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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EME1-ERBB2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EME1-ERBB2
	FusionPDB ID: 26396
	FusionGDB2.0 ID: 26396
		Hgene	Tgene
	Gene symbol	EME1	ERBB2
	Gene ID	146956	2064
	Gene name	essential meiotic structure-specific endonuclease 1	erb-b2 receptor tyrosine kinase 2
	Synonyms	MMS4L\|SLX2A	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1
	Cytomap	17q21.33	17q12
	Type of gene	protein-coding	protein-coding
	Description	crossover junction endonuclease EME1MMS4 homologSLX2 structure-specific endonuclease subunit homolog Aessential meiotic endonuclease 1 homolog 1essential meiotic endonuclease 1 homolog 2hMMS4homolog of yeast EME1 endonuclease	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2
	Modification date	20200313	20200329
	UniProtAcc	Q96AY2	P04626
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000338165, ENST00000393271, ENST00000511648,	ENST00000540042, ENST00000578199, ENST00000584888, ENST00000269571, ENST00000406381, ENST00000445658, ENST00000540147, ENST00000541774, ENST00000584450, ENST00000584601,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 1=4	34 X 40 X 10=13600
	# samples	2	43
	** MAII score	log2(2/4*10)=2.32192809488736	log2(43/13600*10)=-4.9831261814356 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EME1 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EME1(48452873)-ERBB2(37882815), # samples:1
Anticipated loss of major functional domain due to fusion event.	EME1-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EME1-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EME1-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EME1-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ERBB2	GO:0007165	signal transduction	10572067
Tgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Tgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Tgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Tgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Tgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Tgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Tgene	ERBB2	GO:0042060	wound healing	12646923
Tgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Tgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Tgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Tgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Tgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Tgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across EME1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERBB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1F2-01A	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393271	EME1	chr17	48452873	+	ENST00000584601	ERBB2	chr17	37882815	+	1742	529	66	1424	452
ENST00000393271	EME1	chr17	48452873	+	ENST00000406381	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000393271	EME1	chr17	48452873	+	ENST00000541774	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000393271	EME1	chr17	48452873	+	ENST00000445658	ERBB2	chr17	37882815	+	1460	529	66	1424	452
ENST00000393271	EME1	chr17	48452873	+	ENST00000540147	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000393271	EME1	chr17	48452873	+	ENST00000584450	ERBB2	chr17	37882815	+	1172	529	66	824	252
ENST00000393271	EME1	chr17	48452873	+	ENST00000269571	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000338165	EME1	chr17	48452873	+	ENST00000584601	ERBB2	chr17	37882815	+	1742	529	66	1424	452
ENST00000338165	EME1	chr17	48452873	+	ENST00000406381	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000338165	EME1	chr17	48452873	+	ENST00000541774	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000338165	EME1	chr17	48452873	+	ENST00000445658	ERBB2	chr17	37882815	+	1460	529	66	1424	452
ENST00000338165	EME1	chr17	48452873	+	ENST00000540147	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000338165	EME1	chr17	48452873	+	ENST00000584450	ERBB2	chr17	37882815	+	1172	529	66	824	252
ENST00000338165	EME1	chr17	48452873	+	ENST00000269571	ERBB2	chr17	37882815	+	2043	529	66	1424	452
ENST00000511648	EME1	chr17	48452873	+	ENST00000584601	ERBB2	chr17	37882815	+	1684	471	8	1366	452
ENST00000511648	EME1	chr17	48452873	+	ENST00000406381	ERBB2	chr17	37882815	+	1985	471	8	1366	452
ENST00000511648	EME1	chr17	48452873	+	ENST00000541774	ERBB2	chr17	37882815	+	1985	471	8	1366	452
ENST00000511648	EME1	chr17	48452873	+	ENST00000445658	ERBB2	chr17	37882815	+	1402	471	8	1366	452
ENST00000511648	EME1	chr17	48452873	+	ENST00000540147	ERBB2	chr17	37882815	+	1985	471	8	1366	452
ENST00000511648	EME1	chr17	48452873	+	ENST00000584450	ERBB2	chr17	37882815	+	1114	471	8	766	252
ENST00000511648	EME1	chr17	48452873	+	ENST00000269571	ERBB2	chr17	37882815	+	1985	471	8	1366	452

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393271	ENST00000584601	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.008206832	0.9917931
ENST00000393271	ENST00000406381	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000393271	ENST00000541774	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000393271	ENST00000445658	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.008419556	0.9915804
ENST00000393271	ENST00000540147	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000393271	ENST00000584450	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.08464549	0.9153545
ENST00000393271	ENST00000269571	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000338165	ENST00000584601	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.008206832	0.9917931
ENST00000338165	ENST00000406381	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000338165	ENST00000541774	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000338165	ENST00000445658	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.008419556	0.9915804
ENST00000338165	ENST00000540147	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000338165	ENST00000584450	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.08464549	0.9153545
ENST00000338165	ENST00000269571	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005731222	0.9942688
ENST00000511648	ENST00000584601	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.00815844	0.99184155
ENST00000511648	ENST00000406381	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005661003	0.99433905
ENST00000511648	ENST00000541774	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005661003	0.99433905
ENST00000511648	ENST00000445658	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.008179354	0.9918207
ENST00000511648	ENST00000540147	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005661003	0.99433905
ENST00000511648	ENST00000584450	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.1041308	0.89586914
ENST00000511648	ENST00000269571	EME1	chr17	48452873	+	ERBB2	chr17	37882815	+	0.005661003	0.99433905

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26396_26396_1_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000269571_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_2_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000406381_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_3_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000445658_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_4_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000540147_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_5_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000541774_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_6_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000584450_length(amino acids)=252AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP

--------------------------------------------------------------

>26396_26396_7_EME1-ERBB2_EME1_chr17_48452873_ENST00000338165_ERBB2_chr17_37882815_ENST00000584601_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_8_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000269571_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_9_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000406381_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_10_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000445658_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_11_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000540147_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_12_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000541774_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

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>26396_26396_13_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000584450_length(amino acids)=252AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP

--------------------------------------------------------------

>26396_26396_14_EME1-ERBB2_EME1_chr17_48452873_ENST00000393271_ERBB2_chr17_37882815_ENST00000584601_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_15_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000269571_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_16_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000406381_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_17_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000445658_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_18_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000540147_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_19_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000541774_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

>26396_26396_20_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000584450_length(amino acids)=252AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP

--------------------------------------------------------------

>26396_26396_21_EME1-ERBB2_EME1_chr17_48452873_ENST00000511648_ERBB2_chr17_37882815_ENST00000584601_length(amino acids)=452AA_BP=153
MTHKQLSPEDSSSPVKSVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQSSSLAVTKTNSDILP
PQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRMKAQRPEECLKHIIVVLDPGWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRS
PLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48452873/chr17:37882815)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EME1 Q96AY2	ERBB2 P04626
FUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269\|PubMed:12686547, ECO:0000269\|PubMed:12721304, ECO:0000269\|PubMed:14617801, ECO:0000269\|PubMed:17289582}.	FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000269571

720_987

957.3333333333334

1256.0

Domain

Protein kinase

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000541774

720_987

942.3333333333334

1241.0

Domain

Protein kinase

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000269571

676_689

957.3333333333334

1256.0

Motif

Note=Nuclear localization signal

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000541774

676_689

942.3333333333334

1241.0

Motif

Note=Nuclear localization signal

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000269571

726_734

957.3333333333334

1256.0

Nucleotide binding

ATP

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000541774

726_734

942.3333333333334

1241.0

Nucleotide binding

ATP

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000269571

23_652

957.3333333333334

1256.0

Topological domain

Extracellular

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000269571

676_1255

957.3333333333334

1256.0

Topological domain

Cytoplasmic

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000541774

23_652

942.3333333333334

1241.0

Topological domain

Extracellular

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000541774

676_1255

942.3333333333334

1241.0

Topological domain

Cytoplasmic

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000269571

653_675

957.3333333333334

1256.0

Transmembrane

Helical

Tgene

ERBB2

chr17:48452873

chr17:37882815

ENST00000541774

653_675

942.3333333333334

1241.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EME1
ERBB2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to EME1-ERBB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to EME1-ERBB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source