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Fusion Protein:EML4-NTRK3 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: EML4-NTRK3 | FusionPDB ID: 26468 | FusionGDB2.0 ID: 26468 | Hgene | Tgene | Gene symbol | EML4 | NTRK3 | Gene ID | 27436 | 4916 |
| Gene name | EMAP like 4 | neurotrophic receptor tyrosine kinase 3 | |
| Synonyms | C2orf2|ELP120|EMAP-4|EMAPL4|ROPP120 | GP145-TrkC|TRKC|gp145(trkC) | |
| Cytomap | 2p21 | 15q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | echinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120 | NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9HC35 | Q16288 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000318522, ENST00000401738, ENST00000402711, ENST00000453191, ENST00000482660, | ENST00000540489, ENST00000558306, ENST00000317501, ENST00000355254, ENST00000357724, ENST00000360948, ENST00000394480, ENST00000542733, ENST00000557856, ENST00000558676, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 22 X 32 X 18=12672 | 15 X 19 X 11=3135 |
| # samples | 43 | 15 | |
| ** MAII score | log2(43/12672*10)=-4.88116377049015 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/3135*10)=-4.38543103719352 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: EML4 [Title/Abstract] AND NTRK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | EML4(42491871)-NTRK3(88576276), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | EML4-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EML4-NTRK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NTRK3 | GO:0000187 | activation of MAPK activity | 23027130 |
| Tgene | NTRK3 | GO:0001933 | negative regulation of protein phosphorylation | 23027130 |
| Tgene | NTRK3 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 23027130 |
| Tgene | NTRK3 | GO:0008284 | positive regulation of cell proliferation | 23027130 |
| Tgene | NTRK3 | GO:0010628 | positive regulation of gene expression | 23027130 |
| Tgene | NTRK3 | GO:0030335 | positive regulation of cell migration | 23027130 |
| Tgene | NTRK3 | GO:0032148 | activation of protein kinase B activity | 23027130 |
| Tgene | NTRK3 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 23027130 |
| Tgene | NTRK3 | GO:0050927 | positive regulation of positive chemotaxis | 23027130 |
| Tgene | NTRK3 | GO:0090630 | activation of GTPase activity | 23027130 |
| Tgene | NTRK3 | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 23027130 |
| Fusion gene breakpoints across EML4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NTRK3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PAAD | TCGA-FB-AAPP-01A | EML4 | chr2 | 42491871 | - | NTRK3 | chr15 | 88576276 | - |
| ChimerDB4 | PAAD | TCGA-FB-AAPP-01A | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - |
| ChimerDB4 | PAAD | TCGA-FB-AAPP | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - |
| ChimerKB4 | . | . | EML4 | chr2 | 42472644 | + | NTRK3 | chr15 | 42472644 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000394480 | NTRK3 | chr15 | 88576276 | - | 3947 | 929 | 262 | 2010 | 582 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000557856 | NTRK3 | chr15 | 88576276 | - | 2155 | 929 | 262 | 2010 | 582 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000357724 | NTRK3 | chr15 | 88576276 | - | 2197 | 929 | 262 | 2052 | 596 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000355254 | NTRK3 | chr15 | 88576276 | - | 2155 | 929 | 262 | 2010 | 582 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000360948 | NTRK3 | chr15 | 88576276 | - | 2197 | 929 | 262 | 2052 | 596 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000542733 | NTRK3 | chr15 | 88576276 | - | 1954 | 929 | 262 | 1680 | 472 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000558676 | NTRK3 | chr15 | 88576276 | - | 1855 | 929 | 262 | 1674 | 470 |
| ENST00000318522 | EML4 | chr2 | 42491871 | + | ENST00000317501 | NTRK3 | chr15 | 88576276 | - | 3350 | 929 | 262 | 1371 | 369 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000394480 | NTRK3 | chr15 | 88576276 | - | 3770 | 752 | 259 | 1833 | 524 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000557856 | NTRK3 | chr15 | 88576276 | - | 1978 | 752 | 259 | 1833 | 524 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000357724 | NTRK3 | chr15 | 88576276 | - | 2020 | 752 | 259 | 1875 | 538 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000355254 | NTRK3 | chr15 | 88576276 | - | 1978 | 752 | 259 | 1833 | 524 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000360948 | NTRK3 | chr15 | 88576276 | - | 2020 | 752 | 259 | 1875 | 538 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000542733 | NTRK3 | chr15 | 88576276 | - | 1777 | 752 | 259 | 1503 | 414 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000558676 | NTRK3 | chr15 | 88576276 | - | 1678 | 752 | 259 | 1497 | 412 |
| ENST00000402711 | EML4 | chr2 | 42491871 | + | ENST00000317501 | NTRK3 | chr15 | 88576276 | - | 3173 | 752 | 259 | 1194 | 311 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000394480 | NTRK3 | chr15 | 88576276 | - | 3836 | 818 | 151 | 1899 | 582 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000557856 | NTRK3 | chr15 | 88576276 | - | 2044 | 818 | 151 | 1899 | 582 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000357724 | NTRK3 | chr15 | 88576276 | - | 2086 | 818 | 151 | 1941 | 596 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000355254 | NTRK3 | chr15 | 88576276 | - | 2044 | 818 | 151 | 1899 | 582 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000360948 | NTRK3 | chr15 | 88576276 | - | 2086 | 818 | 151 | 1941 | 596 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000542733 | NTRK3 | chr15 | 88576276 | - | 1843 | 818 | 151 | 1569 | 472 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000558676 | NTRK3 | chr15 | 88576276 | - | 1744 | 818 | 151 | 1563 | 470 |
| ENST00000401738 | EML4 | chr2 | 42491871 | + | ENST00000317501 | NTRK3 | chr15 | 88576276 | - | 3239 | 818 | 151 | 1260 | 369 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000318522 | ENST00000394480 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.001821778 | 0.99817824 |
| ENST00000318522 | ENST00000557856 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003835503 | 0.99616456 |
| ENST00000318522 | ENST00000357724 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003684156 | 0.9963159 |
| ENST00000318522 | ENST00000355254 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003835503 | 0.99616456 |
| ENST00000318522 | ENST00000360948 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003684156 | 0.9963159 |
| ENST00000318522 | ENST00000542733 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.00248991 | 0.9975101 |
| ENST00000318522 | ENST00000558676 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002783764 | 0.9972162 |
| ENST00000318522 | ENST00000317501 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.000717415 | 0.99928266 |
| ENST00000402711 | ENST00000394480 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.001661106 | 0.9983388 |
| ENST00000402711 | ENST00000557856 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003165138 | 0.99683493 |
| ENST00000402711 | ENST00000357724 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002755847 | 0.9972441 |
| ENST00000402711 | ENST00000355254 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003165138 | 0.99683493 |
| ENST00000402711 | ENST00000360948 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002755847 | 0.9972441 |
| ENST00000402711 | ENST00000542733 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002212396 | 0.9977876 |
| ENST00000402711 | ENST00000558676 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002146571 | 0.99785346 |
| ENST00000402711 | ENST00000317501 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.000962762 | 0.99903727 |
| ENST00000401738 | ENST00000394480 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.001756421 | 0.9982436 |
| ENST00000401738 | ENST00000557856 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003666509 | 0.9963335 |
| ENST00000401738 | ENST00000357724 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003490247 | 0.99650973 |
| ENST00000401738 | ENST00000355254 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003666509 | 0.9963335 |
| ENST00000401738 | ENST00000360948 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.003490247 | 0.99650973 |
| ENST00000401738 | ENST00000542733 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002208687 | 0.9977913 |
| ENST00000401738 | ENST00000558676 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.002578286 | 0.99742174 |
| ENST00000401738 | ENST00000317501 | EML4 | chr2 | 42491871 | + | NTRK3 | chr15 | 88576276 | - | 0.000654037 | 0.99934596 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >26468_26468_1_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000317501_length(amino acids)=369AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTWVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVEDVNV -------------------------------------------------------------- >26468_26468_2_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000355254_length(amino acids)=582AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPK -------------------------------------------------------------- >26468_26468_3_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000357724_length(amino acids)=596AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI -------------------------------------------------------------- >26468_26468_4_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000360948_length(amino acids)=596AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI -------------------------------------------------------------- >26468_26468_5_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000394480_length(amino acids)=582AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPK -------------------------------------------------------------- >26468_26468_6_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000542733_length(amino acids)=472AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV -------------------------------------------------------------- >26468_26468_7_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000557856_length(amino acids)=582AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPK -------------------------------------------------------------- >26468_26468_8_EML4-NTRK3_EML4_chr2_42491871_ENST00000318522_NTRK3_chr15_88576276_ENST00000558676_length(amino acids)=470AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV -------------------------------------------------------------- >26468_26468_9_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000317501_length(amino acids)=369AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTWVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPEVQSGEVSYPRSHGFREIMLNPISLPGHSKPLNHGIYVEDVNV -------------------------------------------------------------- >26468_26468_10_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000355254_length(amino acids)=582AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPK -------------------------------------------------------------- >26468_26468_11_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000357724_length(amino acids)=596AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI -------------------------------------------------------------- >26468_26468_12_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000360948_length(amino acids)=596AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI -------------------------------------------------------------- >26468_26468_13_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000394480_length(amino acids)=582AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPK -------------------------------------------------------------- >26468_26468_14_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000542733_length(amino acids)=472AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV -------------------------------------------------------------- >26468_26468_15_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000557856_length(amino acids)=582AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPK -------------------------------------------------------------- >26468_26468_16_EML4-NTRK3_EML4_chr2_42491871_ENST00000401738_NTRK3_chr15_88576276_ENST00000558676_length(amino acids)=470AA_BP=222 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV -------------------------------------------------------------- >26468_26468_17_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000317501_length(amino acids)=311AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGILNLKDNRDHLVPSTHYIYEEPEVQSGEVSYPR -------------------------------------------------------------- >26468_26468_18_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000355254_length(amino acids)=524AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT -------------------------------------------------------------- >26468_26468_19_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000357724_length(amino acids)=538AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTES -------------------------------------------------------------- >26468_26468_20_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000360948_length(amino acids)=538AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTES -------------------------------------------------------------- >26468_26468_21_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000394480_length(amino acids)=524AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT -------------------------------------------------------------- >26468_26468_22_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000542733_length(amino acids)=414AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS -------------------------------------------------------------- >26468_26468_23_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000557856_length(amino acids)=524AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS QIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT -------------------------------------------------------------- >26468_26468_24_EML4-NTRK3_EML4_chr2_42491871_ENST00000402711_NTRK3_chr15_88576276_ENST00000558676_length(amino acids)=412AA_BP=164 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPL HHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAV KALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIAS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:42491871/chr15:88576276) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EML4 | NTRK3 |
| FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. | FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 538_839 | 465.3333333333333 | 613.0 | Domain | Protein kinase | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 538_839 | 465.3333333333333 | 826.0 | Domain | Protein kinase | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 538_839 | 465.3333333333333 | 840.0 | Domain | Protein kinase | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 538_839 | 465.3333333333333 | 826.0 | Domain | Protein kinase | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 538_839 | 465.3333333333333 | 613.0 | Domain | Protein kinase | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 544_552 | 465.3333333333333 | 613.0 | Nucleotide binding | ATP | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 544_552 | 465.3333333333333 | 826.0 | Nucleotide binding | ATP | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 544_552 | 465.3333333333333 | 840.0 | Nucleotide binding | ATP | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 544_552 | 465.3333333333333 | 826.0 | Nucleotide binding | ATP | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 544_552 | 465.3333333333333 | 613.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 1_249 | 222.33333333333334 | 982.0 | Region | Microtubule-binding |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 1_249 | 164.33333333333334 | 924.0 | Region | Microtubule-binding |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 259_297 | 222.33333333333334 | 982.0 | Repeat | Note=WD 1 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 301_348 | 222.33333333333334 | 982.0 | Repeat | Note=WD 2 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 356_396 | 222.33333333333334 | 982.0 | Repeat | Note=WD 3 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 403_438 | 222.33333333333334 | 982.0 | Repeat | Note=WD 4 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 445_484 | 222.33333333333334 | 982.0 | Repeat | Note=WD 5 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 500_538 | 222.33333333333334 | 982.0 | Repeat | Note=WD 6 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 543_579 | 222.33333333333334 | 982.0 | Repeat | Note=WD 7 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 582_621 | 222.33333333333334 | 982.0 | Repeat | Note=WD 8 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 625_662 | 222.33333333333334 | 982.0 | Repeat | Note=WD 9 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 668_704 | 222.33333333333334 | 982.0 | Repeat | Note=WD 10 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 711_750 | 222.33333333333334 | 982.0 | Repeat | Note=WD 11 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 760_818 | 222.33333333333334 | 982.0 | Repeat | Note=WD 12 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000318522 | + | 6 | 23 | 825_864 | 222.33333333333334 | 982.0 | Repeat | Note=WD 13 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 259_297 | 164.33333333333334 | 924.0 | Repeat | Note=WD 1 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 301_348 | 164.33333333333334 | 924.0 | Repeat | Note=WD 2 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 356_396 | 164.33333333333334 | 924.0 | Repeat | Note=WD 3 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 403_438 | 164.33333333333334 | 924.0 | Repeat | Note=WD 4 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 445_484 | 164.33333333333334 | 924.0 | Repeat | Note=WD 5 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 500_538 | 164.33333333333334 | 924.0 | Repeat | Note=WD 6 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 543_579 | 164.33333333333334 | 924.0 | Repeat | Note=WD 7 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 582_621 | 164.33333333333334 | 924.0 | Repeat | Note=WD 8 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 625_662 | 164.33333333333334 | 924.0 | Repeat | Note=WD 9 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 668_704 | 164.33333333333334 | 924.0 | Repeat | Note=WD 10 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 711_750 | 164.33333333333334 | 924.0 | Repeat | Note=WD 11 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 760_818 | 164.33333333333334 | 924.0 | Repeat | Note=WD 12 |
| Hgene | EML4 | chr2:42491871 | chr15:88576276 | ENST00000402711 | + | 5 | 22 | 825_864 | 164.33333333333334 | 924.0 | Repeat | Note=WD 13 |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 160_209 | 465.3333333333333 | 613.0 | Domain | Note=LRRCT | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 210_300 | 465.3333333333333 | 613.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 309_382 | 465.3333333333333 | 613.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 160_209 | 465.3333333333333 | 826.0 | Domain | Note=LRRCT | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 210_300 | 465.3333333333333 | 826.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 309_382 | 465.3333333333333 | 826.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 160_209 | 465.3333333333333 | 840.0 | Domain | Note=LRRCT | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 210_300 | 465.3333333333333 | 840.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 309_382 | 465.3333333333333 | 840.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 160_209 | 465.3333333333333 | 826.0 | Domain | Note=LRRCT | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 210_300 | 465.3333333333333 | 826.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 309_382 | 465.3333333333333 | 826.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 160_209 | 465.3333333333333 | 613.0 | Domain | Note=LRRCT | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 210_300 | 465.3333333333333 | 613.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 309_382 | 465.3333333333333 | 613.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 104_125 | 465.3333333333333 | 613.0 | Repeat | Note=LRR 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 128_149 | 465.3333333333333 | 613.0 | Repeat | Note=LRR 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 104_125 | 465.3333333333333 | 826.0 | Repeat | Note=LRR 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 128_149 | 465.3333333333333 | 826.0 | Repeat | Note=LRR 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 104_125 | 465.3333333333333 | 840.0 | Repeat | Note=LRR 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 128_149 | 465.3333333333333 | 840.0 | Repeat | Note=LRR 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 104_125 | 465.3333333333333 | 826.0 | Repeat | Note=LRR 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 128_149 | 465.3333333333333 | 826.0 | Repeat | Note=LRR 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 104_125 | 465.3333333333333 | 613.0 | Repeat | Note=LRR 1 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 128_149 | 465.3333333333333 | 613.0 | Repeat | Note=LRR 2 | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 32_429 | 465.3333333333333 | 613.0 | Topological domain | Extracellular | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 454_839 | 465.3333333333333 | 613.0 | Topological domain | Cytoplasmic | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 32_429 | 465.3333333333333 | 826.0 | Topological domain | Extracellular | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 454_839 | 465.3333333333333 | 826.0 | Topological domain | Cytoplasmic | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 32_429 | 465.3333333333333 | 840.0 | Topological domain | Extracellular | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 454_839 | 465.3333333333333 | 840.0 | Topological domain | Cytoplasmic | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 32_429 | 465.3333333333333 | 826.0 | Topological domain | Extracellular | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 454_839 | 465.3333333333333 | 826.0 | Topological domain | Cytoplasmic | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 32_429 | 465.3333333333333 | 613.0 | Topological domain | Extracellular | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 454_839 | 465.3333333333333 | 613.0 | Topological domain | Cytoplasmic | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000317501 | 11 | 15 | 430_453 | 465.3333333333333 | 613.0 | Transmembrane | Helical | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000355254 | 11 | 18 | 430_453 | 465.3333333333333 | 826.0 | Transmembrane | Helical | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000360948 | 11 | 19 | 430_453 | 465.3333333333333 | 840.0 | Transmembrane | Helical | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000394480 | 12 | 19 | 430_453 | 465.3333333333333 | 826.0 | Transmembrane | Helical | |
| Tgene | NTRK3 | chr2:42491871 | chr15:88576276 | ENST00000540489 | 10 | 14 | 430_453 | 465.3333333333333 | 613.0 | Transmembrane | Helical |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1264_EML4_42491871_NTRK3_88576276_1264_EML4_42491871_NTRK3_88576276_ranked_0.pdb | EML4 | 42491871 | 42491871 | ENST00000317501 | NTRK3 | chr15 | 88576276 | - | MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIEN PQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKF YGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV KIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI | 596 |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
EML4_pLDDT.png  |
NTRK3_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
 |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| EML4 | NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, Nek9, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7, SKP1, EFTUD2, FGF11, MYC, CDK9, KIAA1429, ATG16L1, Bach1, N, HCVgp1, TUBA1B, DDRGK1, TP53, KIF2A, MAPRE1, MAPRE3, TRIM36, TUBA4A, WDR5, C15orf59, C1QTNF1, PABPN1L, BAG2, CAPSL, PRPS2, HSPA8, TUBB6, KXD1, ZNF174, GPS2, NEK9, |
| NTRK3 | NTF3, FRS2, SHC1, PLCG1, SQSTM1, PTPN1, APP, HSP90AA1, IRAK3, TNK2, NTRK1, SH3BP4, PTPRS, MYADM, C1GALT1, GNB2, C6orf120, MTOR, LGALS1, PTCD2, TMEM11, PAG1, EFR3A, TBC1D24, GNB4, TMEM192, INTS7, DENND4A, FAM171A2, KIAA0391, EPHA2, ATP7B, CXCR4, ACAD10, HRAS, EHD4, RPTOR, HEATR6, SLC39A11, NDFIP1, ERBB2, NELFB, HEY1, WDR13, KPNA4, NSD1, DOK6, SORT1, Ngfr, DDX58, UBE3C, LINGO1, NEU3, ACAD9, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| EML4 |  |
| NTRK3 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to EML4-NTRK3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to EML4-NTRK3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EML4 | C0007131 | Non-Small Cell Lung Carcinoma | 6 | CTD_human |
| Hgene | EML4 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Hgene | EML4 | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
| Hgene | EML4 | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Hgene | EML4 | C0153633 | Malignant neoplasm of brain | 1 | CTD_human |
| Hgene | EML4 | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human |
| Hgene | EML4 | C0750974 | Brain Tumor, Primary | 1 | CTD_human |
| Hgene | EML4 | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human |
| Hgene | EML4 | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human |
| Hgene | EML4 | C1527390 | Neoplasms, Intracranial | 1 | CTD_human |
| Tgene | NTRK3 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Tgene | NTRK3 | C0041696 | Unipolar Depression | 2 | PSYGENET |
| Tgene | NTRK3 | C1269683 | Major Depressive Disorder | 2 | PSYGENET |
| Tgene | NTRK3 | C1332965 | Congenital Mesoblastic Nephroma | 2 | ORPHANET |
| Tgene | NTRK3 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | NTRK3 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | NTRK3 | C0019569 | Hirschsprung Disease | 1 | GENOMICS_ENGLAND |
| Tgene | NTRK3 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | NTRK3 | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| Tgene | NTRK3 | C0038220 | Status Epilepticus | 1 | CTD_human |
| Tgene | NTRK3 | C0238463 | Papillary thyroid carcinoma | 1 | ORPHANET |
| Tgene | NTRK3 | C0259783 | mixed gliomas | 1 | CTD_human |
| Tgene | NTRK3 | C0269102 | Endometrioma | 1 | CTD_human |
| Tgene | NTRK3 | C0270823 | Petit mal status | 1 | CTD_human |
| Tgene | NTRK3 | C0311335 | Grand Mal Status Epilepticus | 1 | CTD_human |
| Tgene | NTRK3 | C0393734 | Complex Partial Status Epilepticus | 1 | CTD_human |
| Tgene | NTRK3 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | NTRK3 | C0555198 | Malignant Glioma | 1 | CTD_human |
| Tgene | NTRK3 | C0751522 | Status Epilepticus, Subclinical | 1 | CTD_human |
| Tgene | NTRK3 | C0751523 | Non-Convulsive Status Epilepticus | 1 | CTD_human |
| Tgene | NTRK3 | C0751524 | Simple Partial Status Epilepticus | 1 | CTD_human |
| Tgene | NTRK3 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
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