UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EML4-CASK

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EML4-CASK
	FusionPDB ID: 26456
	FusionGDB2.0 ID: 26456
		Hgene	Tgene
	Gene symbol	EML4	CASK
	Gene ID	27436	8573
	Gene name	EMAP like 4	calcium/calmodulin dependent serine protein kinase
	Synonyms	C2orf2\|ELP120\|EMAP-4\|EMAPL4\|ROPP120	CAGH39\|CAMGUK\|CMG\|FGS4\|LIN2\|MICPCH\|MRXSNA\|TNRC8\|hCASK
	Cytomap	2p21	Xp11.4
	Type of gene	protein-coding	protein-coding
	Description	echinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120	peripheral plasma membrane protein CASKcalcium/calmodulin-dependent serin protein kinasecalcium/calmodulin-dependent serine protein kinase (MAGUK family)calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinaseprotein lin
	Modification date	20200313	20200327
	UniProtAcc	Q9HC35	Q8WXE0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000482660, ENST00000318522, ENST00000401738, ENST00000402711, ENST00000453191,	ENST00000318588, ENST00000361962, ENST00000378158, ENST00000378163, ENST00000378166, ENST00000421587, ENST00000442742, ENST00000378154, ENST00000472704,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 32 X 18=12672	15 X 14 X 9=1890
	# samples	43	17
	** MAII score	log2(43/12672*10)=-4.88116377049015 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1890*10)=-3.47477958297073 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EML4 [Title/Abstract] AND CASK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EML4(42396776)-CASK(41420897), # samples:4
Anticipated loss of major functional domain due to fusion event.	EML4-CASK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-CASK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-CASK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-CASK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CASK	GO:0010839	negative regulation of keratinocyte proliferation	18664494

Fusion gene breakpoints across EML4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CASK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0158-01A	EML4	chr2	42396776	-	CASK	chrX	41420897	-
ChimerDB4	GBM	TCGA-06-0158-01A	EML4	chr2	42396776	+	CASK	chrX	41420897	-
ChimerDB4	GBM	TCGA-06-0158	EML4	chr2	42396776	+	CASK	chrX	41420897	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000318522	EML4	chr2	42396776	+	ENST00000421587	CASK	chrX	41420897	-	6903	287	262	1416	384
ENST00000318522	EML4	chr2	42396776	+	ENST00000318588	CASK	chrX	41420897	-	6957	287	262	1470	402
ENST00000318522	EML4	chr2	42396776	+	ENST00000361962	CASK	chrX	41420897	-	6921	287	262	1434	390
ENST00000318522	EML4	chr2	42396776	+	ENST00000378163	CASK	chrX	41420897	-	2641	287	262	1485	407
ENST00000318522	EML4	chr2	42396776	+	ENST00000378158	CASK	chrX	41420897	-	2202	287	262	1434	390
ENST00000318522	EML4	chr2	42396776	+	ENST00000378166	CASK	chrX	41420897	-	1801	287	262	1470	402
ENST00000318522	EML4	chr2	42396776	+	ENST00000442742	CASK	chrX	41420897	-	1486	287	262	1401	379
ENST00000402711	EML4	chr2	42396776	+	ENST00000421587	CASK	chrX	41420897	-	6900	284	259	1413	384
ENST00000402711	EML4	chr2	42396776	+	ENST00000318588	CASK	chrX	41420897	-	6954	284	259	1467	402
ENST00000402711	EML4	chr2	42396776	+	ENST00000361962	CASK	chrX	41420897	-	6918	284	259	1431	390
ENST00000402711	EML4	chr2	42396776	+	ENST00000378163	CASK	chrX	41420897	-	2638	284	259	1482	407
ENST00000402711	EML4	chr2	42396776	+	ENST00000378158	CASK	chrX	41420897	-	2199	284	259	1431	390
ENST00000402711	EML4	chr2	42396776	+	ENST00000378166	CASK	chrX	41420897	-	1798	284	259	1467	402
ENST00000402711	EML4	chr2	42396776	+	ENST00000442742	CASK	chrX	41420897	-	1483	284	259	1398	379
ENST00000401738	EML4	chr2	42396776	+	ENST00000421587	CASK	chrX	41420897	-	6792	176	151	1305	384
ENST00000401738	EML4	chr2	42396776	+	ENST00000318588	CASK	chrX	41420897	-	6846	176	151	1359	402
ENST00000401738	EML4	chr2	42396776	+	ENST00000361962	CASK	chrX	41420897	-	6810	176	151	1323	390
ENST00000401738	EML4	chr2	42396776	+	ENST00000378163	CASK	chrX	41420897	-	2530	176	151	1374	407
ENST00000401738	EML4	chr2	42396776	+	ENST00000378158	CASK	chrX	41420897	-	2091	176	151	1323	390
ENST00000401738	EML4	chr2	42396776	+	ENST00000378166	CASK	chrX	41420897	-	1690	176	151	1359	402
ENST00000401738	EML4	chr2	42396776	+	ENST00000442742	CASK	chrX	41420897	-	1375	176	151	1290	379

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000318522	ENST00000421587	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000377726	0.9996222
ENST00000318522	ENST00000318588	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000225136	0.9997749
ENST00000318522	ENST00000361962	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000269044	0.9997309
ENST00000318522	ENST00000378163	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000147963	0.99985206
ENST00000318522	ENST00000378158	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000342145	0.99965787
ENST00000318522	ENST00000378166	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.001016354	0.9989837
ENST00000318522	ENST00000442742	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.002948814	0.9970511
ENST00000402711	ENST00000421587	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000377791	0.9996222
ENST00000402711	ENST00000318588	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000225294	0.99977475
ENST00000402711	ENST00000361962	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000269205	0.99973077
ENST00000402711	ENST00000378163	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000148045	0.99985194
ENST00000402711	ENST00000378158	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000345681	0.9996543
ENST00000402711	ENST00000378166	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.001003589	0.99899644
ENST00000402711	ENST00000442742	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.002844635	0.9971553
ENST00000401738	ENST00000421587	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000364263	0.9996357
ENST00000401738	ENST00000318588	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000216091	0.99978393
ENST00000401738	ENST00000361962	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000258111	0.99974185
ENST00000401738	ENST00000378163	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000140788	0.9998592
ENST00000401738	ENST00000378158	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000319306	0.99968076
ENST00000401738	ENST00000378166	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.000851463	0.9991485
ENST00000401738	ENST00000442742	EML4	chr2	42396776	+	CASK	chrX	41420897	-	0.002267891	0.99773204

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26456_26456_1_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000318588_length(amino acids)=402AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHD
QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQR

--------------------------------------------------------------

>26456_26456_2_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000361962_length(amino acids)=390AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQF
EYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDK
YLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL
EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIIN

--------------------------------------------------------------

>26456_26456_3_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000378158_length(amino acids)=390AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQF
EYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDK
YLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL
EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIIN

--------------------------------------------------------------

>26456_26456_4_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000378163_length(amino acids)=407AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY
FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKES

--------------------------------------------------------------

>26456_26456_5_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000378166_length(amino acids)=402AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHD
QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQR

--------------------------------------------------------------

>26456_26456_6_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000421587_length(amino acids)=384AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIP
CKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQ
LDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHE
DAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDET

--------------------------------------------------------------

>26456_26456_7_EML4-CASK_EML4_chr2_42396776_ENST00000318522_CASK_chrX_41420897_ENST00000442742_length(amino acids)=379AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIP
CKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVT
YEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYG
TKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLE

--------------------------------------------------------------

>26456_26456_8_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000318588_length(amino acids)=402AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHD
QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQR

--------------------------------------------------------------

>26456_26456_9_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000361962_length(amino acids)=390AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQF
EYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDK
YLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL
EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIIN

--------------------------------------------------------------

>26456_26456_10_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000378158_length(amino acids)=390AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQF
EYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDK
YLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL
EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIIN

--------------------------------------------------------------

>26456_26456_11_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000378163_length(amino acids)=407AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY
FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKES

--------------------------------------------------------------

>26456_26456_12_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000378166_length(amino acids)=402AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHD
QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQR

--------------------------------------------------------------

>26456_26456_13_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000421587_length(amino acids)=384AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIP
CKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQ
LDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHE
DAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDET

--------------------------------------------------------------

>26456_26456_14_EML4-CASK_EML4_chr2_42396776_ENST00000401738_CASK_chrX_41420897_ENST00000442742_length(amino acids)=379AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIP
CKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVT
YEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYG
TKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLE

--------------------------------------------------------------

>26456_26456_15_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000318588_length(amino acids)=402AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHD
QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQR

--------------------------------------------------------------

>26456_26456_16_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000361962_length(amino acids)=390AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQF
EYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDK
YLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL
EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIIN

--------------------------------------------------------------

>26456_26456_17_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000378158_length(amino acids)=390AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQF
EYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDK
YLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL
EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIIN

--------------------------------------------------------------

>26456_26456_18_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000378163_length(amino acids)=407AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY
FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKES

--------------------------------------------------------------

>26456_26456_19_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000378166_length(amino acids)=402AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ
PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT
WFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHD
QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQR

--------------------------------------------------------------

>26456_26456_20_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000421587_length(amino acids)=384AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIP
CKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQ
LDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHE
DAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDET

--------------------------------------------------------------

>26456_26456_21_EML4-CASK_EML4_chr2_42396776_ENST00000402711_CASK_chrX_41420897_ENST00000442742_length(amino acids)=379AA_BP=7
MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIP
CKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVT
YEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYG
TKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:42396776/chrX:41420897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EML4 Q9HC35	CASK Q8WXE0
FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269\|PubMed:16890222, ECO:0000269\|PubMed:25789526, ECO:0000269\|PubMed:31409757}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

612_682

527.3333333333334

910.0

Domain

SH3

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

739_911

527.3333333333334

910.0

Domain

Guanylate kinase-like

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

612_682

527.3333333333334

927.0

Domain

SH3

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

739_911

527.3333333333334

927.0

Domain

Guanylate kinase-like

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

612_682

527.3333333333334

922.0

Domain

SH3

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

739_911

527.3333333333334

922.0

Domain

Guanylate kinase-like

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

612_682

521.3333333333334

898.0

Domain

SH3

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

739_911

521.3333333333334

898.0

Domain

Guanylate kinase-like

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

612_682

527.3333333333334

899.0

Domain

SH3

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

739_911

527.3333333333334

899.0

Domain

Guanylate kinase-like

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

1_249

8.333333333333334

982.0

Region

Microtubule-binding

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

1_249

8.333333333333334

924.0

Region

Microtubule-binding

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

259_297

8.333333333333334

982.0

Repeat

Note=WD 1

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

301_348

8.333333333333334

982.0

Repeat

Note=WD 2

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

356_396

8.333333333333334

982.0

Repeat

Note=WD 3

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

403_438

8.333333333333334

982.0

Repeat

Note=WD 4

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

445_484

8.333333333333334

982.0

Repeat

Note=WD 5

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

500_538

8.333333333333334

982.0

Repeat

Note=WD 6

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

543_579

8.333333333333334

982.0

Repeat

Note=WD 7

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

582_621

8.333333333333334

982.0

Repeat

Note=WD 8

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

625_662

8.333333333333334

982.0

Repeat

Note=WD 9

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

668_704

8.333333333333334

982.0

Repeat

Note=WD 10

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

711_750

8.333333333333334

982.0

Repeat

Note=WD 11

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

760_818

8.333333333333334

982.0

Repeat

Note=WD 12

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000318522

825_864

8.333333333333334

982.0

Repeat

Note=WD 13

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

259_297

8.333333333333334

924.0

Repeat

Note=WD 1

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

301_348

8.333333333333334

924.0

Repeat

Note=WD 2

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

356_396

8.333333333333334

924.0

Repeat

Note=WD 3

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

403_438

8.333333333333334

924.0

Repeat

Note=WD 4

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

445_484

8.333333333333334

924.0

Repeat

Note=WD 5

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

500_538

8.333333333333334

924.0

Repeat

Note=WD 6

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

543_579

8.333333333333334

924.0

Repeat

Note=WD 7

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

582_621

8.333333333333334

924.0

Repeat

Note=WD 8

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

625_662

8.333333333333334

924.0

Repeat

Note=WD 9

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

668_704

8.333333333333334

924.0

Repeat

Note=WD 10

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

711_750

8.333333333333334

924.0

Repeat

Note=WD 11

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

760_818

8.333333333333334

924.0

Repeat

Note=WD 12

Hgene

EML4

chr2:42396776

chrX:41420897

ENST00000402711

825_864

8.333333333333334

924.0

Repeat

Note=WD 13

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

12_276

527.3333333333334

910.0

Domain

Protein kinase

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

343_398

527.3333333333334

910.0

Domain

L27 1

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

402_455

527.3333333333334

910.0

Domain

L27 2

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

489_564

527.3333333333334

910.0

Domain

PDZ

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

12_276

527.3333333333334

927.0

Domain

Protein kinase

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

343_398

527.3333333333334

927.0

Domain

L27 1

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

402_455

527.3333333333334

927.0

Domain

L27 2

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

489_564

527.3333333333334

927.0

Domain

PDZ

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

12_276

527.3333333333334

922.0

Domain

Protein kinase

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

343_398

527.3333333333334

922.0

Domain

L27 1

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

402_455

527.3333333333334

922.0

Domain

L27 2

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

489_564

527.3333333333334

922.0

Domain

PDZ

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

12_276

521.3333333333334

898.0

Domain

Protein kinase

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

343_398

521.3333333333334

898.0

Domain

L27 1

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

402_455

521.3333333333334

898.0

Domain

L27 2

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

489_564

521.3333333333334

898.0

Domain

PDZ

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

12_276

527.3333333333334

899.0

Domain

Protein kinase

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

343_398

527.3333333333334

899.0

Domain

L27 1

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

402_455

527.3333333333334

899.0

Domain

L27 2

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

489_564

527.3333333333334

899.0

Domain

PDZ

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

18_26

527.3333333333334

910.0

Nucleotide binding

ATP

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

18_26

527.3333333333334

927.0

Nucleotide binding

ATP

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

18_26

527.3333333333334

922.0

Nucleotide binding

ATP

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

18_26

521.3333333333334

898.0

Nucleotide binding

ATP

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

18_26

527.3333333333334

899.0

Nucleotide binding

ATP

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378158

305_315

527.3333333333334

910.0

Region

Note=Calmodulin-binding

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378163

305_315

527.3333333333334

927.0

Region

Note=Calmodulin-binding

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000378166

305_315

527.3333333333334

922.0

Region

Note=Calmodulin-binding

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000421587

305_315

521.3333333333334

898.0

Region

Note=Calmodulin-binding

Tgene

CASK

chr2:42396776

chrX:41420897

ENST00000442742

305_315

527.3333333333334

899.0

Region

Note=Calmodulin-binding

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>823_EML4_42396776_CASK_41420897_ranked_0.pdb	EML4	42396776	42396776	ENST00000442742	CASK	chrX	41420897	-	MDGFAGSLGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQ PKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCT WFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKES	407

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EML4_pLDDT.png

CASK_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
EML4	NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, Nek9, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7, SKP1, EFTUD2, FGF11, MYC, CDK9, KIAA1429, ATG16L1, Bach1, N, HCVgp1, TUBA1B, DDRGK1, TP53, KIF2A, MAPRE1, MAPRE3, TRIM36, TUBA4A, WDR5, C15orf59, C1QTNF1, PABPN1L, BAG2, CAPSL, PRPS2, HSPA8, TUBB6, KXD1, ZNF174, GPS2, NEK9,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EML4
CASK

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to EML4-CASK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EML4-CASK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EML4	C0007131	Non-Small Cell Lung Carcinoma	6	CTD_human
Hgene	EML4	C0027627	Neoplasm Metastasis	2	CTD_human
Hgene	EML4	C0152013	Adenocarcinoma of lung (disorder)	2	CTD_human
Hgene	EML4	C0006118	Brain Neoplasms	1	CTD_human
Hgene	EML4	C0153633	Malignant neoplasm of brain	1	CTD_human
Hgene	EML4	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Hgene	EML4	C0750974	Brain Tumor, Primary	1	CTD_human
Hgene	EML4	C0750977	Recurrent Brain Neoplasm	1	CTD_human
Hgene	EML4	C0750979	Primary malignant neoplasm of brain	1	CTD_human
Hgene	EML4	C1527390	Neoplasms, Intracranial	1	CTD_human