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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EMP2-TERF2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EMP2-TERF2
FusionPDB ID: 26505
FusionGDB2.0 ID: 26505
HgeneTgene
Gene symbol

EMP2

TERF2

Gene ID

2013

7014

Gene nameepithelial membrane protein 2telomeric repeat binding factor 2
SynonymsXMPTRBF2|TRF2
Cytomap

16p13.13

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionepithelial membrane protein 2telomeric repeat-binding factor 2TTAGGG repeat-binding factor 2telomeric DNA-binding proteintelomeric repeat binding protein 2
Modification date2020031320200313
UniProtAcc

P54851

.
Ensembl transtripts involved in fusion geneENST idsENST00000359543, ENST00000536829, 
ENST00000566033, 		ENST00000567296, 
ENST00000569611, ENST00000254942, 
ENST00000603068, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 12 X 10=18008 X 7 X 5=280
# samples 1712
** MAII scorelog2(17/1800*10)=-3.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/280*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EMP2 [Title/Abstract] AND TERF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EMP2(10637427)-TERF2(69419389), # samples:2
Anticipated loss of major functional domain due to fusion event.EMP2-TERF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EMP2-TERF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EMP2-TERF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EMP2-TERF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEMP2

GO:0001954

positive regulation of cell-matrix adhesion

16216233

HgeneEMP2

GO:0003093

regulation of glomerular filtration

24814193

HgeneEMP2

GO:0007015

actin filament organization

19494199

HgeneEMP2

GO:0007155

cell adhesion

19494199

HgeneEMP2

GO:0007160

cell-matrix adhesion

19494199

HgeneEMP2

GO:0008219

cell death

12107182

HgeneEMP2

GO:0008283

cell proliferation

21637765

HgeneEMP2

GO:0010594

regulation of endothelial cell migration

23334331

HgeneEMP2

GO:0016477

cell migration

21637765

HgeneEMP2

GO:0032060

bleb assembly

12107182

HgeneEMP2

GO:0032147

activation of protein kinase activity

21637765

HgeneEMP2

GO:0043534

blood vessel endothelial cell migration

23439602

HgeneEMP2

GO:0043549

regulation of kinase activity

18469192

HgeneEMP2

GO:0045765

regulation of angiogenesis

23334331

HgeneEMP2

GO:0070252

actin-mediated cell contraction

18469192|22728127

HgeneEMP2

GO:2001046

positive regulation of integrin-mediated signaling pathway

16216233

HgeneEMP2

GO:2001212

regulation of vasculogenesis

23334331

TgeneTERF2

GO:0031627

telomeric loop formation

10338214

TgeneTERF2

GO:0032205

negative regulation of telomere maintenance

17055345

TgeneTERF2

GO:0032210

regulation of telomere maintenance via telomerase

23685356

TgeneTERF2

GO:0032211

negative regulation of telomere maintenance via telomerase

17055345

TgeneTERF2

GO:1903770

negative regulation of beta-galactosidase activity

11927518

TgeneTERF2

GO:1905778

negative regulation of exonuclease activity

15200954

TgeneTERF2

GO:1905839

negative regulation of telomeric D-loop disassembly

15200954


check buttonFusion gene breakpoints across EMP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TERF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-7463-01AEMP2chr16

10637427

-TERF2chr16

69419389

-
ChimerDB4LUSCTCGA-77-7463EMP2chr16

10637426

-TERF2chr16

69419389

-
ChimerDB4LUSCTCGA-77-7463EMP2chr16

10637427

-TERF2chr16

69419389

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359543EMP2chr1610637427-ENST00000254942TERF2chr1669419389-29663792101628472
ENST00000359543EMP2chr1610637427-ENST00000603068TERF2chr1669419389-28953792101628472
ENST00000536829EMP2chr1610637427-ENST00000254942TERF2chr1669419389-29773901281639503
ENST00000536829EMP2chr1610637427-ENST00000603068TERF2chr1669419389-29063901281639503
ENST00000359543EMP2chr1610637426-ENST00000254942TERF2chr1669419389-29663792101628472
ENST00000359543EMP2chr1610637426-ENST00000603068TERF2chr1669419389-28953792101628472
ENST00000536829EMP2chr1610637426-ENST00000254942TERF2chr1669419389-29773901281639503
ENST00000536829EMP2chr1610637426-ENST00000603068TERF2chr1669419389-29063901281639503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359543ENST00000254942EMP2chr1610637427-TERF2chr1669419389-0.001162860.9988372
ENST00000359543ENST00000603068EMP2chr1610637427-TERF2chr1669419389-0.0012493730.99875057
ENST00000536829ENST00000254942EMP2chr1610637427-TERF2chr1669419389-0.0011787070.9988213
ENST00000536829ENST00000603068EMP2chr1610637427-TERF2chr1669419389-0.0012626130.9987374
ENST00000359543ENST00000254942EMP2chr1610637426-TERF2chr1669419389-0.001162860.9988372
ENST00000359543ENST00000603068EMP2chr1610637426-TERF2chr1669419389-0.0012493730.99875057
ENST00000536829ENST00000254942EMP2chr1610637426-TERF2chr1669419389-0.0011787070.9988213
ENST00000536829ENST00000603068EMP2chr1610637426-TERF2chr1669419389-0.0012626130.9987374

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26505_26505_1_EMP2-TERF2_EMP2_chr16_10637426_ENST00000359543_TERF2_chr16_69419389_ENST00000254942_length(amino acids)=472AA_BP=56
MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC
SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV
IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA
QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP
SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP

--------------------------------------------------------------

>26505_26505_2_EMP2-TERF2_EMP2_chr16_10637426_ENST00000359543_TERF2_chr16_69419389_ENST00000603068_length(amino acids)=472AA_BP=56
MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC
SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV
IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA
QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP
SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP

--------------------------------------------------------------

>26505_26505_3_EMP2-TERF2_EMP2_chr16_10637426_ENST00000536829_TERF2_chr16_69419389_ENST00000254942_length(amino acids)=503AA_BP=87
MPRTSRRRTSQHIPLWALNVTPRLDSPCPVKMLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALL
VRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKI
LKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEK
PPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRM
TISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKK

--------------------------------------------------------------

>26505_26505_4_EMP2-TERF2_EMP2_chr16_10637426_ENST00000536829_TERF2_chr16_69419389_ENST00000603068_length(amino acids)=503AA_BP=87
MPRTSRRRTSQHIPLWALNVTPRLDSPCPVKMLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALL
VRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKI
LKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEK
PPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRM
TISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKK

--------------------------------------------------------------

>26505_26505_5_EMP2-TERF2_EMP2_chr16_10637427_ENST00000359543_TERF2_chr16_69419389_ENST00000254942_length(amino acids)=472AA_BP=56
MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC
SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV
IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA
QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP
SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP

--------------------------------------------------------------

>26505_26505_6_EMP2-TERF2_EMP2_chr16_10637427_ENST00000359543_TERF2_chr16_69419389_ENST00000603068_length(amino acids)=472AA_BP=56
MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC
SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV
IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA
QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP
SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP

--------------------------------------------------------------

>26505_26505_7_EMP2-TERF2_EMP2_chr16_10637427_ENST00000536829_TERF2_chr16_69419389_ENST00000254942_length(amino acids)=503AA_BP=87
MPRTSRRRTSQHIPLWALNVTPRLDSPCPVKMLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALL
VRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKI
LKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEK
PPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRM
TISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKK

--------------------------------------------------------------

>26505_26505_8_EMP2-TERF2_EMP2_chr16_10637427_ENST00000536829_TERF2_chr16_69419389_ENST00000603068_length(amino acids)=503AA_BP=87
MPRTSRRRTSQHIPLWALNVTPRLDSPCPVKMLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALL
VRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKI
LKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEK
PPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRM
TISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:10637427/chr16:69419389)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EMP2

P54851

.
FUNCTION: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity). {ECO:0000250|UniProtKB:F1QIK8, ECO:0000250|UniProtKB:O88662, ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:16216233, ECO:0000269|PubMed:16487956, ECO:0000269|PubMed:19494199, ECO:0000269|PubMed:21637765, ECO:0000269|PubMed:22728127, ECO:0000269|PubMed:23334331, ECO:0000269|PubMed:23439602, ECO:0000269|PubMed:24814193}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMP2chr16:10637426chr16:69419389ENST00000359543-351_2156.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637426chr16:69419389ENST00000536829-351_2156.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000359543-351_2156.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000536829-351_2156.333333333333336168.0TransmembraneHelical
TgeneTERF2chr16:10637426chr16:69419389ENST00000254942010512_537126.33333333333333543.0DNA bindingH-T-H motif
TgeneTERF2chr16:10637426chr16:69419389ENST00000603068010512_53784.33333333333333501.0DNA bindingH-T-H motif
TgeneTERF2chr16:10637427chr16:69419389ENST00000254942010512_537126.33333333333333543.0DNA bindingH-T-H motif
TgeneTERF2chr16:10637427chr16:69419389ENST00000603068010512_53784.33333333333333501.0DNA bindingH-T-H motif
TgeneTERF2chr16:10637426chr16:69419389ENST00000254942010484_541126.33333333333333543.0DomainHTH myb-type
TgeneTERF2chr16:10637426chr16:69419389ENST00000603068010484_54184.33333333333333501.0DomainHTH myb-type
TgeneTERF2chr16:10637427chr16:69419389ENST00000254942010484_541126.33333333333333543.0DomainHTH myb-type
TgeneTERF2chr16:10637427chr16:69419389ENST00000603068010484_54184.33333333333333501.0DomainHTH myb-type
TgeneTERF2chr16:10637426chr16:69419389ENST00000254942010371_375126.33333333333333543.0MotifNuclear localization signal
TgeneTERF2chr16:10637426chr16:69419389ENST00000603068010371_37584.33333333333333501.0MotifNuclear localization signal
TgeneTERF2chr16:10637427chr16:69419389ENST00000254942010371_375126.33333333333333543.0MotifNuclear localization signal
TgeneTERF2chr16:10637427chr16:69419389ENST00000603068010371_37584.33333333333333501.0MotifNuclear localization signal
TgeneTERF2chr16:10637426chr16:69419389ENST0000060306801084_28784.33333333333333501.0RegionNote=TRFH dimerization
TgeneTERF2chr16:10637427chr16:69419389ENST0000060306801084_28784.33333333333333501.0RegionNote=TRFH dimerization

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMP2chr16:10637426chr16:69419389ENST00000359543-35143_16356.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637426chr16:69419389ENST00000359543-3567_8756.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637426chr16:69419389ENST00000359543-3595_11556.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637426chr16:69419389ENST00000536829-35143_16356.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637426chr16:69419389ENST00000536829-3567_8756.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637426chr16:69419389ENST00000536829-3595_11556.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000359543-35143_16356.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000359543-3567_8756.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000359543-3595_11556.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000536829-35143_16356.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000536829-3567_8756.333333333333336168.0TransmembraneHelical
HgeneEMP2chr16:10637427chr16:69419389ENST00000536829-3595_11556.333333333333336168.0TransmembraneHelical
TgeneTERF2chr16:10637426chr16:69419389ENST0000025494201055_72126.33333333333333543.0Compositional biasNote=Arg-rich (basic)
TgeneTERF2chr16:10637426chr16:69419389ENST0000060306801055_7284.33333333333333501.0Compositional biasNote=Arg-rich (basic)
TgeneTERF2chr16:10637427chr16:69419389ENST0000025494201055_72126.33333333333333543.0Compositional biasNote=Arg-rich (basic)
TgeneTERF2chr16:10637427chr16:69419389ENST0000060306801055_7284.33333333333333501.0Compositional biasNote=Arg-rich (basic)
TgeneTERF2chr16:10637426chr16:69419389ENST0000025494201084_287126.33333333333333543.0RegionNote=TRFH dimerization
TgeneTERF2chr16:10637427chr16:69419389ENST0000025494201084_287126.33333333333333543.0RegionNote=TRFH dimerization


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1068_EMP2_10637427_TERF2_69419389_1068_EMP2_10637427_TERF2_69419389_ranked_0.pdbEMP21063742610637427ENST00000603068TERF2chr1669419389-
MPRTSRRRTSQHIPLWALNVTPRLDSPCPVKMLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALL
VRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKI
LKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEK
PPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRM
TISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKK
503


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EMP2_pLDDT.png
all structure
all structure
TERF2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EMP2
TERF2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EMP2-TERF2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EMP2-TERF2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource