480120870.51987916

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26282_26282_1_ELN-METTL2B_ELN_chr7_73442599_ENST00000252034_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_2_ELN-METTL2B_ELN_chr7_73442599_ENST00000252034_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_3_ELN-METTL2B_ELN_chr7_73442599_ENST00000320399_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_4_ELN-METTL2B_ELN_chr7_73442599_ENST00000320399_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_5_ELN-METTL2B_ELN_chr7_73442599_ENST00000320492_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_6_ELN-METTL2B_ELN_chr7_73442599_ENST00000320492_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_7_ELN-METTL2B_ELN_chr7_73442599_ENST00000357036_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_8_ELN-METTL2B_ELN_chr7_73442599_ENST00000357036_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_9_ELN-METTL2B_ELN_chr7_73442599_ENST00000358929_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_10_ELN-METTL2B_ELN_chr7_73442599_ENST00000358929_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_11_ELN-METTL2B_ELN_chr7_73442599_ENST00000380553_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_12_ELN-METTL2B_ELN_chr7_73442599_ENST00000380553_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_13_ELN-METTL2B_ELN_chr7_73442599_ENST00000380562_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_14_ELN-METTL2B_ELN_chr7_73442599_ENST00000380562_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_15_ELN-METTL2B_ELN_chr7_73442599_ENST00000380575_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_16_ELN-METTL2B_ELN_chr7_73442599_ENST00000380575_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_17_ELN-METTL2B_ELN_chr7_73442599_ENST00000380576_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_18_ELN-METTL2B_ELN_chr7_73442599_ENST00000380576_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_19_ELN-METTL2B_ELN_chr7_73442599_ENST00000380584_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_20_ELN-METTL2B_ELN_chr7_73442599_ENST00000380584_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_21_ELN-METTL2B_ELN_chr7_73442599_ENST00000414324_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_22_ELN-METTL2B_ELN_chr7_73442599_ENST00000414324_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_23_ELN-METTL2B_ELN_chr7_73442599_ENST00000429192_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_24_ELN-METTL2B_ELN_chr7_73442599_ENST00000429192_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_25_ELN-METTL2B_ELN_chr7_73442599_ENST00000445912_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_26_ELN-METTL2B_ELN_chr7_73442599_ENST00000445912_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_27_ELN-METTL2B_ELN_chr7_73442599_ENST00000458204_METTL2B_chr7_128140956_ENST00000262432_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

>26282_26282_28_ELN-METTL2B_ELN_chr7_73442599_ENST00000458204_METTL2B_chr7_128140956_ENST00000480046_length(amino acids)=148AA_BP=
MSSINETSFIFFLFYHYFQIQGLSLFCPGWTPGLNGSSLPQPPEWLGLQACTMPGATNFFLKKLGNTTGLHRVGSRCLLAGAGQKGLAVF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:73442599/chr7:128133857)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELN

P15502

METTL2B

Q6P1Q9

FUNCTION: Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). {ECO:0000250|UniProtKB:P54320}.FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). {ECO:0000269|PubMed:28655767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneELNchr7:73442599chr7:128140956ENST00000252034+133236_74227.333333333333332725.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000252034+13397_10227.333333333333332725.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000320399+133236_74227.333333333333332758.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000320399+13397_10227.333333333333332758.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000357036+132236_74227.333333333333332712.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000357036+13297_10227.333333333333332712.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000380553+125236_74227.333333333333332571.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000380553+12597_10227.333333333333332571.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000380562+133236_74227.333333333333332731.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000380562+13397_10227.333333333333332731.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000380575+130236_74227.333333333333332678.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000380575+13097_10227.333333333333332678.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000380576+132236_74227.333333333333332706.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000380576+13297_10227.333333333333332706.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000380584+129236_74227.333333333333332659.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000380584+12997_10227.333333333333332659.0Compositional biasNote=Poly-Ala
HgeneELNchr7:73442599chr7:128140956ENST00000429192+131236_74227.333333333333332693.0Compositional biasNote=Ala-rich
HgeneELNchr7:73442599chr7:128140956ENST00000429192+13197_10227.333333333333332693.0Compositional biasNote=Poly-Ala


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ELN
METTL2B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ELN-METTL2B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ELN-METTL2B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource