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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EML1-ABL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EML1-ABL1
FusionPDB ID: 26424
FusionGDB2.0 ID: 26424
HgeneTgene
Gene symbol

EML1

ABL1

Gene ID

2009

25

Gene nameEMAP like 1ABL proto-oncogene 1, non-receptor tyrosine kinase
SynonymsBH|ELP79|EMAP|EMAP-1|EMAPLABL|BCR-ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl
Cytomap

14q32.2

9q34.12

Type of geneprotein-codingprotein-coding
Descriptionechinoderm microtubule-associated protein-like 1echinoderm microtubule associated protein like 1tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncated
Modification date2020031320200327
UniProtAcc

O00423

P00519

Ensembl transtripts involved in fusion geneENST idsENST00000262233, ENST00000327921, 
ENST00000334192, ENST00000556758, 
ENST00000318560, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 8 X 11=132021 X 149 X 8=25032
# samples 17154
** MAII scorelog2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(154/25032*10)=-4.02277130765866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EML1 [Title/Abstract] AND ABL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABL1

GO:0006974

cellular response to DNA damage stimulus

15657060

TgeneABL1

GO:0006975

DNA damage induced protein phosphorylation

18280240

TgeneABL1

GO:0018108

peptidyl-tyrosine phosphorylation

7590236|9144171|10713049|11121037

TgeneABL1

GO:0038083

peptidyl-tyrosine autophosphorylation

10518561

TgeneABL1

GO:0042770

signal transduction in response to DNA damage

9037071|15657060

TgeneABL1

GO:0043065

positive regulation of apoptotic process

9037071

TgeneABL1

GO:0046777

protein autophosphorylation

10713049

TgeneABL1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

15657060

TgeneABL1

GO:0051353

positive regulation of oxidoreductase activity

12893824

TgeneABL1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

20823226

TgeneABL1

GO:0070301

cellular response to hydrogen peroxide

10713049

TgeneABL1

GO:0071103

DNA conformation change

9558345

TgeneABL1

GO:0071901

negative regulation of protein serine/threonine kinase activity

11121037

TgeneABL1

GO:1990051

activation of protein kinase C activity

10713049

TgeneABL1

GO:2001020

regulation of response to DNA damage stimulus

9461559


check buttonFusion gene breakpoints across EML1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..EML1chr14

100387214

+ABL1chr9

133729450

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327921EML1chr14100387214+ENST00000318560ABL1chr9133729450+8270296497462771767
ENST00000262233EML1chr14100387214+ENST00000318560ABL1chr9133729450+7354204813953611740
ENST00000334192EML1chr14100387214+ENST00000318560ABL1chr9133729450+7406210013454131759

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26424_26424_1_EML1-ABL1_EML1_chr14_100387214_ENST00000262233_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1740AA_BP=628
MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQT
LPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVF
SAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGH
NDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQK
EEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNR
ISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQ
GHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLS
VMRYSPEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGW
VPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH
HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM
KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVA
DFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE
LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESD
PLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTP
LDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDL
QSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGL
PHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQ
EAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRV
SLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQIC

--------------------------------------------------------------

>26424_26424_2_EML1-ABL1_EML1_chr14_100387214_ENST00000327921_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1767AA_BP=655
MPPASPLGGGAAGRLTQGRPGLLSSASRRLDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPT
KARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKRLNRSVSLLNACKLNRSTPSNIKRTSSSERVSPGGRRESNGDSRG
NRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPT
GETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAF
SKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLC
VTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGK
GDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGT
LTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSIT
KGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYH
YRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKK
YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY
LEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI
DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTR
TSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFRE
MDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRF
LRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIME
SSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLS
RLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPS
TLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDS

--------------------------------------------------------------

>26424_26424_3_EML1-ABL1_EML1_chr14_100387214_ENST00000334192_ABL1_chr9_133729450_ENST00000318560_length(amino acids)=1759AA_BP=647
MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQT
LPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKRLNRSVSLLNACKLNRSTPSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGST
SSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIA
SVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTN
LCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGD
TITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGT
TRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVF
DTETKDLVTVHTDGNEQLSVMRYSPEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVL
GYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASD
GKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK
TLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH
RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL
LEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEH
RDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERR
GAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASC
VPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPP
NLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPP
PPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSA
LAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML1

O00423

ABL1

P00519

FUNCTION: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}.FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (1004) >>>1004.pdbFusion protein BP residue: 628
CIF file (1004) >>>1004.cif		EML1chr14100387214+ABL1chr9133729450+
MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQED
DIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNG
TVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPGGRRESNGD
SRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYM
PKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFI
ASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQ
LPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSND
HVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTL
EGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNR
ISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIP
EQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLA
IHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVA
VGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPEALQRPVASDFEPQ
GLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRV
LGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSES
RFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM
KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVL
LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG
DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY
PGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIH
QAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRD
ISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKS
STLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDL
QSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKN
EEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKG
KLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDA
VNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASS
ALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKL
1740
3D view using mol* of 1004 (AA BP:628)
PDB file (1014) >>>1014.pdbFusion protein BP residue: 647
CIF file (1014) >>>1014.cif		EML1chr14100387214+ABL1chr9133729450+
MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQED
DIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNG
TVLPKKPTGSLPSPSGVRKETAVPATKRLNRSVSLLNACKLNRSTPSNIK
RTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFS
AEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRG
RDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHP
DRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCI
AFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHP
TDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGD
TITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKD
RKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTL
SGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDK
IIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSV
MRYSPEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYD
FVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS
LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV
YHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRN
KPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK
TLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG
NLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV
GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD
VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYEL
MRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVST
LLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPL
LPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSF
REMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNG
ALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASC
VPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENR
SDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQ
VTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAE
ESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQE
AAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKP
SGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPER
IASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYV
DSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSV
1759
3D view using mol* of 1014 (AA BP:647)
PDB file (1020) >>>1020.pdbFusion protein BP residue: 655
CIF file (1020) >>>1020.cif		EML1chr14100387214+ABL1chr9133729450+
MPPASPLGGGAAGRLTQGRPGLLSSASRRLDDSASAASSMEVTDRIASLE
QRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLP
LRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKRLNRSVSLLNACKLN
RSTPSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSES
KPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKL
EWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDD
VKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGF
FDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEA
VFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLC
VTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGT
LVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTR
NFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAV
GHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHT
DGNEQLSVMRYSPEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDP
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPS
NYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSI
SLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTL
HYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKK
YSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI
ITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAY
NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG
CPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQ
GVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLD
HEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPT
PPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPS
NGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRF
LRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALP
RKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNL
TPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPG
GTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGK
PSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPAT
PKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLR
KTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNL
YTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQD
1767
3D view using mol* of 1020 (AA BP:655)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EML1_pLDDT.png
all structure
all structure
ABL1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EML1_ABL1_1004_pLDDT.png (AA BP:628)
all structure
EML1_ABL1_1004_pLDDT_and_active_sites.png (AA BP:628)
all structure
EML1_ABL1_1004_violinplot.png (AA BP:628)
all structure
EML1_ABL1_1014_pLDDT.png (AA BP:647)
all structure
EML1_ABL1_1014_pLDDT_and_active_sites.png (AA BP:647)
all structure
EML1_ABL1_1014_violinplot.png (AA BP:647)
all structure
EML1_ABL1_1020_pLDDT.png (AA BP:655)
all structure
EML1_ABL1_1020_pLDDT_and_active_sites.png (AA BP:655)
all structure
EML1_ABL1_1020_violinplot.png (AA BP:655)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
EML1_ABL1_1004.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
10041.0611651.102803.9920.6670.7390.8410.7610.8640.8810.772Chain A: 50,53,54,57,61,64,226,227,230,232,233,250
,251,252,270,271,273,295,296,301,524,541,542,543,5
44,545,546,547,558,560,570,1346,1347,1348,1349,135
0
10041.0611651.102803.9920.6670.7390.8410.7610.8640.8810.772Chain A: 50,53,54,57,61,64,226,227,230,232,233,250
,251,252,270,271,273,295,296,301,524,541,542,543,5
44,545,546,547,558,560,570,1346,1347,1348,1349,135
0
10141.0791031.118205.4570.4610.7651.082.2980.8612.6670.993Chain A: 961,965,966,969,970,973,1058,1061,1062,10
63,1064,1066,1090,1091,1092,1093,1094,1097,1122,11
31,1132,1135,1136,1139
10201.0482701.0771131.2140.6210.7410.8240.4180.9440.4430.648Chain A: 707,708,709,710,712,736,752,769,770,771,7
72,773,777,789,790,791,792,793,797,798,799,810,812
,856,857,858,859,860,861,862,864,865,901,903,904,9
33,934,937,939,953,954,955,956,979,982,983,986,989
,1009,1010,1011,1013,1015,1127,1128,1131,1132,1133
,1134,1135

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
1014ZINC000035342789DB00323Tolcapone-7.05917-8.59617
1014ZINC000000004321DB00909Zonisamide-8.51605-8.51745
1014ZINC000000020243DB00861Diflunisal-8.24662-8.24662
1014ZINC000000001644DB06795Mafenide-8.18313-8.21273
1014ZINC000001481956DB01267Paliperidone-8.09778-8.10778
1014ZINC000000000850DB00744Zileuton-8.01452-8.03312
1014ZINC000003810860DB00973Ezetimibe-7.94597-7.94657
1014ZINC000000002279DB00465Ketorolac-7.81144-7.81174
1014ZINC000002568036DB01219Dantrolene-7.73827-7.81067
1014ZINC000252679615DB01219Dantrolene-7.73827-7.81067
1014ZINC000001547851DB11868Etiracetam-7.80666-7.80666
1014ZINC000000897291DB00754Ethotoin-7.78525-7.78525
1014ZINC000000403011DB00598Labetalol-7.74208-7.76968
1014InfigratinibDB00598-7.17186-7.73866
1014ZINC000019166988DB01168Procarbazine-6.94168-7.73468
1014ZINC000095616600DB01162Terazosin-7.59107-7.71337
1014ZINC000004213946DB04861Nebivolol-7.68667-7.70647
1014ZINC000000896731DB00744Zileuton-7.64846-7.66706
1014EntrectinibDB00744-7.59693-7.66163
1014ZINC000003938686DB09073Palbociclib-7.20874-7.61564

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000035342789DB00323TolcaponeSmall moleculeCC1=CC=C(C=C1)C(=O)C1=CC(=C(O)C(O)=C1)[N+]([O-])=OApproved|Withdrawn
ZINC000000004321DB00909ZonisamideSmall moleculeNS(=O)(=O)CC1=NOC2=CC=CC=C12Approved|Investigational
ZINC000000020243DB00861DiflunisalSmall moleculeOC(=O)C1=C(O)C=CC(=C1)C1=C(F)C=C(F)C=C1Approved|Investigational
ZINC000000001644DB06795MafenideSmall moleculeNCC1=CC=C(C=C1)S(N)(=O)=OApproved|Vet_approved
ZINC000003810860DB00973EzetimibeSmall molecule[H][C@]1(CC[C@H](O)C2=CC=C(F)C=C2)C(=O)N(C2=CC=C(F)C=C2)[C@]1([H])C1=CC=C(O)C=C1Approved
ZINC000000897291DB00754EthotoinSmall moleculeCCN1C(=O)NC(C1=O)C1=CC=CC=C1Approved
ZINC000000403011DB00598LabetalolSmall moleculeCC(CCC1=CC=CC=C1)NCC(O)C1=CC(C(N)=O)=C(O)C=C1Approved
ZINC000019166988DB01168ProcarbazineSmall moleculeCNNCC1=CC=C(C=C1)C(=O)NC(C)CApproved|Investigational
ZINC000095616600DB01162TerazosinSmall moleculeCOC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1Approved
ZINC000000896731DB00744ZileutonSmall moleculeCC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1Approved|Investigational|Withdrawn
ZINC000003938686DB09073PalbociclibSmall moleculeCC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=OApproved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000035342789273.2453.817507.14288.195223.7195.2470847.54824.59.508367.93400
ZINC000035342789273.2455.603506.16988.195222.204195.7690846.89124.59.828368.23300
ZINC000035342789273.2453.5506.84288.2223.976194.6650847.73424.59.758367.88100
ZINC000000004321212.2236.978398.51740.32185.554172.6440642.453269.667365.95900
ZINC000000020243250.2018.261459.0810144.436231.00583.64751.87911.759.879386.60100
ZINC000000001644186.2287.234386.68948.38203.852132.6441.813608.20845.59.936246.46100
ZINC000000001644186.2288.543384.51348.79201.796132.1141.813604.74745.59.902246.800
ZINC000001481956426.496.141752.005422.303130.375152.60746.7211346.95819.29.231381.77600
ZINC000001481956426.491.857723.955405.195122.93149.10546.7251317.20219.28.974382.30400
ZINC000001481956426.492.145726.939410.514126.461143.23746.7261319.9819.28.896381.61400
ZINC000000000850236.2885.297457.64285.783137.035198.52336.3755.01533.78.91375.35100
ZINC000000000850236.2885.297450.83785.532135.419201.89327.994746.83933.78.57376.55500
ZINC000003810860409.4325.656707.47174.233136.697402.90893.6341265.98724.458.806191.96111
ZINC000000002279255.2733.044495.822105.732131.032259.0580834.473149.205382.04700
ZINC000002568036314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000002568036314.2574.186547.354.729241.127251.4440922.097159.191367.40800
ZINC000252679615314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000252679615314.2572.557527.99664.383238.233225.380905.494159.686367.50600
ZINC000252679615314.2574.186547.354.729241.127251.4440922.097159.191367.40800
ZINC000252679615314.2572.845525.88465.15235.939224.7950902.055159.671367.87500
ZINC000001547851170.2113.554386.861254.133132.72800627.87225.59.606259.07500
ZINC000000897291204.2283.869431.423142.513103.489185.4210709.49613.59.903391.5500
ZINC000000403011328.415.963663.486168.781199.564295.14101140.57745.459.137270.60500
ZINC000000403011328.415.239606.942175.803170.799260.3401103.55145.459.225375.4400
ZINC000019166988221.3025.151533.024317.38679.069136.5690867.03534.59.068263.82500
ZINC000019166988221.3022.959530.183307.97987135.2030867.50734.59.071262.56200
ZINC000019166988221.3024.898530.515312.56881.955135.9930866.07934.59.171263.37600
ZINC000095616600387.4383.484683.684501.80499.56582.31401204.31129.28.08388.39200
ZINC000095616600387.4386.762682.993500.185102.06680.74101202.59229.28.003387.67900
ZINC000095616600387.4387.021685.562503.545100.681.41701204.54629.28.074388.18800
ZINC000004213946405.4415.213712.775270.54687.695260.77393.7611260.0136.49.251394.55500
ZINC000004213946405.4413.313660.255261.06875.583229.84493.761216.09336.49.124395.53300
ZINC000000896731236.2883.773444.59884.301131.134195.10534.058746.48133.78.644378.1800
ZINC000000896731236.2885.297450.81685.528135.414201.88127.993746.81233.78.57376.55600
ZINC000003938686447.5398.82766.315477.598137.176151.54101402.5882118.081376.62700
ZINC000003938686447.5398.648773.964490.638134.585148.74101410.0512118.181377.38600
ZINC000003938686447.5399.527761.155473.791137.885149.47801397.3732118.061376.300


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000035342789Cc1ccc(C(=O)c2cc(O)c(O)c([N+](=O)[O-])c2)cc10.3597350140.498165074
ZINC000000004321NS(=O)(=O)Cc1noc2ccccc120.2545692540.46155884
ZINC000000020243O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O0.4404093730.371648269
ZINC000000001644NCc1ccc(S(N)(=O)=O)cc10.4977746040.389970963
ZINC000001481956Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCC[C@H]2O0.0984468390.237911295
ZINC000000000850C[C@@H](c1cc2ccccc2s1)N(O)C(N)=O0.1363358820.223511692
ZINC000003810860O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc10.1137834410.30369071
ZINC000000002279O=C(c1ccccc1)c1ccc2n1CC[C@H]2C(=O)O0.1838270870.226019126
ZINC000002568036O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N10.2040708230.461176527
ZINC000252679615O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N10.1491321090.500589886
ZINC000001547851CC[C@@H](C(N)=O)N1CCCC1=O0.1573358610.410047131
ZINC000000897291CCN1C(=O)N[C@@H](c2ccccc2)C1=O0.2167644750.437555471
ZINC000000403011C[C@@H](CCc1ccccc1)NC[C@@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000019166988CNNCc1ccc(C(=O)NC(C)C)cc10.3715211350.443020826
ZINC000095616600COc1cc2nc(N3CCN(C(=O)[C@H]4CCCO4)CC3)nc(N)c2cc1OC0.1601562120.285367515
ZINC000004213946O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000000896731C[C@H](c1cc2ccccc2s1)N(O)C(N)=O0.1363358820.223511692
ZINC000003938686CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O0.1541407730.105977064


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EML1ISG20L2, DCUN1D1, TUBA1B, TUBB3, TUBB2A, TUBB2B, DCTN1, Nek9, EML1, TUBA1A, FBXO28, EML4, TUBB, AGR2, KIAA1429, MTDH, MKRN2, FXR1, PTEN, UBE3A, PRPS2, NUDC, KXD1, NEK9, EML2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EML1all structure
ABL1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EML1-ABL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EML1-ABL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEML1C4284594BAND HETEROTOPIA2GENOMICS_ENGLAND;UNIPROT
HgeneEML1C1848201Subcortical Band Heterotopia1ORPHANET
TgeneABL1C0023473Myeloid Leukemia, Chronic3CGI;CTD_human;ORPHANET
TgeneABL1C0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneABL1C0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneABL1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CGI;CTD_human
TgeneABL1C0001418Adenocarcinoma1CTD_human
TgeneABL1C0003706Arachnodactyly1GENOMICS_ENGLAND
TgeneABL1C0005941Bone Diseases, Developmental1CTD_human
TgeneABL1C0006142Malignant neoplasm of breast1CTD_human
TgeneABL1C0006413Burkitt Lymphoma1ORPHANET
TgeneABL1C0014859Esophageal Neoplasms1CTD_human
TgeneABL1C0015544Failure to Thrive1CTD_human
TgeneABL1C0018798Congenital Heart Defects1CTD_human
TgeneABL1C0023903Liver neoplasms1CTD_human
TgeneABL1C0027659Neoplasms, Experimental1CTD_human
TgeneABL1C0032927Precancerous Conditions1CTD_human
TgeneABL1C0039075Syndactyly1GENOMICS_ENGLAND
TgeneABL1C0151491Congenital musculoskeletal anomalies1CTD_human
TgeneABL1C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneABL1C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneABL1C0205643Carcinoma, Cribriform1CTD_human
TgeneABL1C0205644Carcinoma, Granular Cell1CTD_human
TgeneABL1C0205645Adenocarcinoma, Tubular1CTD_human
TgeneABL1C0265610Clinodactyly of fingers1GENOMICS_ENGLAND
TgeneABL1C0282313Condition, Preneoplastic1CTD_human
TgeneABL1C0345904Malignant neoplasm of liver1CTD_human
TgeneABL1C0546837Malignant neoplasm of esophagus1CTD_human
TgeneABL1C0596263Carcinogenesis1CTD_human
TgeneABL1C0678222Breast Carcinoma1CTD_human
TgeneABL1C1257931Mammary Neoplasms, Human1CTD_human
TgeneABL1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneABL1C1458155Mammary Neoplasms1CTD_human
TgeneABL1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CGI;ORPHANET
TgeneABL1C4539857CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME1GENOMICS_ENGLAND;UNIPROT
TgeneABL1C4551485Clinodactyly1GENOMICS_ENGLAND
TgeneABL1C4704874Mammary Carcinoma, Human1CTD_human