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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EP300-HAUS8

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EP300-HAUS8
	FusionPDB ID: 26751
	FusionGDB2.0 ID: 26751
		Hgene	Tgene
	Gene symbol	EP300	HAUS8
	Gene ID	2033	93323
	Gene name	E1A binding protein p300	HAUS augmin like complex subunit 8
	Synonyms	KAT3B\|MKHK2\|RSTS2\|p300	DGT4\|HICE1\|NY-SAR-48
	Cytomap	22q13.2	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	histone acetyltransferase p300E1A-associated protein p300E1A-binding protein, 300kDhistone butyryltransferase p300histone crotonyltransferase p300p300 HATprotein 2-hydroxyisobutyryltransferase p300protein propionyltransferase p300	HAUS augmin-like complex subunit 8HEC1/NDC80 interacting, centrosome associated 1HEC1/NDC80-interacting centrosome-associated protein 1Hec1-interacting and centrosome-associated 1sarcoma antigen NY-SAR-48
	Modification date	20200329	20200313
	UniProtAcc	Q09472	Q9BT25
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263253,	ENST00000253669, ENST00000448593, ENST00000593360,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 17 X 12=4080	7 X 8 X 6=336
	# samples	29	7
	** MAII score	log2(29/4080*10)=-3.81444434684392 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/336*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EP300 [Title/Abstract] AND HAUS8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EP300(41513825)-HAUS8(17166812), # samples:3
Anticipated loss of major functional domain due to fusion event.	EP300-HAUS8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EP300-HAUS8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EP300-HAUS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EP300-HAUS8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EP300	GO:0000122	negative regulation of transcription by RNA polymerase II	10733570
Hgene	EP300	GO:0001666	response to hypoxia	9887100\|15261140
Hgene	EP300	GO:0006110	regulation of glycolytic process	29775581
Hgene	EP300	GO:0006355	regulation of transcription, DNA-templated	15261140
Hgene	EP300	GO:0006473	protein acetylation	21030595\|24939902
Hgene	EP300	GO:0006475	internal protein amino acid acetylation	18722353
Hgene	EP300	GO:0010742	macrophage derived foam cell differentiation	26504087
Hgene	EP300	GO:0010976	positive regulation of neuron projection development	27256286
Hgene	EP300	GO:0016573	histone acetylation	25818647\|27256286
Hgene	EP300	GO:0018076	N-terminal peptidyl-lysine acetylation	12435739
Hgene	EP300	GO:0018393	internal peptidyl-lysine acetylation	17403783
Hgene	EP300	GO:0018394	peptidyl-lysine acetylation	23811396\|23962722
Hgene	EP300	GO:0031333	negative regulation of protein complex assembly	23962722
Hgene	EP300	GO:0034644	cellular response to UV	24939902
Hgene	EP300	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17403783
Hgene	EP300	GO:0043627	response to estrogen	11581164
Hgene	EP300	GO:0043923	positive regulation by host of viral transcription	16687403
Hgene	EP300	GO:0043969	histone H2B acetylation	23415232
Hgene	EP300	GO:0045721	negative regulation of gluconeogenesis	30193097
Hgene	EP300	GO:0045815	positive regulation of gene expression, epigenetic	25818647
Hgene	EP300	GO:0045944	positive regulation of transcription by RNA polymerase II	12586840\|18722353\|23811396
Hgene	EP300	GO:0051091	positive regulation of DNA-binding transcription factor activity	10518217\|25818647
Hgene	EP300	GO:0060765	regulation of androgen receptor signaling pathway	18487222
Hgene	EP300	GO:0061921	peptidyl-lysine propionylation	17267393
Hgene	EP300	GO:0090043	regulation of tubulin deacetylation	18722353
Hgene	EP300	GO:0140066	peptidyl-lysine crotonylation	25818647
Hgene	EP300	GO:0140067	peptidyl-lysine butyrylation	17267393\|29775581
Hgene	EP300	GO:1901224	positive regulation of NIK/NF-kappaB signaling	23811396
Hgene	EP300	GO:1905636	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding	23811396

Fusion gene breakpoints across EP300 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HAUS8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-4Z-AA84-01A	EP300	chr22	41513825	-	HAUS8	chr19	17166812	-
ChimerDB4	BLCA	TCGA-4Z-AA84-01A	EP300	chr22	41513825	+	HAUS8	chr19	17166812	-
ChimerDB4	BLCA	TCGA-4Z-AA84	EP300	chr22	41513825	+	HAUS8	chr19	17166812	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263253	EP300	chr22	41513825	+	ENST00000253669	HAUS8	chr19	17166812	-	2680	1948	1219	2535	438
ENST00000263253	EP300	chr22	41513825	+	ENST00000448593	HAUS8	chr19	17166812	-	2648	1948	1219	2535	438
ENST00000263253	EP300	chr22	41513825	+	ENST00000593360	HAUS8	chr19	17166812	-	2643	1948	1219	2535	438

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263253	ENST00000253669	EP300	chr22	41513825	+	HAUS8	chr19	17166812	-	0.007326284	0.9926737
ENST00000263253	ENST00000448593	EP300	chr22	41513825	+	HAUS8	chr19	17166812	-	0.007775414	0.9922246
ENST00000263253	ENST00000593360	EP300	chr22	41513825	+	HAUS8	chr19	17166812	-	0.007857205	0.9921428

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26751_26751_1_EP300-HAUS8_EP300_chr22_41513825_ENST00000263253_HAUS8_chr19_17166812_ENST00000253669_length(amino acids)=438AA_BP=241
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKIEMLSPFEAVATRFKEQYRTFATALDT
TRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQE

--------------------------------------------------------------

>26751_26751_2_EP300-HAUS8_EP300_chr22_41513825_ENST00000263253_HAUS8_chr19_17166812_ENST00000448593_length(amino acids)=438AA_BP=241
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKIEMLSPFEAVATRFKEQYRTFATALDT
TRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQE

--------------------------------------------------------------

>26751_26751_3_EP300-HAUS8_EP300_chr22_41513825_ENST00000263253_HAUS8_chr19_17166812_ENST00000593360_length(amino acids)=438AA_BP=241
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS
PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA
GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKIEMLSPFEAVATRFKEQYRTFATALDT
TRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41513825/chr19:17166812)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EP300 Q09472	HAUS8 Q9BT25
FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250\|UniProtKB:B2RWS6, ECO:0000269\|PubMed:10733570, ECO:0000269\|PubMed:11430825, ECO:0000269\|PubMed:11511361, ECO:0000269\|PubMed:11701890, ECO:0000269\|PubMed:12402037, ECO:0000269\|PubMed:12586840, ECO:0000269\|PubMed:12929931, ECO:0000269\|PubMed:14645221, ECO:0000269\|PubMed:15186775, ECO:0000269\|PubMed:15448695, ECO:0000269\|PubMed:15890677, ECO:0000269\|PubMed:16617102, ECO:0000269\|PubMed:16762839, ECO:0000269\|PubMed:17267393, ECO:0000269\|PubMed:17761950, ECO:0000269\|PubMed:18451878, ECO:0000269\|PubMed:18722353, ECO:0000269\|PubMed:18995842, ECO:0000269\|PubMed:20810990, ECO:0000269\|PubMed:21030595, ECO:0000269\|PubMed:23415232, ECO:0000269\|PubMed:23911289, ECO:0000269\|PubMed:23934153, ECO:0000269\|PubMed:24939902, ECO:0000269\|PubMed:25514493, ECO:0000269\|PubMed:25818647, ECO:0000269\|PubMed:29775581, ECO:0000269\|PubMed:30193097, ECO:0000269\|PubMed:31645732, ECO:0000269\|PubMed:8945521, ECO:0000305\|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269\|PubMed:10545121, ECO:0000269\|PubMed:11080476}.	FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269\|PubMed:18362163, ECO:0000269\|PubMed:19369198, ECO:0000269\|PubMed:19427217}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

11_17

243.0

2415.0

Motif

Nuclear localization signal

Tgene

HAUS8

chr22:41513825

chr19:17166812

ENST00000593360

156_208

154.0

350.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1519_1526

243.0

2415.0

Compositional bias

Note=Poly-Glu

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

2066_2069

243.0

2415.0

Compositional bias

Note=Poly-Gln

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

2190_2195

243.0

2415.0

Compositional bias

Note=Poly-Gln

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

797_800

243.0

2415.0

Compositional bias

Note=Poly-Ser

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1067_1139

243.0

2415.0

Domain

Bromo

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1287_1663

243.0

2415.0

Domain

CBP/p300-type HAT

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

566_645

243.0

2415.0

Domain

KIX

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1017_1029

243.0

2415.0

Region

Note=CRD1%3B mediates transcriptional repression

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1398_1400

243.0

2415.0

Region

Acetyl-CoA binding

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1410_1411

243.0

2415.0

Region

Acetyl-CoA binding

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1572_1818

243.0

2415.0

Region

Note=Binding region for E1A adenovirus

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1664_1707

243.0

2415.0

Zinc finger

ZZ-type

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

1728_1809

243.0

2415.0

Zinc finger

TAZ-type 2

Hgene

EP300

chr22:41513825

chr19:17166812

ENST00000263253

331_417

243.0

2415.0

Zinc finger

TAZ-type 1

Tgene

HAUS8

chr22:41513825

chr19:17166812

ENST00000253669

156_208

215.0

411.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HAUS8

chr22:41513825

chr19:17166812

ENST00000448593

156_208

214.0

410.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>917_EP300_41513825_HAUS8_17166812_917_EP300_41513825_HAUS8_17166812_ranked_0.pdb	EP300	41513825	41513825	ENST00000593360	HAUS8	chr19	17166812	-	MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSS PNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAA GNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKIEMLSPFEAVATRFKEQYRTFATALDT TRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQE	438

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EP300_pLDDT.png

HAUS8_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EP300
HAUS8

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EP300	chr22:41513825	chr19:17166812	ENST00000263253	+	2	31	1397_1399	243.0	2415.0	histone
Hgene	EP300	chr22:41513825	chr19:17166812	ENST00000263253	+	2	31	2003_2212	243.0	2415.0	HTLV-1 Tax
Hgene	EP300	chr22:41513825	chr19:17166812	ENST00000263253	+	2	31	2041_2240	243.0	2415.0	NCOA2

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Related Drugs to EP300-HAUS8

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to EP300-HAUS8

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EP300	C0279626	Squamous cell carcinoma of esophagus	2	CTD_human
Hgene	EP300	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	EP300	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Hgene	EP300	C0005695	Bladder Neoplasm	1	CTD_human
Hgene	EP300	C0006142	Malignant neoplasm of breast	1	CGI;CTD_human;UNIPROT
Hgene	EP300	C0007137	Squamous cell carcinoma	1	CTD_human
Hgene	EP300	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Hgene	EP300	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Hgene	EP300	C0014170	Endometrial Neoplasms	1	CTD_human
Hgene	EP300	C0014518	Toxic Epidermal Necrolysis	1	CTD_human
Hgene	EP300	C0025202	melanoma	1	CTD_human
Hgene	EP300	C0028754	Obesity	1	CTD_human
Hgene	EP300	C0038325	Stevens-Johnson Syndrome	1	CTD_human
Hgene	EP300	C0079772	T-Cell Lymphoma	1	CTD_human
Hgene	EP300	C0149925	Small cell carcinoma of lung	1	CTD_human
Hgene	EP300	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Hgene	EP300	C0376634	Craniofacial Abnormalities	1	CTD_human
Hgene	EP300	C0476089	Endometrial Carcinoma	1	CTD_human
Hgene	EP300	C0678222	Breast Carcinoma	1	CGI;CTD_human
Hgene	EP300	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	EP300	C1274933	Drug-Induced Stevens Johnson Syndrome	1	CTD_human
Hgene	EP300	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	EP300	C3150941	RUBINSTEIN-TAYBI SYNDROME 2	1	GENOMICS_ENGLAND
Hgene	EP300	C3658301	Mycoplasma-Induced Stevens-Johnson Syndrome	1	CTD_human
Hgene	EP300	C3658302	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	1	CTD_human
Hgene	EP300	C4704874	Mammary Carcinoma, Human	1	CTD_human