UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ELP3-MYO5C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ELP3-MYO5C
	FusionPDB ID: 26329
	FusionGDB2.0 ID: 26329
		Hgene	Tgene
	Gene symbol	ELP3	MYO5C
	Gene ID	55140	55930
	Gene name	elongator acetyltransferase complex subunit 3	myosin VC
	Synonyms	KAT9	-
	Cytomap	8p21.1	15q21.2
	Type of gene	protein-coding	protein-coding
	Description	elongator complex protein 3elongation protein 3 homologprotein lysine acetyltransferase ELP3tRNA uridine(34) acetyltransferase	unconventional myosin-Vcmyosin 5Cmyosin-Vc
	Modification date	20200322	20200313
	UniProtAcc	Q9H9T3	Q9NQX4
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000256398, ENST00000380353, ENST00000521015, ENST00000524103, ENST00000537665, ENST00000542181, ENST00000523760,	ENST00000443683, ENST00000541028, ENST00000261839,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 3=27	5 X 5 X 5=125
	# samples	3	7
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ELP3 [Title/Abstract] AND MYO5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ELP3(28016150)-MYO5C(52500840), # samples:2
Anticipated loss of major functional domain due to fusion event.	ELP3-MYO5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ELP3-MYO5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ELP3-MYO5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ELP3-MYO5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ELP3	GO:0006357	regulation of transcription by RNA polymerase II	11818576

Fusion gene breakpoints across ELP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-7430-01A	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-
ChimerDB4	HNSC	TCGA-CV-7430	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000521015	ELP3	chr8	28016150	+	ENST00000261839	MYO5C	chr15	52500840	-	3853	1340	122	2272	716
ENST00000256398	ELP3	chr8	28016150	+	ENST00000261839	MYO5C	chr15	52500840	-	4147	1634	323	2566	747
ENST00000542181	ELP3	chr8	28016150	+	ENST00000261839	MYO5C	chr15	52500840	-	3680	1167	267	2099	610
ENST00000524103	ELP3	chr8	28016150	+	ENST00000261839	MYO5C	chr15	52500840	-	3773	1260	18	2192	724
ENST00000537665	ELP3	chr8	28016150	+	ENST00000261839	MYO5C	chr15	52500840	-	3658	1145	245	2077	610
ENST00000380353	ELP3	chr8	28016150	+	ENST00000261839	MYO5C	chr15	52500840	-	3661	1148	167	2080	637

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000521015	ENST00000261839	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-	0.000637948	0.99936205
ENST00000256398	ENST00000261839	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-	0.001393076	0.998607
ENST00000542181	ENST00000261839	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-	0.000509036	0.999491
ENST00000524103	ENST00000261839	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-	0.000404131	0.99959594
ENST00000537665	ENST00000261839	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-	0.000542146	0.9994579
ENST00000380353	ENST00000261839	ELP3	chr8	28016150	+	MYO5C	chr15	52500840	-	0.000981549	0.99901843

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26329_26329_1_ELP3-MYO5C_ELP3_chr8_28016150_ENST00000256398_MYO5C_chr15_52500840_ENST00000261839_length(amino acids)=747AA_BP=437
MSLWLHFYLWWLCYGGAEMRQKRKGDLSPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVL
MPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSV
DKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYE
DVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSP
SDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWL
SNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRK
RSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNS
LAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLDTKYLFQVT

--------------------------------------------------------------

>26329_26329_2_ELP3-MYO5C_ELP3_chr8_28016150_ENST00000380353_MYO5C_chr15_52500840_ENST00000261839_length(amino acids)=637AA_BP=327
MCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYR
DYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFH
LAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRV
YRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFM
KHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQL
SYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKK
TTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLDTKYLFQVTFPFTPSPHALEMIQIPSSFK

--------------------------------------------------------------

>26329_26329_3_ELP3-MYO5C_ELP3_chr8_28016150_ENST00000521015_MYO5C_chr15_52500840_ENST00000261839_length(amino acids)=716AA_BP=406
MMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCKPHRCPHIS
FTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDAL
SGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVA
HMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPL
VSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNC
LNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYTTMCQNG
LDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYE

--------------------------------------------------------------

>26329_26329_4_ELP3-MYO5C_ELP3_chr8_28016150_ENST00000524103_MYO5C_chr15_52500840_ENST00000261839_length(amino acids)=724AA_BP=414
MFCGCQLSPWSEFVAAFLSLVALLRRRRNEAEAERVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCK
PHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYF
IRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAK
DSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRVYRV
QRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHN
SPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYF
YTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTD
SDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLDTKYLFQVTFPFTPSPHALEMIQIPSSFKLGF

--------------------------------------------------------------

>26329_26329_5_ELP3-MYO5C_ELP3_chr8_28016150_ENST00000537665_MYO5C_chr15_52500840_ENST00000261839_length(amino acids)=610AA_BP=300
MSTHQFYRKYMCPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSE
RSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIE
QFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALA
RMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDV
AIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFL
IGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNS

--------------------------------------------------------------

>26329_26329_6_ELP3-MYO5C_ELP3_chr8_28016150_ENST00000542181_MYO5C_chr15_52500840_ENST00000261839_length(amino acids)=610AA_BP=300
MSTHQFYRKYMCPTSMRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSE
RSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIE
QFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALA
RMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDV
AIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFL
IGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:28016150/chr15:52500840)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ELP3 Q9H9T3	MYO5C Q9NQX4
FUNCTION: Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576, PubMed:15902492, PubMed:16713582). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). {ECO:0000250\|UniProtKB:D5VRB9, ECO:0000250\|UniProtKB:Q9CZX0, ECO:0000269\|PubMed:11714725, ECO:0000269\|PubMed:11818576, ECO:0000269\|PubMed:15902492, ECO:0000269\|PubMed:16713582, ECO:0000269\|PubMed:19185337, ECO:0000269\|PubMed:29415125}.	FUNCTION: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000256398

82_372

419.0

548.0

Domain

Radical SAM core

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000521015

82_372

405.0

534.0

Domain

Radical SAM core

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000256398

396_547

419.0

548.0

Domain

N-acetyltransferase

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000521015

396_547

405.0

534.0

Domain

N-acetyltransferase

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000256398

474_477

419.0

548.0

Region

Acetyl-CoA binding

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000256398

497_499

419.0

548.0

Region

Acetyl-CoA binding

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000521015

474_477

405.0

534.0

Region

Acetyl-CoA binding

Hgene

ELP3

chr8:28016150

chr15:52500840

ENST00000521015

497_499

405.0

534.0

Region

Acetyl-CoA binding

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

884_1351

1432.0

1743.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

1421_1697

1432.0

1743.0

Domain

Dilute

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

67_753

1432.0

1743.0

Domain

Myosin motor

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

756_779

1432.0

1743.0

Domain

IQ 1

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

780_806

1432.0

1743.0

Domain

IQ 2

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

807_829

1432.0

1743.0

Domain

IQ 3

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

830_854

1432.0

1743.0

Domain

IQ 4

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

855_884

1432.0

1743.0

Domain

IQ 5

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

8_62

1432.0

1743.0

Domain

Myosin N-terminal SH3-like

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

161_168

1432.0

1743.0

Nucleotide binding

ATP

Tgene

MYO5C

chr8:28016150

chr15:52500840

ENST00000261839

632_654

1432.0

1743.0

Region

Actin-binding

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1506_ELP3_28016150_MYO5C_52500840_ranked_0.pdb	ELP3	28016150	28016150	ENST00000261839	MYO5C	chr15	52500840	-	MSLWLHFYLWWLCYGGAEMRQKRKGDLSPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVDIIAAVPPQYRKVL MPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLGHSV DKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYE DVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSP SDLVELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQEIHHKVRPYQEHLEDFEMLSFWL SNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRK RSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNS LAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLDTKYLFQVT	747

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ELP3_pLDDT.png

MYO5C_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ELP3
MYO5C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ELP3-MYO5C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ELP3-MYO5C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source