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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EML4-RTN4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EML4-RTN4
FusionPDB ID: 26473
FusionGDB2.0 ID: 26473
HgeneTgene
Gene symbol

EML4

RTN4

Gene ID

27436

57142

Gene nameEMAP like 4reticulon 4
SynonymsC2orf2|ELP120|EMAP-4|EMAPL4|ROPP120ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Cytomap

2p21

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionechinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5
Modification date2020031320200327
UniProtAcc

Q9HC35

.
Ensembl transtripts involved in fusion geneENST idsENST00000482660, ENST00000318522, 
ENST00000401738, ENST00000402711, 
ENST00000453191, 		ENST00000317610, 
ENST00000337526, ENST00000357376, 
ENST00000357732, ENST00000394609, 
ENST00000394611, ENST00000404909, 
ENST00000405240, ENST00000354474, 
ENST00000402434, ENST00000486085, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 32 X 18=1267227 X 28 X 9=6804
# samples 4335
** MAII scorelog2(43/12672*10)=-4.88116377049015
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/6804*10)=-4.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EML4 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EML4(42396776)-RTN4(55214834), # samples:1
Anticipated loss of major functional domain due to fusion event.EML4-RTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EML4-RTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EML4-RTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EML4-RTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

TgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

TgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365


check buttonFusion gene breakpoints across EML4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H2EML4chr2

42396776

+RTN4chr2

55214834

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318522EML4chr242396776+ENST00000394609RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000405240RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000357376RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000317610RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000357732RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000337526RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000394611RTN4chr255214834-1820287262852196
ENST00000318522EML4chr242396776+ENST00000404909RTN4chr255214834-1820287262852196
ENST00000402711EML4chr242396776+ENST00000394609RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000405240RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000357376RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000317610RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000357732RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000337526RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000394611RTN4chr255214834-1817284259849196
ENST00000402711EML4chr242396776+ENST00000404909RTN4chr255214834-1817284259849196
ENST00000401738EML4chr242396776+ENST00000394609RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000405240RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000357376RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000317610RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000357732RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000337526RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000394611RTN4chr255214834-1709176151741196
ENST00000401738EML4chr242396776+ENST00000404909RTN4chr255214834-1709176151741196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318522ENST00000394609EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000405240EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000357376EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000317610EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000357732EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000337526EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000394611EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000318522ENST00000404909EML4chr242396776+RTN4chr255214834-0.0008217870.99917823
ENST00000402711ENST00000394609EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000405240EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000357376EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000317610EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000357732EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000337526EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000394611EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000402711ENST00000404909EML4chr242396776+RTN4chr255214834-0.0008091260.99919087
ENST00000401738ENST00000394609EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000405240EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000357376EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000317610EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000357732EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000337526EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000394611EML4chr242396776+RTN4chr255214834-0.0008215750.99917835
ENST00000401738ENST00000404909EML4chr242396776+RTN4chr255214834-0.0008215750.99917835

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26473_26473_1_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000317610_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_2_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000337526_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_3_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000357376_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_4_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000357732_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_5_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000394609_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_6_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000394611_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_7_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000404909_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_8_EML4-RTN4_EML4_chr2_42396776_ENST00000318522_RTN4_chr2_55214834_ENST00000405240_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_9_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000317610_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_10_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000337526_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_11_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000357376_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_12_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000357732_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_13_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000394609_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_14_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000394611_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_15_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000404909_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_16_EML4-RTN4_EML4_chr2_42396776_ENST00000401738_RTN4_chr2_55214834_ENST00000405240_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_17_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000317610_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_18_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000337526_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_19_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000357376_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_20_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000357732_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_21_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000394609_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_22_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000394611_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_23_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000404909_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

>26473_26473_24_EML4-RTN4_EML4_chr2_42396776_ENST00000402711_RTN4_chr2_55214834_ENST00000405240_length(amino acids)=196AA_BP=7
MDGFAGSLVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEE
LVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:42396776/chr2:55214834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML4

Q9HC35

.
FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRTN4chr2:42396776chr2:55214834ENST0000039460907143_14811.333333333333334200.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000003946090730_4711.333333333333334200.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST00000317610071005_1192185.33333333333334374.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000337526291005_11921004.33333333333341193.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000357376291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000357732181005_1192204.33333333333334393.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000394609071005_119211.333333333333334200.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000394611291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000404909291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000405240291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr2:42396776chr2:55214834ENST00000317610071040_1133185.33333333333334374.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000317610071155_1192185.33333333333334374.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000337526291040_11331004.33333333333341193.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000337526291155_11921004.33333333333341193.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000357376291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000357376291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000357732181040_1133204.33333333333334393.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000357732181155_1192204.33333333333334393.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000394609071040_113311.333333333333334200.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000394609071155_119211.333333333333334200.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000394611291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000394611291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000404909291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000404909291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000405240291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr2:42396776chr2:55214834ENST00000405240291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000317610071019_1039185.33333333333334374.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000317610071134_1154185.33333333333334374.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000337526291019_10391004.33333333333341193.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000337526291134_11541004.33333333333341193.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000357376291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000357376291134_1154798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000357732181019_1039204.33333333333334393.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000357732181134_1154204.33333333333334393.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000394609071019_103911.333333333333334200.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000394609071134_115411.333333333333334200.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000394611291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000394611291134_1154798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000404909291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000404909291134_1154798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000405240291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr2:42396776chr2:55214834ENST00000405240291134_1154798.3333333333334987.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+1231_2498.333333333333334982.0RegionMicrotubule-binding
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+1221_2498.333333333333334924.0RegionMicrotubule-binding
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123259_2978.333333333333334982.0RepeatNote=WD 1
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123301_3488.333333333333334982.0RepeatNote=WD 2
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123356_3968.333333333333334982.0RepeatNote=WD 3
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123403_4388.333333333333334982.0RepeatNote=WD 4
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123445_4848.333333333333334982.0RepeatNote=WD 5
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123500_5388.333333333333334982.0RepeatNote=WD 6
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123543_5798.333333333333334982.0RepeatNote=WD 7
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123582_6218.333333333333334982.0RepeatNote=WD 8
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123625_6628.333333333333334982.0RepeatNote=WD 9
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123668_7048.333333333333334982.0RepeatNote=WD 10
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123711_7508.333333333333334982.0RepeatNote=WD 11
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123760_8188.333333333333334982.0RepeatNote=WD 12
HgeneEML4chr2:42396776chr2:55214834ENST00000318522+123825_8648.333333333333334982.0RepeatNote=WD 13
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122259_2978.333333333333334924.0RepeatNote=WD 1
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122301_3488.333333333333334924.0RepeatNote=WD 2
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122356_3968.333333333333334924.0RepeatNote=WD 3
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122403_4388.333333333333334924.0RepeatNote=WD 4
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122445_4848.333333333333334924.0RepeatNote=WD 5
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122500_5388.333333333333334924.0RepeatNote=WD 6
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122543_5798.333333333333334924.0RepeatNote=WD 7
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122582_6218.333333333333334924.0RepeatNote=WD 8
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122625_6628.333333333333334924.0RepeatNote=WD 9
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122668_7048.333333333333334924.0RepeatNote=WD 10
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122711_7508.333333333333334924.0RepeatNote=WD 11
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122760_8188.333333333333334924.0RepeatNote=WD 12
HgeneEML4chr2:42396776chr2:55214834ENST00000402711+122825_8648.333333333333334924.0RepeatNote=WD 13
TgeneRTN4chr2:42396776chr2:55214834ENST0000031761007143_148185.33333333333334374.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000003176100730_47185.33333333333334374.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST0000033752629143_1481004.33333333333341193.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000003375262930_471004.33333333333341193.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST0000035737629143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000003573762930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST0000035773218143_148204.33333333333334393.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000003577321830_47204.33333333333334393.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST0000039461129143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000003946112930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST0000040490929143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000004049092930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST0000040524029143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr2:42396776chr2:55214834ENST000004052402930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr2:42396776chr2:55214834ENST00000317610071_1018185.33333333333334374.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000337526291_10181004.33333333333341193.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000357376291_1018798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000357732181_1018204.33333333333334393.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000394609071_101811.333333333333334200.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000394611291_1018798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000404909291_1018798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr2:42396776chr2:55214834ENST00000405240291_1018798.3333333333334987.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EML4NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, Nek9, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7, SKP1, EFTUD2, FGF11, MYC, CDK9, KIAA1429, ATG16L1, Bach1, N, HCVgp1, TUBA1B, DDRGK1, TP53, KIF2A, MAPRE1, MAPRE3, TRIM36, TUBA4A, WDR5, C15orf59, C1QTNF1, PABPN1L, BAG2, CAPSL, PRPS2, HSPA8, TUBB6, KXD1, ZNF174, GPS2, NEK9,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EML4all structure
RTN4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EML4-RTN4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EML4-RTN4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
HgeneEML4C0027627Neoplasm Metastasis2CTD_human
HgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
HgeneEML4C0006118Brain Neoplasms1CTD_human
HgeneEML4C0153633Malignant neoplasm of brain1CTD_human
HgeneEML4C0496899Benign neoplasm of brain, unspecified1CTD_human
HgeneEML4C0750974Brain Tumor, Primary1CTD_human
HgeneEML4C0750977Recurrent Brain Neoplasm1CTD_human
HgeneEML4C0750979Primary malignant neoplasm of brain1CTD_human
HgeneEML4C1527390Neoplasms, Intracranial1CTD_human